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7,930 Possible Causes for (inhibitor), 1,, 11, 2, phosphatase, protein, pseudogene, regulatory, subunit

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  • Carney Complex

    We studied 101 subjects, including 51 affected members, from 11 North American kindreds with Carney complex.[] Acronym CNC1 Synonyms CAR Carney complex, type 1 Carney myxoma-endocrine complex Carney syndrome LAMB syndrome Myxoma, spotty pigmentation, and endocrine overactivity NAME[] Analysis of 11 kindreds and linkage to the short arm of chromosome 2.[] Application of a PKA inhibitor inhibited the basal currents in these adenoma cells, results that were not observed in nonadenomatous somatotrophs.[] Although next generation sequencing technologies and our bioinformatics analysis significantly reduce the contribution of pseudogene sequences or other highly-homologous sequences[] AMP-Dependent Protein Kinase RIalpha Subunit PRKAR1A protein, human RNA, Messenger RNA, Small Interfering SMAD3 protein, human Smad3 Protein Transforming Growth Factor beta[] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[] To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[] Eur J Pediatr. 2009 Nov;168(11):1401-4. doi: 10.1007/s00431-009-0935-y. Epub 2009 Feb 14. Author information 1 Department of Clinical Genetics, Guy's and St.[]

  • Influenza

    […] deliver/fulltext/jgv/92/11/2485.html?[] IL-1 receptor (IL-1R1).[] Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside[] Selected Treatment Trials of Neuraminidase Inhibitors.[] Like hemagglutinin and neuraminidase, the M2 protein is an integral membrane protein of the influenza A virus 4 , 5 .[] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[] DOI: 10.1128/AAC.38.8.1864 ABSTRACT Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug[] The greatest problems for new and better vaccines appear to be associated with regulatory hurdles and the lack of an adequate market.[]

    Missing: pseudogene
  • Carney Complex Type 1

    II, alpha 0.956614 ACBD3 acyl-CoA binding domain containing 3 0.956196 PTEN phosphatase and tensin homolog 0.881882 MLANA melan-A 0.852402 STK11 serine/threonine kinase 11[] Acronym CNC1 Synonyms CAR Carney complex, type 1 Carney myxoma-endocrine complex Carney syndrome LAMB syndrome Myxoma, spotty pigmentation, and endocrine overactivity NAME[] Invest. 97 (2): 1-7, 1996 ). Two additional kindreds (7 affected individuals) were recently recruited.[] […] in this test detects most deletions and duplications; however aberrations in a small percentage of regions may not be accurately detected due to sequence paralogy (e.g. pseudogenes[] Compensatory regulation of RIa protein levels in protein kinase A mutant mice . J. Biol. Chem. 272 , 3993– 3998 (1997). 21. Scott, J.D.[] ) ARF : SAR1B ( Chylomicron retention disease ) ARL13B ( Joubert syndrome 8 ) · ARL6 ( Bardet–Biedl syndrome 3 ) MAP kinase Cardiofaciocutaneous syndrome Other kinase / phosphatase[] % Genes 100 % Carney complex, type 1.[] […] of the sporadic pituitary tumour samples while decreased RNA expression was seen in cell lines derived from CNC1 patients, which could be restored by an RNA degradation inhibitor[] Elsevier Health Sciences , 11 iun. 2016 This issue of the Surgical Pathology Clinics, edited by Drs.[]

  • Interleukin-2

    A 100% complete local response rate with long-term follow-up (average of 24 months) was seen in all 11 patients treated with this proposed regimen.[] […] were enrolled and randomly assigned (in a 1:1:1:1 ratio, by computer-generated randomisation list, with block size four) to placebo or IL2 at 0.33 MIU/day, 1 MIU/day, or[] […] low dose rIL-2.[] Polymorphisms in the TGF-β1 (rs1982037) and IL-2 (rs2069762, rs4833248) genes are not associated with inhibitor development in Iranian patients with hemophilia A.[] Evidence was presented to indicate that TCGF and RAF2, a pseudogene of the oncogene RAF1 (164760), is not closely linked to TCGF although it is on chromosome 4.[] Search results for IL2 Gene & protein summaries for IL2 Gene summary for IL2 Gene & protein summary for IL2 ORGANISMS human Homo sapiens human Homo sapiens house mouse Mus[] This synergistic effect was stopped by CD4 CD25 regulatory T cells (Treg), which depleted IL-2 in a cell number-dependent manner.[] Increased phosphorylation of VE-cadherin was also accompanied by a reduction of Src homology 2 domain-containing protein-tyrosine phosphatase 2, known to maintain vascular[] Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits[]

  • Novobiocin

    To determine if novobiocin and the 11-mer shared a common allosteric binding site, a biologically-active analog of the 11-mer peptide ([Bio-DOPA]11-mer) was chemically cross-linked[] RESULTS: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher.[] Abstract We conducted the first phase 2 and pharmacologic study to evaluate the combination of novobiocin (a coumeromycin antibiotic that has been shown to augment alkylating[] Blagg Chemistry - A European Journal 2016 22 (20), 6921-6931 Anticancer Inhibitors of Hsp90 Function Gaurav Garg , Anuj Khandelwal , Brian S.J.[] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[] Therefore, NovG and StrR apparently belong to the same family of DNA-binding regulatory proteins.[] A Phosphatase-Novobiocin-Mannose-Inhibition Test (PNMI-Test) together with a high NaCl concentration (10%) in combination with a coagulase test seems to be an acceptable compromise[] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[] Novobiocin induced the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature[]

    Missing: pseudogene
  • Barth Syndrome

    […] metabolism 5C52 Inborn errors of lipid metabolism H00654 Barth syndrome Pathway hsa00564 Glycerophospholipid metabolism Gene TAZ [HSA: 6901 ] [KO: K13511 ] Other DBs ICD-11[] Adwani 1 B.F. Whitehead 1 P.G. Rees 1 A. Morris 2 D.M. Turnball 2 M.J. Elliott 1 M.R. de Leval 1 1.[] Fig. 2.[] Furthermore, we show that treatment of Barth syndrome patients' lymphoblasts in tissue culture with the iPLA(2) inhibitor, bromoenol lactone, partially restores their cardiolipin[] ., pseudogenes, segmental duplications), sequence properties, deletion/duplication size (e.g., 1-3 exons vs. 4 or more exons), and inadequate coverage.[] Combining those profiles with gene set enrichment analysis allows detecting significantly affected protein complexes.[] Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and function. J Bioenerg Biomembr . Epub November 29, 2014. 131.[] Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.[] In the post-transplant period immunosuppression usually comprises a steroid-free double therapy with a calcineurin inhibitor and a purine synthesis inhibitor.[]

  • Hepatitis C Virus

    Many of these HCV types comprised a number of more closely related subtypes, leading to a current total of 11 genetically distinct viral populations.[] In addition, shHO-1 inhibited HCV replication. CONCLUSION: In conclusion, hypericin inhibits HCV replication via down-regulation of HO-1 expression and deacetylation.[] In this paper, we study the molecular epidemiology of HCV genotype 2 in its region of endemic origin, west and central Africa.[] KEYWORDS: Direct-acting antiviral; HIV; NS3/4A protease inhibitor; hepatitis C[] (A) The map shows the full-length OCLN gene with exons 1 to 9 and an inverted partly duplicated OCLN pseudogene (LOC647859) that includes exons 5 to 9.[] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[] Salusky and Martin Hewison , Suppression of Iron-Regulatory Hepcidin by Vitamin D , Journal of the American Society of Nephrology , 10.1681/ASN.2013040355 , 25 , 3 , (564-[] […] genetics Dual-Specificity Phosphatases/metabolism* Exoribonucleases/genetics Exoribonucleases/metabolism* Gene Knockout Techniques Genome, Viral Hepacivirus/pathogenicity[] This binding was competitively inhibited by a peptide from the V3 loop of a human immunodeficiency virus glycoprotein subunit (gp120) known to bind with cell surface heparin[]

  • Cantharidin

    Accordingly, analogue 13 exhibited potent inhibitory activity on protein phosphatase 2A, and analogues 9, 11 and 12 showed weak inhibitory activity, while other analogues[] Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[] However, cantharidin also induced apoptosis and G(2)/M phase arrest in HT 29 cells, but did not induce COX 2 over-expression.[] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[] […] drug effects T-Lymphocytes, Regulatory/immunology T-Lymphocytes, Regulatory/radiation effects Substances CTLA-4 Antigen Ctla4 protein, mouse Cantharidin[] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[] InChI 1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6 ,9 ,10- Download the identifier in a file .[] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[] RESULTS: Fourteen patients (93%) were completely cleared of their warts with topical CPS, while 11 patients (73%) showed complete clearance with long-pulsed Nd:YAG laser with[]

    Missing: pseudogene
  • Congenital Lipoid Adrenal Hyperplasia due to STAR Deficiency

    -beta-hydroxylase deficiency Indicated by increased 11-deoxycorticosterone and 11-deoxycortisol levels 17-hydroxylase (17-OH) deficiency Characterized by increased pregnenolone[] 1 Recommendations info_outline Changes Clinical Practice Interesting Hypothesis Classified as close Changes Clinical Practice 1 Interesting Hypothesis 1 file_download close[] Papadimitriou 1,2 , Ioanna ountzoula 2 , Georgia Tzortzatou 2 , Himangshu S.[] […] topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors[] Examples include rs7769409(C;T) rs7755898(C;T) i5005436(C;T) This is presumably due to the presence of a nearby CYP21 pseudogene as documented in omim The most common forms[] Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science. 1995;267:1828–31.[] Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. J Biol Chem. 2003 Jan 31; 278(5):2837-44. Bose HS, Lingappa VR, Miller WL.[] […] highest expression level in metanephros CleanEx i HS_STAR ExpressionAtlas i P49675 baseline and differential Genevisible i P49675 HS Organism-specific databases Interaction i Subunit[] An experimental type of drug therapy—a three-drug combination, with an androgen blocking agent (flutamide), an aromatase inhibitor (testolactone), and low dose hydrocortisone—is[]

  • Phosphorylase Kinase Deficiency

    J Pediatr Gastroenterol Nutr 55:90–92 PubMed CrossRef Google Scholar 11.[] We analysed the gene of the human alpha-subunit of liver phosphorylase kinase (PHKA2) in four Japanese families with X-linked liver phosphorylase kinase deficiency type 1[] Column 2: 5ml HiTrap S Column 2 Buffers : Buffer A: 25 mM HEPES, pH 7.0; 200 mM NaCl; 0.5 mM TCEP. Buffer B: 25 mM HEPES, pH 7.0; 2 mM NaCl; 0.5 mM TCEP.[] In phosphorylase kinase-deficient muscle, glucose 6-phosphate, a powerful phosphorylase inhibitor, was 56% of that in normal muscle. 6.[] A pseudogene has been found on chromosome 1.[] The report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic[] Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.[] […] storage diseases such as GSD due to liver phosphorylase deficiency (GSD type VI), GSD due to glycogen debranching enzyme deficiency (GSD type III), and GSD due to glucose-6-phosphatase[] The complete coding sequences of the liver gamma subunit and of the beta subunit of phosphorylase kinase of the proband were analyzed for the presence of mutations, by either[]