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682 Possible Causes for (S) Isomer, Monohydrochloride,, Topotecan

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  • Topotecan

    Abstract Topotecan undergoes both renal and hepatic elimination, with topotecan urinary recovery ranging from 60 to 70%.[ncbi.nlm.nih.gov] View PDF IUPAC: (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione monohydrochloride Usage: Topotecan[cancerquest.org] […] sarcoma. 1 , 2 Technical Information Formal Name 10- [(dimethylamino)methyl]- 4S- ethyl- 4,9- dihydroxy- 1H- pyrano[3’,4’:6,7]indolizino[1,2- b]quinoline- 3,14(4H,12H)- dione, monohydrochloride[caymanchem.com]

    Missing: (S) Isomer
  • Irinotecan

    […] activity than both topotecan and irinotecan in NCI-H1048 tumors that had progressed on previous carboplatin plus etoposide treatment.[ncbi.nlm.nih.gov] Name [1,4'-bipiperidine]-1'- carboxylic acid, (4S)- 4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo -1H-pyrano[3',4':6,7] indolizino[1,2-b] quinolin-9-yl ester, monohydrochloride[caymanchem.com] Serious adverse events were reported in two patients in the topotecan group and seven patients in the combination group.[oncologypro.esmo.org]

    Missing: (S) Isomer
  • Doxorubicin

    Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer . J Clin Oncol 1999 ; 17 : 658 – 667 .[academic.oup.com] 10S)- 10- [(3- amino- 2,3,6- trideoxy- α- L- lyxo- hexopyranosyl)oxy]- 7,8,9,10- tetrahydro- 6,8,11- trihydroxy- 8- (2- hydroxyacetyl)- 1- methoxy- 5,12- naphthacenedione, monohydrochloride[caymanchem.com] For ovarian cancer, Caelyx was as effective as topotecan in extending time until the disease got worse.[ema.europa.eu]

    Missing: (S) Isomer
  • Oxyphencyclimine

    The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes.[ncbi.nlm.nih.gov] Benzeneacetic Acid, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl Ester, Monohydrochloride 72.[pharmacompass.com] Order: 1G Purity: 98% Supply Ability: 100KG OXYPHENCYCLIMINE Basic information Product Name: OXYPHENCYCLIMINE Synonyms: dominil ; enterex ; inyl)methylester,monohydrochloride[chemicalbook.com]

    Missing: Topotecan
  • Mecamylamine

    In vivo studies suggested that the R-isomer might be somewhat more potent than the S isomer at blocking CNS effects of nicotine.[ncbi.nlm.nih.gov] […] be of use in various nicotine- responsive, neuropsychiatric disorders. 1 , 2 , 3 Technical Information Formal Name N,2,3,3- tetramethyl- bicyclo[2.2.1]heptan- 2- amine, monohydrochloride[caymanchem.com] […] appeared to be significant differences in the off-rates for the mecamylamine isomers from the receptors.[ncbi.nlm.nih.gov]

    Missing: Topotecan
  • Methadone

    Methadone is a racemic mixture; the L isomer has approximately 50 times higher affinity for the opioid receptors than the S isomer. 1,3 In addition to its affinity for the[practicalpainmanagement.com] RMs and CRMs produced to accreditation standards: ISO/IEC 17025:2005 · ISO Guide 34:2009 Technical Information Formal Name 6- (dimethylamino)- 4,4- diphenyl- 3- heptanone, monohydrochloride[caymanchem.com]

    Missing: Topotecan
  • Ondansetron

    […] clindamycin, cyclophosphamide, cytarabine, dactinomycin, dopamine, heparin, hydromorphone, magnesium sulfate, meperidine, morphine sulfate, paclitaxel, potassium chloride, topotecan[reference.medscape.com] ISO/IEC 17025:2005 · ISO Guide 34:2009 Technical Information Formal Name 1,2,3,9- tetrahydro- 9- methyl- 3- [(2- methyl- 1H- imidazol- 1- yl)methyl]- 4H- carbazol- 4- one, monohydrochloride[caymanchem.com]

    Missing: (S) Isomer
  • Anticonvulsant

    Topotecan treatment of adults with primary malignant glioma. Proc Am Soc Clin Oncol 1998; 17 : 390A. Abstract. Chang TK, Chen G, Waxman DJ.[neurology.org] (11) with a ED 50 value of 75.9 mg kg -1 (MES test) and N-[{4-(3,4-dichlorophenyl)piperazin-1-yl}ethyl]-3-methylpyrrolidine-2,5-dione monohydrochloride (18) with ED 50 88.2[ncbi.nlm.nih.gov] […] cytochrome P450 enzyme system results in markedly accelerated metabolism of a wide spectrum of chemotherapeutic agents including nitrosoureas, paclitaxel, cyclophosphamide, topotecan[neurology.org]

    Missing: (S) Isomer
  • Teniposide

    Bristol-myers brand OF teniposide MeSH Bristol-myers squibb brand OF teniposide MeSH Demethyl epipodophyllotoxin thenylidine glucoside MeSH Teniposide, (5a alpha,9 alpha(s*[hmdb.ca] ; Uracil yTegafur; Ritonavir; Tenipósido 3 3004.20.62 Daunorubicina 3 3004.39.26 Octreotida 3 3004.50.60 Acido retinoico (Tretinoína) 3 3004.90.78 Topotecan; Uracil y Tegafur[sice.oas.org] Topoisomerase I inhibitors: Ironotecan, topotecan Topoisomerase II inhibitors: Amsacrine, etoposide, etoposide phosphate, teniposide Note: We strongly encourage you to talk[chemocare.com]

    Missing: Monohydrochloride
  • Etomidate

    R and S- isomers: only the R isomer is anesthetically active (5 times as potent as S- isomer) Is etomidate stable at room temperature?[quizlet.com] R 8110 109872-40-4 1H- Imidazole- 5- carboxylic acid, 1- (1- (4- fluorophenyl)ethyl)- , ethyl ester, monohydrochloride Etomidate/*analogs & derivatives.[reference.md] R( ) * R( ) has 5 times the potency as S(-) Pharmacodynamics Mechanisms of action Etomidate is a relatively selective modulator of GABAa receptor -- Binds directly to site[ld99.com]

    Missing: Topotecan