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10,338 Possible Causes for (inhibitor), 1,, 13, human, like, phosphatase, protein, protein,, regulatory, subunit

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  • Influenza

    IL-1 receptor (IL-1R1).[dx.doi.org] Abstract During May 20-October 13, 2018,* low levels of influenza activity were reported in the United States, with a mix of influenza A and B viruses circulating.[ncbi.nlm.nih.gov] Selected Treatment Trials of Neuraminidase Inhibitors.[dx.doi.org] Conclusion This flexible tool can help to determine the interventions most likely to contain an influenza pandemic.[dx.doi.org] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[dx.doi.org] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[guidance.nice.org.uk] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] SEARCH METHODS: We searched trial registries, electronic databases (to 22 July 2013) and regulatory archives, and corresponded with manufacturers to identify all trials.[ncbi.nlm.nih.gov]

  • Insulin-Like Growth Factor I

    Insulin-like Growth Factor-1 (IGF-1): IGF-1 LR3 VS IGF-1 DES IGF-1 (Insulin-like growth factor) is an endocrine hormone that is produced in the liver.[wumeitech.com] […] annually between the ages 13 to 16.[ncbi.nlm.nih.gov] Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.[guidetopharmacology.org] BACKGROUND/AIMS: Growth hormone insensitivity syndrome (GHIS) is caused by a defective growth hormone receptor (GHR) and is associated with insulin-like growth factor-I (IGF-I[ncbi.nlm.nih.gov] The encoded protein is processed from a precursor, bound by a specific receptor, and secreted.[genecards.org] IGF-I may be a regulatory factor for serum GHBP activity in man.[ncbi.nlm.nih.gov] IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase[ncbi.nlm.nih.gov] […] with altered growth hormone (GH) secretion, the changes of insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP-3), and acid-labile subunit[ncbi.nlm.nih.gov] Growth hormone (GH) plays an essential role in controlling somatic growth and in regulating multiple physiological processes in humans and other species.[ncbi.nlm.nih.gov] OBJECTIVE: This study is designed to evaluate the correlations of insulin-like growth factor I (IGF-I) and insulin-like growth factor I receptor (IGF-IR) expressions with[ncbi.nlm.nih.gov]

  • Novobiocin

    RESULTS: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher.[ncbi.nlm.nih.gov] […] induction of differentiation in two human promyelocytic HL-60 leukemia cell variants that are either susceptible or resistant to differentiation induced by phorbol-12-myristate-13[ncbi.nlm.nih.gov] Blagg Chemistry - A European Journal 2016 22 (20), 6921-6931 Anticancer Inhibitors of Hsp90 Function Gaurav Garg , Anuj Khandelwal , Brian S.J.[doi.org] In these fibroblast-like cells, the production of type III procollagen was increased and the DNase I hypersensitivity of c-myc gene was reduced.[ncbi.nlm.nih.gov] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[ncbi.nlm.nih.gov] Therefore, NovG and StrR apparently belong to the same family of DNA-binding regulatory proteins.[mic.microbiologyresearch.org] A Phosphatase-Novobiocin-Mannose-Inhibition Test (PNMI-Test) together with a high NaCl concentration (10%) in combination with a coagulase test seems to be an acceptable compromise[ncbi.nlm.nih.gov] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[ncbi.nlm.nih.gov] Bio-DOPA]11-mer complex revealed that novobiocin markedly decreased cross-linking of the [Bio-DOPA]11-mer to the receptor, but cross-linking of the α-factor analog [Bio-DOPA]13[ncbi.nlm.nih.gov] Novobiocin induced the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature[ncbi.nlm.nih.gov]

  • Herpes Simplex Virus 1 Infection

    Herpes simplex virus type 1 (HSV-1) is the more common type of Herpes simplex virus.[symptoma.com] Positive immunostaining for HSV-1 specific antigens was consistently detectable using 11 10(6)PFU from 13 h onwards, mainly on cells located in the submucosa, and in the perivascular[ncbi.nlm.nih.gov] Inhibition was achieved by adding cdk9 inhibitors 5,6-dichlorobenzimidazone-1-β-D-ribofuranoside (DRB) or flavopiridol (FVP) or by expression of a dominant-negative cdk9 or[ncbi.nlm.nih.gov] Receptor 3/physiology* Toll-Like Receptor 8/physiology* Toll-Like Receptors/biosynthesis Toll-Like Receptors/genetics Substances Interferon Inducers Interferon Regulatory[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] The disruption of F-actin dynamics by chemical inhibitors significantly reduced the efficiency of viral infection and intracellular HSV-1 replication.[ncbi.nlm.nih.gov] Robert-Rössle-Strasse 10, 13125, Berlin, Germany. [email protected] 9 IRI Life Sciences, Institute für Biologie, Humboldt Universität zu Berlin, Philippstraße 13[ncbi.nlm.nih.gov] Also, caspase-1 was "trapped" in actin clusters at later time points that likely blocked the NLRP3/IFI16 inflammasome activity.[ncbi.nlm.nih.gov] Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection, the gamma(1)34.5 protein inhibits the activity of PKR by mediating dephosphorylation[ncbi.nlm.nih.gov] Abstract Herpes simplex virus 1 (HSV-1) infection triggers specific metabolic changes in its host cell.[ncbi.nlm.nih.gov]

  • LIG4 Syndrome

    […] and 2.39 at 1 and 24 hours, respectively) and NK cells (HC1, 49.80 and 3.26 at 1 and 24 hours, respectively; HC2, 58.38 and 2.57 at 1 and 24 hours, respectively).[bloodadvances.org] GRCh37 Chromosome 13, 108862211: 108862211 6 LIG4 NM_002312.3(LIG4): c.1406G A (p.Gly469Glu) single nucleotide variant Pathogenic rs104894420 GRCh38 Chromosome 13, 108209863[malacards.org] Desk 1 Inhibition of apoE secretion by dynamin inhibitors. Ctrl.[perlierusa.com] Clinical description LIG4 syndrome presents in childhood with microcephaly, unusual facial features that have been described as ''bird-like'' (beak-like nose and micrognathia[orpha.net] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Zebrafish have p53, p63 and p73 genes, as well as the regulatory mdm2 and mdm4 genes (Lu and Abrams, 2006).[zdoc.site] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[doi.org] Epub 2004 Jun 11. 2004 23XRCC6, LIG4, PRKDC, XRCC4, XRCC5 Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4[genatlas.medecine.univ-paris5.fr] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org] Adenoma Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.[brenda-enzymes.org]

  • Cantharidin

    Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[abcam.com] In addition, the mode of inhibition of cantharidin and analogue 13 on protein phosphatase 2A was determined by enzymatic kinetics assay.[ncbi.nlm.nih.gov] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[ncbi.nlm.nih.gov] There are however some studies regarding such data in animal models like beagle dogs [ 4 ] .[drugbank.ca] […] drug effects T-Lymphocytes, Regulatory/immunology T-Lymphocytes, Regulatory/radiation effects Substances CTLA-4 Antigen Ctla4 protein, mouse Cantharidin[ncbi.nlm.nih.gov] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[ncbi.nlm.nih.gov] Here we report that cantharidin inhibits migration and invasion of A549 human lung cancer cell.[ncbi.nlm.nih.gov] This work provides insight into how cantharidin and its analogs bind to PP5c at the atomic level and will facilitate modification of cantharidin-like chemicals to rationally[ncbi.nlm.nih.gov] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[alomone.com] We aimed to examine the effect of CTD on human myeloid dendritic cells (DCs) by examining immature DCs differentiated and maturated from CD14 monocytes.[ncbi.nlm.nih.gov]

  • Porphyromonas Gingivalis

    KEYWORDS: Porphyromonas gingivalis; adhesion; adhérence; galectin-1; galectin-3; galectine-1; galectine-3; invasion[ncbi.nlm.nih.gov] Chen TS 1, 2 , Kuo CH 3 , Battsengel S 2, 4 , Pan LF 5, 6 , Day CH 7 , Shen CY 7 , Chung LC 8 , Padma VV 9 , Yao CK 10 , Lin YM 11, 12 , Huang CY 2, 13, 14, 15 .[ncbi.nlm.nih.gov] To block this neurotoxicity, we designed and synthesized small-molecule inhibitors targeting gingipains.[ncbi.nlm.nih.gov] KEYWORDS: Porphyromonas gingivalis ; cell signaling; gingival fibroblasts; protease-activated receptors; toll-like receptors[ncbi.nlm.nih.gov] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[ncbi.nlm.nih.gov] We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcription factor in oral keratinocytes was stimulated by the periodontal pathogen[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[uniprot.org] […] gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators.[ncbi.nlm.nih.gov] The immune-regulatory B7-H1 receptor, also known as programmed death-ligand 1 (PD-L1), plays an important role in cell-mediated immune response.[ncbi.nlm.nih.gov]

  • Treponema Denticola

    In this study we investigated the ability of T. denticola to bind the complement regulatory proteins factor H and factor H-like protein 1 (FHL-1).[ncbi.nlm.nih.gov] A total of 66 children aged 8 to 13 years old were involved in this study. Five milliliters of blood samples were taken to detect the serum IgA and IgG levels.[ncbi.nlm.nih.gov] To identify specific inhibitors by structure-based in silico methods, we first validated the crystal structure of cystalysin as a reliable starting point for the design of[ncbi.nlm.nih.gov] In the present study, we investigated the response of human macrophage-like cells to stimulation by peptidoglycan isolated from T. denticola.[ncbi.nlm.nih.gov] In total, 219 non-redundant proteins were identified including numerous virulence factors, lipoproteins, ABC transporter proteins and enzymes involved in the metabolism of[ncbi.nlm.nih.gov] Abstract Nothing is currently known regarding the global regulatory networks of Treponema denticola and other oral spirochetes.[ncbi.nlm.nih.gov] Nucleotide (GenBank) : L25421 Treponema denticola phosphatase gene, 5' end. Nucleotide (GenBank) : AF082511 Treponema denticola mgl operon, partial sequence.[lgcstandards-atcc.org] […] are ordered K-I-D-B-A, with a subunit E gene located 300 kb upstream), and the subunit I gene contains a frameshift, which might render the ATPase nonfunctional.[doi.org] Immortalized human gingival epithelial HOK-16B cells were infected with 5- (and 6-) carboxy-fluorescein diacetate succinimidyl ester (CFSE)-labeled live or heat-killed T.[ncbi.nlm.nih.gov] We have purified from Escherichia coli recombinant Msp (rMsp) polypeptides corresponding to the following: full-length Msp (rMsp) minus 13 N-terminal amino acid (aa) residues[ncbi.nlm.nih.gov]

  • Lafora Disease

    […] hit PTHR11697:SF49 PTHR11697:SF49, 1 hit Sequence (1 ) i Sequence status i : Complete.[expasy.org] Photosensitivity completely disappeared after age 13 years 10 months.[ncbi.nlm.nih.gov] Here we show that malin and laforin co-localize in endoplasmic reticulum (ER) and that they form centrosomal aggregates when treated with proteasomal inhibitors in both neuronal[ncbi.nlm.nih.gov] We found that laforin interacts with a phylogenetically conserved protein HIRIP5 that harbors a NifU-like domain.[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] We have developed a human LD mutation database using a new generic biological database cross‐referencing platform.[doi.org] This gene encodes laforin, which is a tyrosine kinase inhibitor that plays a significant role in the regulation of glycogen metabolism.[wiki.med.umich.edu] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[hmg.oxfordjournals.org] J Biol Chem. 2013 Mar 29;288(13):9482-90. doi: 10.1074/jbc.M112.416180. Epub 2013 Feb 13.[ncbi.nlm.nih.gov]

  • Human Herpesvirus 8

    Among HIV-1 positive samples, HHV-8 seropositivity rate was 61% based on combined reactivity using both ELISA and IFA techniques.[ncbi.nlm.nih.gov] We report an HIV-negative, 13-year-old patient of Sicilian descent with HHV-8-associated classic KS to facilitate the diagnosis and treatment of this entity in children.[ncbi.nlm.nih.gov] Highly-active antiretroviral therapy (HAART) reduces the incidence of KS, and regimens that contain protease inhibitors (PIs) may be particularly effective.[ncbi.nlm.nih.gov] These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.[doi.org] […] response signaling in addition to enhancing viral protein folding.[ncbi.nlm.nih.gov] Here, we report that human herpesvirus 8 (HHV-8) gene product viral interferon regulatory factor 1 (vIRF-1) is targeted to mDRM during virus replication and negatively regulates[ncbi.nlm.nih.gov] phosphatase technique.[nejm.org] […] endoplasmic reticulum (ER)-localized CatD precursor, pro-CatD (pCatD), and vIL-6 with the previously uncharacterized ER membrane protein vitamin K epoxide reductase complex subunit[ncbi.nlm.nih.gov] In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8).[ncbi.nlm.nih.gov] HIV-1-infected patients without clinical evidence of KS, (3) 171 HIV-negative blood donors, (4) 27 consecutive kidney transplant recipients, who were HIV-negative, and (5) 13[ncbi.nlm.nih.gov]