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1,680 Possible Causes for (inosine, 2,, IMP, dehydrogenase, human, monophosphate)

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  • Malnutrition

    The history revealed a restrictive diet of commercial pureed fruit and coconut juice for 2 years.[ncbi.nlm.nih.gov] Inosine monophosphate dehydrogenase (IMPDH) regulates intracellular fat accumulation, pre-adipicytes maturation, and is a target of mycophenolic acid (MPA) used as a standard[ncbi.nlm.nih.gov] A survey of hominin diets over time shows that humans have thrived on a broad range of foods.[ncbi.nlm.nih.gov] Trallero MDR 2, 6 , Montoro M 7 , Vázquez I 2, 7 , Charro M 8 , Barragán A 2, 8 , Martínez-Cerezo F 9 , Megias-Rangil I 2, 9 , Huguet JM 10 , Marti-Bonmati E 11, 10 , Calvo[ncbi.nlm.nih.gov] Background: Early childhood development provides an important foundation for the development of human capital.[ncbi.nlm.nih.gov] In the past 3 decades, parenteral nutrition, enriched preterm formula, and fortification of human milk have been used to alleviate these adverse effects.[ncbi.nlm.nih.gov]

  • Legionella Pneumophila

    KEYWORDS: Innate immunity; Legionella pneumophila; Toll-like receptor 2[ncbi.nlm.nih.gov] (HGPRT) (EC 2.4.2.8) reversibly catalyzes the transfer of the 5-phophoribosyl group from 5-phosphoribosyl-alpha-1-pyrophosphate (PRPP) to hypoxanthine or guanine to form inosine[ncbi.nlm.nih.gov] Lp infection increased extracellular lactate dehydrogenase levels and decreased the number of living cells.[ncbi.nlm.nih.gov] We describe here that trans-translation is essential in the human pathogen Legionella pneumophila, the etiologic agent of Legionnaire's disease (LD), a severe form of nosocomial[ncbi.nlm.nih.gov] Upon translocation into U937 cells, RavN was almost exclusively found in the cytosolic fraction together with the marker protein glyceraldehyde 3-phosphate dehydrogenase ([journals.plos.org] […] and human alveolar epithelial (A549) cells.[ncbi.nlm.nih.gov]

  • Xanthinuria

    J Urol. 1988 Feb;139(2):338-9. Author information 1 Department of Surgery, Al Qassimi Hospital, Sharjah, United Arab Emirates.[ncbi.nlm.nih.gov] […] monophosphate dehydrogenase 1 4 56,478,383 56,493,987 RGD:10402751 G Itpa inosine triphosphatase 3 123,209,611 123,221,266 RGD:10402751 G Nme6 NME/NM23 nucleoside diphosphate[rgd.mcw.edu] Abstract Xanthinuria due to xanthine dehydrogenase (XDH) deficiency is a rare genetic disorder characterized by hypouricemia and the accumulation of xanthine in the urine.[ncbi.nlm.nih.gov] […] acid Pemetrexed Pralatrexate Many others Others Precursors: Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine IMP[en.wikipedia.org] Human diseases associated with genetically determined dysfunction of XOR are termed xanthinuria, because of the excretion of xanthine in urine.[ncbi.nlm.nih.gov] The duodenal mucosa from the subject had no xanthine dehydrogenase protein while the mRNA level was not reduced.[ncbi.nlm.nih.gov]

  • Treponema Denticola

    MMP-2 activation was detected by zymography. MMP-2, MT1/MMP and TIMP-2 expression following T. denticola challenge was determined by qRT-PCR.[ncbi.nlm.nih.gov] Glycosaminoglycan metabolism Terpenoid backbone biosynthesis Sterol biosynthesis Other terpenoid biosynthesis Nucleotide and amino acid metabolism Purine metabolism M00048 Inosine[genome.jp] A gene matching the 3-oxo-5alpha-steroid 4-dehydrogenase family protein (gene ID: 2739284; locus tag: TDE2697) has been identified in T. denticola ATCC 35405.[ncbi.nlm.nih.gov] Individual human sera showed specificity for one or more Msp types.[ncbi.nlm.nih.gov] […] denticola cultures are capable of metabolising cholesterol, progesterone, 4-androstenedione and testosterone by means of 5alpha-reductase, 3beta-and 17beta-hydroxysteroid dehydrogenase[ncbi.nlm.nih.gov] Cell death of bacteria-stimulated macrophages was examined using a lactate dehydrogenase (LDH) assay and propidium iodide (PI)/annexin V (AV) staining.[ncbi.nlm.nih.gov]

  • Antimetabolite

    Abstract The analysis of the new antimetabolite 2',2'-difluoro-2'-deoxycytidine (Gemcitabine, Eli Lilly Corp.) and of its metabolic deamination product, 2',2'-difluoro-2'-[ncbi.nlm.nih.gov] However, other cellular target enzymes, including thymidylate synthase, inosinate dehydrogenase, cytidine-5'-triphosphate synthetase, and other enzymes from the de novo nucleotide[ncbi.nlm.nih.gov] […] were evaluated for methylenetetrahydrofolate reductase (MTHFR) gene C667T, thymidilate synthase (TS) gene 5' UTR variable number of tandem repeats (VNTR), dihydroprymidine dehydrogenase[ncbi.nlm.nih.gov] Structure rendered from 2h31.pdb . 16.3.6 Synthesis of AMP from IMP The synthesis of AMP from IMP occurs in two steps.[watcut.uwaterloo.ca] Our results suggest that CAV has real potential as a lead compound for the development of analogues with enhanced activity against human pancreatic cancer.[ncbi.nlm.nih.gov] Purine antagonist: 6-Mercaptopurine • Mechanism of action: • 6-MP inhibit the conversion of inosine monophosphate to adenine and guanine nucleotides that are building blocks[slideshare.net]

  • Toxoplasma Gondii

    Methods: : Four different strains of human Toxoplasma gondii were cultured: a type 1 and type 2 strain isolated from patients in France; a type 2 strain from a US patient[iovs.arvojournals.org] KEYWORDS: Apicomplexan; Differentiation; Inosine monophosphate dehydrogenase; Mycophenolic acid; Tissue cyst; Toxoplasma[ncbi.nlm.nih.gov] This study was mainly focused on an estradiol regulatory factor-Hydroxysteroid dehydrogenase (HSD) gene in T. gondii.[ncbi.nlm.nih.gov] A few case reports have described pulmonary toxoplasmosis in human immunodeficiency virus-infected patients in association with Toxoplasma gondii central nervous system disease[ncbi.nlm.nih.gov] […] in human villous explants from the third trimester.[ncbi.nlm.nih.gov] Han Y 1, 2 , Nie L 3 , Ye X 1, 2 , Zhou Z 2 , Huang S 2 , Zeng C 2 , Guo C 2 , Ou M 1, 2 , Xiao D 2 , Zhang B 1, 2 , Huang C 2 , Ye X 2 , Jing C 4, 5 , Yang G 6, 7 .[ncbi.nlm.nih.gov]

    Missing: IMP
  • Retinitis Pigmentosa 32

    PMID: 29498230 Free PMC Article Anil K, Garip G BMC Ophthalmol 2018 Jan 30;18(1):21. doi: 10.1186/s12886-018-0689-2.[ncbi.nlm.nih.gov] Research article Biochemical Journal Aug 09, 2005, 390 (1) 41-47; DOI: 10.1042/BJ20042051 Abstract Two mutations of IMPDH1 (inosine 5′-monophosphate dehydrogenase type I),[biochemj.org] Earlier research funded by the Foundation Fighting Blindness helped advance this therapeutic approach toward a human study.[blindness.org] Heterologous Expression and Western Blot Human full-length CNGA1 and CNGB1 channel subunits were PCR amplified from human retinal cDNA and subcloned into the pcDNA3 vector[journals.plos.org] The resultant bands were photographed after electrophoresis on a 2% agarose gel and stained with ethidium bromide.[jmg.bmj.com] METHODS: To find the disease locus responsible for this condition, the authors performed a genome-wide search using genetic loci spaced at 10 to 20-cM intervals spanning human[ncbi.nlm.nih.gov]

  • Ribavirin

    Efficacy Table 2. Table 2. Response during and after Treatment.[nejm.org] It is generally understood that the inosine triphosphatase-CC genotype does not have a significantly lower reduction by pegylated interferon combined with ribavirin in the[ncbi.nlm.nih.gov] Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell 85 : 921 -930. 22. Smee, D. F., M.[jvi.asm.org] An antiviral must be broadly effective against the natural spectrum of RSV genotypes and must attain concentrations capable of inhibiting viral replication within the human[ncbi.nlm.nih.gov] Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase.[sigmaaldrich.com] Through this pathway, the antiviral compound ribavirin 5'-monophosphate is significantly incorporated but also readily excised from RNA, which may explain its limited efficacy[ncbi.nlm.nih.gov]

  • Retinitis pigmentosa, Y-Linked

    7 aak-2 X; 22.49 41 AMP-activated protein kinase alpha 2. 8 aakb-1 X; 13.29 18 AMP-Activated Kinase Beta subunit. 9 aakb-2 III; 6.94 16 AMP-Activated Kinase Beta subunit.[ncbi.nlm.nih.gov] Research article Biochemical Journal Aug 09, 2005, 390 (1) 41-47; DOI: 10.1042/BJ20042051 Abstract Two mutations of IMPDH1 (inosine 5′-monophosphate dehydrogenase type I),[biochemj.org] Summary » Homo sapiens » RPY cDNA ORF clone RPY Summary Gene Symbol RPY Entrez Gene ID 79051 Full Name Retinitis pigmentosa, Y-linked Gene Type unknown Organism Homo sapiens(human[genscript.com] User Ratings 5.0 out of 5 stars ease 1 of 5 2 of 5 3 of 5 4 of 5 5 of 5 0 / 5 features 1 of 5 2 of 5 3 of 5 4 of 5 5 of 5 0 / 5 design 1 of 5 2 of 5 3 of 5 4 of 5 5 of 5 0[sourceforge.net] The LY & RPY has a 2 pole change-over configuration. It’s wide terminals allow for reliability at large currents.[us.greystoneenergy.com] Aarskog syndrome Acanthocytosis Acatalasemia Acetyl-CoA carboxylase deficiency Achondroplasia ACTH deficiency Acute hepatic porphyria Acute intermittent porphyria Acyl-CoA dehydrogenase[easternbiotech.com]

  • Suramin

    Abstract Falcipain-2 is a cysteine protease of the malaria parasite Plasmodium falciparum that plays a key role in the hydrolysis of hemoglobin, a process that is required[ncbi.nlm.nih.gov] Mycophenolic acid Pemetrexed Pralatrexate Many others Others Precursors: Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine[en.wikipedia.org] HepG2 cell proliferation was measured by MTT and lactate dehydrogenase (LDH) assays.[ncbi.nlm.nih.gov] Abstract Sirtuins are NAD( )-dependent protein deacetylases and are emerging as molecular targets for the development of pharmaceuticals to treat human metabolic and neurological[ncbi.nlm.nih.gov] Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin Author affiliations * Corresponding authors a Graduate Program in Biochemistry[pubs.rsc.org] The data demonstrate that suramin has marked in vitro effects on human osteosarcoma cells supporting further clinical investigation.[ncbi.nlm.nih.gov]