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5,552 Possible Causes for (inhibitor), 1,, 14A,, mouse, phosphatase, protein, regulatory, subunit

Did you mean: (inhibitor), 1, 14A, morus, phosphatase, proteus, regulatory, subunit

  • Lafora Disease

    […] hit PTHR11697:SF49 PTHR11697:SF49, 1 hit Sequence (1 ) i Sequence status i : Complete.[expasy.org] Glycogen metabolizing enzymes were analyzed in a transgenic mouse over-expressing a dominant negative form of laforin that accumulates Lafora bodies in several tissues.[ncbi.nlm.nih.gov] Here we show that malin and laforin co-localize in endoplasmic reticulum (ER) and that they form centrosomal aggregates when treated with proteasomal inhibitors in both neuronal[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] To test this possibility we have created a double mutant mouse, by crossing the laforin deficient LD mouse with the leptin receptor mutant (db/db) and have characterized the[academic.oup.com] This gene encodes laforin, which is a tyrosine kinase inhibitor that plays a significant role in the regulation of glycogen metabolism.[wiki.med.umich.edu] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[hmg.oxfordjournals.org]

    Missing: 14A
  • Influenza

    IL-1 receptor (IL-1R1).[dx.doi.org] Compound 2 shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains, and shows an efficacy profile in a mouse influenza[doi.org] Selected Treatment Trials of Neuraminidase Inhibitors.[dx.doi.org] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[dx.doi.org] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[guidance.nice.org.uk] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] SEARCH METHODS: We searched trial registries, electronic databases (to 22 July 2013) and regulatory archives, and corresponded with manufacturers to identify all trials.[ncbi.nlm.nih.gov]

    Missing: 14A
  • Carney Complex

    Acronym CNC1 Synonyms CAR Carney complex, type 1 Carney myxoma-endocrine complex Carney syndrome LAMB syndrome Myxoma, spotty pigmentation, and endocrine overactivity NAME[uniprot.org] To validate this hypothesis, we generated stable Prkar1a knockdown in both mouse and human cells.[ncbi.nlm.nih.gov] Application of a PKA inhibitor inhibited the basal currents in these adenoma cells, results that were not observed in nonadenomatous somatotrophs.[ncbi.nlm.nih.gov] AMP-Dependent Protein Kinase RIalpha Subunit PRKAR1A protein, human RNA, Messenger RNA, Small Interfering SMAD3 protein, human Smad3 Protein Transforming Growth Factor beta[ncbi.nlm.nih.gov] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[books.google.com] To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[ncbi.nlm.nih.gov] Abstract Carney Complex (CNC) and Multiple Endocrine Neoplasia type 1 (MEN1) are forms of multiple endocrine neoplasia of dominant autosomal inheritance.[ncbi.nlm.nih.gov] Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.[ncbi.nlm.nih.gov]

    Missing: 14A
  • Cantharidin

    Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[abcam.com] In vivo, A431 cell xenograft mouse model were examined.[ncbi.nlm.nih.gov] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[ncbi.nlm.nih.gov] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] […] drug effects T-Lymphocytes, Regulatory/immunology T-Lymphocytes, Regulatory/radiation effects Substances CTLA-4 Antigen Ctla4 protein, mouse Cantharidin[ncbi.nlm.nih.gov] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[ncbi.nlm.nih.gov] In vivo therapeutic efficacy was investigated in imprinting control region mice bearing mouse sarcoma S180.[ncbi.nlm.nih.gov] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[alomone.com]

    Missing: 14A
  • Inflammation

    Immunofluorescence was negative in 1 patient.[ncbi.nlm.nih.gov] This figure shows Flow Cytometry Analysis of mouse bone marrow stained with anti-mouse CD44-PE (yellow). Isotype control labeling is shown in gray. Learn More[emdmillipore.com] KEYWORDS: Autoimmunity; Histone deacetylase inhibitor; Inflammation; Macrophage polarization[ncbi.nlm.nih.gov] The rate of protein synthesis in vivo was measured by the incorporation of [3H]phenylalanine into liver proteins in a chronic (5 day) intra-abdominal abscess model.[doi.org] Aspergillus protease-mediated mitochondrial ROS production was associated with downregulation of uncoupling protein (UCP)- 2 expression by TGF-β-SMAD4 signaling, which may play a regulatory[ncbi.nlm.nih.gov] Following this, caspase‑3/9, Bax, phosphatase and tensin homolog (PTEN), nuclear factor (NF)‑κB and phosphorylated‑(p)‑protein kinase B (Akt) protein expression were analyzed[ncbi.nlm.nih.gov] It is estimated that a total of 30 million people worldwide use NSAIDs on a daily basis (14a).[doi.org] […] major player in the development of the mucosa-associated lymphoid tissue and in the regulation of such adaptive responses as IgA production and the function of effector and regulatory[ncbi.nlm.nih.gov]

  • Porphyromonas Gingivalis

    KEYWORDS: Porphyromonas gingivalis; adhesion; adhérence; galectin-1; galectin-3; galectine-1; galectine-3; invasion[ncbi.nlm.nih.gov] […] publication date) these investigators report on in-vivo high-resolution magnetic resonance imaging (MRI) to document P. gingivalis mediated inflammation and atherosclerosis in a mouse[sciencedaily.com] To block this neurotoxicity, we designed and synthesized small-molecule inhibitors targeting gingipains.[ncbi.nlm.nih.gov] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[ncbi.nlm.nih.gov] We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcription factor in oral keratinocytes was stimulated by the periodontal pathogen[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[uniprot.org] This altered oral commensal microbiota is responsible for pathologic bone loss in the mouse.[ncbi.nlm.nih.gov]

    Missing: 14A
  • Novobiocin

    RESULTS: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher.[ncbi.nlm.nih.gov] Rosen and co-workers prepared a biotinylated taxol derivative and performed affinity chromatography experiments with lysates from both mouse brain and macrophage cell lines[ncbi.nlm.nih.gov] Blagg Chemistry - A European Journal 2016 22 (20), 6921-6931 Anticancer Inhibitors of Hsp90 Function Gaurav Garg , Anuj Khandelwal , Brian S.J.[doi.org] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[ncbi.nlm.nih.gov] Therefore, NovG and StrR apparently belong to the same family of DNA-binding regulatory proteins.[mic.microbiologyresearch.org] A Phosphatase-Novobiocin-Mannose-Inhibition Test (PNMI-Test) together with a high NaCl concentration (10%) in combination with a coagulase test seems to be an acceptable compromise[ncbi.nlm.nih.gov] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[ncbi.nlm.nih.gov] Click the right mouse button, as you would to replace the caps and lids. Instead you will be prompted to add an antibiotic disk.[vumicro.com]

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  • Herpes Simplex Virus 1 Infection

    Herpes simplex virus type 1 (HSV-1) is the more common type of Herpes simplex virus.[symptoma.com] In a mouse model of ocular infection, a UL24-deficient virus exhibited a reduction in viral titres in tear films of 1 log10, whilst titres in TG are often below the level[ncbi.nlm.nih.gov] Inhibition was achieved by adding cdk9 inhibitors 5,6-dichlorobenzimidazone-1-β-D-ribofuranoside (DRB) or flavopiridol (FVP) or by expression of a dominant-negative cdk9 or[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] Investigation of the mechanisms showed that poly-I:C or ssRNA treatment enhanced the expression of several IFN regulatory factors.[ncbi.nlm.nih.gov] The disruption of F-actin dynamics by chemical inhibitors significantly reduced the efficiency of viral infection and intracellular HSV-1 replication.[ncbi.nlm.nih.gov] The ability to suppress infection in human and pig cornea ex vivo and mouse in vivo models were also assessed.[ncbi.nlm.nih.gov] In contrast to the mouse model, co-localization with neuronal markers Ret or CGRP mirrored the magnitude of these neuron populations, whereas for the other four neuronal markers[ncbi.nlm.nih.gov]

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  • Dementia

    […] assisted.jpg 1 600 1 065; 229 KB Old woman walk.jpg 1 600 1 200; 665 KB Pet scans of aids patient with dementia.jpg 2 700 1 800; 1,7 MB Portrait Emil Kraepelin.[commons.wikimedia.org] […] similarly effective, and that both treatments reversed cognitive deficiencies, and modified disease pathology not only in an animal model of AD, but also in the DM-hTAU mouse[nature.com] inhibitors.[doi.org] The pathogenesis of AD is complex, involving specific disease-linked proteins (amyloid-beta [Aß] and tau), inflammation, and neurotransmitter dysregulation.[doi.org] Furthermore, nursing homes fear regulatory scrutiny of weight loss and wrongly believe that the use of feeding tubes signifies that everything possible is being done.[ncbi.nlm.nih.gov] Serum levels of human alkaline phosphatase isozymes in relation to blood groups.[ncbi.nlm.nih.gov] Recent observations showed that the major subunit of fibrillary amyloid deposits is a small 4–4.2-kDa peptide (Aβ), which derives by proteolytic cleavage from a larger transmembrane[doi.org] Comply with legislation mandates and regulatory and accreditation guidelines. Decrease the use of psychotropic medications.[crisisprevention.com]

  • LIG4 Syndrome

    […] and 2.39 at 1 and 24 hours, respectively) and NK cells (HC1, 49.80 and 3.26 at 1 and 24 hours, respectively; HC2, 58.38 and 2.57 at 1 and 24 hours, respectively).[bloodadvances.org] […] send to {{ username }} {{geneWatchAttr}} Analyze Gene Strain QTL List Functional Annotation unavailable Annotation Distribution unavailable Genomic Variants unavailble for Mouse[rgd.mcw.edu] Desk 1 Inhibition of apoE secretion by dynamin inhibitors. Ctrl.[perlierusa.com] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Zebrafish have p53, p63 and p73 genes, as well as the regulatory mdm2 and mdm4 genes (Lu and Abrams, 2006).[zdoc.site] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[doi.org] Epub 2004 Jun 11. 2004 23XRCC6, LIG4, PRKDC, XRCC4, XRCC5 Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4[genatlas.medecine.univ-paris5.fr] Term Browser Genes (2) Models (2) Disease References using Mouse Models (2)[informatics.jax.org]

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