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5,181 Possible Causes for (inhibitor), 1,, 12A, human, phosphatase, protein, protein,, regulatory, subunit

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  • Influenza

    IL-1 receptor (IL-1R1).[doi.org] Selected Treatment Trials of Neuraminidase Inhibitors.[content.nejm.org] Like hemagglutinin and neuraminidase, the M2 protein is an integral membrane protein of the influenza A virus 4 , 5 .[doi.org] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[guidance.nice.org.uk] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] The greatest problems for new and better vaccines appear to be associated with regulatory hurdles and the lack of an adequate market.[doi.org] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org]

    Missing: 12A
  • Porphyromonas Gingivalis

    1.935 1.515 1.68 0.988 1.70 IL-10 8.113 5.979 25.923 9.26 2.80 NFKBIA 2.179 1.44 1.51 5.85 4.711 STAT3 1.014 1.308 1.754 0.61 2.88 CCL5 1.574 1.571 25.162 3.016 8.34 IL-12A[ncbi.nlm.nih.gov] KEYWORDS: Porphyromonas gingivalis; adhesion; adhérence; galectin-1; galectin-3; galectine-1; galectine-3; invasion[ncbi.nlm.nih.gov] To block this neurotoxicity, we designed and synthesized small-molecule inhibitors targeting gingipains.[ncbi.nlm.nih.gov] UniProt Primary Accession # UniProt Secondary Accession # NCBI Official Full Name Gingipain R1 UniProt Protein Name Gingipain R1 UniProt Synonym Protein Names Arg-gingipain[mybiosource.com] We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcription factor in oral keratinocytes was stimulated by the periodontal pathogen[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[uniprot.org] […] gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators.[ncbi.nlm.nih.gov]

  • Novobiocin

    RESULTS: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher.[ncbi.nlm.nih.gov] Blagg Chemistry - A European Journal 2016 22 (20), 6921-6931 Anticancer Inhibitors of Hsp90 Function Gaurav Garg , Anuj Khandelwal , Brian S.J.[doi.org] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[ncbi.nlm.nih.gov] Therefore, NovG and StrR apparently belong to the same family of DNA-binding regulatory proteins.[mic.microbiologyresearch.org] A Phosphatase-Novobiocin-Mannose-Inhibition Test (PNMI-Test) together with a high NaCl concentration (10%) in combination with a coagulase test seems to be an acceptable compromise[ncbi.nlm.nih.gov] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[ncbi.nlm.nih.gov] Novobiocin induced the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature[ncbi.nlm.nih.gov] Novobiocin does not bind the ATP binding site but rather the interface between the ATPase subunits and the transmembrane subunits of the LPS transporter.[ncbi.nlm.nih.gov]

    Missing: 12A
  • Cantharidin

    Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[abcam.com] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[ncbi.nlm.nih.gov] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] […] drug effects T-Lymphocytes, Regulatory/immunology T-Lymphocytes, Regulatory/radiation effects Substances CTLA-4 Antigen Ctla4 protein, mouse Cantharidin[ncbi.nlm.nih.gov] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[ncbi.nlm.nih.gov] Here we report that cantharidin inhibits migration and invasion of A549 human lung cancer cell.[ncbi.nlm.nih.gov] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[alomone.com] We aimed to examine the effect of CTD on human myeloid dendritic cells (DCs) by examining immature DCs differentiated and maturated from CD14 monocytes.[ncbi.nlm.nih.gov]

    Missing: 12A
  • Herpes Simplex Virus 1 Infection

    Herpes simplex virus type 1 (HSV-1) is the more common type of Herpes simplex virus.[symptoma.com] Inhibition was achieved by adding cdk9 inhibitors 5,6-dichlorobenzimidazone-1-β-D-ribofuranoside (DRB) or flavopiridol (FVP) or by expression of a dominant-negative cdk9 or[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] Investigation of the mechanisms showed that poly-I:C or ssRNA treatment enhanced the expression of several IFN regulatory factors.[ncbi.nlm.nih.gov] The disruption of F-actin dynamics by chemical inhibitors significantly reduced the efficiency of viral infection and intracellular HSV-1 replication.[ncbi.nlm.nih.gov] Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection, the gamma(1)34.5 protein inhibits the activity of PKR by mediating dephosphorylation[ncbi.nlm.nih.gov] Gov't MeSH terms Apoptosis Regulatory Proteins/genetics Apoptosis Regulatory Proteins/metabolism Gene Expression Regulation, Viral/drug effects Genome, Human* HeLa Cells Herpes[ncbi.nlm.nih.gov] Abstract Herpes simplex virus 1 (HSV-1) infection triggers specific metabolic changes in its host cell.[ncbi.nlm.nih.gov]

    Missing: 12A
  • Carney Complex Type 1

    […] and Unusual Appearance Microdontia Hypodontia Short Stature Microphthalmia, Syndromic 7 Microspherophakia with Hernia MIRAGE SYNDROME mitochondrial DNA depletion syndrome 12a[rgd.mcw.edu] Acronym CNC1 Synonyms CAR Carney complex, type 1 Carney myxoma-endocrine complex Carney syndrome LAMB syndrome Myxoma, spotty pigmentation, and endocrine overactivity NAME[uniprot.org] […] skeletal muscle, perinatal 1.62157 GNAS GNAS complex locus 1.51633 PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 1.38559 CDKN1B cyclin-dependent kinase inhibitor[amp.pharm.mssm.edu] Compensatory regulation of RIa protein levels in protein kinase A mutant mice . J. Biol. Chem. 272 , 3993– 3998 (1997). 21. Scott, J.D.[nature.com] ) ARF : SAR1B ( Chylomicron retention disease ) ARL13B ( Joubert syndrome 8 ) · ARL6 ( Bardet–Biedl syndrome 3 ) MAP kinase Cardiofaciocutaneous syndrome Other kinase / phosphatase[dictionnaire.sensagent.leparisien.fr] The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology[ingentaconnect.com] % Genes 100 % Carney complex, type 1.[mendelian.co] […] of the sporadic pituitary tumour samples while decreased RNA expression was seen in cell lines derived from CNC1 patients, which could be restored by an RNA degradation inhibitor[endocrine-abstracts.org]

  • Lafora Disease

    […] hit PTHR11697:SF49 PTHR11697:SF49, 1 hit Sequence (1 ) i Sequence status i : Complete.[expasy.org] Here we show that malin and laforin co-localize in endoplasmic reticulum (ER) and that they form centrosomal aggregates when treated with proteasomal inhibitors in both neuronal[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] We have developed a human LD mutation database using a new generic biological database cross‐referencing platform.[doi.org] This gene encodes laforin, which is a tyrosine kinase inhibitor that plays a significant role in the regulation of glycogen metabolism.[wiki.med.umich.edu] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[hmg.oxfordjournals.org] The current perspective in LD is high-throughput screening for small molecules that act on the disease pathway, that is, partial inhibitors of GS, which opens a therapeutic[ncbi.nlm.nih.gov]

    Missing: 12A
  • Inflammation

    […] with major depression, relative to controls, showed differential expression of a large set of both anti- and pro-inflammatory markers (including IL1α, 2, 3, 5, 8, 9, 10, 12A[doi.org] Immunofluorescence was negative in 1 patient.[ncbi.nlm.nih.gov] KEYWORDS: Autoimmunity; Histone deacetylase inhibitor; Inflammation; Macrophage polarization[ncbi.nlm.nih.gov] The rate of protein synthesis in vivo was measured by the incorporation of [3H]phenylalanine into liver proteins in a chronic (5 day) intra-abdominal abscess model.[doi.org] Aspergillus protease-mediated mitochondrial ROS production was associated with downregulation of uncoupling protein (UCP)- 2 expression by TGF-β-SMAD4 signaling, which may play a regulatory[ncbi.nlm.nih.gov] Following this, caspase‑3/9, Bax, phosphatase and tensin homolog (PTEN), nuclear factor (NF)‑κB and phosphorylated‑(p)‑protein kinase B (Akt) protein expression were analyzed[ncbi.nlm.nih.gov] The DNA binding subunit is functionally related to c-Rel p75 and Rel B p68.[emdmillipore.com] School of Human Kinetics and Allan McGavin Sports Medicine Centre, 3055 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada CA 3.[doi.org]

  • LIG4 Syndrome

    PEX16138.50.960.92Peroxisome biogenesis disorder 8A, (Zellweger),614876 PEX16138.50.960.92Peroxisome biogenesis disorder 8B,614877 PEX1912110.99Peroxisome biogenesis disorder 12A[qgenomics.com] […] and 2.39 at 1 and 24 hours, respectively) and NK cells (HC1, 49.80 and 3.26 at 1 and 24 hours, respectively; HC2, 58.38 and 2.57 at 1 and 24 hours, respectively).[bloodadvances.org] Desk 1 Inhibition of apoE secretion by dynamin inhibitors. Ctrl.[perlierusa.com] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Zebrafish have p53, p63 and p73 genes, as well as the regulatory mdm2 and mdm4 genes (Lu and Abrams, 2006).[zdoc.site] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[doi.org] Epub 2004 Jun 11. 2004 23XRCC6, LIG4, PRKDC, XRCC4, XRCC5 Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4[genatlas.medecine.univ-paris5.fr] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org]

  • Bile Salt

    ,27-tetrol AMP PTGIS NCOA2 RXRA TCDCA DCA 5bCHOL3a,7a,24(s)-triol TCDCA AKR1C2 4CHOL7a,12a,27TONE[wikipathways.org] The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17α-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing[ncbi.nlm.nih.gov] Subsequently, the model was used for docking-based classification of a set of 1212 compounds (405 BSEP inhibitors, 807 non-inhibitors).[ncbi.nlm.nih.gov] The effect of mutations in prtS (protease), mucBP (MUCin-Binding Protein), and srtA genes in ST LMD-9 in these mechanisms were examined.[ncbi.nlm.nih.gov] These observations necessitate an intense study into the biochemical, structural and regulatory features of BSH enzymes to better understand their role in regulating bacterial[ncbi.nlm.nih.gov] […] posttranslational regulations are mediated via signaling pathways involving cAMP, calcium, nitric oxide, phosphoinositide-3-kinase (PI3K), protein kinase C (PKC) and protein phosphatases[ncbi.nlm.nih.gov] […] c-jun and c-fos (AP-1 subunits) to the IL-8 promoter.[ncbi.nlm.nih.gov] In this study, we examine the kinetics associated with human NTCP-dependent transport of two quantitatively important bile acids comprising the human bile acid pool, chenodeoxycholic[ncbi.nlm.nih.gov]