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2,190 Possible Causes for (MMHCC), , , Beta, Cell, Cell, Endocrine, Islet, Langerhans, Pancreas, of

  • Echovirus

    KEYWORDS: acinar cells; echovirus; enterovirus; inflammation; islet of Langerhans; pancreas; tropism[ncbi.nlm.nih.gov] E4 did not cause any effects on cell lysis, however it was able to replicate in 2 out of 7 islet donors. Beta-cell function was hampered in all infected islets (P[ncbi.nlm.nih.gov] By contrast, E4 replicated in all examined insulinoma cells with no apparent cell destruction.[ncbi.nlm.nih.gov] Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies.[ncbi.nlm.nih.gov] Thus, after attachment to the same cell surface receptor, these closely related viruses enter the same cells by different mechanisms.[ncbi.nlm.nih.gov] These monoclonal antibodies, which prevented virus attachment to specific receptor sites, recognized the alpha and beta subunits of the integrin VLA-2 (alpha 2 beta 1), a[science.sciencemag.org] Generally, TRIO acts as a key component in the regulation of axon guidance and cell migration.[ncbi.nlm.nih.gov] This study aimed to investigate the capability of echovirus strains to infect human exocrine and endocrine pancreatic cells.[ncbi.nlm.nih.gov] Human islets from non-diabetic donors (n 7) were infected with the virus strains E4, E16 and E30, all isolated from patients with aseptic meningitis who seroconverted to islet[ncbi.nlm.nih.gov]

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  • Toxoplasma Gondii

    Pathological examination revealed the presence of T. gondii zoites adjacent to the islets of Langerhans and in pancreatic parenchyma of acutely infected mice.[ncbi.nlm.nih.gov] School of Medicine, Jinan University, Guangzhou, 510632, China. 2 Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 510632, China. 3 Department of Endocrine[ncbi.nlm.nih.gov] She had had pancreas transplantation 2 years previously and had recently completed a course of antirejection medication.[ncbi.nlm.nih.gov] All patients who transmitted T. gondii showed significant changes in the mean levels of immune cells.[ncbi.nlm.nih.gov] Abstract Genetic and pathologic data suggest that amyloid beta (Aβ), produced by processing of the amyloid precursor protein, is a major initiator of Alzheimer's disease ([ncbi.nlm.nih.gov] Direct activation of STAT3 by the parasite enhance anti-inflammatory function of IL-10 and TGF beta.[genome.jp] Furthermore, we assessed the immune response of the primary macrophages by long-term investigation of gene expression of IL-1 beta, IL-12p40, Lipopolysaccharide induced TNF-alpha[ncbi.nlm.nih.gov] By contrast, Toxoplasma-specific T-cell responses were activated by HLA-DR molecules (presumably present on antigen-presenting cells).[ncbi.nlm.nih.gov] […] in a cell type-dependent manner.[ncbi.nlm.nih.gov]

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  • Islet Cell Tumor

    […] that the amyloid protein from insulinoma is derived from islet amyloid polypeptide (or amylin) that is produced by tumor cells originating from beta cells of the islet of Langerhans[ncbi.nlm.nih.gov] BACKGROUND: Islet cell tumor (ICT) metastasis is one of the potentially lethal outcomes of multiple endocrine neoplasia type 1 (MEN 1).[ncbi.nlm.nih.gov] Islet cell tumors are a collective group of neoplasms that arise from the islet cells of the pancreas.[symptoma.com] You are here Home Types of Cancer Neuroendocrine Tumor of the Pancreas Neuroendocrine Tumor of the Pancreas This is Cancer.Net’s Guide to Neuroendocrine Tumor of the Pancreas[cancer.net] It is a rare syndrome caused by non-beta cell islet-cell tumors (gastrinomas) located in or in proximity to the pancreas.[ncbi.nlm.nih.gov] Other names for a pancreatic islet cell tumor are: islet of Langerhans tumor pancreatic endocrine tumor neuroendocrine tumor Islet cell tumors can be either nonfunctional[healthline.com] Alternative Names Islet cell tumors; Islet of Langerhans tumor; Neuroendocrine tumors Causes, Incidence, and Risk Factors In the normal pancreas, cells called islet cells[medicine.georgetown.edu] Abstract A case of multiple nonfunctional pancreatic islet cell tumor in multiple endocrine neoplasia type I (MEN I) is reported.[ncbi.nlm.nih.gov] Abdominal computed tomography showed multiple cysts in the whole pancreas and a calcified solid mass in the pancreatic head.[ncbi.nlm.nih.gov]

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  • Pheochromocytoma-Islet Cell Tumor Syndrome

    Pheochromocytoma and islet cell tumor are endocrine neoplasms that may occur in families harboring mutations leading to von Hippel-Lindau disease (VHL), multiple endocrine[symptoma.com] Marcador principal Enfermedad mayor Otras patologías AFP Carcinoma hepatocelular primario Teratoblastoma de ovario y testículo -HCG Tumores pituitarios ß2M Neoplasia de células beta[infobioquimica.com] Similarly, surgery is the main treatment of islet cell tumors.[symptoma.com] Mieloma múltiple, linfoma de células beta, leucemia linfocítica crónica, enf. de Waldenström CA 15.3 Cáncer de mama Varios carcinomas CA 19.9 Cáncer gástrico y pancreático[infobioquimica.com] PICT patients may present with an islet cell tumor of the pancreas, with pheochromocytoma, or both.[symptoma.com] […] crecimiento insulino simil-1 PSA: antígeno prostático específico VIP:péptido intestinal vasoactivo SCC: antígeno de carcinoma de células escamosas IL-2: interleuquina 2 ß2M: beta[infobioquimica.com] Similarly, surgery is the main treatment of islet cell tumors.[symptoma.com] In any case, signs and symptoms correspond to the local and systemic effects of the endocrine neoplasms.[symptoma.com] PICT patients may present with an islet cell tumor of the pancreas, with pheochromocytoma, or both.[symptoma.com]

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  • Enterovirus Infection

    To this end, we studied the response of human islets of Langerhans upon mock or CVB3 infection.[ncbi.nlm.nih.gov] Autopsy reports have shown that interferon-α was expressed on the surface of beta cells, but not other islet endocrine cells, in patients who died soon after diagnosis of[diapedia.org] CONCLUSIONS/INTERPRETATION: The results show a definite islet-cell tropism of enteroviruses in the human pancreas.[ncbi.nlm.nih.gov] Mice pancreas samples were provided and submitted by the JDRF nPOD-Virus Group (under ethical approvement R13028).[jyx.jyu.fi] These infections appeared to be temporally related to increased percentage of V beta 7 gene transcripts.[ncbi.nlm.nih.gov] […] infections cause or enhance inflammation in genetically predisposed individuals, triggering an interferon (IFN) response and the upregulation of MHC-I molecules in pancreatic endocrine[diabetes.diabetesjournals.org] No CXCL10 was expressed in exocrine pancreas. Serum levels of CXCL10 were increased.[ncbi.nlm.nih.gov] Non-diabetic mothers who had islet autoantibodies (n 365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA[ncbi.nlm.nih.gov] […] primary endothelial cells.[ncbi.nlm.nih.gov]

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  • Nesidioblastosis

    […] examination of the pancreas revealed that the cause of hyperinsulinemic hypoglycemia was nesidioblastosis characterized by the presence of enlarged, irregular islets of Langerhans[ncbi.nlm.nih.gov] Abstract A patient is described in whom a small 0.8-mm-diameter endocrine tumor was found in association with localized pancreatitis, stricture of the main pancreatic duct[ncbi.nlm.nih.gov] Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 /- 6.4 vs. control islets, from cadaveric organ normal[ncbi.nlm.nih.gov] Key Words: Pancreas ; Persistent neonatal hypoglycemia ; Nesidioblastosis ; Pathogenesis[jpatholtm.org] These findings may be related to local tissue hypoxia and/or increased metabolic energy needs in sickle cell disease.[ncbi.nlm.nih.gov] Among the various indicators of islet changes, beta-cell hypertrophy characterized by enlarged and hyperchromatic beta-cell nuclei was the most significant and diagnostic[ncbi.nlm.nih.gov] It is caused by hypertrophy and hyperplasia of the islands of Langerhans, and can lead to persistent hyperinsulinemic hypoglycemia.[ncbi.nlm.nih.gov] We describe a report of adult nesidioblastosis in association with a pancreatic endocrine microadenoma.[ncbi.nlm.nih.gov] The endocrine microadenoma and nesidioblastosis stained for insulin, suggesting both likely contributed to hypoglycemia.[ncbi.nlm.nih.gov]

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  • Calcitonin

    The neuroimmune dialogue between peripheral neurons and Langerhans cells (LCs) within mucosal epithelia protects against incoming pathogens.[ncbi.nlm.nih.gov] BACKGROUND: Although pancreatic endocrine tumor can produce a variety of hormones, few pancreatic tumors produce a high systemic calcitonin concentration.[ncbi.nlm.nih.gov] Abstract Verner-Morrison syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide-secreting islet[ncbi.nlm.nih.gov] Investigation revealed hypercalcemia, hyperphosphatemia, hypercalcitonemia and a well-defined mass in the head of the pancreas on CT scan.[ncbi.nlm.nih.gov] In all patients, complete remission of the giant cell granuloma was observed, without signs of recurrence.[ncbi.nlm.nih.gov] METHODS: The expression of CT, transforming growth factor-beta 1(TGF-β1) and bone morphogenetic protein (BMP) in gingival crevicular fluid (GCF) was measured by ELISA.[ncbi.nlm.nih.gov] Abstract We present an unusual case of a 52-year-old woman with severe, uncontrollable, refractory diarrhea attributable to pancreatic endocrine carcinoma (ECA) with markedly[ncbi.nlm.nih.gov] Islet amyloid polypeptide (IAPP) [ PMID: 2407732 ] (also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated[ebi.ac.uk] KEYWORDS: amyloid beta-peptides; aromatic interactions; crystal structures; iodination; peptides[ncbi.nlm.nih.gov]

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  • Graft Rejection

    الصفحة 37 - An electron microscope study of basal melanocytes and high-level clear cells (Langerhans cells) in vitiligo. ‏[books.google.com] ) lost their grafts because of chronic rejections, and 2 patients still had impaired endocrine function.[diabetes.diabetesjournals.org] In Group2, with an increased number of transplanted islets in the presence of BMX-001, more healthy insulin-positive islet masses were obtained at biopsy and necropsy (4 weeks[ncbi.nlm.nih.gov] […] solitary pancreas recipients.[ncbi.nlm.nih.gov] KEYWORDS: FFPE kidney biopsies; chronic T cell-mediated rejection; effector memory T cells; transcriptomics[ncbi.nlm.nih.gov] Beta-catenin balances immunity. Science 329: 767-769.[omicsonline.org] Although the surgical expertise for the transplantation of skin, kidneys, heart, lungs, liver, spleen, bone marrow, and endocrine organs is now well in hand, it outpaces thus[humpath.com] Islet transplantation has been hampered by inefficient islet isolation techniques, which are timeconsuming and yield low islet numbers from each donor pancreas.[surgwiki.com] The heterogeneity of the monocyte/macrophage lineage cells could be one of the reasons why these cells have been neglected up to now.[ncbi.nlm.nih.gov]

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  • Ischemic Stroke

    Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by a xanthogranulomatous infiltration of tissues by spumous histiocytes.[ncbi.nlm.nih.gov] K ATP channels mediate insulin secretion in pancreatic islet beta cells, and controlling vascular tone.[ncbi.nlm.nih.gov] […] to assist the cell-based therapy.[ncbi.nlm.nih.gov] Treatment for thyroid storm with beta-blocker, glucocorticoid, and potassium iodide-iodine was started and MR venography was performed on hospital day 3 for further evaluation[ncbi.nlm.nih.gov] KEYWORDS: Ischemic stroke; Mesenchymal stem cells; Stem cells; Transplantation[ncbi.nlm.nih.gov] Meandering of the left temporal artery (TA) with induration and high inflammatory responses (white blood cell count 22,500 per microliter, C-reactive protein 35.0 mg/dL, and[ncbi.nlm.nih.gov] Abstract ATP-sensitive potassium (K ATP ) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain.[ncbi.nlm.nih.gov] However, ischemia-induced spontaneous neurogenesis is not suffcient, thus cell-based therapy, including infusing exogenous stem cells or stimulating endogenous stem cells[ncbi.nlm.nih.gov] In the field of regenerative medicine, mesenchymal stem cells (MSCs) have an increasingly prominent position due to their advantages of multiple differentiation, low immunogenicity[ncbi.nlm.nih.gov]

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  • Theophylline

    Abstract In vitro research in the field of type I diabetes is frequently limited by the availability of a functional model for islets of Langerhans.[ncbi.nlm.nih.gov] Therefore, theophylline causes havoc to body’s endocrine system (a network of biochemical signaling systems integrated by hormones) that is necessary for maintaining bone[atlasofscience.org] Acta Diabetologica Latina (1989) 24-h blood glucose pattern in type I and type II diabetics after oral treatment with pentoxifylline as assessed by artificial endocrine pancreas[nature.com] […] for gene- and cell-based therapies in the future.[ncbi.nlm.nih.gov] Abstract It has been proposed that beta-blocker therapy reverses metabolic and cardiovascular disorders in acute theophylline poisoning.[ncbi.nlm.nih.gov] Many patients with chronic obstructive pulmonary disease continue to experience significant functional limitation despite the use of both long-acting anticholinergic and beta-agonist[ncbi.nlm.nih.gov] Of these, 29 study arms included an active control, such as adrenaline, beta-2 agonists, or leukotriene receptor antagonists, and 23 study arms compared theophylline (with[ncbi.nlm.nih.gov] Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low[ncbi.nlm.nih.gov] In this study, we observed that TINCR was up-regulated in bladder cancer tissues and cells and contributed to oncogenesis and cancer progression.[ncbi.nlm.nih.gov]

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