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8,238 Possible Causes for (PTPRF, domain, functional, human, interacting), protein,, triple

Did you mean: (PTPRF, domain, functional, human, interacting), proteus, triple

  • Influenza

    McKimm-Breschkin , Influenza Virus Neuraminidase Structure and Functions , Frontiers in Microbiology , 10.3389/fmicb.2019.00039 , 10 , (2019) .[dx.doi.org] More information is available on FluView Interactive at .[cdc.gov] This report describes a triple-reassortant influenza A virus with a HA that resembles H3 of human seasonal influenza from 2004 to 2005, N2 from influenza A virus already established[ncbi.nlm.nih.gov] However, the extracellular domain of the minor, virus-coded M2 protein is nearly invariant in all influenza A strains.[doi.org] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] Content-negotiable representations Turtle (text/turtle) JSON-LD (application/ld json) RDF/XML (application/rdf xml) N-TRIPLES (text/plain) HTML RDFa (text/html)[worldcat.org] We here review the major progress that has been made in recent years in unravelling the structure and functions of this protein complex, enabling structure‐aided drug design[doi.org]

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  • Hepatitis C Virus

    These results suggest that membrane fluidity is important for the function of the membranous web.[nature.com] The various molecular interactions of hepatitis C virus proteins with the membranes and lipids of the infected cell highlight how a virus can exploit the diversity of interactions[ncbi.nlm.nih.gov] Eight (100%) patients had previously failed PEG/RBV dual therapy at least once in addition to prior failure with triple therapy.[ncbi.nlm.nih.gov] domain of VAPB, with an average dissociation constant (Kd) of 5 µM. 2).[ncbi.nlm.nih.gov] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[ncbi.nlm.nih.gov] They also cannot easily be reconciled with the recent evidence for species–associated variants of HBV and HGV/GBV–C in a range of non–human primates.[doi.org] Combined with protein interaction data, these results suggest that NS2 interacts with NS3 and NS5A in replication complexes adjacent to LDs and also interacts with envelope[ncbi.nlm.nih.gov]

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  • Werner Syndrome

    Characterization and study of the Werner protein (WRN) suggests that it participates in several important DNA metabolic pathways, and that its primary function may be in DNA[ncbi.nlm.nih.gov] We mapped the interaction between XPG and WRN to the C-terminal domains of each, and show that interaction with the C-terminal domain of XPG strongly stimulates WRN helicase[ncbi.nlm.nih.gov] Proc-Natl-Acad-Sci-U-S-A. 2001 Mar 13; 98(6): 3174-9 Brosh,-R-M Jr; Majumdar,-A; Desai,-S; Hickson,-I-D; Bohr,-V-A; Seidman,-M-M Unwinding of a DNA triple helix by the Werner[malattierare.regione.veneto.it] Three of the amino acids in the WRN RQC domain that exhibited the largest G4-specific changes in NMR signal were then mutated alone or in combination.[ncbi.nlm.nih.gov] Here we report that the WS protein does indeed catalyze DNA unwinding.[ncbi.nlm.nih.gov] To examine the expression and distribution of WRN proteins in the retinas, immunohistochemistry for WRN proteins was performed in human retinas.[ncbi.nlm.nih.gov] It appears that the central function of WRN is in DNA repair.[doi.org]

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  • LIG4 Syndrome

    To better characterize the physical and functional interactions between XRCC4 and LigIV, we determined the crystal structure of a functional fragment of human XRCC4, consisting[mcb.asm.org] Triple-staining for BrdU, TUNEL, and Tuj1 demonstrated that BrdU treatment alone did not induce apoptosis ( Fig. 7 c ).[jneurosci.org] DNA ligase IV has a conserved ligase domain at its N-terminal and two C-terminal BRCT domains.[academic.oup.com] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org] The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.[humpath.com] We have generated a knock-in mouse model with a homozygous Lig4 R278H mutation that corresponds to the first LIG4 mutation reported in humans.[ncbi.nlm.nih.gov] Cerebellar Ataxia Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress.[brenda-enzymes.org]

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  • Lafora Disease

    Analyses of LD patient mutations define the mechanism by which subsets of mutations disrupt laforin function.[ncbi.nlm.nih.gov] […] i Subunit structure i Interacts with EPM2A.[expasy.org] Content-negotiable representations Turtle (text/turtle) JSON-LD (application/ld json) RDF/XML (application/rdf xml) N-TRIPLES (text/plain) HTML RDFa (text/html)[worldcat.org] EPM2A encodes a 331-amino acid protein containing a carboxyl-terminal phosphatase catalytic domain.[ncbi.nlm.nih.gov] We have developed a human LD mutation database using a new generic biological database cross‐referencing platform.[doi.org] These data suggest that in addition to forming a functional complex, laforin and perhaps malin may also have independent functions.[ncbi.nlm.nih.gov] domain (DSPD).[ncbi.nlm.nih.gov]

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  • Nephronophthisis 4

    Functional characterization of the gene (NPHP4) causing nephronophthisis type 4.[grantome.com] We demonstrated the interaction of nephrocystin-4 with nephrocystin suggesting that these two proteins participate in a common signaling pathway.[ncbi.nlm.nih.gov] In general, sensitivity for single, double, or triple exon CNVs is 70% and for CNVs of four exon size or larger is 95%, but may vary from gene-to-gene based on exon size,[preventiongenetics.com] Analysis of nephrocystin amino acid sequences from human and other species revealed three distinct conserved domains including Src homology 3 and coil-coil domains in the[doi.org] 21555462 NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway Habbig, S , Bartram, MP , Müller, RU , Schwarz, R , Andriopoulos, N , Chen, S , Sägmüller[reactome.org] The organelles of human cells include: mitochondria, endoplasmic reti...[ncbi.nlm.nih.gov] […] juvenile) homolog (human) (Nphp4) 4930564O18Rik protein nmf192 protein NPHP4 protein POC10 protein SLSN4 protein Protein level used designations for Nephronophthisis 4 Proteins[antibodies-online.com]

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  • Treponema Denticola

    In order to analyze the functions of LrrA in T. denticola, an lrrA-inactivated mutant of strain ATCC 35405 and an lrrA gene expression transformant of strain ATCC 33520 were[ncbi.nlm.nih.gov] An interaction effect was significantly detected between these three variables.[ncbi.nlm.nih.gov] Two triple mutants of P. gingivalis lacking Arg-gingipain A (RgpA), Lys-gingipain (Kgp) and Hemagglutinin A (HagA) or RgpA, Arg-gingipain B (RgpB) and Kgp showed significantly[ncbi.nlm.nih.gov] In total, 219 non-redundant proteins were identified including numerous virulence factors, lipoproteins, ABC transporter proteins and enzymes involved in the metabolism of[ncbi.nlm.nih.gov] Individual human sera showed specificity for one or more Msp types.[ncbi.nlm.nih.gov] Treponomics: Treponema denticola Genome and Functions, p 149-161. In Kolenbrander P (ed), Oral Microbial Communities .[asmscience.org] We will achieve this goal by carrying out two specific aims: (1) Determine how LOS biosynthesis and assembly is modulated in the TDE1418 mutant. (2) Assess the functional[grantome.com]

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  • Dengue Virus

    The functions of many viral proteins are poorly understood.[ncbi.nlm.nih.gov] NS4A-NS4B interaction.[doi.org] A Triple Threat Ashley P. Taylor May 22, 2017 The mosquitoes that carry Zika may be able to transmit two other viruses at the same time.[the-scientist.com] ED3 domain for the detection of IgMs against DENV.[ncbi.nlm.nih.gov] The non-structural protein (NS) 4A is one of the least characterized DV proteins.[ncbi.nlm.nih.gov] In the present study, we have demonstrated that primary human naive CD4 and CD8 T cells are permissive for DV infection.[ncbi.nlm.nih.gov] Content-negotiable representations Turtle (text/turtle) JSON-LD (application/ld json) RDF/XML (application/rdf xml) N-TRIPLES (text/plain) HTML RDFa (text/html)[worldcat.org]

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  • Bloom Syndrome

    In contrast, expression of RecG has no impact on either of these phenotypes in human cells with functional BLM protein.[ncbi.nlm.nih.gov] Here, we report a physical and functional interaction between BLM and WRN.[ncbi.nlm.nih.gov] Here we show that purified Bloom and Werner helicases can unwind a DNA triple helix.[ncbi.nlm.nih.gov] Structural similarities to bacterial DNA helicases suggest that the HRDC domain functions as an auxiliary domain in RecQ helicases.[ncbi.nlm.nih.gov] PRKAR1A and other protein kinase A (PKA) subunits were expressed in Bloom syndrome cells and their level of expression differed by subunit and cell type.[ncbi.nlm.nih.gov] […] overexpression was significantly associated with high histologic grade, larger tumor size, estrogen receptor-negative (ER(-)), progesterone receptor-negative (PR(-)), and triple-negative[ncbi.nlm.nih.gov] Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases Brosh-RM; Majumdar-A; Desai-S; Hickson-ID; Bohr-VA; Seidman-MM JOURNAL-OF-BIOLOGICAL-CHEMISTRY.[malattierare.regione.veneto.it]

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  • Human Albumin

    Abstract Adequate intravascular volume maintenance is essential to ensure early graft function during renal transplantation.[ncbi.nlm.nih.gov] This led to the hypothesis that the used proinflammatory cytokines may interact with albumin.[ncbi.nlm.nih.gov] Acute Liver Failure In acute liver failure, AlbuRx 25, Albumin (Human) 25% solution may serve the triple purpose of stabilizing the circulation, correcting an oncotic deficit[globalrph.com] Abstract Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential[ncbi.nlm.nih.gov] […] followed by proteomics identified this protein as CUG binding protein 1 (CUG-BP1, also known as CELF1).[ncbi.nlm.nih.gov] Discover the range of Biowest Human Origin Products : Human Serum HIV tested, Human Serum AB male HIV tested, pooled Human Plasma, Human Serum Albumin.[biowest.net] Sites of vapor TDI conjugation to albumin were quantitatively limited compared with those recently described for liquid phase TDI, especially in domains IIA and IIIB of albumin[ncbi.nlm.nih.gov]

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