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7,128 Possible Causes for 1, Drosophila, bridging, factor, multiprotein, protein

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  • Usher Syndrome

    J AAPOS. 2009 Feb;13(1):97-8. doi: 10.1016/j.jaapos.2008.07.012. Epub 2008 Nov 20.[] Using a forward genetic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essential gene for auditory organ development.[] PDZ domain-containing 7 protein (PDZD7) is a paralog of the scaffolding proteins harmonin and whirlin, which are implicated in Usher type 1 and type 2 syndromes.[] […] results indicate that mutations in the USH2A gene and the resulting phenotype are probably modulated by other variables, such as modifying genes, epigenetics or environmental factors[] Studies on the proteins encoded by these USH genes suggest that USH proteins interact among one another and function in multiprotein complexes in vivo.[] Interaction between WHRN and PDZD7 is the bridge between USH2A and GPR98. Additionally, the USH2 quaternary complex has a variable stoichiometry.[]

  • Bloom Syndrome

    Since Werner (WRN) and Bloom (BLM) helicases are crucial in cell repair and aging, their peripheral blood mononuclear cells (PBMC) mRNA levels were compared in HIV-1 infected[] L averty et al. , 1999 The Berkeley Drosophila Genome Project gene disruption project: single P -element insertions mutating 25% of vital Drosophila genes.[] PRKAR1A and other protein kinase A (PKA) subunits were expressed in Bloom syndrome cells and their level of expression differed by subunit and cell type.[] The present observation demonstrates the variable expression of the disorder probably depending on ethnic and constitutional factors.[] Our study provides the first biochemical characterization of a multiprotein FA complex and suggests a connection between the BLM and FA pathways of genomic maintenance.[] RAD51 downregulation was associated with an increase in the frequency of BLM-positive anaphase bridges, but not of BLM-associated ultrafine bridges.[]

  • Spondyloepiphyseal Dysplasia

    Direct sequencing of the PCR products for exon 19 revealed a single base mutation that converted the codon of -GGT- for glycine at alpha 1-247 to -AGT-, a codon for serine[] […] isopropyl β-D-thiogalactoside; Ni-NTA, Ni2 –nitrilotriacetate; ORF, open reading frame; SEDT, spondyloepiphyseal dysplasia tarda; SNARE, soluble N-ethylmaleimide-sensitive factor-attachment[] The function of the SEDL protein is not known although it is speculated that it may participate in the ER-to-Golgi transport as part of a novel highly conserved multiprotein[] Homologues of the SEDL gene include a transcribed retropseudogene on chromosome 19, as well as expressed genes in mouse, rat, Drosophila melanogaster Caenorhabditis elegans[] Quickly understand complex topics thanks to a concise text-atlas format that provides a context bridge between primary and specialized medicine.[] Abstract SEDL is an evolutionarily highly conserved protein in eukaryotic organisms.[]

  • Chlamydia Infection

    CONCLUSION: Our data suggest that the damage to the carotid wall in HIV-1 patients was not due to C. pneumoniae.[] The risk factors associated with seroprevalence were determined by a multivariate logistic regression analysis.[] For instance, we identified members of the Tim-Tom complex, a multiprotein complex involved in the recognition and import of nuclear-encoded proteins to the mitochondria,[] Article Google Scholar Lourdes Mahilum-Tapay VL, Wawrzyniak JJ, Sarah A, Alison S, Penelope B, Ines U-L, Goh BT, Catherine I, Lee HH: New point of care Chlamydia Rapid Test—bridging[] Infection of the JY lymphoblastoid cell line limited the accumulation of a model host protein and increased presentation of the model-protein-derived peptides.[] Author information 1 Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. 2 1] Department of Molecular Biology[]

  • Ehrlichia Chaffeensis

    -1 inhibitor), and NS-50 (inhibitor of NF-κB nuclear translocation) inhibited the cytokine gene expression.[] Electrophoretic mobility shift assay revealed that the activity of a transcription factor PU.1 was also downregulated by E. chaffeensis infection.[] Abstract During infection, some intracellular pathogenic bacteria use a dedicated multiprotein complex known as the type IV secretion system to deliver type IV effector (T4E[] Our group identified two host genes that control E. chaffeensis replication and infection in vivo in Drosophila, Uridine cytidine kinase and separation anxiety.[] Additional E. chaffeensis surface proteins detected were OMP85, hypothetical protein ECH_0525 (here named Esp73), immunodominant surface protein gp47, and 11 other proteins[] However, sequence analysis of TRP120 does not identify the presence of DNA-binding or trans-activation domains typical of classical eukaryotic transcription factors.[]

    Missing: bridging
  • Ataxia Telangiectasia

    In the current study, we found that phospho-p21-activated kinase-1 (Pak1) and Pak1 expression was high in clinical samples of sunlight-induced premalignant skin lesions assessed[] Other mammalian ortholog(s) used D. melanogaster Gene Information (1) Comments on ortholog(s) Ortholog of human ATM (1 Drosophila to 1 human).[] Here we identified that Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT.[] The epidermal growth factor receptor (EGFR) tyrosine kinase signaling pathways regulate cellular activities.[] A multiprotein cascade operates at sites of DNA double-strand breaks (DSBs) to recognize, signal and repair damage.[] Heterologous expression studies using Sf9 cells revealed that the ATM-p400 complex can be reconstituted without other mammalian bridging proteins.[]

  • Hidradenitis Suppurativa

    We report the use of liraglutide, a glucagon-like peptide-1 agonist, in a patient with HS, leading to subsequent weight loss and improvement in disease control.[] Such measures are likely to be influenced by contextual factors.[] In familial HS, the odds of developing SCC are likely greater because of independent loss-of-function mutations in the γ-secretase multiprotein complex, which regulates the[] […] connection between the two diseases, it is possible that an interaction between sarcoendoplasmic reticulum calcium transport ATPase and Notch homolog 1, translocation-associated (Drosophila[] Stage 3 In advanced stages, bands of scar tissue and bridging fibrosis develop.[] OBJECTIVES: To assess inflammatory serum markers including serum proinflammatory cytokines, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) according to[]

  • Barth Syndrome

    ORTHOLOGY (1) KEGG GENES (1) Literature (2) PubMed (2) All databases (7) Download RDF DBGET integrated database retrieval system[] Studying insulin-like growth factor (IGF)-1 and growth hormone and the inflammatory cytokines interleukin (IL)-6 and tumour necrosis factor (TNF)-alpha by high-sensitivity[] New Results doi: Abstract Motivation: Complexome profiling combines native gel electrophoresis with mass spectrometry to obtain the inventory, composition and abundance of multiprotein[] Next, we asked whether the tafazzin mutation has any functional phenotype in Drosophila .[] We present a ten year old boy who underwent heart transplantation after bridging with an assist device at 8 months, and propose a surveillance plan prior to transplantation[] 9 (n   1) and intron 10 (n   1).[]

  • Enterococcus Faecalis

    Jahansepas A 1, 2 , Aghazadeh M 1, 2 , Rezaee MA 1, 2 , Hasani A 1, 2 , Sharifi Y 3 , Aghazadeh T 4 , Mardaneh J 5 .[] The virulence factors esp and hyl were identified in 27 (58.7%) and 25 (54.3%) of isolates, respectively.[] The core of the T4SS is a multiprotein complex that spans the bacterial envelope as a channel for macromolecular secretion.[] Future studies on Drosophila immunity should consider the pathogen genomic content.[] Although the binding proteins of Ef.LTA may play an important role for mediating infection and immunity in the oral cavity, little is known about Ef.LTA-binding proteins ([] These findings strongly suggest a specific linkage of Bee-2 to Bee-1 and Bee-3 within a complex by Srt-1.[]

    Missing: bridging
  • Keloid

    In addition, IWR-1 significantly increased the expression of MMPs, such as MMP-1, MMP-3 and MMP-13, along with the increase of gelatinase activity.[] Activation of the transforming growth factor-β (TGF-β)-mediated signaling pathway plays a key role in the scar pathogeneses, and high temperature requirement factor A1 (HTRA1[] Combined therapy with recombinant lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase (Dm‑dNK) and prodrug has been widely studied and used for cancer treatment[] Road, London, SE1 7EH, UK. 3 Dermatological Surgery & Laser Unit, St John's Institute of Dermatology,, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.[] DNA methylation of the CDC2L1 gene promoter region dramatically inhibits the expression of CDK11p58 protein in keloid tissues.[] KEYWORDS: Akt; Keloid; microRNA-205; vascular endothelial growth factor[]

    Missing: multiprotein