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  • Spinocerebellar Ataxia Type 1

    In control subjects, granular immunoreactivity for an epitope common to all known isoforms of 14-3-3 proteins (14-3-3 COM) found in the cytoplasm of some pontine and dentate[ncbi.nlm.nih.gov] Neuronal potential and lineage determination by neural stem cells . Curr. Opin. Cell Biol. 13 , 666–672 (2001). 30. Temple, S. The development of neural stem cells .[doi.org] At least five codons occupy the region corresponding to the polyglutamine tract at the SCA1 locus in mice, rats, and other rodents.[ncbi.nlm.nih.gov] Notably, impairment of mGluR-mediated dendritic Ca2 signals linearly correlated with a reduction of PC capacitance (cell surface area) in disease progression.[ncbi.nlm.nih.gov] Here we show that the expanded polyglutamine tract differentially affects the function of the host protein in the context of different endogenous protein complexes.[ncbi.nlm.nih.gov] Using an in vitro RNA-binding assay, we demonstrate that ataxin-1 does bind RNA and that this binding diminishes as the length of its polyglutamine tract increases.[ncbi.nlm.nih.gov] Each type arises due to a specific genetic mutation and in the case of spinocerebellar ataxia type 1 (SCA1), the ataxin-1 gene (located on chromosome 6) is expanded by trinucleotide[symptoma.com] As compared with the controls (n 14), mean putamen concentrations of [3H]WIN 35,428 binding (-45%), dopamine transporter protein (-61%), and [3H]DTBZ binding (-48%) were significantly[ncbi.nlm.nih.gov]

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  • Insulin Resistance

    Nutrients. 2018 Mar 14;10(3). pii: E350. doi: 10.3390/nu10030350.[ncbi.nlm.nih.gov] Figure 2: The neural circuit activated by leptin.[doi.org] Starches that are high in amylopectin are digested and absorbed more quickly than starches with a high amylose content and produce insulin resistance in rats during long-term[ncbi.nlm.nih.gov] Diabetes 54 : 8 –14, 2005 Akimoto T, Ribar TJ, Williams RS, Yan Z: Skeletal muscle adaptation in response to voluntary running in Ca2 /calmodulin-dependent protein kinase[doi.org] Macrophages in turn secrete Gal3, which then acts as a signaling protein attracting more macrophages, thus resulting in the production of even more Gal3.[ucsdnews.ucsd.edu] Decreased insulin binding with hydrocortisone and dexamethasone was caused by decreased binding affinity rather than by a decreased number of receptors.[ncbi.nlm.nih.gov] CONTEXT: Type B insulin resistance is a very rare disease caused by autoantibodies against the insulin receptor.[ncbi.nlm.nih.gov] Manjarrez‐Reyna, Marcela Esquivel‐Velázquez, Guillermo Melendez‐Mier, Sergio Islas‐Andrade, Araceli Rojas‐Bernabé, Julia Kzhyshkowska and Galileo Escobedo , Infliximab ameliorates[doi.org]

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  • Spinal Muscular Atrophy

    Safety and efficacy of olesoxime were assessed in patients aged 3-25 years with genetically confirmed type 2 or non-ambulatory type 3 SMA.[ncbi.nlm.nih.gov] Our SMA Neural stem cells are GMP certified and administered with all documentation provided.[stemcellthailand.org] Moreover, VPA was able to increase SMN protein levels through transcription activation in organotypic hippocampal brain slices from rats.[ncbi.nlm.nih.gov] . , 2000 , vol. 140 (pg. 541 - 551 ) 67 Dynamic interactions of an intracellular Ca2 clock and membrane ion channel clock underlie robust initiation and regulation of cardiac[doi.org] Salbutamol increases SMN mRNA and protein levels in spinal muscular atrophy cells C Angelozzi , F Borgo , F D Tiziano , A Martella , G Neri , C Brahe Istituto di Genetica[doi.org] Using RNA-affinity chromatography and mass spectrometry, we further uncovered binding of the RNA-binding protein HuR to the -44 region, where it acts as a splicing repressor[ncbi.nlm.nih.gov] Progressive respiratory muscle weakness with bulbar involvement is the main cause of morbidity and mortality in type I and severe type II spinal muscular atrophy.[ncbi.nlm.nih.gov] Hippocampi were dissected from E18 Sprague Dawley rat embryos (Charles River).[doi.org]

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  • Glucocorticoid

    .; n 3) respectively. 2. Endogenous membrane bound phospholipase A2 was measured with labelled phospholipids used as substrates.[ncbi.nlm.nih.gov] Neural Activity in Schizophrenia UPI and other news outlets recently reported on a new American Journal of Psychiatry article on brain patterns in individuals with a schizophrenia[ajp.psychiatryonline.org] rats both in 6- and 24-hour Dex pretreated rats ( Fig. 5A, B ).[doi.org] Bartelsman , Suicide attempt in ulcerative colitis patient after 4months of infliximab therapy — A case report , Journal of Crohn's and Colitis , 4 , 5 , (591) , (2010) .[doi.org] […] binding protein; RU24858; STAT, signal transducer and activator of transcription; MAPK, mitogen-activated protein kinase; MKP-1, mitogen-activated protein kinase phosphatase[doi.org] […] function during early postnatal life, and its production in the pulmonary vasculature rises markedly during that period because of increasing expression of cyclooxygenase type[ncbi.nlm.nih.gov] In the 3 years since stopping steroid medication, the patient has shown gradual but possibly incomplete resolution of his cognitive deficits.[ncbi.nlm.nih.gov] Lerch , The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity , Neural Plasticity , 2017 , (1) , (2017) .[doi.org]

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  • Osteoporosis

    […] and n–3 fatty acids ( 14 ).[doi.org] […] at risk for folate deficiency Delineation of dietary sources Evidence on which to base a recommended intake Differences in bio-availability of folic acid and food folate Neural[fao.org] Osteoporotic rats were treated with ABPs, and serum was then sampled for metabolic analysis.[ncbi.nlm.nih.gov] Dynamic weight bearing exercise low force plus Ca2 versus Ca2 Comparison 13.[doi.org] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[doi.org] CA1 and S100P may regulate the process of MIO by modulation of calcification and dysregulation of calcium binding.[ncbi.nlm.nih.gov] Increased ß-adrenergic activity can decrease bone mass, but other neural pathways may be involved ( 104 , 105 ).[web.archive.org] In the orchidectomy arm, the rats were either sham-operated (n 8) or orchidectomized (n 8).[ncbi.nlm.nih.gov]

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  • Dengue Virus

    However, only limited data on DENV-3 in Saudi Arabia are available.[ncbi.nlm.nih.gov] Perhaps Fc receptors on the placenta and neural tissues allow entry of Zika virus only when bound to dengue virus antibody.[virology.ws] […] anti-rat antibody (1:1,000 dilution) and visualized as above.[doi.org] Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2 disturbances, and cell death in renal epithelial cells .[doi.org] The non-structural protein (NS) 4A is one of the least characterized DV proteins.[ncbi.nlm.nih.gov] We demonstrate here that the polymerase of the virus, NS5, binds to STAT2 and is necessary and sufficient for its reduced level of expression.[ncbi.nlm.nih.gov] Abstract Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia.[ncbi.nlm.nih.gov] Phylogenetic analysis of the envelope gene showed that 2 genetically related virus isolates belonged to dengue virus type 3 genotype III.[ncbi.nlm.nih.gov]

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  • Novobiocin

    KEYWORDS: 4-PP; 4-pyrrolidinopyridine; 4′,6-diamidino-2-phenylindole; Biological activity; DAPI; DCC; EDC; FITC; Heat shock protein 90 (HSP90); N-(3-dimethylaminopropyl)-N[ncbi.nlm.nih.gov] PHD: predicting one-dimensional protein structure by profile-based neural networks. Methods Enzymol 266, 525 –539. [Google Scholar] Sambrook, J. & Russell, D.[mic.microbiologyresearch.org] […] into rat.[ncbi.nlm.nih.gov] […] by novobiocin or indirectly by glucocorticoid, may lead to the exposure and unmasking of internucleosomal linker DNA regions which are substrates for a constitutive non-Ca2[ncbi.nlm.nih.gov] BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the[ncbi.nlm.nih.gov] Novobiocin is an orally active antibiotic that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit.[ncbi.nlm.nih.gov] Abstract 1-beta-D-Arabinofuranosylcytosine (ara C) induces chromosome-type aberrations in mammalian cells by inhibiting repair replication in the G1 phase.[ncbi.nlm.nih.gov] The N-terminal domain contains an ATP-binding site that binds the natural products geldanamycin and radicicol.[ncbi.nlm.nih.gov]

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  • Meningitis

    Each episode typically lasts 1–3 days, but 1 report recorded persistence of symptoms for 3 weeks with subsequent recurrences every few weeks [ 5 ].[web.archive.org] […] neurologic deficits; death may occur within 24 hours of disease onset; pathologic features include a purulent exudate in the subarachnoid space, and diffuse inflammation of neural[icd9data.com] Therefore, fewer bacteria are required to overwhelm the immune system, compared with the immune system in nonimplanted rats.[dx.doi.org] […] of Ca2 stores.[humpath.com] CSF protein and glucose measurements are therefore essential in management but may be neglected in clinical practice.[ncbi.nlm.nih.gov] […] protein (FbpA) Iron binding Lactoferrin binding protein (LbpA) Lactoferrin binding Neiserrial surface protein A (NspA) Immunogenic surface protein Opacity associated protein[doi.org] Some common types of bacterial meningitis are: Hib meningitis - caused by Haemophilus influenzae type b (Hib) bacteria.[conditions.health.qld.gov.au] By using a combination of otoacoustic emissions, auditory brainstem responses, and tympanometry the differences between cochlear, neural, and conductive defects were distinguished[ncbi.nlm.nih.gov]

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  • Poliovirus

    Jafari , MD 3 , Steven G.F. Wassilak , MD 2 , Eric E. Mast , MD 2 , Ousmane M. Diop , PhD 3 , Rudolf H. Tangermann , MD 3 , Gregory L.[cdc.gov] These studies have given an insight into the mechanisms of blood-brain barrier permeation and neural transport.[ncbi.nlm.nih.gov] By using anti-poliovirus rat serum, we demonstrated excellent correlation between neutralizing antibody titers measured by cNA and pNA.[ncbi.nlm.nih.gov] Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca2 in the cytoplasm of infected cell.[uniprot.org] Abstract A small protein, VPg, is covalently linked to the 5′ end of the plus-stranded poliovirus genomic RNA 1 , 2 , 3 .[nature.com] Our assay shows a good correlation with the NT and an excellent correlation with the ELISA-based binding inhibition assay (POBI).[ncbi.nlm.nih.gov] Wild poliovirus type 3 has not been detected since November 2012, and wild poliovirus type 2 was officially declared eradicated in September 2015.[ncbi.nlm.nih.gov] Intercellular Junctions/metabolism* Kidney/cytology Ligands Membrane Proteins* Mice Nectins Neoplasm Proteins/metabolism Neuroblastoma PC12 Cells Protein Structure, Tertiary Rats[ncbi.nlm.nih.gov]

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  • Vitamin K

    Cross-sectional correlations among measures of vitamin K and D status and demographic, nutritional, and laboratory variables a Table 3.[doi.org] ; required for cell division, maturation of red blood cells impaired formation of red blood cells, weakness, irritability, headache, palpitations, inflammation of mouth, neural[britannica.com] Urinary Gla excretion in normal rats fed a standard diet that contained about 500 ng of vitamin K1 per gram of diet was 2.35 /- 0.25 mumoles/day, but the level in rats fed[ncbi.nlm.nih.gov] FURIE, MARIANNE BOROWSKI, BRUCE KEYT and BRUCE FURIE , γ-Carboxyglutamic Acid-Containing Ca2 -Binding Proteins , Calcium and Cell Function , 10.1016/B978-0-12-171402-4.50013[doi.org] Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex.[ncbi.nlm.nih.gov] The cytoplasmic tail of PRGP2 seemed to bind specifically to YAP, because it did not bind to WWOX, a WW domain-containing tumor suppressor (data not shown).[doi.org] […] reported the beneficial role of vitamin K supplementation in improving insulin sensitivity and glucose tolerance, preventing insulin resistance, and reducing the risk of type[ncbi.nlm.nih.gov] Food and Drug Administration (1993) Food Labeling: health claims and label statements; neural tube defects. Fed Regist 58:53254–53295 Google Scholar 56.[doi.org]

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