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35 Possible Causes for (S, RAD1, homolog

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  • Split Hand-Split Foot Malformation

    In two different datasets, the expression of SHFM1 positively correlated with genes involved in DNA synthesis, homologous recombination (ATR, TOPBP1, RAD1, RAD50, POLD2, NBN[bloodjournal.org] In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: methods in molecular biology.[springerlink.com] DSS1 is predicted to encode a highly acidic polypeptide with no significant similarity to any known proteins but 100% amino acid sequence identify with its murine homolog[ncbi.nlm.nih.gov]

  • Gemcitabine

    Also, gemcitabine activated the Rad9-Hus1-Rad1 complex and the protein kinases ATM and ATR and checkpoint kinase 1 (Chk1), which blocked cell-cycle progression and influence[apexbt.com] MATERIALS AND METHODS: S-1 was administered at 50-70 mg/m 2 /day with radiotherapy in 2.5-3.6 Gy/day for 10-12 fractions.[ncbi.nlm.nih.gov] Extracellular signal-regulated kinase (ERK)-v-myc avian myelocytomatosis viral oncogene homolog (MYC) pathway was investigated by western blotting and quantitative real-time[ncbi.nlm.nih.gov]

  • Werner Syndrome

    Here, we have evaluated a potential role of WRN (mutated in Werner syndrome) and RECQ1 (the most abundant homolog of WRN) in hydroquinone (HQ)- and benzo[a]pyrene (BaP)-induced[ncbi.nlm.nih.gov] Hyperrecombination was partially independent of both RAD52 and RAD1 .[genetics.org] Nishioka M 1 , Kamei S 1 , Kinoshita T 1 , Sanada J 1 , Fushimi Y 1 , Irie S 1 , Hirata Y 1 , Tanabe A 1 , Hirukawa H 1 , Kimura T 1 , Obata A 1 , Tatsumi F 1 , Kohara K 1[ncbi.nlm.nih.gov]

  • Hereditary Breast Cancer

    Variants in ATM, MYC, PLAU, RAD1, and RRM2B were enriched in female HBOC patients compared with controls (odds ratio 1.16-2.16).[ncbi.nlm.nih.gov] Rafiq S, Khan S, Tapper W, Collins A, Upstill-Goddard R, Gerty S, et al.[southampton.ac.uk] Many other genes have also been implicated due to their role in the same pathway of DNA repair where the BRCA1/2 genes are involved: homologous recombination (HR).[ncbi.nlm.nih.gov]

  • Xeroderma Pigmentosum Complementation Group F

    Involved in homologous recombination that assists in removing interstrand cross-link.[genecards.org] […] repair cross-complementing rodent repair deficiency, complementation group 4 antibody excision-repair, complementing defective, in Chinese hamster antibody FANCQ antibody RAD1[bethyl.com] F. , Keeney , S. , Smith , C. A. , Taylor , J. S. , Linn , S. & Sancar , A. ( 1993 ).[cambridge.org]

  • Spinocerebellar Ataxia with Axonal Neuropathy

    […] of trinucleotide repeat containing 8 vertebrate LIN2 homolog CASK FGS4 300172 1497 coenzyme Q8A aarF domain containing kinase 3 chaperone, ABC1 activity of bc1 complex homolog[ukgtn.nhs.uk] Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage . Proc. Natl Acad. Sci. USA 99 , 13669–13674 (2002) 7.[nature.com] Katyal, S., S. F. el-Khamisy, et al. TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J 2007;26(22): 4720-31.[rarediseases.org]

  • Xeroderma Pigmentosum

    We, particularly, developed the correction of XP-C skin cells using the fidelity of the homologous recombination pathway during repair of double-strand break (DSB) in the[ncbi.nlm.nih.gov] X-ray and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes .[cambridge.org] Fe-S proteins including XPD.[ncbi.nlm.nih.gov]

  • Xeroderma

    X-ray and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes .[cambridge.org] Takahashi Y 1 , Endo Y 1 , Kusaka-Kikushima A 1 , Nakamaura S 1 , Nakazawa Y 2 , Ogi T 2, 3 , Uryu M 4 , Tsuji G 4 , Furue M 4 , Moriwaki S 5 .[ncbi.nlm.nih.gov] The repair mechanisms for UV rays are nucleotide excision repair and translesion synthesis while for X-rays, they are base excision repair, homologous recombination, and nonhomologous[ncbi.nlm.nih.gov]

  • Seckel Syndrome

    LIG4 syndrome is conferred by hypomorphic mutations in DNA ligase IV, an essential component of DNA non-homologous end-joining (NHEJ), and is associated with pancytopaenia[ncbi.nlm.nih.gov] Rad17/Rfc2-5 and Rad9/Rad1/Hus1 complexes are recruited to the site of damage independently of ATR but are phosphorylated in an ATR-dependent manner ( 3 , 11 ).[academic.oup.com] E 1 , Yigit G , Aslan Y , Brown KE , Pohl E , Bicknell LS , Kayserili H , Li Y , Tüysüz B , Nürnberg G , Kiess W , Koegl M , Baessmann I , Buruk K , Toraman B , Kayipmaz S[ncbi.nlm.nih.gov]

  • Xeroderma Pigmentosum Complementation Group C

    "Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease". Science 265 (5181): 2082–5.[gl.wikipedia.org] -I. and Haga, T. and Aiba, S. Case Reports in Dermatology. 2013; 5(1): 64-68 [Pubmed][ijmpo.org] […] are functional homologs.[ncbi.nlm.nih.gov]