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4,842 Possible Causes for (PP2C, 1J, containing), domain, phosphatase, protein

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  • Lafora Disease

    Cumulatively, our data suggest that laforin monomer is the dominant form of the protein and that it contains phosphatase activity.[ncbi.nlm.nih.gov] EPM2A encodes a 331-amino acid protein containing a carboxyl-terminal phosphatase catalytic domain.[ncbi.nlm.nih.gov] Binary interactions i GO - Molecular function i identical protein binding Protein-protein interaction databases Structure i 3D structure databases Family & Domains i Phylogenomic[expasy.org] The database, which currently contains 66 entries is accessible on the World Wide Web ().[ncbi.nlm.nih.gov] domain (DSPD).[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov]

    Missing: (PP2C 1J
  • Influenza

    Containment is unlikely if R 0 exceeds 1.8 for the new pandemic strain.[doi.org] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] However, the extracellular domain of the minor, virus-coded M2 protein is nearly invariant in all influenza A strains.[doi.org] Thereafter, alkaline phosphatase-labeled goat anti-mouse antibodies to IgG, IgM, and IgA (Southern Biotechnology Associates, Inc.) were added at room temperature for 2 h,[doi.org] The predicted membrane-spanning domains of A/M2 and BM2 are 20 amino acids long, and the N-terminal domain of the BM2 protein (7 residues) is shorter than that of the A/M2[doi.org] Other interventions aimed at reducing population contact rates are also examined as reinforcements to an antiviral-based containment policy.[ncbi.nlm.nih.gov]

    Missing: (PP2C 1J
  • Helicobacter Pylori

    TerY-P triad is composed by three genes: TerY, STY Kinase, and PP2C.[doi.org] However, binding to the N-domain alone was weaker than to the N-A1-B CEACAM1 variant, which bound less than the N-A1-B-A2 variant ( Fig. 1e and Supplementary Fig. 1j ), suggesting[nature.com] Regular intake of yogurt containing Bb12 and La5 effectively suppressed H. pylori infection in humans.[ncbi.nlm.nih.gov] Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis . Blood 103 , 2325–2331 (2004).[doi.org] METHODS: PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia[ncbi.nlm.nih.gov] A novel series of aniline-containing hydroxamic acids were designed, synthesized and evaluated as anti-virulence agents for the treatment of gastritis and gastric ulcer caused[ncbi.nlm.nih.gov]

  • Hepatitis C Virus

    Murphy , Full-length genomes of 16 hepatitis C virus genotype 1 isolates representing subtypes 1c, 1d, 1e, 1g, 1h, 1i, 1j and 1k, and two new subtypes 1m and 1n, and four[doi.org] These proteins contain a large N-terminal ectodomain and a C-terminal transmembrane domain, and they assemble as a noncovalent heterodimer.[ncbi.nlm.nih.gov] […] genetics Dual-Specificity Phosphatases/metabolism* Exoribonucleases/genetics Exoribonucleases/metabolism* Gene Knockout Techniques Genome, Viral Hepacivirus/pathogenicity[ncbi.nlm.nih.gov] domain of VAPB, with an average dissociation constant (Kd) of 5 µM. 2).[ncbi.nlm.nih.gov] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[ncbi.nlm.nih.gov] NS3 also contains an RNA helicase domain at its C-terminus. NS3 forms a heterodimeric complex with NS4A.[ncbi.nlm.nih.gov]

    Missing: (PP2C
  • Rubella Virus

    Five genotypes were identified: 1E, 2B, 1J, 1I, and 1a.[ncbi.nlm.nih.gov] The virus structural proteins contain all of the information necessary to mediate the assembly of virus-like particles in the Golgi complex.[ncbi.nlm.nih.gov] To increase the affinity of capsids for RNA, samples were first treated with phosphatase prior to binding analyses ( 31 ).[ncbi.nlm.nih.gov] This finding was of interest because p32 protein also binds to the RUBV capsid protein.[ncbi.nlm.nih.gov] The RUB genomic RNA contains two long open reading frames (ORFs), a 5'-proximal ORF of 6656 nucleotides and a 3'-proximal ORF of 3189 nucleotides which encodes the structural[ncbi.nlm.nih.gov] Only viral RNA of genotype 1j was detected in both isolates and clinical specimens.[ncbi.nlm.nih.gov]

    Missing: (PP2C
  • Mulibrey Nanism Syndrome

    TRIM37 may be regulated at translational level. 18 In the complementary strand, partly overlapping the 3′ UTR of TRIM37 is the 3′ end of PPMIE , a gene belonging to the PP2C[nature.com] 1FF; 613286; TNNI3 Cardiomyopathy, dilated, 1G; 604145; TTN Cardiomyopathy, dilated, 1GG; 613642; SDHA Cardiomyopathy, dilated, 1I; 604765; DES Cardiomyopathy, dilated, 1J[howlingpixel.com] Genes involved and Proteins Gene Name TRIM37 (tripartite motif-containing 37) Alias Tripartite Motif Containing 37 MUL Tripartite Motif-Containing Protein 37 RING-B-Box-Coiled-Coil[atlasgeneticsoncology.org] ., 2001, MIDI, mutated in Opitz symdrome encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nat. Genet. 29 :287–294.[link.springer.com] TRIM37 contains a tripartite motif and a MATH domain C-terminal to the coiled-coil domain.[ebi.ac.uk] […] phosphate, triglycerides, cholesterol, thyroid-stimulation hormone (TSH), parathyroid hormone (PTH), alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase[academic.oup.com]

  • Entamoeba Histolytica

    Ac and Eh seem to expand different types of protein phosphatases: 2C domain containing phosphatases (PP2C domain) are more typical for Eh (seven gene copies, while only one[ijbs.com] However, it remains unknown whether the E. histolytica mitosomes also partially contain the NIF system.[pnas.org] Abstract Protein tyrosine phosphatase of regenerating liver (PRL) is a group of phosphatases that has not been broadly studied in protozoan parasites.[ncbi.nlm.nih.gov] […] and Ca( ) Here, we show that carbohydrate recognition domain (CRD) of the lectin binds to calcium through DPN motif.[ncbi.nlm.nih.gov] KEYWORDS: ALIX family proteins; EhADH; Entamoeba histolytica; cysteine proteases; molecular dynamics simulation; proteinprotein docking[ncbi.nlm.nih.gov] Abstract The versatility in the recognition of various interacting proteins by the SH3 domain drives a variety of cellular functions.[ncbi.nlm.nih.gov]

    Missing: 1J
  • Oculocerebrorenal Syndrome

    DXS42 was mapped to the derivative chromosome X containing Xpterq25, and DXS10 was mapped to the derivative chromosome 3 containing Xq25-qter.[ncbi.nlm.nih.gov] Abstract Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking.[ncbi.nlm.nih.gov] We have recently determined the X-ray structure of the Rab-binding domain of OCRL1 in complex with Rab8.[doi.org] References "The Lowe's oculocerebrorenal syndrome gene encodes a protein highlyhomologous to inositol polyphosphate-5-phosphatase."[genscript.com] In one lens containing congenital-like riders a posterior subcapsular cataract had developed.[ncbi.nlm.nih.gov] […] identification of additional tightly linked flanking markers extends the number of markers available for use in genetic counseling and begins to define the physical map of the region containing[ncbi.nlm.nih.gov]

    Missing: (PP2C 1J
  • Usher Syndrome Type 1J

    Term Name: Usher syndrome type 1J Search Ontology: Synonyms: USH1J Usher syndrome type IJ Definition: An Usher syndrome type 1 that has_material_basis_in caused by homozygous[zfin.org] The calyceal processes were virtually absent in cones and displayed markedly reduced F-actin content in rods, suggesting that protocadherin-15-containing links are essential[f1000.com] Adenosindesaminase Adenosindesaminase im Punktat Adiponektin ADMA Adrenalin im Urin AFP im Fruchtwasser AH-100 ALAT (Alanin-Aminotransferase) Albumin Aldolase Alkalische Phosphatase[laborberlin.com] MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumour suppressor has been put forward.[ebi.ac.uk] The State of Victoria and the Department of Health & Human Services shall not bear any liability for reliance by any user on the materials contained on this website.[betterhealth.vic.gov.au] Here, we report that mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J[ncbi.nlm.nih.gov]

    Missing: (PP2C
  • Bacillus Subtilis

    A PP2C phosphatase containing a PAS domain is required to convey signals of energy stress to the ς B transcription factor of Bacillus subtilis . Mol.[ncbi.nlm.nih.gov] Compared to BSAP-254, the molar ratios of Asp or Asn, Ser, Val, and Leu were different and only AMP IC-1 contained Arg, but not Trp.[ncbi.nlm.nih.gov] The alkaline phosphatase assay of rhBMP2 (0, 50, 100, 200, and 400 ng/ml) was analyzed on C2C12 cells and maximum 200 ng/ml activity was observed in dose dependent manner.[ncbi.nlm.nih.gov] This prompted us to re-analyse cardiolipin domains also in the Gram-positive model organism Bacillus subtilis .[biorxiv.org] . yloA of the model bacterium Bacillus subtilis shows high homology to genes encoding fibronectin-binding proteins of Gram-positive pathogens.[ncbi.nlm.nih.gov] Sequence and structure comparisons with proteins from eukaryotes, prokaryotes, and archaea suggest that YndB is very similar to the eukaryote protein Aha1, which binds to[ncbi.nlm.nih.gov]

    Missing: 1J