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6,240 Possible Causes for (inhibitor), 1,, 13B,, human, phosphatase, protein, regulatory, subunit

Did you mean: (inhibitor), 1, 13B, human, phosphatase, proteus, regulatory, subunit

  • Cantharidin

    Since cantharidin is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), PPP1R13B, the regulatory subunit 13B of PP1, is particularly interesting.[dx.doi.org] Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[abcam.com] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[ncbi.nlm.nih.gov] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] […] drug effects T-Lymphocytes, Regulatory/immunology T-Lymphocytes, Regulatory/radiation effects Substances CTLA-4 Antigen Ctla4 protein, mouse Cantharidin[ncbi.nlm.nih.gov] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[ncbi.nlm.nih.gov] Here we report that cantharidin inhibits migration and invasion of A549 human lung cancer cell.[ncbi.nlm.nih.gov] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[alomone.com]

  • Influenza

    IL-1 receptor (IL-1R1).[dx.doi.org] Selected Treatment Trials of Neuraminidase Inhibitors.[dx.doi.org] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[dx.doi.org] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[guidance.nice.org.uk] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] SEARCH METHODS: We searched trial registries, electronic databases (to 22 July 2013) and regulatory archives, and corresponded with manufacturers to identify all trials.[ncbi.nlm.nih.gov]

    Missing: 13B
  • Novobiocin

    RESULTS: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher.[ncbi.nlm.nih.gov] Blagg Chemistry - A European Journal 2016 22 (20), 6921-6931 Anticancer Inhibitors of Hsp90 Function Gaurav Garg , Anuj Khandelwal , Brian S.J.[doi.org] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[ncbi.nlm.nih.gov] Therefore, NovG and StrR apparently belong to the same family of DNA-binding regulatory proteins.[mic.microbiologyresearch.org] A Phosphatase-Novobiocin-Mannose-Inhibition Test (PNMI-Test) together with a high NaCl concentration (10%) in combination with a coagulase test seems to be an acceptable compromise[ncbi.nlm.nih.gov] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[ncbi.nlm.nih.gov] Novobiocin induced the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature[ncbi.nlm.nih.gov] Novobiocin does not bind the ATP binding site but rather the interface between the ATPase subunits and the transmembrane subunits of the LPS transporter.[ncbi.nlm.nih.gov]

    Missing: 13B
  • Herpes Simplex Virus 1 Infection

    Herpes simplex virus type 1 (HSV-1) is the more common type of Herpes simplex virus.[symptoma.com] Inhibition was achieved by adding cdk9 inhibitors 5,6-dichlorobenzimidazone-1-β-D-ribofuranoside (DRB) or flavopiridol (FVP) or by expression of a dominant-negative cdk9 or[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] Investigation of the mechanisms showed that poly-I:C or ssRNA treatment enhanced the expression of several IFN regulatory factors.[ncbi.nlm.nih.gov] The disruption of F-actin dynamics by chemical inhibitors significantly reduced the efficiency of viral infection and intracellular HSV-1 replication.[ncbi.nlm.nih.gov] Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection, the gamma(1)34.5 protein inhibits the activity of PKR by mediating dephosphorylation[ncbi.nlm.nih.gov] Gov't MeSH terms Apoptosis Regulatory Proteins/genetics Apoptosis Regulatory Proteins/metabolism Gene Expression Regulation, Viral/drug effects Genome, Human* HeLa Cells Herpes[ncbi.nlm.nih.gov] Abstract Herpes simplex virus 1 (HSV-1) infection triggers specific metabolic changes in its host cell.[ncbi.nlm.nih.gov]

    Missing: 13B
  • Carney Complex

    Acronym CNC1 Synonyms CAR Carney complex, type 1 Carney myxoma-endocrine complex Carney syndrome LAMB syndrome Myxoma, spotty pigmentation, and endocrine overactivity NAME[uniprot.org] Application of a PKA inhibitor inhibited the basal currents in these adenoma cells, results that were not observed in nonadenomatous somatotrophs.[ncbi.nlm.nih.gov] AMP-Dependent Protein Kinase RIalpha Subunit PRKAR1A protein, human RNA, Messenger RNA, Small Interfering SMAD3 protein, human Smad3 Protein Transforming Growth Factor beta[ncbi.nlm.nih.gov] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[books.google.com] To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[ncbi.nlm.nih.gov] His laboratory has been interested in the role of oxidants as signaling molecules and the participation of free radicals in human disease. Dr. J.[books.google.ro] Abstract Carney Complex (CNC) and Multiple Endocrine Neoplasia type 1 (MEN1) are forms of multiple endocrine neoplasia of dominant autosomal inheritance.[ncbi.nlm.nih.gov] Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.[ncbi.nlm.nih.gov]

    Missing: 13B
  • Lafora Disease

    […] hit PTHR11697:SF49 PTHR11697:SF49, 1 hit Sequence (1 ) i Sequence status i : Complete.[expasy.org] Here we show that malin and laforin co-localize in endoplasmic reticulum (ER) and that they form centrosomal aggregates when treated with proteasomal inhibitors in both neuronal[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] We have developed a human LD mutation database using a new generic biological database cross‐referencing platform.[doi.org] This gene encodes laforin, which is a tyrosine kinase inhibitor that plays a significant role in the regulation of glycogen metabolism.[wiki.med.umich.edu] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[hmg.oxfordjournals.org] The current perspective in LD is high-throughput screening for small molecules that act on the disease pathway, that is, partial inhibitors of GS, which opens a therapeutic[ncbi.nlm.nih.gov]

    Missing: 13B
  • Porphyromonas Gingivalis

    KEYWORDS: Porphyromonas gingivalis; adhesion; adhérence; galectin-1; galectin-3; galectine-1; galectine-3; invasion[ncbi.nlm.nih.gov] To block this neurotoxicity, we designed and synthesized small-molecule inhibitors targeting gingipains.[ncbi.nlm.nih.gov] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[ncbi.nlm.nih.gov] We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcription factor in oral keratinocytes was stimulated by the periodontal pathogen[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[uniprot.org] […] gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators.[ncbi.nlm.nih.gov] The immune-regulatory B7-H1 receptor, also known as programmed death-ligand 1 (PD-L1), plays an important role in cell-mediated immune response.[ncbi.nlm.nih.gov]

    Missing: 13B
  • Hereditary Sensory Neuropathy

    KIF1A comprises 47 exons (46 coding) plus three alternatively spliced coding exons that are refered to as 13b, 25b, and 36b accordingly to Rivière et al [2011] .[ncbi.nlm.nih.gov] Title Other Names: HSAN 1; Neuropathy hereditary sensory radicular, autosomal dominant; Neuropathy hereditary sensory and autonomic type 1; HSAN 1; Neuropathy hereditary sensory[rarediseases.info.nih.gov] Inhibitor; Roche Molecular Biochemicals, Mannheim, Germany) by sonication.[jci.org] Full-length versions of both mutant protein chains were expressed in E. coli at levels approaching that of the WT chains.[ncbi.nlm.nih.gov] Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain . J. Cell. Biochem. 106 , 521–528 (2009). 19. Cardoso, M.C. & Leonhardt, H.[doi.org] Serine palmitoyltransferase (SPT) is a heterodimeric molecule made up of two subunits, SPTLC1 and SPTLC2.[ncbi.nlm.nih.gov] Based on the radiation hybrid map of the human genome, we estimate that the size of this interval is less than 2,500 kb.[ncbi.nlm.nih.gov] Identification of a positive regulatory element in the myelin-specific promoter of the PMP22 gene. J Neurosci Res . 2001 Sep 15. 65(6):508-19. [Medline] .[emedicine.medscape.com]

  • CDK4-linked Melanoma

    Israeli team Megaphages detected in the intestinal tract of humans who eat high-fiber, low-fat diet NIH funds first artificial pancreas trial for pregnant women with type 1[news-medical.net] In detail, inhibitors of cyclin-dependent kinase 4 are developed to specifically downregulate the overactivated pathway involving cyclin-dependent kinase 4, its inhibitor[symptoma.com] […] showed overexpression of CDK4 and/or CCND1, suggest that functional inactivation of pRb through this pathway may be involved in the development or progression of sporadic human[ncbi.nlm.nih.gov] Analytik Jena Advertisement Trending Stories Latest Interviews Top Health Articles Cancer cure within a year, claims Israeli team Megaphages detected in the intestinal tract of humans[news-medical.net] What's more, p16 depends on retinoblastoma protein, a tumor suppressor which is phosphorylated and deactivated by cyclin-dependent kinase 4.[symptoma.com] As the p16 protein is involved in a cell cycle regulatory pathway consisting of at least pRb, cdk4 and cyclin D1, the tumours were also screened for amplifications of the[ncbi.nlm.nih.gov] Sleep deprivation linked with DNA damage New study uncovers key protein in the production of insulin Enhancing HD-MEA Systems with CMOS David Jäckel At SfN 2018, we spoke[news-medical.net] Cyclin-dependent kinase 4 is the catalytic subunit of a complex formed with D-type cyclins, which fulfill regulatory functions.[symptoma.com]

    Missing: 13B phosphatase
  • Treponema Denticola

    In this study we investigated the ability of T. denticola to bind the complement regulatory proteins factor H and factor H-like protein 1 (FHL-1).[ncbi.nlm.nih.gov] To identify specific inhibitors by structure-based in silico methods, we first validated the crystal structure of cystalysin as a reliable starting point for the design of[ncbi.nlm.nih.gov] In total, 219 non-redundant proteins were identified including numerous virulence factors, lipoproteins, ABC transporter proteins and enzymes involved in the metabolism of[ncbi.nlm.nih.gov] Abstract Nothing is currently known regarding the global regulatory networks of Treponema denticola and other oral spirochetes.[ncbi.nlm.nih.gov] Nucleotide (GenBank) : L25421 Treponema denticola phosphatase gene, 5' end. Nucleotide (GenBank) : AF082511 Treponema denticola mgl operon, partial sequence.[lgcstandards-atcc.org] […] are ordered K-I-D-B-A, with a subunit E gene located 300 kb upstream), and the subunit I gene contains a frameshift, which might render the ATPase nonfunctional.[doi.org] Immortalized human gingival epithelial HOK-16B cells were infected with 5- (and 6-) carboxy-fluorescein diacetate succinimidyl ester (CFSE)-labeled live or heat-killed T.[ncbi.nlm.nih.gov] .: #20218] Marker Gene (GenBank Direct submission) Treponema denticola Hpr kinase/phosphatase (hprK) gene, complete cds AY611605 990 158 * [Ref.: #20218] Marker Gene (DDBJ[bacdive.dsmz.de]

    Missing: 13B