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2,128 Possible Causes for (acceptor), activity, Aldehyde, dehydrogenase

  • Aldehyde

    […] as electron acceptor 55 Indoleacetaldehyde - pH 8.4, 85 C, benzyl viologen as electron acceptor 272 isovalerylaldehyde - pH 8.4, 85 C, benzyl viologen as electron acceptor[brenda-enzymes.org] Maximum activation was observed at 1 μg/ml of cabbage extract with 2.6 fold increase in the activity.[ncbi.nlm.nih.gov] Some aldehydes are substrates for aldehyde dehydrogenase enzymes which metabolize aldehydes in the body.[en.wikipedia.org] These enzymes include alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and exist[ncbi.nlm.nih.gov]

  • Xanthinuria

    This enzyme participates in purine metabolism and this enzyme belongs to the family of oxidoreductases, to be specific, those acting on CH or CH2 groups with NAD or NADP as acceptor[wikivisually.com] Xanthine oxidase activity was virtually absent in the patients' duodenal mucosa, a finding that established the diagnosis of hereditary xanthinuria.[ncbi.nlm.nih.gov] […] lack aldehyde oxidase activity.[emedicine.com] The duodenal mucosa from the subject had no xanthine dehydrogenase protein while the mRNA level was not reduced.[doi.org]

  • Disulfiram

    Structure and Physico-chemical Properties 2D Structure Calculated Physico-chemical Properties Hydrogen bond acceptors 2 Hydrogen bond donors 0 Rotatable bonds 9 Topological[guidetopharmacology.org] DSF's anticancer activity has been demonstrated in both in vitro and in vivo model systems, and has been tested in human clinical trials for various cancer types.[ncbi.nlm.nih.gov] Disulfiram (DSF), an inhibitor of aldehyde dehydrogenase, is currently in clinical use for treating alcoholism.[ncbi.nlm.nih.gov] .* (oxidoreductase acting on donor aldehyde/oxo group with NAD or NADP as acceptor) inhibitor that interferes with the action of aldehyde dehydrogenase (NAD ), EC 1.2.1.3.[ebi.ac.uk]

  • Influenza

    Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] Further analysis showed that both splicing events utilized a consensus dinucleotide motif GT/AG: GT present at the extreme 5′ (donor) with AG detected at the extreme 3′ (acceptor[doi.org] Infectivity of the virion is easily inactivated by all alcoholic disinfectants, chlorine, aldehydes and temperature above 70 C. Sources www.gov.uk/...[news-medical.net] […] lymphopenia, elevated amino-transaminases, thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time, increased D-Dimer, increased serum lactate dehydrogenase[ncbi.nlm.nih.gov]

  • Sjogren-Larsson Syndrome

    A moderate decrease in FAO activity has also been reported in heterozygote SLS subjects.[ncbi.nlm.nih.gov] Toxicity of long-chain aldehydes for FALDH-deficient cells decreased almost to the level of unaffected keratinocytes.[ncbi.nlm.nih.gov] Studies of mutations in SLS should prove useful for understanding structure-function correlations in FALDH and other aldehyde dehydrogenase proteins.[ncbi.nlm.nih.gov] Analysis of fibroblast fatty alcohol:NAD oxidoreductase or fatty aldehyde dehydrogenase activity (or of both) was determined in each.[ncbi.nlm.nih.gov]

    Missing: (acceptor)
  • Apparent Mineralocorticoid Excess

    The L or type 1 isozyme is expressed at high levels in the liver, uses NADP as an electron acceptor, and is reversible, catalyzing both dehydrogenation and reduction (conversion[hyper.ahajournals.org] Mutations L179R and R208H abolished activity in whole cells.[ncbi.nlm.nih.gov] Aldosterone synthase (choice A) converts a CH3 group at C18 of the steroid molecule to an aldehyde group, from whence comes the name aldosterone.[valuemd.com] CONVERSION OF CORTISOL TO CORTISONE: 11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) is a microsomal enzyme complex which, in humans, catalyses the interconversion between[ncbi.nlm.nih.gov]

  • Molybdenum Cofactor Deficiency Complementation Group B

    Our data demonstrate that C. glutamicum ATCC 13032 possesses an FDH with a currently unknown electron acceptor.[mic.microbiologyresearch.org] […] deficiency—complementation group B Joe Segen 2016-11-27T08:13:00 00:00 METABOLISM, NEUROLOGY An autosomal recessive condition (OMIM:252160) caused by a lack of molybdoenzyme activity[newmedicalterms.com] […] catalysing diverse redox reactions, however, only four of them have been found in plants. (1) Nitrate reductase catalyses the key step in inorganic nitrogen assimilation, (2) aldehyde[paperity.org] Determination of Enzyme Activities.[pnas.org]

  • Azotobacter Vinelandii

    Rhodanese is an ubiquitous enzyme that in vitro catalyses the transfer of a sulfur atom from suitable donors to nucleophilic acceptors by way of a double displacement mechanism[ncbi.nlm.nih.gov] Página 60 - Cloning of the membranebound aldehyde dehydrogenase gene of Acetobacter polyoxogenes and improvement of acetic acid production by use of the cloned gene.[books.google.es] It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).[uniprot.org] […] cysts is induced by chemical factors and is accompanied by metabolic shifts, changes in catabolism, respiration, and biosynthesis of macromolecules; it is also affected by aldehyde[en.wikipedia.org]

  • Isovaleric Acidemia

    Several of the mutations were predicted by individual information analysis to inactivate or significantly weaken adjacent donor or acceptor sites.[ncbi.nlm.nih.gov] Residual activities of the nine isovaleric acidemia lines tested ranged from 0 to 0.67 pmol 3H2O/min/mg protein (controls 19.4 /- 8.0).[ncbi.nlm.nih.gov] 91-8 CAS C00011 KEGG Compound C00010 KEGG Compound Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Oxygen P21953 UniProt 3-HYDROXY-3-METHYL-GLUTARYL-COA BioCyc Aldehyde[smpdb.ca] We subsequently identified and purified isovaleryl-CoA dehydrogenase (IVD) and 2-methyl-branched chain acyl-CoA dehydrogenase, which were previously unknown.[ncbi.nlm.nih.gov]

  • Xanthinuria Type 1

    Abstract Two brothers with classical xanthinuria who lacked xanthine dehydrogenase activity were encountered.[ncbi.nlm.nih.gov] Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type.[link.springer.com] Allopurinol was metabolized to oxypurinol and pyrazinamide to 5-hydroxypyrazinamide in spite of no activity of xanthine oxidase, suggesting that aldehyde oxidase converted[ncbi.nlm.nih.gov] In type II deficiency, mutations in the genes coding for both XOR and aldehyde oxidase are unlikely, because these genes are located far apart, albeit both on chromosome 2[jmg.bmj.com]

    Missing: (acceptor)

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