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113 Possible Causes for 1,2,6,7,8,9,10,11 octahydro 1,6 dimethyl 10,11 dioxo ,, Phenanthro(1,2 b)furan 6 carboxylic, acid,, ester, methyl

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  • Danazol

    […] ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol[cancer.gov] We report a patient with MDS who achieved a complete remission in response to combination therapy of danazol, retinoic acid, and prednisone.[ncbi.nlm.nih.gov] Average 4.0 of 1 Ratings Thank you for rating![step1.medbullets.com] Fourteen intermediate or high-risk MF patients were enrolled at 2 institutions.[ncbi.nlm.nih.gov] This aberrant secretion of IL-6 might play a role in the formation of ectopic endometrial implants in adenomyosis.[ncbi.nlm.nih.gov] […] affect HDL-C concentration (1.1 [0.5] vs baseline, 1.2 [0.5] pmol/L), HDL-related transfer proteins such as paraoxonase-1 activity (92 [62] vs 80 [40] U/mM), cholesteryl-ester[ncbi.nlm.nih.gov] Although progesterone and MPA increased G-CSF and IL-8 secretion by ESCs in similar manner to 8-Br-cAMP, danazol had no such effects.[ncbi.nlm.nih.gov] She had been diagnosed with severe aplastic anemia 1 year previously and, while hospitalized, had received methyl prednisolone pulse therapy, which was not successful.[ncbi.nlm.nih.gov] […] c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17 ,18 ,20 ,21 ,22 /m1/s1[anabolika.de] Danazol competitively inhibited aromatase activity (by 1.7 x 10(-6) M of calculated Ki and 2.9 x 10(-5) M of Ki') of endometriosis microsomes.[ncbi.nlm.nih.gov]

    Missing: 11 octahydro 1 11 dioxo 2 b)furan 6 carboxylic
  • Aristolochic Acid

    English: 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylicacid Aristinic acid Aristolochia A Aristolochia yellow Aristolochic acid [Wiki] Aristolochic acid 1[charchem.org] Coincubation with L-lactic acid or benzoic acid, typical substrates for the proton-linked monocarboxylic acid transporters (MCTs), significantly decreased the AAI uptake,[ncbi.nlm.nih.gov] Author information 1 Department of Nephropathy, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.[ncbi.nlm.nih.gov] SG group it decreased during the 3-6 month period and remained stable within 1 year.[ncbi.nlm.nih.gov] We conclude from these studies that AL-NOHs, formed following partial nitroreduction of aristolochic acids, serve as substrates for SULT1B1, producing N-sulfated esters, which[ncbi.nlm.nih.gov] In summary, our in vitro data demonstrated a poor beneficial effect of rhBMP-7 to reverse cell toxicity while, in vivo, there was no beneficial effect of rhBMP-7.[ncbi.nlm.nih.gov] Polymerase chain reaction-based resequencing methods were used to detect mutations in the target regions of exons 2 and 3 of the HRas gene and exons 5, 6, 7, and 8 of the[ncbi.nlm.nih.gov] However, AAI exposure did not alter hypermethylation of the BLCAP promoter, determined by methyl-specific polymerase chain reaction (PCR) and bisulfate sequencing.[ncbi.nlm.nih.gov] Patient survival was 100% in AAN patients at 5, 10, and 15 years after transplantation. Graft survival at 5, 10, and 15 years was 95%, 83%, and 75%.[ncbi.nlm.nih.gov] Both the upstream kinases of JNK including MEKK4, MKK4, and MKK7, and the downstream transcription factor of JNK, AP-1, may also participate in this process.[ncbi.nlm.nih.gov]

    Missing: 11 octahydro 1 6 dimethyl 10 11 dioxo 2 b)furan 6 carboxylic
  • Irinotecan

    […] explain the reduced exposure to SN-38 in the presence of valproic acid.[ncbi.nlm.nih.gov] 100 mg/m 2 iv day 1 every 3 weeks, followed by second line S-1 20 mg/m 2 days 1-14 irinotecan 180 mg/m 2 day 1 every 3 week) for older patients ( 70 years) with mCRC who[ncbi.nlm.nih.gov] The authors performed a phase 2 cooperative group study (North Central Cancer Treatment Group N0543, Alliance) using genotype-dosed capecitabine, irinotecan, and oxaliplatin[ncbi.nlm.nih.gov] We report here a case of a metastatic colorectal cancer patient who is heterozygous for the UGT1A1 28 polymorphism (TA 6/7) as well as the UGT1A1 6 polymorphism (G/A).[ncbi.nlm.nih.gov] Heteroaromatic compounds Trialkylamines Carboxylic acid esters Lactams Lactones Organic carbonic acids and derivatives Azacyclic compounds Oxacyclic compounds Monocarboxylic[hmdb.ca] This severe toxicity was attributed to a UGT1A1 7/7 genotype and resolved to grade 2 after 8 weeks of supportive care.[ncbi.nlm.nih.gov] 8 , Drummond DC 8 , Bayever E 8 , Fitzgerald JB 8 .[ncbi.nlm.nih.gov] The objective response rate and the disease control rate (DCR) were 55% (5/9) and 78% (7/9), respectively. The median progress free survival time was 8.3 months.[ncbi.nlm.nih.gov] -1H-pyrano[3',4':6,7] indolizino[1,2-b] quinolin-9-yl ester, monohydrochloride Synonyms Camptothecin 11 CPT 11 Topotecin U 101440E Molecular Formula C 33 H 38 N 4 O 6 • HCl[caymanchem.com] Study objective was to evaluate the correlation of tumour sidedness, EGFR promoter methylation and EGFR GCN with clinical outcome.[ncbi.nlm.nih.gov]

    Missing: 11 octahydro 1 6 dimethyl 10 Phenanthro(1 2 b)furan 6 carboxylic
  • Methsuximide

    Abstract The authors investigated whether methsuximide affects serum levels of valproic acid.[ncbi.nlm.nih.gov] In patients with good seizure control, fasting plasma levels of N-desmethylmethsuximide, the principal active metabolite of MSM, were 25.3-44.7 mg l(-1)(mean 36.0 mg l(-1)[ncbi.nlm.nih.gov] Methsuximide Synonyms: 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; ( /-)-Mesuximide; 1,3-Dimethyl-3-phenylsuccinimide; Celontin; Mesuximide; Mesuximidum; Methsuximid; N,2-[trc-canada.com] -8-carboxylate Molecular Formula C 13 H 10 O 6 Molecular Weight 262.2149 InChI InChI 1/C13H10O6/c1-19-13(18)7-4-6-2-3-8(14)11(16)10(6)12(17)9(15)5-7/h2-5,14,16H,1H3,(H,15,17[chemnet.com] 2-Butenoic acid, 2-cyano-3-phenyl-, methyl ester 29840-30-0 C 13 H 12 N 2 O 2 α,β-dicyano-β-methylhydrocinnamic acid methyl ester Hydrocinnamic acid, α,β-dicyano-β-methyl[pharmaceutical-substances.thieme.com] 1 9 5 10 2 10 6 11 1 11 9 12 2 12 10 13 1 13 7 9 1 14 11 13 2 15 1 14 1 16 7 15 1[genome.jp] 2-methyl-2-phenylsuccinimide A-METHYL-A-PHENYLSUCCINIMIDE ALPHA-METHYL-ALPHA-PHENYLSUCCINIMIDE, 99 % 3-Methyl-3-phenyl-1H-pyrrole-2,5(3H,4H)-dione 3-Methyl-3-phenylpyrrolidine[chemicalbook.com] […] pharmacokinetic values: accumulation half-life, 49.7 hours; time to steady state, 10.4 days; elimination half-life, 72.2 hours; therapeutic range of plasma concentration, 10[ncbi.nlm.nih.gov] 4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3 IUPAC Name 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione SMILES CN1C( O)CC(C)(C1 O)C1 CC CC C1 Indication For the control of absence[drugbank.ca] ChemicalBook Produktkatalog Aktive pharmazeutische Wirkstoffe (APIs) Nervensystem Drogen Antiepileptika (AEDs) Mesuximid 77-41-8 CAS-Nr. 77-41-8 Bezeichnung: Mesuximid Englisch[chemicalbook.com]

    Missing: 11 octahydro 1 11 dioxo Phenanthro(1 2 b)furan 6 carboxylic
  • Nisoldipine

    […] number: N489125 Chemical name: Nisoldipine Synonyms: Bay k 5552; Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid[trc-canada.com] […] x month(-1) in the lisinopril group compared with 0.2 /- 0.4 ml x min(-1) x month(-1) in the nisoldipine group (P 0.01).[ncbi.nlm.nih.gov] […] main efficacy analysis, and the rest randomized into one of four treatment groups, to receive either placebo, or nisoldipine CC at doses of 10, 20, or 30 mg once daily for 6[ncbi.nlm.nih.gov] Preincubation of these arteries with nisoldipine (1 x 10(-7) mol/l) reduced contraction measured as AUC by 46 /- 10% and preincubation with nifedipine (1 x 10(-7) mol/l) by[ncbi.nlm.nih.gov] Flow-mediated dilation (FMD), and plasma levels of nitric oxide (NO), endothelin-1 (ET-1), high-sensitive C-reactive protein (hs-CRP), 8-isoprostane (also named 8-isoPGF2α[ncbi.nlm.nih.gov] Cardiovasc Drugs Ther. 1997 Jan;10 Suppl 3:873-9. [3]. D.J. Duncker, J.M. Hartog, P.G. Hugenholtz, et al.[medchemexpress.com] Accurate Fuzzy Regular Expression Search Criteria: All Chemical Names Registry Numbers Catalogue Numbers Click picture or here to close IUPAC name 3-methyl 5-(2-methylpropyl[en.chembase.cn] Structure Chemical name ( )-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate. Molecular formula C 20 H 24 N 2 O 6 .[alomone.com] Naunyn-Schmiedeberg's Arch Pharmacol 324 [Suppl]: R-49 Google Scholar 10.[springerlink.com] acid Mepacrine Niflumic acid Talniflumate Tolfenamic acid Trifluoperazine Others TRPs See here instead.[en.wikipedia.org]

    Missing: 11 octahydro 1 11 dioxo Phenanthro(1 2 b)furan 6 carboxylic
  • Solvent

    To develop a safer, more stable and potent formulation of gefitinib (GFB), micro-spheres of GFB encapsulated into poly (l-lactic acid) (PLLA) have been prepared by supercritical[ncbi.nlm.nih.gov] CASE SERIES: We report a cohort of six cases of 1-bromopropane neurotoxicity occurring in foam cushion gluers exposed to 1-bromopropane vapors from spray adhesives.[ncbi.nlm.nih.gov] Taking into consideration the principles of green chemistry, 2-methyltetrahydrofuran (2-MeTHF) is proposed as a suitable replacement for the structurally similar solvent tetrahydrofuran[ncbi.nlm.nih.gov] J Urol. 1992 May;147(5):1365-6. Author information 1 Department of Environmental Health, Medical University of Yamanashi, Japan.[ncbi.nlm.nih.gov] Biochemical analysis showed an increase of very long chain fatty acids in the white matter cholesterol esters.[ncbi.nlm.nih.gov] Orozco-Gonzalez Y 1, 2, 3 , Manathunga M 3 , Marín MDC 4 , Agathangelou D 1 , Jung KH 5 , Melaccio F 4 , Ferré N 6 , Haacke S 1 , Coutinho K 7 , Canuto S 7 , Olivucci M 1,[ncbi.nlm.nih.gov] Br J Cancer. 2017 Oct 10;117(8):1246-1254. doi: 10.1038/bjc.2017.285. Epub 2017 Sep 14.[ncbi.nlm.nih.gov] Herein, meconium was the chosen matrix to evaluate cannabis exposure through identification and quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic (THCCOOH).[ncbi.nlm.nih.gov] The paint base consisted primarily of toluene and methyl ethyl ketone. Nausea, headaches, dizziness, respiratory difficulty and other symptoms began after exposures.[ncbi.nlm.nih.gov] O 3 106.12 246 -10 1.1197 10 31.8 124 diethyl ether C 4 H 10 O 74.12 34.5 -116.2 0.713 7.5 4.267 -45 diglyme (diethylene glycol dimethyl ether) C 6 H 14 O 3 134.17 162 -68[organicdivision.org]

    Missing: 11 octahydro 1 11 dioxo Phenanthro(1 2 b)furan 6 carboxylic
  • Isosorbide

    It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds.[ncbi.nlm.nih.gov] Propensity-matched scoring created two sets of matched cohort pairs on a 1:1 basis, each set comparing FDC-ISDN/HYD with one of the off-label combinations.[ncbi.nlm.nih.gov] There was no reduction, but instead an increase in headache intensity 2 hours after sumatriptan ( p   0.003).[ncbi.nlm.nih.gov] We found 6 search results for isosorbid. 5 drugs , 1 diseases , 0 anatomy, 0 articles, 0 tests Search results: Ischemic heart disease (diseases) Ischemic Heart Disease, also[medicalook.com] Dicarbamates and 5-keto derivatives were markedly less potent than the ester class.[ncbi.nlm.nih.gov] Isosorbide mononitrate, 98 % 16051-77-7 10g 296 2018-11-13 Buy Alfa Aesar J63674 Isosorbide mononitrate, 98 % 16051-77-7 25g 618 2018-11-13 Buy Isosorbide 5-mononitrate Chemical[chemicalbook.com] The mean AUCt and Cmax in the fed state were 8 793.5 ng · h/mL and 559.9 ng/mL, respectively, for the Imdur Long-Acting tablet 60 mg, and 8 639.8 ng · h/mL and 617.9 ng/mL[ncbi.nlm.nih.gov] […] in methylation reactions [24-35] .[beilstein-journals.org] H 10 O 4 Molecular Weight: 146.14 Isosorbide dimethyl ether 1 Product Result Match Criteria: Product Name, Property, Description Synonym: 1,4:3,6-Dianhydro-2,5-di- O -methyl[sigmaaldrich.com] 10 mg. APO-ISOSORBIDE DINITRATE 30 mg: Each tablet contains Isosorbide dinitrate 30 mg.[home.intekom.com]

    Missing: 11 octahydro 1 11 dioxo Phenanthro(1 2 b)furan 6 carboxylic
  • Nalbuphine

    The spectrophotometric method involves addition of a known excess of Ce(IV) to NLB in acid medium, followed by determination of residual Ce(IV) by reacting with a fixed amount[ncbi.nlm.nih.gov] Intravenous morphine [patient-controlled analgesia (PCA)/continuous infusion] was associated with Pr in 68% of subjects over a wide dose range (9.4-63.2 mug.kg(-1).hr(-1))[ncbi.nlm.nih.gov] Product attributes Scientific Smiles Cl.O[[email protected]]1CC[[email protected]@]2(O)[[email protected]]3Cc4ccc(O)c5O[[email protected]@H]1[[email protected]]2(CCN3CC6CCC6)c45 Inch 1H/t15-,16 ,19-,20-,21 ;InChI 1S/C21H27NO4.ClH/c23-14-5-4-13-[lgcstandards.com] Blood was collected from 3 mice per treatment at 5, 10, 20, and 30 min and 1, 2, 3, 6, 12, and 24 h after administration.[ncbi.nlm.nih.gov] […] sensitive and selective ultraperformance liquid chromatography-tandem spectrometry (UPLC-MS/MS) method for the determination of nalbuphine and its prodrug sebacoly dinalbuphine ester[ncbi.nlm.nih.gov] Thereafter, 2 mg and 3 mg of morphine were administered via the epidural route at 8 p.m. and 8 a.m., respectively, for a 48-hour observation period.[ncbi.nlm.nih.gov] The severity of pruritus was significantly lower at 3, 6, 9 and 12 h postpartum in the N-5 group and the N-10 group had a lower degree of pruritus at 3 and 6 h postpartum[ncbi.nlm.nih.gov] The Food and Drug Administration (FDA) is announcing its determination that NUBAIN (nalbuphine hydrochloride) injection, 10 and 20 milligrams/milliliter (mg/ml), was not withdrawn[federalregister.gov] The optimal pH conditions for the SPE were found at pH 8.[ncbi.nlm.nih.gov] Salicylates Aspirin (acetylsalicylic acid) # ( paracetamol/caffeine ) Benorylate Diflunisal Ethenzamide Magnesium salicylate Salicin Salicylamide Salsalate Wintergreen ( methyl[en.wikipedia.org]

    Missing: 6 dimethyl 10 11 dioxo Phenanthro(1 2 b)furan 6 carboxylic
  • Thiopental

    , mefenamic acid , niflumic acid , tolfenamic acid ) Fluoxetine Flupirtine Hopantenic acid Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol[en.wikipedia.org] 1 Record 1, Abbreviations, English Record 1, Textual support, English Record number: 1, Textual support number: 1 DEF A barbiturate that is administered intravenously for[btb.termiumplus.gc.ca] Sensitivity to hypoxic damage was restored by pharmacologic repression of eukaryotic elongation factor 2 kinase.[ncbi.nlm.nih.gov] Epub 2009 Jul 6.[ncbi.nlm.nih.gov] ester Reprosil Chiral -OM N-Z-proline ethyl ester Reprosil Chiral -AM N-Z-S-benzyl-cysteine benzyl ester Reprosil Chiral -OM N-Z-S-benzyl-cysteine ethyl ester Reprosil Chiral[chirapedia.com] For our secondary outcomes of adverse events, infection was seen in 7/14 patients versus 5/7 patients in the propofol and thiopental sodium groups, respectively ( RR 0.70;[cochrane.org] Keywords 71-73-8 Thiopental sodium 99% Thiopental sodium Quick Details ProName: Thiopental sodium CasNo: 71-73-8 ProductionCapacity: Metric Ton/Day Purity: 99% LimitNum: 0[shreejipharma.lookchem.com] This review uses a previously published 9-step decision-making algorithm to determine whether TDM of thiopental in TBI is warranted.[ncbi.nlm.nih.gov] Chemical formula : C 11 H 17 N 2 Na O 2 S IUPAC name : ( RS )-[5-ethyl-4,6-dioxo-5-(pentan-2-yl)-1,4,5,6-tetrahydropyrimidin-2-yl]sulfanide sodium Trade name : Pentothal,[doctoralerts.com] Hemodynamic parameters were recorded at the time of patient entrance to the operation room and at the 1, 2, 5, 10, 15, 20, 25, 30, 35, and 40 minutes following anesthesia.[ncbi.nlm.nih.gov]

    Missing: 11 octahydro 1 6 dimethyl 10 Phenanthro(1 2 b)furan 6 carboxylic
  • Stanozolol

    [2,3-c]pyrazol-1-ol, 1,2,3,3a,3b,4,5,5a,6,7,10,10a,10b,11,12,12a-hexadecahydro-1,10a,12a-trimethyl- (6CI, 7CI) Cyclopenta[7,8]phenanthro[2,3-c]pyrazole, 2'H-androst-2-eno[[chemicalbook.com] Similar steroid substances stimulate the activity of delta-aminolaevulinic acid synthase (ALA S), the rate limiting enzyme of haem biosynthesis, in rat hepatocytes and chick[ncbi.nlm.nih.gov] In contrast, As147/8BSA is highly specific for St with an IC(50) of 0.16 microg L(-1) and a limit of dection of just 0.022 microg L(-1).[ncbi.nlm.nih.gov] Serum creatinine was around 1.5 mg/dL in both of the patients 2 months after discharge.[ncbi.nlm.nih.gov] Molecules. 2017 Jun 12;22(6). pii: E976. doi: 10.3390/molecules22060976.[ncbi.nlm.nih.gov] (e.g., levonorgestrel butanoate ) Lynestrenol Lynestrenol phenylpropionate Norethisterone Norethisterone esters (e.g., norethisterone acetate , norethisterone enanthate )[en.wikipedia.org] Using a human breast cancer cell line, MCF-7, as an experimental model we found that both nandrolone and stanozolol caused a dose-dependent induction of aromatase expression[ncbi.nlm.nih.gov] In contrast, testosterone decreased HDL-cholesterol concentration by only 9% and the decrease was in the HDL3 subfraction.[ncbi.nlm.nih.gov] Suppliers Detailed List Identification Name Stanozolol Synonyms Androstanazol; Winstrol l; 17beta-Hydroxy-17-methyl-5alpha-androstano[3,2-c]pyrazole Molecular Structure Molecular[chemblink.com] Stanol 10 is a strong anabolic substance with androgenic action.[magnum-pharmaceuticals.asia]

    Missing: 11 octahydro 1 6 dimethyl 10 11 dioxo 2 b)furan 6 carboxylic