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374 Possible Causes for 1, W2, and, basic, domains, leucine, zipper

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  • Influenza

    Native M2 is a tetrameric protein and this conformation of the M2e part can also be mimicked by fusing this sequence to a tetramerizing leucine zipper.[doi.org] IL-1 receptor (IL-1R1).[doi.org] However, the extracellular domain of the minor, virus-coded M2 protein is nearly invariant in all influenza A strains.[doi.org] Affiliations Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK Neil M.[doi.org] Author information 1 Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 2 Department of Genome Sciences, University of Washington, Seattle[ncbi.nlm.nih.gov] The estimated proportion of the population with A/H1N1 immunity before September 1918 implies a median basic reproductive number of less than four.[ncbi.nlm.nih.gov] We show that elimination of a nascent pandemic may be feasible using a combination of geographically targeted prophylaxis and social distancing measures, if the basic reproduction[ncbi.nlm.nih.gov]

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  • Herpes Simplex Virus 1

    Extragenic suppressors of the UL34(Q163A) phenotype were isolated, and all of them carry a single mutation of arginine 229 to leucine in UL31.[ncbi.nlm.nih.gov] The Us11 protein of herpes simplex virus 1 (HSV-1) is an accessory factor with multiple functions.[ncbi.nlm.nih.gov] Here, we mapped the nuclear foci-targeting sequence to the central region containing the first leucine zipper (a.a.415-519), and found that the integrity of the whole region[ncbi.nlm.nih.gov] The functional regions of gD responsible for viral entry have been mapped to its extracellular domain, whereas the gD cytoplasmic domain plays no obvious role in viral entry[ncbi.nlm.nih.gov] College London, UK Correspondence to: K J Looker Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary’s Campus, Norfolk Place, London W2[sti.bmj.com] Author information 1 Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China [email protected] 2 Department of Microbiology[ncbi.nlm.nih.gov] Jiangsu, China. 5 Microbiology and Immunology College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. 6 Department of Immunology, School of Basic[ncbi.nlm.nih.gov]

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  • Adult T-Cell Leukemia - Lymphoma

    Satou Y, Yasunaga J, Yoshida M, et al: HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells.[karger.com] All donors tested negative for HTLV-1. Only one HTLV-1 carrier did not present with ATL or HAM development after allo-HSCT.[ncbi.nlm.nih.gov] Two viral regulatory proteins, Tax and HTLV-1 basic zipper protein (HBZ), encoded by the sense and antisense viral transcripts, respectively, are thought to play indispensable[ncbi.nlm.nih.gov] In addition, findings obtained with DNA microarray suggested Bim activation and, interestingly, the contribution of the NLR family, pyrin domain containing 3 (NLRP3) inflammasome[ncbi.nlm.nih.gov] Author information 1 National Centre for Human Retrovirology, Imperial College Healthcare NHS Trust, Winston Churchill Wing, St Mary's Hospital, Praed Street, London, W2 1NY[ncbi.nlm.nih.gov] […] kinase 9 (CDK9), a subunit of the positive transcription elongation factor b (P-TEFb) complex, regulates gene transcription elongation by phosphorylating the C-terminal domain[ncbi.nlm.nih.gov] HTLV-I basic leucine zipper (HTLV-I bZIP; HBZ) is an antisense transcript of HTLV-I, is steadily expressed in ATL cells, and interacts with several host genes and suppresses[clinicalgate.com]

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  • Recurrent Infection due to Specific Granule Deficiency

    In this study, we report a 55-y-old woman affected with SGD caused by a novel homozygous 2-aa deletion (ΔRS) in the leucine zipper domain of the C/EBPε gene.[ncbi.nlm.nih.gov] J Leukoc Biol 75:190–197 PubMed Google Scholar Copyright information Springer-Verlag GmbH Berlin Heidelberg 2009 Authors and Affiliations Masaaki Shiohara 1 1.[link.springer.com] See just the essential information with "need-to-know" basic science information and key references.[books.google.com] […] γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) CARD CARD NBD N-term LRRs C-term Binds muramyl dipeptide (MDP) CARD (Caspase-activating and recruitment domain) NBD (Nucleotide binding Domain) LRRs (Leucine-Rich[slideshare.net] "Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene[en.wikipedia.org] In this study, we report a 55-y-old woman affected with SGD caused by a novel homozygous 2-aa deletion (ΔRS) in the leucine zipper domain of the C/EBPε gene.[ncbi.nlm.nih.gov] References 1. Strauss RG, Bove KE, Jones JF, Mauer AW, Fulginiti VA (1974) An anomaly of neutrophil morphology with impaired function.[link.springer.com]

    Missing: W2 and
  • Orlistat

    Cl 2 , rt, 96%; (c) N -Cbz- l -leucine, DIAD, PPh 3 , THF, 0 C, 98%; (d) N -Cbz- d -leucine, DIAD, PPh 3 , THF, 0 C, 98%.[dx.doi.org] Review: orlistat and sibutramine are modestly effective for weight loss at 1 year Christopher D Byrne , FRCP, FRCPath, PhD 1 , Sarah Wild , MRCP, MRCGP, MFPHM, PhD 2 1 Southampton[dx.doi.org] We determined the 2.3-A-resolution crystal structure of the thioesterase domain of FAS inhibited by Orlistat.[ncbi.nlm.nih.gov] The trial by Jarrett et al used a factorial design, assessing one pharmacological and one lifestyle intervention. w2 In our analysis we assumed the two interventions did not[doi.org] Author information 1 Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA. 2 Department of Basic Pharmaceutical[ncbi.nlm.nih.gov] We determined the 2.3-Å-resolution crystal structure of the thioesterase domain of FAS inhibited by Orlistat.[doi.org] Table 2 further describes severe shortcomings in what we perceive as basic appropriate standard clinical management of the obese patient.[nature.com]

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  • Translocation Renal Cell Carcinoma

    Factors/genetics* Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism Carcinoma, Renal Cell/genetics* Carcinoma, Renal Cell/pathology Carcinoma, Renal[ncbi.nlm.nih.gov] […] of recurrence Franzini 2007 1 1 79 NA 1 100.0% 0 : 1 12 1 none metastases in 1 m Hora 2008 2 2 0 57 34-80 1 50.0% 1:1 46 1 1 none one died 1 mfor generalisation Camparo 2008[springerplus.springeropen.com] domain and nuclear localization signal.[pathology.jhu.edu] Gov't MeSH terms Adult Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism Carcinoma[ncbi.nlm.nih.gov] Gov't MeSH terms Adult Aged Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics Carcinoma, Renal Cell/diagnosis Carcinoma, Renal Cell/genetics* Chromosome[ncbi.nlm.nih.gov] Qu Y 1, 2 , Gu C 1, 2 , Wang H 1, 2 , Chang K 1, 2 , Yang X 2, 3 , Zhou X 2, 3 , Dai B 1, 2 , Zhu Y 1, 2 , Shi G 1, 2 , Zhang H 1, 2 , Ye D 1, 2 .[ncbi.nlm.nih.gov] Xia QY 1 , Wang Z 2 , Chen N 3 , Gan HL 4 , Teng XD 5 , Shi SS 1 , Wang X 1 , Wei X 1 , Ye SB 1 , Li R 1 , Ma HH 1 , Lu ZF 1 , Zhou XJ 1 , Rao Q 1 .[ncbi.nlm.nih.gov]

    Missing: W2 and
  • LIG4 Syndrome

    Compared with the genomic sequence, base-pair substitutions were observed at positions 2091 (C to A) and 2093 (C to A), resulting in a leucine-to-isoleucine change.[genetics.org] […] and 2.39 at 1 and 24 hours, respectively) and NK cells (HC1, 49.80 and 3.26 at 1 and 24 hours, respectively; HC2, 58.38 and 2.57 at 1 and 24 hours, respectively).[bloodadvances.org] A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency. The Journal of Immunology.[ped.w3.kanazawa-u.ac.jp] DNA ligase IV has a conserved ligase domain at its N-terminal and two C-terminal BRCT domains.[academic.oup.com] […] highly conserved histidine residues (corresponding to H150, H151, H188, and H189 in yeast Rpd3 Download as PDF, TXT or read online B C H150 N149 D114 H207 W3 W1 H286 D117 W2[clippingpathtoindia.com] Consequently, the position from the flcERE during light emission is basically randomized, leading to depolarization of all from the emitted light.[perlierusa.com] 125853 Diabetes mellitus, permanent neonatal 606176 Diabetes mellitus, transient neonatal 2 610374 Hyperinsulinemic hypoglycemia, familial, 1 256450 Hypoglycemia of infancy, leucine-sensitive[institutobernabeu.com]

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  • Tuberculosis

    In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Inf. Immun. 63 , 1004–1012.[dx.doi.org] RESULTS: We composed QLICD-PT with 3 domains (28 items) for general QOL and 1 pulmonary TB specific domain (12 items).[ncbi.nlm.nih.gov] Mary’s Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK Susannah A. A. Bloch & Onn M.[nature.com] […] in the basic laboratory.[ncbi.nlm.nih.gov] A study of 33 polymorphisms in the TIRAP gene found that heterozygosity for a serine-to-leucine substitution was associated with protection again invasive pneumococcal disease[emedicine.com] The slide set is in the public domain. You may reproduce these slides without permission.[web.archive.org] Impact of Structural Domains of the Heparin Binding Hemagglutinin of Mycobacterium tuberculosis on Function.[ncbi.nlm.nih.gov]

    Missing: and zipper
  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2G

    […] zipper and W2 domains 2 6 55,586,754 55,647,650 RGD:8554872 G Crppa CDP-L-ribitol pyrophosphorylase A 6 55,880,136 56,159,466 RGD:8554872 RGD:7240710 G Lrrc72 leucine rich[rgd.mcw.edu] Mariz Vainzof 1 Mayana Zatz 1 Maria Rita Passos-Bueno 1 1.[link.springer.com] Seite 119 - Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins. Proc. Natl.[books.google.de] This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant[books.google.com] […] i Phylogenomic databases Family and domain databases Gene3D i 2.20.160.10 , 1 hit InterPro i View protein in InterPro IPR015667 Telethonin IPR023111 Titin-like_dom_sf PANTHER[uniprot.org] Basic research, carried out in collaboration with scientists in the research laboratories of Boston Children's and other institutions, focuses on the description of novel[books.google.com] basic FUNCTION required for the structural integrity of sarcomere muscle assembly regulating factor, mediating the antiparallel assembly of titin (ttn) molecules at the sarcomeric[genatlas.medecine.univ-paris5.fr]

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  • Mumps Virus

    This region comprises approximately 90 amino acids and is rich in leucine and isoleucine.[scielo.br] , interleukin-1 receptor type 1 (IL-1R1), and TLR3 complexes in the plasma membrane of infected cells.[ncbi.nlm.nih.gov] . – A berring- bone or zipper- like RNP is frequently seen to leak from the virions in preparation examined by electron microscope (common to all paramyxoviruses).[microbeonline.com] A1Up contains an amino-terminal ubiquitin-like (UbL) domain, a carboxy-terminal ubiquitin-associated (UbA) domain and two stress-inducible heat shock chaperonin-binding (Sti1[ncbi.nlm.nih.gov] […] and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK. 3 1 Imperial College London, Faculty of Medicine, Division of Infectious Disease, Norfolk Place, London W2[ncbi.nlm.nih.gov] Author information 1 School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. 2 Institute[ncbi.nlm.nih.gov] We have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a host kinase that phosphorylates P and have found that phosphorylation of P by PLK1 is enhanced[ncbi.nlm.nih.gov]

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