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117 Possible Causes for 1,, dimethylaminohydrolase, dimethylarginine, mouse

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  • Citrullinemia

    Treatment of citrullinemia type 1 consists of a protein-restricted diet, ammonia scavenger drugs, and L-arginine supplementation.[] We have also cloned and characterized the mouse homologue (Slc25a13), which is predicted to encode a protein of 676 amino acids with 96% amino acid identity to SLC25A13.[] Asymmetric dimethylarginine is hydrolyzed by the enzyme dimethylarginine dimethylaminohydrolase to l-citrulline and dimethylamine.[] OBJECTIVES: Citrullinemia type 1 (CTLN1) is an autosomal recessive genetic disorder caused by mutations in the argininosuccinate synthetase 1 (ASS1) gene, which encodes for[]

  • Arginine

    Overexpression of PRMT5 and caveolin-1 enhanced levels of membrane-bound extracellular Eno-1 and, conversely, pharmacological inhibition of PRMT5 attenuated Eno-1 cell-surface[] We treated mouse primary astrocytes with SPH as well as with its positively charged chromatographic fraction.[] The final penalized model retained the three most significant variables, i.e. the total dimethylarginine-to-arginine ratio (Total DMA/Arginine), the sum of the polyunsaturated[] Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase[]

  • Probucol

    In contrast, probucol attenuated oxLDL-stimulated caspase-3 expression in THP-1 macrophages.[] Although AGI1067 did not have marked lipid-lowering effects in two transgenic mouse models (the LDL-receptor-deficient and apolipoprotein-E-deficient models) fed a high-fat[] HYPOTHESIS: Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor (NOS), may play an important role in endothelium dysfunction.[] Although probucol could stabilize even murine SR-BI, when transfected into a human cell line, HepG2, human SR-BI was not stabilized in a mouse hepatoma cell line, Hepa 1-6[]

  • Accelerated Atherosclerosis

    Furthermore, overexpressed Ref-1 upregulated NF-kappaB and MCP-1 promoter activity, and antisense Ref-1 reduced Hcy-induced NF-kappaB DNA-binding activity and MCP-1 secretion[] To examine the relevance of the ER stress pathway in vivo, we used a streptozotocin-induced hyperglycemic apolipoprotein E-deficient mouse model of atherosclerosis.[] NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine[] […] signaling and the contribution of glycogen synthase kinase (GSK)-3β activation in hyperglycemic, hyperhomocysteinemic, and high-fat-fed apolipoprotein E-deficient (apoE(-/-)) mouse[]

  • Lactobacillus Casei

    The yield was 1·325 0·065 μg mg -1 of bacterial cells.[] By contrast, normal cells appeared to be stimulated rather than inhibited by the peptide, whereas primary mouse embryo fibroblasts behaved similarly to tumour cells.[] Most importantly, Syk inhibition significantly attenuated the LCWE-induced expression of VEGF-A, dimethylarginine dimethylaminohydrolase (DDAH)-1, and endothelial nitric oxide[] This paper is focused on studying the protective role of Lactobacillus casei ATCC 393 in a chemically induced mouse model of colon carcinogenesis, directing our attention[]

  • Homocystinuria

    Gong B 1 , Liu L 2 , Li Z 2 , Ye Z 1 , Xiao Y 2 , Zeng G 1 , Shi Y 1 , Wang Y 2 , Feng X 1 , Li X 1 , Hao F 1 , Liu X 1 , Qu C 3 , Li Y 1 , Mu G 2 , Yang Z 1 .[] The PD of PEG-CBS in mouse was dose-dependent, but less than dose-proportional, with the maximal efficacy achieved at 8 mg/kg.[] Abstract Plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis from L-arginine and a cardiovascular risk factor[] France, 1 Norway, 1 Belgium).[]

  • Ornithine Transcarbamylase Deficiency

    Author information 1 Hunter Genetics, P.O.[] In this report, we describe a new animal model of OTCD caused by a spontaneous mutation in the mouse Otc gene (c.240T A, p.K80N).[] Blood concentrations of nitrate/nitrite (NOx) as stable NO-metabolites, asymmetric dimethylarginine (ADMA) inhibiting NO synthesis, and endothelin-1 (ET-1) raising vascular[] In conclusion, we developed a model system of acute metabolic decompensation due to infection in a mouse model of a UCD.[]

    Missing: dimethylaminohydrolase
  • Cushing Syndrome

    The expression of Menin in MEN-1-associated tumors declined.[] We investigate CVD risk markers such as asymmetric dimethylarginine (ADMA), lipoprotein-associated phospholipase A2 (Lp-PLA2), highsensitive C-reactive protein (hsCRP), homocysteine[] Model 1 consisted of age and body mass index (BMI).[] The patients were well at follow-up (1-23 years); 24-hour urinary cortisol excretion was elevated in the patient who had unilateral adrenalectomy.[]

    Missing: mouse
  • Onion

    Abstract Neuropilin-1 (NRP-1) is a transmembrane glycoprotein receptor whose distinct sites bind semaphorins and vascular endothelial growth factor family members to mediate[] The inhibitory effect of lipid oxidation of onion extract was higher in the high-fat-fed mouse brain lipids than that in the low-fat-fed mouse brain lipids.[] KEYWORDS: ABP ambulatory blood pressure; ACE angiotensin-converting enzyme; ADMA asymmetric dimethylarginine; BP blood pressure; Blood pressure; Cardiovascular diseases; DBP[] Author information 1 Research Laboratories for Alcohol Beverages, Asahi Breweries Ltd., 1-21 Midori 1-chome, Moriya-shi, Ibaraki 302-0106, Japan.[]

    Missing: dimethylaminohydrolase
  • Diabetic Retinopathy

    Flatmount diabetic membranes showed co-localization of endothelin-1 with S100A4 and CD31.[] KEYWORDS: Bovine retinal pericyte cells; Diabetic mouse model; Diabetic retinopathy; Eicosanoid metabolomics; PGF2α[] This study aims to investigate whether Asymmetric dimethylarginine (ADMA) impacts the pathogenesis of DR via focusing on promoting retinal neovascularization and its underlying[] BACKGROUND: Type 1 diabetes mellitus (T1D) is a metabolic disease causing hyperglycemia due to β-cell destruction.[]

    Missing: dimethylaminohydrolase