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769 Possible Causes for 1, 2, 5, ANC, Blood, CTCAE, Grade, Grade, Infection, neutrophils, Normal, or, or, with

  • Fluorouracil

    Condylomata acuminata (CA), or anogenital warts, are typically benign lesions caused by human papillomavirus infection.[ncbi.nlm.nih.gov] We started a combination therapy with S-1, oxaliplatin and bevacizumab.[ncbi.nlm.nih.gov] Data on toxicity was reported according to CTCAE. RESULTS: 15% of the patients developed severe 5FU-related toxicity, with neutropenia accounting for 67% of the cases.[ncbi.nlm.nih.gov] MATERIAL AND METHODS Cell viability was determined by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay.[ncbi.nlm.nih.gov] CD/5-FC systems.[ncbi.nlm.nih.gov] […] prior to registration and must be repeated if initial labs were done greater than 7 calendar days prior to the start of therapy: Bone marrow: Absolute neutrophil count (ANC[clinicaltrials.gov] There is also a role for 5-fluorouracil in the management of recurrent or persistent high-grade vaginal intraepithelial neoplasia.[ncbi.nlm.nih.gov] Simultaneously, subnanogram TCP-1/TNFα treatment normalized tumor blood vessels.[ncbi.nlm.nih.gov] Under such experimental condition, CXCL1 gene, protein levels of neutrophil elastase and myeloperoxidase upregulation induced by 5-FU in the colon was attenuated by HST.[ncbi.nlm.nih.gov] Risk of infection This treatment can reduce the number of white blood cells in your blood. These cells fight infection.[macmillan.org.uk]

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  • Caspofungin

    Abstract Hormographiella aspergillata, a filamentous basidiomycete, has rarely been involved in human infections.[ncbi.nlm.nih.gov] Caspofungin Acetate Catalogue number: C184900 Chemical name: Caspofungin Acetate Synonyms: 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl][trc-canada.com] […] levels CTCAE Grade 2).[ncbi.nlm.nih.gov] […] an important fungal pathogen with a diploid genome that can adapt to caspofungin, a major drug from the echinocandin class, by a reversible loss of one copy of chromosome 5[ncbi.nlm.nih.gov] Patients receive fluconazole IV over 1-2 hours or orally (PO) QD beginning within 24-72 hours following the last dose of chemotherapy for each course and continuing until ANC[clinicaltrials.gov] RATIONALE: A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for quantification of caspofungin in dried blood spots (DBS) was developed and validated.[ncbi.nlm.nih.gov] Eastern Cooperative Oncology Group (ECOG) score, cardiovascular disease, hemoptysis, and absolute neutrophil count (ANC)[ncbi.nlm.nih.gov] Valiante V 1 , Monteiro MC 2 , Martín J 2 , Altwasser R 3 , El Aouad N 2 , González I 2 , Kniemeyer O 4 , Mellado E 5 , Palomo S 2 , de Pedro N 2 , Pérez-Victoria I 2 , Tormo[ncbi.nlm.nih.gov] After dose reduction to 50 mg with an AUC of 100 mg h/L, liver enzymes normalized.[ncbi.nlm.nih.gov] C. krusei was recovered from blood cultures and voriconazole monotherapy was initiated but proved unsuccessful.[ncbi.nlm.nih.gov]

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  • Temozolomide

    Lymphocytopenia is reported to be the most frequent and severe adverse effect of TMZ and leads to opportunistic infections.[ncbi.nlm.nih.gov] Shipping & Storage Shipping Wet ice in continental US; may vary elsewhere References & Product Citations Product Description References 1.[caymanchem.com] Two patients experienced no toxicity per CTCAE guidelines.[ncbi.nlm.nih.gov] KEYWORDS: O(6)-methylguanine-DNA methyltransferase; Reactive oxygen species; Specificity protein 1; Superoxide dismutase 2; Temozolomide[ncbi.nlm.nih.gov] Ichimura K 10 , Sakai R 5 , Namba H 11 , Mori K 7 .[ncbi.nlm.nih.gov] […] cycle if: ANC 1000-1500/mm³ or platelet 50,000-100,000/mm³: Postpone treatment until ANC 1500/mm³ and platelet 100,000/mm³; maintain initial dose ANC Postpone therapy until[reference.medscape.com] Temozolomide appears to be effective in patients with recurrent high-grade gliomas.[ncbi.nlm.nih.gov] (ALP) : 1143 IU/L (normal range 40-150) ; γ-glutamyl transpeptidase(GGT) : 514 IU/L (normal range 9-64 IU/L) ; total bilirubin : 15.1 mg/dL (normal range 0-1.2) ; direct bilirubin[ncbi.nlm.nih.gov] Patients with a 40% decrease in neutrophils showed significantly longer OS than those with[ncbi.nlm.nih.gov] The blood-brain barrier (BBB) is major obstacle in drug or stem cell treatment in chronic stroke.[ncbi.nlm.nih.gov]

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  • Interleukin-2

    Unfortunately, primary HIV-1 infection results in the massive loss of these cells within weeks of infection, which is mainly driven by inflammation and massive infection by[ncbi.nlm.nih.gov] Curr Diab Rep. 2016 Jun;16(6):46. doi: 10.1007/s11892-016-0739-1.[ncbi.nlm.nih.gov] CTCAE grade 3 or higher infections developed in three patients.[nejm.org] In naive Th cells, Ets-2 mRNA expression, Ets-2 protein levels, and Ets-2 binding to ARRE-2 decrease upon cell activation followed by the concomitant expression of IL-2.[ncbi.nlm.nih.gov] Consequently, few liver-infiltrating T reg demonstrate signal transducer and activator of transcription-5 (STAT-5) phosphorylation.[ncbi.nlm.nih.gov] After adjustment for IMDC risk criteria, NLR remained a significant predictor of OS (ANC/ALC 4 vs 4, HR 0.41, 95% CI 1.09-5.46, p   0.03; ANC/ALC continuous variable per unit[ncbi.nlm.nih.gov] We assessed the overall certainty of the evidence using the GRADE approach.[ncbi.nlm.nih.gov] Author information 1 Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China. [email protected][ncbi.nlm.nih.gov] It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e.[ncbi.nlm.nih.gov] […] creatinine 1.5-2.0 mg/dL Creatinine clearance 60 ml/min Laboratory All patients Bilirubin 2.0 mg/dL Values within normal limits Platelet count 100,000 Hemoglobin 9.0 g/100 ml ANC[jitc.biomedcentral.com]

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  • Hamartoma

    Endobronchial hamartoma can cause coughing, hemoptysis, and pulmonary infection; thus, it should be treated right away by surgery or fiberoptic bronchoscopy.[ncbi.nlm.nih.gov] C677C gene polymorphisms can be associated with a higher optic glioma, hamartoma, and epilepsy incidence, respectively, in patients diagnosed with neurofibromatosis type 1.[ncbi.nlm.nih.gov] Specific Aims /Objectives Primary objective -To evaluate the safety of everolimus compared with placebo in patients with PTEN mutations focusing on NCI CTCAE Grade 3 and 4[clinicaltrials.gov] BACKGROUND: To present a coincidence of macular telangiectasia type 2 and solitary retinal astrocytic hamartoma in one patient.[ncbi.nlm.nih.gov] Hamartoma is a topic covered in the 5-Minute Clinical Consult .[unboundmedicine.com] Term : hamartoma Origin: Anc Greek αμαρτία / hamartia( sin, quilt, crime, pity) - ωμα / oma ( complete set of, or a condition . ) The Greek word "hamartia" is translated in[bioetymology.blogspot.com] The biopsy result was low-grade, non-intestinal type adenocarcinoma, and the patient was referred to our hospital.[ncbi.nlm.nih.gov] CONCLUSION: The normal :F-FDG PET/CT findings suggested that, at least in this patient, splenic hamartoma may display a similar :F-FDG avidity when compared to normal splenic[ncbi.nlm.nih.gov] […] fashion •Surrounding dermal stroma is well demarcated from the adjacent normal dermal collagenous stroma •Lesions are often secondarily inflamed with focal aggregates of neutrophils[cal.vet.upenn.edu] Angiomyomatous hamartoma of lymph nodes (AMH-LN) is an uncommon benign proliferation of smooth muscle, blood vessels, collagenous stroma, and adipocytes, most commonly affecting[ncbi.nlm.nih.gov]

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  • Soft Tissue Sarcoma

    No tumor existed, and no infection occurred. CONCLUSIONS: It was demonstrated that this method was safe and easy.[ncbi.nlm.nih.gov] Five (2%) patients died from treatment-related causes in the combination group (sepsis [n 2], septic shock [n 1], congestive cardiac failure [n 1], and unknown cause [n 1][ncbi.nlm.nih.gov] […] of local failure, Kaplan-Meier method estimated survival, competing-risk regression model determined predictors of disease outcome, and toxicity was reported according to CTCAE[ncbi.nlm.nih.gov] We present the cytomorphology of 2 cases of anaplastic lymphoma kinase (ALK) ALCL that displayed a perivascular arrangement, thereby mimicking a sarcoma.[ncbi.nlm.nih.gov] Grade 2 late complications included lymphedema (10%), fracture (5%), and fibrosis (5%).[ncbi.nlm.nih.gov] AIM: The aim of this study was to determine the effect of local recurrence on overall survival in patients with intermediate high-grade localized primary soft tissue sarcoma[ncbi.nlm.nih.gov] All patients had bone marrow involvement, including six with normal complete blood count at diagnosis. Cerebrospinal fluid was normal in six patients.[ncbi.nlm.nih.gov] BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) has been reported to possess significant prognostic value in multiple types of cancer.[ncbi.nlm.nih.gov] During four cycles of induction chemotherapy, peripheral blood stem cells (PBSCs) were harvested.[ncbi.nlm.nih.gov] Initially the patient was treated for an infection of the hemiarthroplasty but subsequent removal of the loose prosthesis and biopsy revealed the presence of a malignant tumour[ncbi.nlm.nih.gov]

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  • Docetaxel

    Docetaxel-induced hypersensitivity pneumonitis was diagnosed by excluding infection and tumor spread with bronchoalveolar lavage and lung biopsy.[ncbi.nlm.nih.gov] Therefore, we treated paclitaxel-resistant angiosarcoma patient with S-1/docetaxel chemotherapy.[ncbi.nlm.nih.gov] Safety was evaluated using US National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 3.0.[ncbi.nlm.nih.gov] […] phase II study that will investigate the activity and safety of docetaxel, oxaliplatin, and 5-fluorouracil (DOF) in combination with trastuzumab in human epidermal receptor-2[ncbi.nlm.nih.gov] Abstract DCF chemotherapy regimen includes docetaxel, cisplatin, and 5-fluorouracil (5-FU).[ncbi.nlm.nih.gov] Both ANC presented particle size 150 nm and showed similar or higher in vitro antiproliferative activities than standard treatment, ANC-1 performing better than ANC-2.[ncbi.nlm.nih.gov] High-grade mucoepidermoid carcinomas are highly aggressive tumours.[ncbi.nlm.nih.gov] The aim of this study was to elucidate the relationship between PN and systemic inflammation parameters, namely the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte[ncbi.nlm.nih.gov] KEYWORDS: Docetaxel; Dried blood spots; LC–MS/MS; Therapeutic drug monitoring[ncbi.nlm.nih.gov] Risk of infection This treatment can reduce the number of white blood cells in your blood. These cells fight infection.[macmillan.org.uk]

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  • Cyclic Neutropenia

    Abstract Atraumatic Clostridium septicum infection is rare in infancy and childhood and is associated with a high mortality rate.[ncbi.nlm.nih.gov] Increasing the TLp to MOb ratios to 3:1 or 5:1 progressively decreased CSA.[ncbi.nlm.nih.gov] The peak and nadir counts of neutrophils and the peak counts of monocytes were significantly elevated, and the period of cycling decreased from 3 to 2 weeks.[ncbi.nlm.nih.gov] Epidemiology Most patients present before the age of 5 years: 32% are 27% are between ages 1 and 5 years.[unboundmedicine.com] The nadir ANC improved from 30/microliters before therapy to 546/microliters and 198/microliters on treatment.[ncbi.nlm.nih.gov] Further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia.[ncbi.nlm.nih.gov] CFU-GM in the normal granulocyte count period were sensitive to the inhibitors, but CFU-GM in the neutropenic phase were resistant.[ncbi.nlm.nih.gov] The authors hypothesized that congenital neutropenia is also due to mutations of neutrophil elastase.[ncbi.nlm.nih.gov] Abstract A 16-month-old male patient with cyclic neutropenia was found to have cyclic fluctuations of monocytes, lymphocytes, platelets, and eosinophils in the peripheral blood[ncbi.nlm.nih.gov] Grade 1 mobility was noticed with tooth 36 and 46.[ijabmr.org]

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  • Leukopenia

    Despite numerous case reports of pure red cell aplasia in lung transplant (LT) recipients after PVB infection, the epidemiology remains poorly outlined.[ncbi.nlm.nih.gov] Huang X 1 , Du Y 1 , Hu X 2 , Ma H 1 , Wang H 1 , You A 1 , Kang K 1 , Chen H 1 , Zhang L 3 , Liu G 1 , Xu B 1 .[ncbi.nlm.nih.gov] Yang SK 1 , Hong M 2 , Baek J 2 , Choi H 2 , Zhao W 3 , Jung Y 2 , Haritunians T 4 , Ye BD 1 , Kim KJ 1 , Park SH 1 , Park SK 1 , Yang DH 1 , Dubinsky M 5 , Lee I 6 , McGovern[ncbi.nlm.nih.gov] All T/T homozygous patients (5/5) developed early severe-grade leukopenia (white blood cells -3 ) and severe alopecia.[ncbi.nlm.nih.gov] Two months later, his WBC count and ANC were 800 and 500 cells/μL, respectively.[ncbi.nlm.nih.gov] III or IV were randomised to standard doses (group standard) or doses tailored to achieve grade III leukopenia (group tailored) at courses 2-7.[ncbi.nlm.nih.gov] If a bone marrow biopsy is normal, that is very comforting. does the condition need to be treated?[biology.stackexchange.com] BACKGROUND: Antibodies to neutrophil-specific antigens are the best characterized cause of transfusion-related acute lung injury (TRALI).[ncbi.nlm.nih.gov] Blood Disorders (Anemia, Leukopenia, and Thrombocytopenia) Blood is a body fluid that carries essential nutrients to tissues throughout the body.[lifeextension.com] Fever is a strong indication of some infection. Pneumonia: Once infection enters the body, it is most likely to infect lungs. It could be viral or bacterial.[symptoma.com]

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  • Acute Leukemia

    Abstract Parvovirus B19 infection may be seen in acute leukemia patients and clinical findings and cytopenia caused by the viral infection may complicate the evaluation of[ncbi.nlm.nih.gov] Any gene in the Tier 1: Familial Myelodysplastic Syndrome/Acute Leukemia Panel can also be ordered individually.[dnatesting.uchicago.edu] This was substantiated by the significantly high rate of serious adverse events (SAE) (CTCAE Grade 3 toxicity) experienced by patients with relapse/refractory acute leukemia[ncbi.nlm.nih.gov] The second child was 13-month old, presented with pallor, vomiting, abdominal enlargement, and oliguria 2 days before admission.[ncbi.nlm.nih.gov] Abstract The present study aimed to investigate the association between the genetic polymorphism of cytochrome P450 family 3 subfamily A member 5 (CYP3A5) and the activity[ncbi.nlm.nih.gov] The cumulative incidence of acute GvHD grade II-IV was 16.4%, incidence of chronic GvHD 24.9%, and of extensive cGvHD 21.4%, respectively.[ncbi.nlm.nih.gov] The dominance of leukemic cells over normal progenitors may result in either direct suppression of functional hematopoiesis or remodeling of microenvironmental niches, contributing[ncbi.nlm.nih.gov] About neutrophils Neutrophils are normal white blood cells with granules inside the cell. They are also sometimes called mature granulocytes.[cancer.net] Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes.[ncbi.nlm.nih.gov] Locatelli F 1, 2 , Merli P 1 , Pagliara D 1 , Li Pira G 1 , Falco M 3 , Pende D 4 , Rondelli R 5 , Lucarelli B 1 , Brescia LP 1 , Masetti R 5 , Milano GM 1 , Bertaina V 1[ncbi.nlm.nih.gov]

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