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  • Febrile Neutropenia

    […] decrease the level of gut colonisation with pathogenic bacteria, but may also lead to reduction in the duration of neutropenia, accelerate the restitution of the intestinal mucosa[clinicaltrials.gov] Background Neutrophils are a type of white blood cell crucial to the defence of the immune system against many infective pathogens including bacteria.[cochrane.org] The proportion of severe adverse events (CTC-NCI grades 3/4) was low in both periods (4 and 1%).[bloodjournal.org] Neutropenia is defined as an absolute neutrophil count (polymorphonuclear cells plus band forms) of 500/ml or less.[jpgmonline.com] Polymicrobial infection in patients with cancer: an underappreciated and underreported entity. Clin Infect Dis. 2007;45:228-233. 29.[uspharmacist.com] 1/1 (100) 1/1 (100) Bladder cancer 1/32 (3.1) 0/1 (0) 1/1 (100) Colorectal cancer 1/32 (3.1) 0/1 (0) 1/1 (100) Thyroid cancer 1/32 (3.1) 0/1 (0) 1/1 (100) Melanoma 1/32 (3.1[medcraveonline.com] If ANC 0.5 x 2 consecutive days, please see section below.[sunnybrook.ca] Medication errors are a common cause of preventable adverse events in hospitalized patients.( 1 ) Adverse events associated with high-toxicity drugs such as chemotherapy,[psnet.ahrq.gov] It is defined as a temperature higher than 38.3 degrees Celsius or 100.5 degrees Farenheit in the presence of any severity of neutropenia, which is typically an absolute neutrophil[mdmag.com] In adults, the lower limit of normal neutrophils is 1500 neutrophils per microliter of blood; any number below that is considered neutropenia.[jamanetwork.com]

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  • Agranulocytosis

    The infections may be superficial, involving mainly the oral mucosa, gums, skin, and sinuses, or they may be systemic [spread throughout the bloodstream], with life-threatening[cchrflorida.org] All patients were administrated recombinant human granulocyte colony-stimulating factor daily until they had a neutrophil count 1 000/μL, which was defined as recovery.[ncbi.nlm.nih.gov] He was diagnosed as dengue hemorrhagic fever, grade I because he had hemoconcentration, thrombocytopenia without bleeding and positive IgM dengue antibody On the 5th day,[ncbi.nlm.nih.gov] Evaluation of a peripheral blood smear showed leukopenia with severe absolute neutropenia.[ncbi.nlm.nih.gov] OUTCOMES: After 24 hours of cesarean section, the temperature and neutrophil granulocyte returned to normal.[ncbi.nlm.nih.gov] Treatment of agranulocytosis consists of the immediate and permanent withdrawal of the offending drug and control of the infection with antibiotics.[britannica.com] Epub 2017 Aug 1. Koh S 1 , Koh H 1 , Kubo Y 2 , Kuroda M 1 , Nishimoto M 1 , Yoshimura T 1 , Nakashima Y 1 , Nakane T 1 , Nakamae H 1 , Ohsawa M 2 , Hino M 1 .[ncbi.nlm.nih.gov] Pharmacogenetics testing showed that he was a carrier of NAT2 *5/*6 genotype, predisposing to low activity of the N-acetyltransferase 2 enzyme.[ncbi.nlm.nih.gov] This case report highlights a rare adverse event of a commonly used antibiotic.[ncbi.nlm.nih.gov] Oral lesions are ulceronecrotic, involving the gingivae, tongue, buccal mucosa, or lips. Regional lymphadenopathy and lymphadenitis are prevalent.[medical-dictionary.thefreedictionary.com]

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  • Leukopenia

    Colloidal bismuth subcitrate and sodium bicarbonate were administered to protect gastric mucosa and maintain an alkaline diuresis in patients with serious gastrointestinal[doi.org] BACKGROUND: Antibodies to neutrophil-specific antigens are the best characterized cause of transfusion-related acute lung injury (TRALI).[ncbi.nlm.nih.gov] III or IV were randomised to standard doses (group standard) or doses tailored to achieve grade III leukopenia (group tailored) at courses 2-7.[ncbi.nlm.nih.gov] Leukopenia (low white blood cell count) occurs in up to 50 percent of anorexic patients. It is detected through a blood test, also called a complete blood count.[eatingdisorders.com] METHODS: Little is known about the immune status of preterm neonates; therefore, we analyzed the frequency and absolute counts of different immune populations in 211 cord[ncbi.nlm.nih.gov] If a bone marrow biopsy is normal, that is very comforting. does the condition need to be treated?[biology.stackexchange.com] Despite numerous case reports of pure red cell aplasia in lung transplant (LT) recipients after PVB infection, the epidemiology remains poorly outlined.[ncbi.nlm.nih.gov] Huang X 1 , Du Y 1 , Hu X 2 , Ma H 1 , Wang H 1 , You A 1 , Kang K 1 , Chen H 1 , Zhang L 3 , Liu G 1 , Xu B 1 .[ncbi.nlm.nih.gov] Yang SK 1 , Hong M 2 , Baek J 2 , Choi H 2 , Zhao W 3 , Jung Y 2 , Haritunians T 4 , Ye BD 1 , Kim KJ 1 , Park SH 1 , Park SK 1 , Yang DH 1 , Dubinsky M 5 , Lee I 6 , McGovern[ncbi.nlm.nih.gov] The most common and serious adverse event of treatment with thiopurines altered by doctors is leukopenia.[ncbi.nlm.nih.gov]

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  • Idiopathic Neutropenia

    A break in the skin or the mucosa of the gastrointestinal tract will allow penetration of bacteria, and the neutrophils are too few to act as the first line of defense to[hematologyandoncology.net] Neutrophil marrow cellularity was determined from neutrophil-normoblast ratios in marrow sections and ferrokinetic estimation of normoblasts.[ncbi.nlm.nih.gov] These findings provide additional evidence for the existence of an unrecognized low-grade chronic inflammatory process in NI-CINA patients and coroborate our previously reported[ncbi.nlm.nih.gov] Treating a low white blood cell count A blood test can tell you if your white blood cell count is low.[nhs.uk] The absolute number of blood NK cells was reduced, and a diagnosis of nonimmune chronic idiopathic neutropenia of adult was made.[ncbi.nlm.nih.gov] Using CD56 -enriched PBL suspensions, it was shown that patients' NK cells displayed normal tumor cell binding capacity and produced in vitro normal amounts of natural killer[ncbi.nlm.nih.gov] This prospective study confirmed the existence of an association between H. pylori infection and CIN, suggesting the screening for H. pylori infection and eradicating bacterium[ncbi.nlm.nih.gov] Author information 1 Haematology and Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil. [email protected] Abstract Chronic idiopathic[ncbi.nlm.nih.gov] Mastrodemou S 1 , Stalika E 2 , Vardi A 2 , Gemenetzi K 2 , Spanoudakis M 1 , Karypidou M 2 , Mavroudi I 1 , Hadzidimitriou A 2 , Stavropoulos-Giokas C 3 , Papadaki HA 1 ,[ncbi.nlm.nih.gov] The majority of reported events occurred upon initial exposure. Provide symptomatic treatment for allergic reactions.[zarxio.com]

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  • Congenital Neutropenia

    The mutant allele was detected in the donor's spermatozoa, representing 18% of the ELANE gene pool, but not in DNA from his lymphocytes, neutrophils, or buccal mucosa, indicating[ncbi.nlm.nih.gov] These results demonstrate that precursors containing the mutation are selectively lost during myelopoiesis or fail to develop into neutrophils.[ncbi.nlm.nih.gov] Cumulative incidence (day 90) of acute graft-versus-host disease (GVHD) grade 2-4 was 21%.[ncbi.nlm.nih.gov] Treating a low white blood cell count A blood test can tell you if your white blood cell count is low.[nhs.uk] […] nationwidechildrens.org Abstract Severe congenital neutropenia is an autosomal recessive disorder characterized by maturation arrest at the promyelocyte/myelocyte phase in the bone marrow, absolute[ncbi.nlm.nih.gov] Patient BM stromal layers exhibited normal myelopoiesis supporting capacity as shown by the CFU-GM content of irradiated LTBMC recharged with normal CD34 cells.[ncbi.nlm.nih.gov] Abstract Severe congenital neutropenia is one of primary immunodeficiency disorders that characterized by severe neutropenia and is associated with severe systemic bacterial infections[ncbi.nlm.nih.gov] An earlier report by Li et al. 1 demonstrated that LEF-1 was expressed in bone marrow cells and myeloid cell lines and identified a LEF-1 binding domain that was mutated in[hematology.org] We report the case of 2 siblings with SCN who were the children of consanguineous parents. The HAX1 mutation was identified in both siblings.[ncbi.nlm.nih.gov] […] of the major complications of CN is spontaneous leukaemia, which is preceded by clonal somatic evolution, and can be screened by a targeted NGS panel focused on somatic events[ncbi.nlm.nih.gov]

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  • Filgrastim

    Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated[drugbank.ca] Secondary engraftment endpoints included time to neutrophil and platelet engraftment, number of blood product transfusions required before engraftment, events of febrile neutropenia[ncbi.nlm.nih.gov] […] febrile neutropenia, and neutropenia of any grade.[ncbi.nlm.nih.gov] We describe a 43-year-old woman suffering from myelokathexis, with the absolute neutrophil count ranging between 0.03 and 1.35 x 10(9)/L.[ncbi.nlm.nih.gov] Efficacy was evaluated by the recovery of absolute neutrophil count following FSK0808 administration based on the duration of neutropenia in patients who received pre- or[ncbi.nlm.nih.gov] Twelve weeks after discharge she is fine and her blood parameters are all normal.[ncbi.nlm.nih.gov] The patient had no significant toxicity to the CyA or the filgrastim and he has not experienced any serious infections or required hospitalization.[ncbi.nlm.nih.gov] A dosage of 10 micrograms kg-1 day-1 can be recommended.[ncbi.nlm.nih.gov] 2 treatment.[ncbi.nlm.nih.gov] PURPOSE: The objective of this study is to specify the most reported adverse events as preferred terms (PTs) and to compare the reported adverse events about some properties[ncbi.nlm.nih.gov]

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  • Cyclic Neutropenia

    Recurrent mucosa and skin infections with fever had occurred frequently, but gradually decreased in severity on reaching adulthood.[ncbi.nlm.nih.gov] The authors hypothesized that congenital neutropenia is also due to mutations of neutrophil elastase.[ncbi.nlm.nih.gov] Further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia.[ncbi.nlm.nih.gov] Cyclic therapy with G-CSF (5 micrograms/kg/d s.c. for 1 week every 21 d) maintained peripheral neutrophil count above the normal range, reduced the incidence of severe infections[ncbi.nlm.nih.gov] When G-CSF therapy was discontinued, the leukocyte and absolute neutrophil counts again declined.[ncbi.nlm.nih.gov] CFU-GM in the normal granulocyte count period were sensitive to the inhibitors, but CFU-GM in the neutropenic phase were resistant.[ncbi.nlm.nih.gov] Abstract Atraumatic Clostridium septicum infection is rare in infancy and childhood and is associated with a high mortality rate.[ncbi.nlm.nih.gov] Increasing the TLp to MOb ratios to 3:1 or 5:1 progressively decreased CSA.[ncbi.nlm.nih.gov] The peak and nadir counts of neutrophils and the peak counts of monocytes were significantly elevated, and the period of cycling decreased from 3 to 2 weeks.[ncbi.nlm.nih.gov] Long-term, daily, or alternate-day administration reduces fever, mouth ulcers, and other inflammatory events associated with this disorder.[ncbi.nlm.nih.gov]

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  • Kostmann Syndrome

    & symptoms: * Recurring & persistent infections * Presence of necrotic ulcers in the mucus membrane epithelium of the mouth * Presence of necrotic ulcers in the genital mucosa[signssymptoms.org] Mutations in the transcriptional repressor GFI1 and the cytoskeletal regulator WASP also lead to defective neutrophil production.[doi.org] The latest classification schemes and criteria for malignancy, incorporated throughout, enable you to include the most current gradings in your reports.[books.google.com] , and a differential count showing 86 percent eosinophils.[ncbi.nlm.nih.gov] Examination of the bone marrow revealed normal cellularity of the granulocyte precursors with arrested maturation. These findings are consistent with Kostmann syndrome.[ncbi.nlm.nih.gov] There was no admitting history to the hospital related to infection, and he has resumed a normal life style with regular school attendance.[jahjournal.org] […] basophils and 1% neutrophils.[imagebank.hematology.org] An elevated degree of apoptosis was observed in the bone marrow of these patients, and a selective decrease in B-cell lymphoma-2 (Bcl-2) expression was seen in myeloid progenitor[ncbi.nlm.nih.gov] More follow-up, with other patients, led us to consider the mutation of the G-CSF receptor sometimes as a transient event, not systematically resulting in malignancy.[ncbi.nlm.nih.gov] If and how rHuG-CSF treatment impacts on these adverse events remains unclear since there are no historical controls for comparison.[ncbi.nlm.nih.gov]

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  • Anakinra

    Gene expression databases Bgee i ENSG00000136689 Expressed in 163 organ(s), highest expression level in lower esophagus mucosa ExpressionAtlas i P18510 baseline and differential[uniprot.org] […] of diseases termed neutrophilic dermatoses.[ncbi.nlm.nih.gov] After 6 months of treatment, in 5 patients the PGA score was graded from none to minimal.[ncbi.nlm.nih.gov] Université Montpellier I, Montpellier, France. [email protected] Abstract Sweet's syndrome is a neutrophilic dermatosis characterized by fever, an elevated neutrophil count[ncbi.nlm.nih.gov] Except for absolute contraindications, all patients were previously treated with full or decreased dose of NSAID, colchicine, and/or glucocorticoids, with unsatisfactory response[ncbi.nlm.nih.gov] The chest CT scan showed ground-glass pattern predominantly in central and upper lobes and the BAL shows an increase in the percentage of lymphocyte with normal subpopulations[ncbi.nlm.nih.gov] Abstract Febrile infection-related epilepsy syndrome (FIRES) is a devastating epileptic encephalopathy with limited treatment options and an unclear etiology.[ncbi.nlm.nih.gov] Sönnichsen A 1 , Saulite I 1 , Mangana J 1 , Kerl K 1 , Mehra T 2 , Desislava I 1 , Chang YT 1 , Petrausch U 3 , Schmid-Grendelmeier P 1 , Hoetzenecker W 1 , Cozzio A 1 ,[ncbi.nlm.nih.gov] Abstract We report three Caucasian patients affected by gout and type 2 diabetes, who were treated with the recombinant nonglycosylated human interleukin-1 receptor antagonist[ncbi.nlm.nih.gov] (1.65 events/100 patient-years).[dx.doi.org]

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  • Drug-induced Neutropenia

    On intra-oral examination, multiple, irregular and deep ulcers were seen on the tip and left lateral border of the tongue, lower labial mucosa and buccal mucosae [Figure 1[jiaomr.in] Because several target antigens of ANCA are expressed on the surface of neutrophils, it was suggested that ANCA might contribute to neutropenia.[ncbi.nlm.nih.gov] The patient suffered continuous high-grade fever and maculopapular rash, therefore IL-1Ra therapy was started (100 mg/day).[em-consulte.com] A complete blood count will reveal a reduced neutrophil count (and normal hemoglobin and platelet counts).[symptoma.com] In addition, the delta MNV and delta MNS were respectively correlated well with delta absolute neutrophil counts when neutropenia occurred.[ncbi.nlm.nih.gov] However, bone marrow and peripheral blood GM-CFC were within normal limits.[ncbi.nlm.nih.gov] Author information 1 School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, NE, USA [email protected] 2 School of Pharmacy and Health Professions[ncbi.nlm.nih.gov] Expert opinion: Idiosyncratic agranulocytosis remains a potentially serious adverse event due to the frequency of severe sepsis with severe deep tissue infections (e.g., pneumonia[ncbi.nlm.nih.gov] Various limits are given; e.g., absolute neutropenia may exist when the total is less than 1700 cells/mm 3 regardless of the percentage, whereas relative neutropenia may exist[medical-dictionary.thefreedictionary.com] This relatively rare disorder has an annual incidence of 2–15 cases/million [ 2 ].[link.springer.com]

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