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  • Portal Hypertension

    Multiple plastic stents were placed in 15 patients and fully covered self-expanding metallic stent (FCSEMS) in 1 patient and 1 patient required direct endoscopic necrosectomy[] The post-TIPS medical database was reviewed with univariate and multivariate analysis to identify the risk factors for new nodules retrospectively.[] These cytokines were mainly enriched in cytokine-cytokine receptor interactions, Jak-STAT and MAPK signaling pathways, and pathways in cancer.[] The recent discovery of bile acid (BA) receptors and a better delineation of the multiple roles of BAs in relevant biological processes have revamped BA research.[] Bacterial toxins in the gut, including ammonia and other substances such as gamma-aminobutyric acid (GABA) are normally neutralized in the liver.[]

  • Insulin-Like Growth Factor I

    Insulin-like Growth Factor-1 (IGF-1): IGF-1 LR3 VS IGF-1 DES IGF-1 (Insulin-like growth factor) is an endocrine hormone that is produced in the liver.[] In the current study, the prognostic and predictive values of serum transforming growth factor-β1 (TGF-β1), insulin-like growth factor I (IGF-I)/IGF-I receptor (IGF-IR) and[] In PathHunter assay measuring receptor-β-arrestin interaction, amitriptyline, mianserin and fluoxetine failed to induce activation of LPA2 and LPA3 stably expressed in CHO-K1[] Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER( ) (MCF-7) and ER(-) (MDA-MB-231) breast cancer cells.[] However, HK532-IGF-I cells preferentially differentiate into gamma-aminobutyric acid-ergic neurons, a subtype dysregulated in AD; produce increased vascular endothelial growth[]

  • Esophageal Carcinoma

    In resected specimens, p53 staining was strong and diffuse in the tumor and MIB-1 immunoreactivity was strong and patchy in the tumor and the basal layer of squamous mucosa[] This meta-analysis was carried out to explore hypoxia inducible factor 1 alpha in esophageal carcinoma and its correlation with clinicopathological features and prognosis,[] Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been considered as a tumor suppressor.[] Supernatant lactic acid concentrations were also detected.[] The KEGG analysis with 349 overlapping genes showed that the calcium signaling pathway and the neuroactive ligand-receptor interaction were the most relevant pathways.[]

  • Valproic Acid

    […] activity in response to stromal cell-derived factor 1 (SDF-1) concomitant with the activation of both MAPKp42/44 and AKT signaling cascades.[] […] growth factor (VEGF) in human retinal Müller cells under hypoxic conditions.[] The MMP2 gene showed the highest number of interactions with other persistently expressed genes, among which LCN2 which is a key modulator of lipid homeostasis.[] During valproic acid treatment, it is difficult for prescribers to predict its individual response.[] The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting[]

  • Huntington's Disease

    BACKGROUND Recent studies have shown that increased mobilization of Long Interspersed Nuclear Elements-1 (L1) can promote the pathophysiology of multiple neurological diseases[] Recently, the striatum-enriched transcription factor Foxp2 was implicated in the development of these synapses.[] interaction and cytosolic DNA‑sensing) were identified.[] We report the development of a new class of nucleic acid ligands that is comprised of Janus bases and the MPγPNA backbone and is capable of binding rCAG repeats in a sequence-specific[] This expansion leads to neuronal loss in the medium spiny gamma-aminobutyric acid ( GABA ) projection neurons in the striatum, with neuronal loss also occurring in the neocortex[]

  • Pentobarbital

    The pentobarbital EC(50) values were similar; 119 and 158 microM for alpha(1)beta(1) and alpha(1)beta(1)(T12'Q) receptors, respectively.[] Thus, the effect of pentobarbital on tumor necrosis factor-alpha (TNF-alpha) release was determined.[] interaction hsa04727 GABAergic synapse Interaction Structure map map07032 Hypnotics map07230 GABA-A receptor agonists/antagonists Brite Anatomical Therapeutic Chemical (ATC[] acid prior to administration did not change the anesthetic effect.[] This study was conducted to search for the residues of the beta3 subunit which affect pentobarbital action on the gamma-aminobutyric acid type A (GABAA) receptor.[]

  • Schizoaffective Disorder

    320 dilution, 1:200 dilution, visual score 1; enzyme-linked immunosorbent assay [ELISA]: 90(th) percentile of control titers).[] BDp differed in all 12 factors.[] interactions.[] , but the status of the second GABA-synthesizing enzyme, glutamic acid decarboxylase 65-kDa isoform (GAD65), remains unclear.[] The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels.[]

  • Perphenazine

    Perphenazine Catalogue number: P291100 Chemical name: Perphenazine Synonyms: 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; 1-(2-Hydroxyethyl)-4-[3-(2-[] Patients treated with citalopram or perphenazine showed statistically significant improvement on several Neurobehavioral Rating Scale factor scores.[] […] antagonist Disease Schizophrenia [DS: H01649 ] Comment Phenothiazine derivative Target DRD2 [HSA: 1813 ] [KO: K04145 ] Pathway hsa04080 Neuroactive ligand-receptor interaction[] BL-1020, a novel gamma aminobutyric acid (GABA) ester of perphenazine, is a new oral antipsychotic with a strong affinity for dopamine and serotonin receptors.[] Perphenazine Sulfoxide Catalogue number: P291105 Chemical name: Perphenazine Sulfoxide Synonyms: 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol S-Oxide;[]

  • Carphenazine

    Record 1, Synonyms, French Record 1, Spanish Record 1, Campo(s) temático(s) Entrada(s) universal(es) Record 1 Record 1, Abbreviations, Spanish Record 1, Synonyms, Spanish[] In Canada Annual Reports NAPRA Governance NAPRA Notes National Drug Schedules Expand/Collapse National Drug Schedules Drug Scheduling in Canada NDS Process and Scheduling Factors[] […] antagonist Comment Phenothiazine derivative Target DRD1 [HSA: 1812 ] [KO: K04144 ] DRD2 [HSA: 1813 ] [KO: K04145 ] Pathway hsa04080 Neuroactive ligand-receptor interaction[] SDS fluphenazine dimaleate CAS#:3093-66-1 C 26 H 30 F 3 N 3 O 5 S Molecular Weight:553.59400 Density:N/A Boiling Point:N/A Melting Point:N/A MSDS/SDS (Z)-but-2-enedioic acid[] 1-acid glycoprotein 1 ORM1 0.0077 153 Dopamine beta-hydroxylase DBH 0.0077 3939 Amine oxidase [flavin-containing] B MAOB 0.0075 923 Glutamate receptor 3 GRIA3 0.0074 872 Gamma-aminobutyric-acid[]

  • Chlorpheniramine

    Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons.[] For CP, the enantioselectivity (alpha) of the separation was 1.12 with a resolution factor (R(s)) of 1.17.[] […] antagonist Target HRH1 [HSA: 3269 ] [KO: K04149 ] Pathway hsa04080 Neuroactive ligand-receptor interaction hsa04750 Inflammatory mediator regulation of TRP channels Interaction[] A validated method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and several metabolites is presented.[] Midazolam, a benzodiazepine gamma-aminobutyric acid type A receptor agonist, induces spinally mediated analgesia.[]