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  • LIG4 Syndrome

    […] send to {{ username }} {{geneWatchAttr}} Analyze Gene Strain QTL List Functional Annotation unavailable Annotation Distribution unavailable Genomic Variants unavailble for Mouse[rgd.mcw.edu] […] and 2.39 at 1 and 24 hours, respectively) and NK cells (HC1, 49.80 and 3.26 at 1 and 24 hours, respectively; HC2, 58.38 and 2.57 at 1 and 24 hours, respectively).[bloodadvances.org] […] as seckel-type dwarfism 2, microcephalic primordial dwarfism 2.[mendelian.co] Sorry for the inconvenience.To improve our services, we have momentarily shutdown our site.[rccghouseofredemption.org] […] cell lineages and increased risk for development of acute myeloid leukemia.[bdtd.ibict.br] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Analytical, diagnostic and therapeutic context of LIG4 Because nonhomologous integration is eliminated in a LIG4-disrupted strain, integration occurs only at the targeted[wikigenes.org] Management and treatment Supportive treatment is with prophylactic antibiotics and anti-virals.[orpha.net] LIG4 syndrome is conferred by hypomorphic mutations in DNA ligase IV, an essential component of DNA non-homologous end-joining (NHEJ), and is associated with pancytopaenia[ncbi.nlm.nih.gov] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org]

    Missing: Meis1
  • Influenza

    Compound 2 shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains, and shows an efficacy profile in a mouse influenza[doi.org] IL-1 receptor (IL-1R1).[doi.org] Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside[ncbi.nlm.nih.gov] If you are an Acquia Cloud customer and expect to see your site at this address, you'll need to add this domain name to your site via the Acquia Network management console[pida.nihlibrary.com] […] of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation" Gary et al. (2015) Full text Testimonials "To establish a novel role for myeloid[shop.jpt.com] Like hemagglutinin and neuraminidase, the M2 protein is an integral membrane protein of the influenza A virus 4 , 5 .[doi.org] […] demonstrate that the native morphology of influenza A virions is regular but is disrupted by ultracentrifugation, and that the cytoplasmic tail of M2 is important for virion integrity[ncbi.nlm.nih.gov] Present evidence reveals successive recycling in pandemics, of only 3 of the 15 possible avian viral HAs.[ncbi.nlm.nih.gov] Heterologous mean HI titers were normalized to mean homologous HI titers (mean heterologous titers/mean homologous titers).[doi.org] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov]

    Missing: Meis1 ecotropic
  • Human Immunodeficiency Virus

    HIV Gag-p24 Materials provided Capture Ab : 0.5 mg/mL of mouse anti-HIV-1 P24 monoclonal antibody (in PBS, pH 7.4).[sinobiological.com] IMPORTANCE In HIV-1-producing cells, gp41 exists in a complexed form with caveolin-1, an interaction most probably mediated by the caveolin-1 binding motif.[ncbi.nlm.nih.gov] Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected[jgv.microbiologyresearch.org] Welcome to the New AIDS Origins Site Submitted by Ed Hooper on Fri, 05/07/2013 - 1:21pm Welcome to the new AIDS Origins site: July 4th, 2013.[aidsorigins.com] NF-kB is constitutively activated in primary monocytes and myeloid cell lines chronically infected with HIV-1 ( 7 ).[doi.org] Localization of lipid-protein and protein-protein interactions within the murine retrovirus gag precursor by a novel peptide-mapping technique.[ncbi.nlm.nih.gov] Most of the genes had only a single integrant (659 integrants, 67%); these integrants were not shown to be from clonally expanded cells.[doi.org] To investigate the impact of recombination on viral diversity, we developed a technique that permits the isolation of contemporaneous clonal viral populations resulting from[ncbi.nlm.nih.gov] […] analysis (large subunit of RNA polymerase II and 18S ribosomal RNA internal transcribed spacer 1) from the tissue biopsy sample revealed the pathogen sequences to be highly homologous[ncbi.nlm.nih.gov] In this study we examine the conditions needed for SIV to complete the genetic transition from individual human SIV infections to epidemic HIV in humans.[doi.org]

    Missing: Meis1
  • Human Herpesvirus 6

    (Santa Cruz Biotechnology) or chicken IgY anti-GFAP (Aves Labs) to identify the astroglial phenotypes, mouse IgM anti-O4 (Millipore) or mouse IgM targeting the low - affinity[doi.org] (HIV-1)--in a human neoplastic T-cell line.[ncbi.nlm.nih.gov] Coagulopathy with hypercytokinemia was observed in 2 patients. One demonstrated thermolabile variation in carnitine palmitoyltransferase 2.[ncbi.nlm.nih.gov] We found that the expression of the fusion U27 promoter was dependent on the presence of the E2F binding site.[ncbi.nlm.nih.gov] Ondrej Cinek, Katerina Hyncicova, Hana Hrstkova, Petr Sedlacek and Jan Stary , Prevalence of HHV‐6 integrated chromosomally among children treated for acute lymphoblastic or myeloid[doi.org] […] two major tegument proteins, U14 and U11.[ncbi.nlm.nih.gov] […] of human chromosomes during integration are discussed.[ncbi.nlm.nih.gov] The amino acid sequences of 13 of the 17 ORFs at the right end of U differ by more than 10%, with the notable exception of U94, the adeno-associated virus type 2 rep homolog[ncbi.nlm.nih.gov] DOI: 10.1128/CMR.10.3.521 SUMMARY Human herpesvirus 6 variant A (HHV-6A) and human herpesvirus 6 variant B (HHV-6B) are two closely related yet distinct viruses.[doi.org] We describe a male infant with carnitine palmitoyltransferase 2 (CPT2) deficiency who presented with acute encephalopathy related to human herpesvirus-6 (HHV-6) infection.[ncbi.nlm.nih.gov]

    Missing: Meis1 ecotropic
  • Hepatitis C Virus

    USP1 associated factor 1, human Viral Nonstructural Proteins Rad51 Recombinase Rad51 protein, mouse[ncbi.nlm.nih.gov] In addition, shHO-1 inhibited HCV replication. CONCLUSION: In conclusion, hypericin inhibits HCV replication via down-regulation of HO-1 expression and deacetylation.[ncbi.nlm.nih.gov] In this paper, we study the molecular epidemiology of HCV genotype 2 in its region of endemic origin, west and central Africa.[doi.org] […] binding site.[ncbi.nlm.nih.gov] Arora , Functional reconstitution of defective myeloid dendritic cells in chronic hepatitis C infection on successful antiviral treatment , Liver International , 32 , 7 ,[doi.org] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[ncbi.nlm.nih.gov] A recent study identified occludin (OCLN), an integral tight junction protein, as one of the key factors for HCV entry into cells.[ncbi.nlm.nih.gov] […] kinetic data from viral inoculation to steady state.[ncbi.nlm.nih.gov] To address this challenge, we searched for homologous viruses in small mammals, including wild rodents.[ncbi.nlm.nih.gov] They also cannot easily be reconciled with the recent evidence for species–associated variants of HBV and HGV/GBV–C in a range of non–human primates.[doi.org]

    Missing: Meis1 ecotropic
  • Herpes Simplex Virus 2

    The hCD4/R5/cT1 mice represent a new preclinical mouse model to evaluate vaginal HIV-1 acquisition. Copyright 2015, American Society for Microbiology.[ncbi.nlm.nih.gov] The objective of this study was to determine HSV-2 prevalence and incidence and associated risk factors in a HIV-1-positive and at risk HIV-1-negative adolescent population[ncbi.nlm.nih.gov] Product Name: Herpes Simplex Virus 2 (HSV 2) IgM - ELISA # of Samples: 1 x 96 Assays Intended Use: The HSV 2 IgM recombinant ELISA allows the detection of HSV 2 infection[genwaybio.com] This study demonstrates that arginine mutagenesis at appropriate evolution sites may significantly enhance the antiviral activity of HD5, which also paves a facile way to[ncbi.nlm.nih.gov] Products associated with HSV-2 gD recombinant protein Pathways associated with HSV-2 gD recombinant protein[mybiosource.com] LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.[labcorp.com] It would be helpful to identify a genital viral load threshold necessary for transmission, as clinical interventions that maintain viral quantity below this level would be[ncbi.nlm.nih.gov] Genotyping of all HSV-2-positive samples showed 100% sequence homology for three recipients.[ncbi.nlm.nih.gov] Using this approach, we identified epitopes that elicit strong humoral responses in humans, as well as other epitopes that elicit much weaker responses.[ncbi.nlm.nih.gov] During the latent phase the viral DNA is integrated into the genome of the host cell.[novusbio.com]

    Missing: Meis1 ecotropic
  • HIV-2 Infection

    For analysis of chemokine receptor molecules on CD34 CD38 cells, mouse MoAb to CXCR-4 (12G5, mIgG 2a ) and CCR-5 (12D1, mIgG 2a ; both MoAbs obtained from the AIDS Research[bloodjournal.org] THURSDAY, Aug. 8, 2013 (HealthDay News) -- The first rapid test to detect the HIV-1 antigen, as well as blood antibodies for the HIV-1 and HIV-2 strains, has been approved[consumer.healthday.com] […] plasma HIV-2 RNA.[ncbi.nlm.nih.gov] […] per synonymous site to nonsynonymous substitutions per nonsynonymous site suggested selection to be neutral or negative.[ncbi.nlm.nih.gov] Here we investigated the susceptibility of primary myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) to infection by HIV-2.[ncbi.nlm.nih.gov] […] fusion proteins and which seems to drive fusion.[prospecbio.com] Abstract The mechanisms that enable preservation of gut mucosal integrity during persistent viral replication and inherent inflammation remain unclear.[ncbi.nlm.nih.gov] We assessed, for the first time, the direct impact of HIV-2 infection on the human thymus.[ncbi.nlm.nih.gov] Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.[med.nagoya-u.ac.jp] "Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins".[en.wikipedia.org]

    Missing: Meis1 ecotropic
  • Poliovirus

    […] for poliovirus receptor (PVR) into the genome of mouse strain ICR.[doi.org] Enterovirus C Genbank AJ132961 Human poliovirus 1, complete genome.[genome.jp] Abstract Wild poliovirus type-2 has been eradicated, use of live type-2 vaccine has been terminated globally, and all type-2 polioviruses are under strict laboratory containment[ncbi.nlm.nih.gov] Analysis based on 5-m mesh DSM was also conducted for three cities in Niger to prioritise the selection of new sites.[ncbi.nlm.nih.gov] Yet, a powerful innate inflammatory response coincided with chemokine induction and myeloid cell infiltration into tumors that was, interestingly, dominated by neutrophils[ncbi.nlm.nih.gov] Abstract A small protein, VPg, is covalently linked to the 5′ end of the plus-stranded poliovirus genomic RNA 1 , 2 , 3 .[nature.com] Integrated global immunization programs using live-attenuated oral (OPV) and/or inactivated (IPV) PV vaccines have systematically reduced its spread and paved the way for[ncbi.nlm.nih.gov] […] extreme C-terminal domains resulting in differential localization in epithelia and polarity of viral infection.[ncbi.nlm.nih.gov] Furthermore, this isolate had higher homology to the isolates from North Vietnam than those from Pakistan or Finland, suggesting that the Shiga strain was imported from Asian[ncbi.nlm.nih.gov] We previously isolated chimpanzee and human mAbs capable of neutralizing multiple PV types (cross-neutralization).[ncbi.nlm.nih.gov]

    Missing: Meis1 ecotropic
  • Dengue Virus

    ), mouse MAb against DENV-2 NS4A protein (generated in-house [unpublished data]), mouse MAb D2C1 against DENV-2 capsid ( 35 ), mouse MAb 4G2 (ATCC) against DENV E protein[doi.org] KEYWORDS: DENV-1; Dengue; Genome; Indonesia; Surabaya[ncbi.nlm.nih.gov] 001474 Dengue virus 2, complete genome.[genome.jp] Amino acid variation sites in NS5 (NS5-553I/M, NS5-629 T, and NS5-820E) differentiated the DENV3/III-C from other DENV3 viruses.[ncbi.nlm.nih.gov] Abstract This is a case report of a patient with chronic myeloid leukemia (CML) undergoing imatinib treatment who became infected with dengue virus.[ncbi.nlm.nih.gov] The non-structural protein (NS) 4A is one of the least characterized DV proteins.[ncbi.nlm.nih.gov] Abstract The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage[ncbi.nlm.nih.gov] In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.[ncbi.nlm.nih.gov] Comparison of the amino acid sequences shows that amino acid sequence homology is not uniformly distributed among the proteins; highest homology is found in some domains of[web.archive.org] In the present study, we have demonstrated that primary human naive CD4 and CD8 T cells are permissive for DV infection.[ncbi.nlm.nih.gov]

    Missing: Meis1 ecotropic
  • Adenovirus

    These findings indicate that studies in mouse serum accurately predict the behavior of Ad5 vectors in human serum, but mouse serum is not an accurate model system for all[ncbi.nlm.nih.gov] What does CAV-1 do to the eye? 20% of CAV-1 cases will develop cornea edema (blue eye) What % of dogs develop blue eye after vaccination for CAV-1?[brainscape.com] Abstract Human adenovirus 7d, a genomic variant with no reported circulation in the United States, was isolated from 2 adults with severe respiratory infections in Illinois[ncbi.nlm.nih.gov] The most heavily phosphorylated protein was the DNA binding protein (DBP) with 15 different sites.[ncbi.nlm.nih.gov] We show here that the complex of Dd with antigen is a potent activator of human myeloid dendritic cells (MDC), and that it is efficiently presented by MDC to M1-specific CD8[ncbi.nlm.nih.gov] KEYWORDS: 22K; 33K; 52K; BAdV-3; NLS; Protein- protein interaction[ncbi.nlm.nih.gov] Site of integration, structure of integrate and genetics of the host cell are contributing factors.[web.archive.org] To allow proper viral replication, the genome is imported through the nuclear pore complex associated with viral core proteins.[ncbi.nlm.nih.gov] The adenovirus partial polymerase gene is 100% homologous to that of California sea lion adenovirus 1 (CSLAdV-1).[ncbi.nlm.nih.gov] […] complications Adenovirus Infections, Human/virology* Adenoviruses, Human/genetics* Adenoviruses, Human/physiology* Adolescent Adult Antigens, Viral, Tumor/genetics BK Virus[ncbi.nlm.nih.gov]

    Missing: Meis1 ecotropic