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  • Troglitazone

    Abstract Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes[] Mol Med Rep. 2011 Jan-Feb;4(1):93-7. doi: 10.3892/mmr.2010.381. Epub 2010 Oct 11.[] PPAR gamma coactivator-1 alpha (PGC-1 alpha) functioning as an inverse agonist.[] The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a related nuclear hormone receptor that can be activated by its ligands, including the thiazolidinediones[] Ligand type- specific interactions of peroxisome proliferator- activated receptor γ with transcriptional coactivators The Journal of Biological Chemisty 275, (2000) . 3.[]

  • Familial Partial Lipodystrophy

    We studied peroxisome proliferator-activated receptor-gamma (PPARgamma) gene as a candidate gene in seven FPL patients who did not appear to have Dunnigan variety.[] Guillín-Amarelle C 1, 2 , Sánchez-Iglesias S 1 , Castro-Pais A 2, 3 , Rodriguez-Cañete L 1, 2 , Ordóñez-Mayán L 2, 3 , Pazos M 2, 3 , González-Méndez B 1 , Rodríguez-García[] […] not caused by impaired corepressor release, but due to reduced dimerization with retinoic acid X receptor alpha in combination with reduced ligand binding and subsequent coactivator[] […] lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated receptor-gamma[] , Savage DB : Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator[]

  • Rosiglitazone

    Abstract Anti-inflammatory effects of peroxisome proliferator-activated receptor gamma (PPRAγ) ligands are thought to be largely due to PPARγ-mediated transrepression.[] HIV-1 Tat induced overexpression of ICAM-1 but not VCAM-1 in both hCMEC/D3 and brain microvessels, this response was attenuated by treatment with the PPARƔ agonist rosiglitazone[] Up-regulated eRNAs occurred almost exclusively at PPARγ-binding sites, to which rosi treatment recruited coactivators, including MED1, p300, and CBP.[] Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated[] (via organic amino compound ) insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma[]

  • Pioglitazone

    Abstract The peroxisome proliferator-activated receptor gamma (PPAR γ) agonists have been reported to have antiproliferative and tumor-suppressive effects.[] Abstract Although recent studies recommended that insulin should be administered to patients with slowly progressive type 1 diabetes, even those with non-insulin dependent[] PPAR alpha and PPAR gamma coactivation rapidly induces Egr-1 in the nuclei of the dorsal and ventral urinary bladder and kidney pelvis urothelium of rats.[] Abstract Pioglitazone (PGZ), a peroxisome proliferator-activated receptor γ agonist, which is known as a type 2 diabetes drug, inhibits cell proliferation in various cancer[] gamma (PPAR-gamma).[]

  • Telmisartan

    In humans, mutations in the peroxisome proliferator-activated receptor-gamma (PPARgamma) have been reported to cause the full-blown metabolic syndrome, and drugs that activate[] Those who showed NAS improvement 2 or NAS improvement 1 with fibrosis improvement 1 were considered as responders.[] Joaquín Pérez-Schindler, Kristoffer Svensson, Elyzabeth Vargas-Fernández, Gesa Santos, Walter Wahli and Christoph Handschin , The coactivator PGC-1α regulates skeletal muscle[] Peroxisome proliferator-activated receptor δ (PPARδ), a versatile regulator of metabolic homeostasis, may be a potential therapeutic target.[] receptor-gamma (PPARγ) ligand.[]

  • Clofibrate

    Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid.[] […] that clofibrate up-regulates HO-1 gene transcription.[] High level of coactivators steroid receptor coactivator-1 (SRC-1) and histone acetylase CBP-300 (CREB binding protein-300) were observed in the nuclear complexes of clofibrate[] Liver biopsies were taken after 2, 4, and 7 yr, to follow the peroxisomal response.[] […] category: 2183 ATC code: C10AB01 Chemical structure group: DG00358 Product (DG00358): D00279 JP Efficacy Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated[]

  • Bezafibrate

    We evaluated the efficacy of bezafibrate in PFIC-1.[] Abstract Pharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been[] Author information 1 Department of Nutrition and Food, Harbin Medical University, Heilongjiang, China. [email protected] Abstract Fibrates, the ligands of peroxisome proliferator-activated[] This role is fulfilled by peroxisome proliferator activated receptor (PPAR)-γ coactivator-1α (PGC-1α); a pivotal transcriptional co-factor widely considered the master regulator[] The goal of this study was to evaluate the effect of the peroxisome proliferator-activated receptor ligand bezafibrate on the progression of impaired fasting glucose phase[]

  • Glucocorticoid

    […] splenic macrophages expressed both receptors, and that these glucocorticoids decreased the level of each Fc gamma receptor protein expressed, rather than altering receptor[] (COX-1).[] AU-rich element; JNK, c-Jun N-terminal kinase; GILZ, glucocorticoid-inducible leucine zipper; Dok, downstream of tyrosine kinase; Pol, RNA polymerase; SRC, steroid receptor coactivator[] This includes inhibitory effects on lymphocyte proliferation, as in the treatment of lymphomas and leukemias, and the mitigation of side effects of anticancer drugs.[] […] protein level i Names & Taxonomy i Organism-specific databases Subcellular location i Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome[]

  • Osteoporosis

    gamma gene: PPAR gamma expression in osteoblasts.[] BACKGROUND: Insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of bone formation and mineralization.[] Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone . Diabetes 2000 ; 49: 539 – 47 .[] gamma (PPAR-γ) and promotes survival of osteoblast lineage cells. [30] Several human bone abnormalities have been linked to the Wnt pathway.[] FIGURE 1. Wedge fracture. FIGURE 2. Burst fracture.[]

    Missing: COACTIVATOR
  • Multiple Endocrine Neoplasia Type 1

    As MEN1 patients frequently develop lipomas and peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in several MEN1-related tumor types, we investigated[] IMPORTANCE: We believe this to be the first documented report of multiple endocrine neoplasia type-1 (MEN-1) in which the diagnosis was suspected based purely on cutaneous[] Adenomatosis, Type I Multiple Endocrine Adenomatosis Type 1 Men 1 MEN Type 1 MULTIPLE ENDOCRINE NEOPLASIA, TYPE I MEA Type 1 Multiple Endocrine Adenomatosis Type I Multiple[] All of these are rare in MEN 1.Nonfunctioning pancreatic tumors also occur in patients with MEN 1 and may be the most common type of pancreatoduodenal tumor in MEN 1.[] Ligand-dependent coactivation, however, is dependent on the LXXLL motif of menin and the intact helix 12 of PPARgamma.[]