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7,350 Possible Causes for (inhibitor), 1,, 2,, phosphatase, protein, rat, regulatory, subunit

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  • Sophora

    It inhibited the migration of THP-1 cells induced by MCP-1 with IC50 value of 19.2 microg/mL.[ncbi.nlm.nih.gov] […] chemokine that is produced constitutively by keratinocytes and is highly up-regulated in inflammatory skin conditions such as atopic dermatitis and contact dermatitis. (2S)-2[ncbi.nlm.nih.gov] The pharmacophore model generated recognized the common functional groups of known PDE10A inhibitors.[ncbi.nlm.nih.gov] Tissue distribution of kurarinone and kurarinone glucuronides was analyzed in rats receiving ESF (2.5 g/kg).[ncbi.nlm.nih.gov] Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been[ncbi.nlm.nih.gov] To study the molecular mechanisms of cell cycle regulation by AESR, we also measured the intracellular levels of cell cycle regulatory proteins such as cyclin D, cyclin-dependent[ncbi.nlm.nih.gov] […] lectin subunit that binds to the glycotope was identified by photoaffinity glycan probes.[biochemj.org] CSF enhances wound healing in a rat model of perianal ulceration.[ncbi.nlm.nih.gov]

  • Fasciola Hepatica

    1 region.[ncbi.nlm.nih.gov] ITS-2 rDNA were cloned, sequenced, and compared with published sequences ITS-2 rDNA of other species of trematodes in the family Fasciolidae using the GenBank Blast program[ncbi.nlm.nih.gov] We also propose novel compounds as FhCL3 inhibitors.[ncbi.nlm.nih.gov] An in vivo study in the laboratory rat model has been carried out to monitor changes to the tegument and gut of adult Fasciola hepatica following treatment with myrrh ('Mirazid[ncbi.nlm.nih.gov] The protein shows strongest sequence similarity to egg antigen proteins from Schistosoma mansoni, Schistosoma japonicum and Clonorchis sinensis.[ncbi.nlm.nih.gov] Comparing the cellular expression levels with extracellular vesicles, we found all miRNAs expressed and enriched for miRNAs with immuno-regulatory function, tissue growth[ncbi.nlm.nih.gov] Teaching Hospital (TUTH), Kathmandu, Nepal on August, 2015 with fever, right hypochondriac pain, jaundice and occasional vomiting with anorexia for 4 months whose alkaline phosphatase[ncbi.nlm.nih.gov] Polymerase chain reaction targeting Fasciola hepatica cytochrome oxidase subunit 1 (COI) gene and sequencing of the products confirmed Fasciola infection.[ncbi.nlm.nih.gov]

  • Isoproterenol

    It is well known that the two chemical compounds endothelin-1 (ET-1) and isoproterenol (ISO) can individually induce cardiac hypertrophy through G protein-coupled receptors[ncbi.nlm.nih.gov] Fold changes in RNA expression were quantified with the 2 (-ΔΔCt) method.[ncbi.nlm.nih.gov] Metacarb and isocarb proved to be selective BChE inhibitors, as they progressively inhibited AChE 960 to 80 times more slowly than BChE(UU).[ncbi.nlm.nih.gov] Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart[ncbi.nlm.nih.gov] We conducted experiments to identify the mechanisms involved in the regulatory functions of adrenergic signaling on erythroid differentiation and the expression of hemoglobin[ncbi.nlm.nih.gov] Addition of okadaic acid, inhibitor of protein phosphatase(s), reverses the decline of complex I activity in serum-limited fibroblast cultures and activates the complex in[ncbi.nlm.nih.gov] In contrast, β2 subunit protein levels decreased (down to 49%), while mRNA levels remained unchanged.[ncbi.nlm.nih.gov] Importantly, these inhibitors had no effect on cAMP increases associated with the incubation of erythrocytes with Ilo.[ncbi.nlm.nih.gov]

  • Peptostreptococcus

    Pyogenic Brain Abscess Caused by Peptostreptococcus in a Patient with HIV-1 Infection. Diseases 2017 , 5 , 26.[mdpi.com] ) and 44 non-diabetic subjects as control (group 2).[ijpsr.com] Penetration of the Matrigel by P. micros HG1262 was inhibited by the presence of a serine protease inhibitor.[ncbi.nlm.nih.gov] It disappeared when the rat bile-pancreatic duct was ligatured or when the rats ingested a trypsin inhibitor.[ncbi.nlm.nih.gov] One per cent SDS and M urea both extracted a major 78 kDa protein from all strains of P anaerobius.[ncbi.nlm.nih.gov] Total cholesterol levels were significantly increased in colon cell lines exposed to P anaerobius via activation of sterol regulatory element-binding protein 2.[ncbi.nlm.nih.gov] The phosphorylation of macrophage kinases, including cAMP-dependent protein-serine kinase (PKA) catalytic subunit beta, G protein-coupled receptor-serine kinase 2, mitogen-activated[ncbi.nlm.nih.gov] […] tested for their ability to produce various enzymes, including catalase, hippurate hydrolase, serine dehydratase, threonine dehydratase, collagenase, gelatinase, alkaline phosphatase[ncbi.nlm.nih.gov]

  • Newcastle Disease

    Eight of these strains are listed in Table 1 . Table 1: Eight strains of Newcastle disease virus used in live vaccines Strain Description F Lentogenic.[fao.org] Interleukin-2 (IL-2) could boost the immune response against the tumor cells.[ncbi.nlm.nih.gov] Finally, we observed an enhanced oncolysis in NSCLC cells treated with NDV in the presence of an autophagy inhibitor 3-methyladenine (3-MA).[ncbi.nlm.nih.gov] Total cytoplasmic RNA samples isolated from control and MTH-68/H-infected cells were analyzed using a rat specific Affymetrix exon chip.[ncbi.nlm.nih.gov] Green fluorescent protein (GFP) used as a powerful marker of gene expression in vivo has so far been applied widely in studying the localizations and functions of protein[ncbi.nlm.nih.gov] Additionally, NDV produced from HeLa-S3 cells is more resistant to complement than NDV from 293F cells, which correlated with higher expression and incorporation of complement regulatory[ncbi.nlm.nih.gov] No correlation between the IC50 values and the rate of extracellular signal-regulated kinase (ERK) and AKT phosphorylation and phosphatase and tensin homologue (PTEN) expression[ncbi.nlm.nih.gov] HIF-1 is a heterodimeric transcriptional factor consisting of a regulated α (HIF-1α) and a constitutive β subunit (HIF-1β).[ncbi.nlm.nih.gov]

  • Echinococcus Multilocularis

    1996 - v1 9A2870CCFB4F2697 GO Experimental Info Feature key Position(s) Description Actions Graphical view Length Non-terminal residue i 1 1 Non-terminal residue i 65 1 Sequence[uniprot.org] Upon exposure to EmF, p38, c-Jun N-terminal kinase (JNK) and ERK1/2 were also activated in hepatocytes in vitro, as well as MEK1/2 and RSK, in the absence of any toxic effect[ncbi.nlm.nih.gov] EmMPK2 activity could be effectively inhibited in the presence of ML3403 and SB202190, two ATP-competitive pyridinyl imidazole inhibitors of p38 MAPKs, in a concentration-dependent[ncbi.nlm.nih.gov] The cDNA clone coding a major vault protein (MVP)-like protein was derived from Echinococcus multilocularis cysts.[ncbi.nlm.nih.gov] Beside immunomodulating IL-10, TGFβ-driven regulatory T cells have been shown to play a crucial role in the parasite-modulated progressive course of AE.[ncbi.nlm.nih.gov] Stop solution, 25 ml Negative control serum (rabbit), 200 µl Cut-off serum (rabbit), 200 µl Positive control serum (rabbit), 200 µl Protein A - AP conjugate, 300 µl Alk. phosphatase[bordier.ch] In conclusion, we have constructed a subunit vaccine LTB-EMY162 which has prevention and therapeutic effect against E. multilocularis infection.[ncbi.nlm.nih.gov] Addition of an insulin receptor inhibitor resulted in metacestode killing, prevented metacestode development from parasite stem cells, and impaired the activation of insulin[ncbi.nlm.nih.gov]

  • Rift Valley Fever

    The Ser/Thr protein phosphatase 1 (PP1) has previously been shown to play a significant role in the replication of several viruses.[ncbi.nlm.nih.gov] The objective of this Phase 2 clinical trial was to (a) further examine the safety and immunogenicity of RVF MP-12 in RVF virus-naïve humans and (b) characterize isolates[ncbi.nlm.nih.gov] […] that RVFV infection activated Wnt signaling, was enhanced when Wnt signaling was preactivated, was reduced with knockdown of β-catenin, and was blocked using Wnt signaling inhibitors[ncbi.nlm.nih.gov] These recombinant viruses were demonstrated to be protective and immunogenic in rats, mice, and sheep, without producing clinical illness in these animals.[ncbi.nlm.nih.gov] Through the cullin 1-Skp1-Fbox E3 ligase complex, the NSs protein promotes the degradation of at least two host proteins, the TFIIH p62 and the PKR proteins.[ncbi.nlm.nih.gov] TANK-binding kinase 1 (TBK1) into NSs-induced cytoplasmic structures and this interaction could effectively inhibit downstream phosphorylation and dimerization of interferon regulatory[ncbi.nlm.nih.gov] SCF complexes have a variable F-box protein subunit that determines substrate specificity for ubiquitination.[ncbi.nlm.nih.gov] Of 34 RVF MP-12 recipients available for testing 1 year following inoculation, 28 (82%) remained seropositive (PRNT80 1:20); this included 20 of 23 vaccinees (87%) from IM[ncbi.nlm.nih.gov]

  • Francisella Tularensis

    Based on the measured kinetic parameters for the enzyme catalyzed CO2 hydration reaction (kcat of 9.8 105s-1 and a kcat/KM of 8.9 107M-1s-1), FtuβCA is a highly effective[ncbi.nlm.nih.gov] Safety, reactogenicity, take and/or antibody levels were assessed on days 0, 1, 2, 8, 14, 28, 56, and 180.[ncbi.nlm.nih.gov] The successful delivery into the rat trachea is critical for pulmonary delivery.[ncbi.nlm.nih.gov] Bacterial outer membrane proteins (OMPs) are involved in various virulence processes, including protein secretion, host cell attachment, and intracellular survival.[ncbi.nlm.nih.gov] The posttranscriptional regulatory protein Hfq was shown to be an important determinant of the stress resistance and full virulence in the dangerous human pathogen Francisella[ncbi.nlm.nih.gov] Additional studies demonstrated that miR-155 acted by translational repression to downregulate the TLR adapter protein MyD88 and the inositol 5'-phosphatase SHIP-1 in MDMs[ncbi.nlm.nih.gov] FTL578 (ornithine cyclodeaminase), FTL663 (heat shock protein), and FTL1228 (iron-sulfur activator complex subunit SufD) have been previously described as virulence-associated[ncbi.nlm.nih.gov] We also demonstrated for the first time that lipin-1 and PAP2a contribute to macrophage inflammation in response to F. tularensis.[ncbi.nlm.nih.gov]

  • Clonorchis Sinensis

    The cysteine protease inhibitor CsStein-1 isolated from Clonorchis sinensis belongs to the type 1 stefin of cystatins.[ncbi.nlm.nih.gov] The CCC, PXSC, and CG motives characteristic to extracellular loop 2 (EC2) region of TSP-2 were well conserved.[ncbi.nlm.nih.gov] Significantly raised eosinophil levels were found in the blood of C. sinensis/C. hepatica co-infected rats (CS CH) compared to the blood of rats infected singly with C. sinensis[ncbi.nlm.nih.gov] We identified antigenic proteins from adult C. sinensis liver flukes using immunoproteomic analysis.[ncbi.nlm.nih.gov] In addition, Mg(2 ) or K( ) played a regulatory role in enzyme activity of CsFBPase.[ncbi.nlm.nih.gov] […] results of liver-function tests were abnormal, showing elevated levels of aspartate aminotransferase (350 IU per liter), alanine aminotransferase (352 IU per liter), alkaline phosphatase[nejm.org] In this study, a full-length sequence encoding a vacuolar ATP synthase subunit ε-like protein of Clonorchis sinensis (CsATP-ε) was isolated from our cDNA library.[ncbi.nlm.nih.gov] -15, insect-derived growth factor, cytochrome c oxidase subunit VI, DNAH1 protein, and kinesin light chain.[ncbi.nlm.nih.gov]

  • Sulfone

    Patients will be evaluated to determine whether polyp numbers have been reduced after 1 year relative to baseline.[ncbi.nlm.nih.gov] Clinical investigations have demonstrated a link between use of the sulfone cyclooxygenase-2 (COX-2) inhibitor, rofecoxib, and increased risk for atherothrombotic events.[ncbi.nlm.nih.gov] […] treated rats.[ncbi.nlm.nih.gov] We hypothesized that other protein cross-linkers enhance toxicity similarly.[ncbi.nlm.nih.gov] Regulatory Information The Regulatory Information fields include information from the U.S.[cameochemicals.noaa.gov] Redox regulation of protein tyrosine phosphatase 1B (PTP1B) involves oxidative conversion of the active site cysteine thiolate into an electrophilic sulfenyl amide residue[ncbi.nlm.nih.gov] Thus, most efforts towards the development of proteasome inhibitors have focused on the selective inhibition of the β5 subunit active site.[ncbi.nlm.nih.gov] H32 preferentially inhibited the activities of the cell cycle controlling Cdc25A phosphatase likely by binding to its catalytic cysteine.[ncbi.nlm.nih.gov]