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7,749 Possible Causes for (inhibitor), 1,, 14c, mouse, phosphatase, protein, protein,, regulatory, subunit

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  • Lafora Disease

    […] hit PTHR11697:SF49 PTHR11697:SF49, 1 hit Sequence (1 ) i Sequence status i : Complete.[] Glycogen metabolizing enzymes were analyzed in a transgenic mouse over-expressing a dominant negative form of laforin that accumulates Lafora bodies in several tissues.[] Here we show that malin and laforin co-localize in endoplasmic reticulum (ER) and that they form centrosomal aggregates when treated with proteasomal inhibitors in both neuronal[] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[] To test this possibility we have created a double mutant mouse, by crossing the laforin deficient LD mouse with the leptin receptor mutant (db/db) and have characterized the[] This gene encodes laforin, which is a tyrosine kinase inhibitor that plays a significant role in the regulation of glycogen metabolism.[] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[] The current perspective in LD is high-throughput screening for small molecules that act on the disease pathway, that is, partial inhibitors of GS, which opens a therapeutic[]

    Missing: 14c
  • Carney Complex

    Acronym CNC1 Synonyms CAR Carney complex, type 1 Carney myxoma-endocrine complex Carney syndrome LAMB syndrome Myxoma, spotty pigmentation, and endocrine overactivity NAME[] To validate this hypothesis, we generated stable Prkar1a knockdown in both mouse and human cells.[] Application of a PKA inhibitor inhibited the basal currents in these adenoma cells, results that were not observed in nonadenomatous somatotrophs.[] AMP-Dependent Protein Kinase RIalpha Subunit PRKAR1A protein, human RNA, Messenger RNA, Small Interfering SMAD3 protein, human Smad3 Protein Transforming Growth Factor beta[] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[] To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[] Abstract Carney Complex (CNC) and Multiple Endocrine Neoplasia type 1 (MEN1) are forms of multiple endocrine neoplasia of dominant autosomal inheritance.[] Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.[] Displaying 1-4 of 4 results. Except otherwise noted, content on this site is licensed under a Creative Commons Attribution 3.0 License[]

    Missing: 14c
  • Insulin-Like Growth Factor I

    We investigated this possibility by examining binding and hormone-stimulated [14C]glucose uptake, [3H]thymidine uptake, and receptor autophosphorylation by both insulin and[] Insulin-like Growth Factor-1 (IGF-1): IGF-1 LR3 VS IGF-1 DES IGF-1 (Insulin-like growth factor) is an endocrine hormone that is produced in the liver.[] […] but abrogated IGF-I-induced receptor autophosphorylation and phosphorylation of downstream kinases protein kinase B/Akt and MAPK/Erk (mouse proteins are reported).[] Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.[] The encoded protein is processed from a precursor, bound by a specific receptor, and secreted.[] IGF-I may be a regulatory factor for serum GHBP activity in man.[] IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase[] […] with altered growth hormone (GH) secretion, the changes of insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP-3), and acid-labile subunit[] Humans with defects of the NF-kappaB pathway exhibit growth failure, which suggests a possible regulatory role for NF-kappaB in statural growth.[]

  • Novobiocin

    RESULTS: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher.[] Rosen and co-workers prepared a biotinylated taxol derivative and performed affinity chromatography experiments with lysates from both mouse brain and macrophage cell lines[] Blagg Chemistry - A European Journal 2016 22 (20), 6921-6931 Anticancer Inhibitors of Hsp90 Function Gaurav Garg , Anuj Khandelwal , Brian S.J.[] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[] Therefore, NovG and StrR apparently belong to the same family of DNA-binding regulatory proteins.[] A Phosphatase-Novobiocin-Mannose-Inhibition Test (PNMI-Test) together with a high NaCl concentration (10%) in combination with a coagulase test seems to be an acceptable compromise[] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[] Click the right mouse button, as you would to replace the caps and lids. Instead you will be prompted to add an antibiotic disk.[] Novobiocin induced the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature[]

    Missing: 14c
  • Porphyromonas Gingivalis

    KEYWORDS: Porphyromonas gingivalis; adhesion; adhérence; galectin-1; galectin-3; galectine-1; galectine-3; invasion[] […] publication date) these investigators report on in-vivo high-resolution magnetic resonance imaging (MRI) to document P. gingivalis mediated inflammation and atherosclerosis in a mouse[] To block this neurotoxicity, we designed and synthesized small-molecule inhibitors targeting gingipains.[] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[] We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcription factor in oral keratinocytes was stimulated by the periodontal pathogen[] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[] This altered oral commensal microbiota is responsible for pathologic bone loss in the mouse.[] The immune-regulatory B7-H1 receptor, also known as programmed death-ligand 1 (PD-L1), plays an important role in cell-mediated immune response.[]

    Missing: 14c
  • Cantharidin

    Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[] In vivo, A431 cell xenograft mouse model were examined.[] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[] […] drug effects T-Lymphocytes, Regulatory/immunology T-Lymphocytes, Regulatory/radiation effects Substances CTLA-4 Antigen Ctla4 protein, mouse Cantharidin[] […] α (IKKα) and NF‑κB inhibitor α (IκBα) in cells, and an increased NF‑κB p65 subunit level in the nucleus.[] In vivo therapeutic efficacy was investigated in imprinting control region mice bearing mouse sarcoma S180.[] […] cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 2 and 2A 3 by competitively docking in the ligand binding site at the beta catalytic subunit[] Please mouse over Product Literature References MAP kinases associate with high molecular weight multiproteincomplexes : C.J. Bequette, et al.; J. Exp.[]

    Missing: 14c
  • LIG4 Syndrome

    […] and 2.39 at 1 and 24 hours, respectively) and NK cells (HC1, 49.80 and 3.26 at 1 and 24 hours, respectively; HC2, 58.38 and 2.57 at 1 and 24 hours, respectively).[] […] send to {{ username }} {{geneWatchAttr}} Analyze Gene Strain QTL List Functional Annotation unavailable Annotation Distribution unavailable Genomic Variants unavailble for Mouse[] Desk 1 Inhibition of apoE secretion by dynamin inhibitors. Ctrl.[] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[] Zebrafish have p53, p63 and p73 genes, as well as the regulatory mdm2 and mdm4 genes (Lu and Abrams, 2006).[] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[] Epub 2004 Jun 11. 2004 23XRCC6, LIG4, PRKDC, XRCC4, XRCC5 Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4[] Term Browser Genes (2) Models (2) Disease References using Mouse Models (2)[] Adenoma Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.[]

    Missing: 14c
  • Herpes Simplex Virus 1 Infection

    Herpes simplex virus type 1 (HSV-1) is the more common type of Herpes simplex virus.[] In a mouse model of ocular infection, a UL24-deficient virus exhibited a reduction in viral titres in tear films of 1 log10, whilst titres in TG are often below the level[] Inhibition was achieved by adding cdk9 inhibitors 5,6-dichlorobenzimidazone-1-β-D-ribofuranoside (DRB) or flavopiridol (FVP) or by expression of a dominant-negative cdk9 or[] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[] Investigation of the mechanisms showed that poly-I:C or ssRNA treatment enhanced the expression of several IFN regulatory factors.[] The disruption of F-actin dynamics by chemical inhibitors significantly reduced the efficiency of viral infection and intracellular HSV-1 replication.[] The ability to suppress infection in human and pig cornea ex vivo and mouse in vivo models were also assessed.[] In contrast to the mouse model, co-localization with neuronal markers Ret or CGRP mirrored the magnitude of these neuron populations, whereas for the other four neuronal markers[] Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection, the gamma(1)34.5 protein inhibits the activity of PKR by mediating dephosphorylation[]

    Missing: 14c
  • Influenza

    IL-1 receptor (IL-1R1).[] Compound 2 shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains, and shows an efficacy profile in a mouse influenza[] Selected Treatment Trials of Neuraminidase Inhibitors.[] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[] SEARCH METHODS: We searched trial registries, electronic databases (to 22 July 2013) and regulatory archives, and corresponded with manufacturers to identify all trials.[] Abstract Soluble, recombinant forms of influenza A virus haemagglutinin and neuraminidase have been produced in cells of lower eukaryotes, and shown in a mouse model to induce[]

    Missing: 14c
  • Suramin

    It is nonmetallic and tetravalent—making four electrons available to form covalent chemical bonds, three isotopes occur naturally, 12C and 13C being stable, while 14C is a[] […] work, we found that NF449 inhibits virus attachment to target cells, and specifically blocks virus interaction with two identified receptors--the P-selectin ligand, PSGL-1,[] Human and mouse P2X(1) receptors were expressed in human embryonic kidney cells, and membrane currents evoked by ATP were recorded.[] This screen identified suramin, a drug used to treat African trypanosomiasis, and its analogues NF023 and NF449 as inhibitors of the SH2 domains of STAT5a/b.[] […] to the G protein alpha subunit).[] We discuss the importance of exosite 2 as a regulatory site for ligands in both the procoagulant and inhibitory scenarios. Copyright  2012 Elsevier Inc.[] Suramin decreased the secretion of alkaline-phosphatase after stimulation by 1,25-dihydroxy-Vitamin D(3) up to 50% and decreased telomerase activity by up to 40%.[] Observations with a purified system of recombinant G protein subunits without a receptor yielded direct evidence that suramin suppresses the association between these subunits[] […] legislation of Ontario, Alberta, Saskatchewan and Québec (the Jurisdictions) that the Applicant is not a reporting issuer The Applicant has applied to the local securities regulatory[]