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10,273 Possible Causes for 1,, 2A, human, inhibitor, phosphatase, protein

Did you mean: 1, 2A, human, inhibitor, phosphatase, proteus

  • Cantharidin

    Product name Cantharidin, Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Description Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor Biological description Protein[abcam.com] It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor[ncbi.nlm.nih.gov] Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] Here we report that cantharidin inhibits migration and invasion of A549 human lung cancer cell.[ncbi.nlm.nih.gov] We aimed to examine the effect of CTD on human myeloid dendritic cells (DCs) by examining immature DCs differentiated and maturated from CD14 monocytes.[ncbi.nlm.nih.gov] Here, we exploited the pharmacophoric features of both the parent ligands for the design of novel hybrid HSF1 inhibitors.[ncbi.nlm.nih.gov]

  • Influenza

    IL-1 receptor (IL-1R1).[doi.org] Selected Treatment Trials of Neuraminidase Inhibitors.[dx.doi.org] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[doi.org] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] […] und -2, Coxsackie-Virus Typ B1 und A7 Feld D: Echo-Virus Typ 7, Borrelia afzelii, burgdorferi (CH), garinii Feld E: CMV, Haemophilus influenzae*, Listeria monocytogenes 1/2a[euroimmun.de]

  • Hepatitis C Virus

    In addition, shHO-1 inhibited HCV replication. CONCLUSION: In conclusion, hypericin inhibits HCV replication via down-regulation of HO-1 expression and deacetylation.[ncbi.nlm.nih.gov] […] genetics Dual-Specificity Phosphatases/metabolism* Exoribonucleases/genetics Exoribonucleases/metabolism* Gene Knockout Techniques Genome, Viral Hepacivirus/pathogenicity[ncbi.nlm.nih.gov] KEYWORDS: Direct-acting antiviral; HIV; NS3/4A protease inhibitor; hepatitis C[ncbi.nlm.nih.gov] They also cannot easily be reconciled with the recent evidence for species–associated variants of HBV and HGV/GBV–C in a range of non–human primates.[doi.org] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[ncbi.nlm.nih.gov] Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus (HCV) from two crystal forms have been determined.[ncbi.nlm.nih.gov]

  • Osteoporosis

    BACKGROUND: Insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of bone formation and mineralization.[ncbi.nlm.nih.gov] Famularo G, Gasbarrone L, Minisola G (2013) Hypomagnesemia and proton-pump inhibitors.[doi.org] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[doi.org] Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization.[ncbi.nlm.nih.gov] Vertebrae from young adult humans and chimpanzees, gorillas, orangutans, and gibbons (T8 vertebrae, n   8-14 per species, male and female, humans: 20-40 years of age) were[ncbi.nlm.nih.gov] Am J Med. 1997;103(2A):12S-17S. v "Facts and statistics about osteoporosis and its impact." International Osteoporosis Foundation.[amgen.com]

  • Porphyromonas Gingivalis

    KEYWORDS: Porphyromonas gingivalis; adhesion; adhérence; galectin-1; galectin-3; galectine-1; galectine-3; invasion[ncbi.nlm.nih.gov] To block this neurotoxicity, we designed and synthesized small-molecule inhibitors targeting gingipains.[ncbi.nlm.nih.gov] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] […] gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators.[ncbi.nlm.nih.gov] In contrast, wild-type and DAP fimbriae were similarly effective in inducing CD14-TLR2 coassociation (Fig. 2A ).[ncbi.nlm.nih.gov]

  • Amprenavir

    Abstract In an attempt to determine whether mutations in Gag in human immunodeficiency virus type 1 (HIV-1) variants selected with a protease inhibitor (PI) affect the development[ncbi.nlm.nih.gov] […] study, we evaluated the behavior of fosamprenavir, a phosphate ester prodrug of amprenavir, in the Caco-2 system and in aspirated human intestinal fluids (HIF), both showing phosphatase[ncbi.nlm.nih.gov] In this study, we explore for the first time the effect of the HIV protease inhibitor amprenavir on gingival epithelium growth and differentiation.[ncbi.nlm.nih.gov] Abstract A sensitive bio-analytical assay for amprenavir, a human immunodeficiency virus protease inhibitor, based on reversed-phase liquid chromatography and fluorescence[ncbi.nlm.nih.gov] Abstract This secondary analysis explored changes in protein-unbound concentrations of lopinavir and amprenavir when coadministered in HIV-infected subjects.[ncbi.nlm.nih.gov] […] equilibrium, the root mean square deviation (RMSD) of the backbone atoms relative to the corresponding crystal structure during simulations were computed and plotted in Figure 2A[nature.com]

  • Lafora Disease

    […] hit PTHR11697:SF49 PTHR11697:SF49, 1 hit Sequence (1 ) i Sequence status i : Complete.[expasy.org] Here we show that malin and laforin co-localize in endoplasmic reticulum (ER) and that they form centrosomal aggregates when treated with proteasomal inhibitors in both neuronal[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] We have developed a human LD mutation database using a new generic biological database cross‐referencing platform.[doi.org] (disorder) Lafora's disease MYOCLONIC EPILEPSY OF LAFORA Melf Epilepsy, Progressive Myoclonic, 2B Progressive myoclonus epilepsy type 2 Epilepsy, Progressive Myoclonic, 2A[wikidata.org] This gene encodes laforin, which is a tyrosine kinase inhibitor that plays a significant role in the regulation of glycogen metabolism.[wiki.med.umich.edu]

  • T-cell Acute Lymphoblastic Leukemia

    Seki M 1 , Kimura S 1, 2 , Isobe T 1 , Yoshida K 3 , Ueno H 3 , Nakajima-Takagi Y 4 , Wang C 4 , Lin L 5 , Kon A 3 , Suzuki H 3 , Shiozawa Y 1 , Kataoka K 3 , Fujii Y 3 ,[ncbi.nlm.nih.gov] […] mercaptopurine, asparaginase, and doxorubicin) but are synergistic with glucocorticoids, an mTOR inhibitor, and gamma secretase inhibitor.[ncbi.nlm.nih.gov] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[ncbi.nlm.nih.gov] Abstract Recent evidence suggests that inhibition of protein phosphatase 2A (PP2A) tumor suppressor activity via the SET oncoprotein contributes to the pathogenesis of various[ncbi.nlm.nih.gov] Plumbagin is a natural, plant derived compound, which exerts an anti-proliferative activity against many types of human cancer.[ncbi.nlm.nih.gov] […] for Annexin V) and/or late apoptotic (positive for both Annexin V and PI) cells after 48 h of treatment of T-ALL cell lines MOLT-4, JURKAT, P12-ICHIKAWA, and DND41 (Fig. 2a[jhoonline.biomedcentral.com]

  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    Table 1 Causes of hypophosphatemic rickets (HR).[ec.bioscientifica.com] ; the father, high alkaline phosphatases.[ncbi.nlm.nih.gov] Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R (2005) Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing[link.springer.com] M137 thus may uncouple sodium-phosphate cotransport, suggesting that this amino acid residue has an important functional role in human NaPi-IIc.[ncbi.nlm.nih.gov] Pages: 1 NPT2C Polyclonal Antibody Gene Names: NPT2C ; SLC34A3; HHRH; NPTIIc Other Names: Sodium-dependent phosphate transport protein 2C; Sodium-phosphate transport protein[mybiosource.com] […] biallelic, while four individuals were heterozygous for sequence variants in SLC34A1 , predicted to change the amino acid sequence of the sodium-dependent co-transporter 2a[asbmr.org]

  • Indinavir

    Values for the clearance, volume of distribution and the absorption rate constant were 46.8 l h(-1) (24.2% IIV), 82.3 l (24.6% IIV) and 02.62 h(-1), respectively.[ncbi.nlm.nih.gov] Concomitantly, levels of protein tyrosine phosphatase 1B (PTP1B), suppressor of cytokines signaling-1 and -3 (SOCS-1 and -3), Src homology 2B (SH2B) and adapter protein with[ncbi.nlm.nih.gov] OBJECTIVES: To report the association between the protease inhibitor indinavir and the development of urolithiasis.[ncbi.nlm.nih.gov] Abstract We report the first case of acute cholecystitis due to indinavir-induced cholelithiasis in a patient infected with human immunodeficiency virus who had been receiving[ncbi.nlm.nih.gov] Spiked protein/plasma solutions were dialyzed against isotonic phosphate buffer, at 37 degrees C.[ncbi.nlm.nih.gov] Figure 2A shows the proportion of patients in each group who had decreases in HIV RNA levels to less than 500 copies per milliliter.[doi.org]