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252 Possible Causes for (S) isomer, 2 (N,N dipropyl)amino 5,6 dihydroxytetralin

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  • Zileuton

    3.4-fold greater for the S-isomer (5.2 /- 0.7).[ncbi.nlm.nih.gov] Zileuton Catalogue number: Z420000 Chemical name: Zileuton Synonyms: N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyurea; A-64077; Abbott 64077; Leutrol; Zyflo; Impurity: CAS Number[trc-canada.com] […] chemical compound A-64077 ZYFLO Leutrol N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea ( -)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea[wikidata.org] […] of warfarin metabolism and clearance is mainly affected by zileuton, while the S -isomer is not (because of metabolism via different enzymes).[en.wikipedia.org]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Phenylbutazone

    In warfarin and human serum albumin mixed solution, the unbound concentration of (R)-warfarin was 1.22 times higher than that of the S-isomer.[ncbi.nlm.nih.gov] […] phen·yl·bu·ta·zone \ ˌfe-nᵊl-ˈbyü-tə-ˌzōn \ Definition of phenylbutazone : a drug C 19 H 20 N 2 O 2 that is used for its analgesic and anti-inflammatory properties especially[merriam-webster.com] […] of the R isomer.[jci.org] To a 30-mL portion of the filtrate add 1 mL of 2 N nitric acid and 1 mL of silver nitrate TS : the filtrate shows no more chloride than corresponds to 0.10 mL of 0.020 N hydrochloric[pharmacopeia.cn]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Oxyphencyclimine

    The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes.[ncbi.nlm.nih.gov] Derivative Type: Hydrochloride CAS Registry Number: 125-52-0 Molecular Formula: C 20 H 28 N 2 O 3 .HCl Molecular Weight: 380.91 Percent Composition: C 63.06%, H 7.67%, N 7.35%[drugfuture.com] (2 (di … Wikipedia Diisopromine — Systematic (IUPAC) name N,N diisopropyl 3,3 diphenylpropan 1 amine Clinical data Pregnancy cat. ?[medicine.academic.ru] :DUDKAZCAISNGQN-UHFFFAOYSA-N (what is this?)[wikinow.co]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Opiate Addiction

    Steady-state pharmacokinetic values for total, (R)- (active) and (S)- (inactive) isomers of methadone were derived from plasma concentrations versus time data.[ncbi.nlm.nih.gov] Lingford-Hughes A 1 , Myers J 2 , Watson B 3 , Reid AG 3 , Kalk N 2 , Feeney A 4 , Hammers A 5 , Riaño-Barros DA 5 , McGinnity CJ 5 , Taylor LG 6 , Rosso L 5 , Brooks DJ 7[ncbi.nlm.nih.gov] Aliabadi A, Andisheh S, Tayarani-Najaran Z,Tayarani-Najarand M (2013) 2-(4-Fluorophenyl)-N-phenylacetamide Derivatives as Anticancer Agents: Synthesis and In-vitro Cytotoxicity[colorectal-cancer.imedpub.com]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Ceftazidime

    isomer of ofloxacin, with intravenous ceftazidime in the empirical treatment of acute exacerbations of bronchiectasis.[erj.ersjournals.com] 221) and bla KPC-2 ( n 145), respectively.[ncbi.nlm.nih.gov] , 0.25/1 μg/ml; 99.2% susceptible), extensively drug-resistant (XDR; n 448; MIC 50/90 , 0.5/2 μg/ml; 97.8% susceptible), and CRE ( n 513; MIC 50/90 , 0.5/2 μg/ml; 97.5% susceptible[ncbi.nlm.nih.gov] Ceftazidime-avibactam was very active against P. aeruginosa ( n 3,402; MIC 50 /MIC 90 , 2 and 4 μg/ml; 96.6% susceptible), including isolates nonsusceptible to meropenem ([ncbi.nlm.nih.gov]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Agranulocytosis

    Abstract We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole.[ncbi.nlm.nih.gov] Pharmacogenetics testing showed that he was a carrier of NAT2 *5/*6 genotype, predisposing to low activity of the N-acetyltransferase 2 enzyme.[ncbi.nlm.nih.gov] Automatic linear modeling (n 56, R 2 45.2%) showed a significant inverse association with platelets (R 2 17.5%), hemoglobin, and alanine transaminase, and a direct association[ncbi.nlm.nih.gov] In der weitergehenden Labordiagnostik zeigte sich bei der Patientin eine extreme Aktivitätsminderung der N-Azetyltransferase 2, dem wichtigsten Dapson metabolisierenden Enzym[link.springer.com]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Tamoxifen

    Although the exact mechanism of the interaction is unknown, one theory is that tamoxifen inhibits CYP2C9, which metabolizes the S-isomer of warfarin.[ncbi.nlm.nih.gov] In our previous studies, protein arginine N-methyltransferase 2 (PRMT2), a co-regulator of estrogen receptor-α (ER-α), was confirmed to interact with ER-α66 and has the ability[ncbi.nlm.nih.gov] Ji F 1 , Guo B 2 , Wang N 1 , Zhong C 1 , Huang L 1 , Huang Y 1 , Wei L 1 , Su M 1 , Jiang Y 1 , Jin Q 1 , Liu Y 1 , Zhang Z 1 , Yang J 1 , Chen T 1 .[ncbi.nlm.nih.gov] (4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)- , (Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine , Tamoxifen , 1-p-beta-dimethylamino-ethoxyphenyl-trans[fpnotebook.com]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Mecamylamine

    In vivo studies suggested that the R-isomer might be somewhat more potent than the S isomer at blocking CNS effects of nicotine.[ncbi.nlm.nih.gov] 2,3,3-Tetramethyl-2-norbornamine N,2,3,3-Tetramethyl-2-norcamphanamine N-Methyl-2-isocamphanamine Revertina Versamine Systematic Names 2-Norbornanamine, N,2,3,3-tetramethyl[chem.nlm.nih.gov] […] appeared to be significant differences in the off-rates for the mecamylamine isomers from the receptors.[ncbi.nlm.nih.gov] ; 2-Norbornanamine, N,2,3,3-tetramethyl-; 2-Norbornanamine, N,2,3,3-tetramethyl-, hydrochloride; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride; Inversine[druglib.com]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Fosamprenavir

    (VIII) (IX) (II) a S-isomer a S-isomer b R-isomer b R-isomer Scheme 5: process for preparation of (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate Commercially available ([google.com] […] carbonate (Ila) with (2R,3S)-N- (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzene sulphonamide (III) to obtain (3S)-tetrahydro-3-furanyl N-[(1 S, 2R)-l -benzyl-[google.com] […] the level of intermediate R-isomer impurity (lib) in a sample of (S)-3- tetrahydrofuranyl-N-succinimidyl carbonate (11a); b) selecting a sample of (S)-3-tetrahydrofuranyl-N-succinimidyl[google.com] - hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzene sulphonamide (III) to give compound (3S)-tetrahydro-3-furanyl N-[(l S, 2R)-1 -benzyl-2-hydroxy-3-(N-isobutyl-4-nitrobenzene[google.com]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin
  • Sulfonamide

    Furthermore, molecular docking was performed to analyze the binding modes of R- and S-isomers.[ncbi.nlm.nih.gov] Abstract We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase[ncbi.nlm.nih.gov] R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched.[ncbi.nlm.nih.gov] R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched.[ncbi.nlm.nih.gov]

    Missing: N dipropyl)amino 5 6 dihydroxytetralin