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7,914 Possible Causes for 10,, C T, CHOLESTEROL, DENSITY, HIGH, LEVEL, LIPOPROTEIN, LOCUS, QUANTITATIVE, TRAIT

  • Weight Loss

    Similar results were observed for acute insulin response, triglycerides, non-HDL cholesterol concentration, low density lipoprotein (LDL) particle size and high density lipoprotein[ncbi.nlm.nih.gov] BACKGROUND: apolipoprotein E (ApoE) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease.[ncbi.nlm.nih.gov] Our objective was to identify factors predicting long-term successful weight reduction maintenance achieved during a DM2 prevention program in patients with high DM2 risk[ncbi.nlm.nih.gov] PMID 22323350 . a b c d e f Itoh, M; Tsuji, T; Nemoto, K; Nakamura, H; Aoshiba, K (Apr 18, 2013). "Undernutrition in patients with COPD and its treatment" .[en.wikipedia.org] To address this, we design a large-scale protein quantitative trait locus (pQTL) analysis based on a set of 1129 proteins from 494 obese subjects before and after a weight[ncbi.nlm.nih.gov] OBJECTIVES: To evaluate and compare POP levels in serum before and after bariatric surgery, and to assess if the POP levels exceeded health based guideline values, with particular[ncbi.nlm.nih.gov] Of the TRIAL patients, ten obtained a poor result ( 10% decreased BMI).[ncbi.nlm.nih.gov] BACKGROUND: "Living High-Training Low" (LHTL) is effective for the improvement of athletic ability; however, little is known about the effect of LHTL on obese individuals.[ncbi.nlm.nih.gov] As part of the telephone survey participants were also asked to identify other impacts of the Challenge; these were analysed descriptively (quantitative items) and thematically[ncbi.nlm.nih.gov] […] group with a high-FOS diet only.[ncbi.nlm.nih.gov]

  • Mood Disorder

    BACKGROUND: Although many studies have identified factors associated with mood disorder, the association between high-density lipoprotein cholesterol (HDL-C) and mood disorder[ncbi.nlm.nih.gov] J., Ehlers, C. L., Monk, T., Cornes, C., Carter, S., et al. (1994).[nobaproject.com] What is now called major depressive disorder, however, differs both quantitatively and qualitatively from normal sadness or grief.[webspace.ship.edu] Nevertheless, lithium is a toxic element and its therapeutic range is extremely narrow, with levels of 0.61.0 mEq considered normal, whereas levels above 1.5 mEq are toxic[ncbi.nlm.nih.gov] Although studies have suggested that personality traits are possible risk factors for suicide, no study has been conducted among Chinese to compare the temperament traits[ncbi.nlm.nih.gov] This locus was implicated originally as being involved in susceptibility to schizophrenia. 36 It was a novel locus with a designation of G72.[nature.com] […] year of non-draft ICD-10-CM) 2017 (effective 10/1/2016) : No change 2018 (effective 10/1/2017) : No change 2019 (effective 10/1/2018) : No change Disorder (of) - see also[icd10data.com] , P-value 0.027) compared with areas with the highest density, after adjustment for deprivation and population density.[ncbi.nlm.nih.gov] […] thirsty, need to urinate more than usual, feel very hungry, feel weak or tired, feel sick to your stomach, feel confused, or your breath smells fruity Increased fat levels (cholesterol[latuda.com] A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder. J Child Adolesc Psychopharmacol . 2008 Dec. 18(6):595-605. [Medline] .[emedicine.medscape.com]

  • Ehrlichia Chaffeensis

    TRP120 ubiquitination sites were mapped using a high-density microfluidic peptide array and confirmed by ectopic expression of TRP120 lysine mutants in cells.[ncbi.nlm.nih.gov] To study in vivo E. chaffeensis lipoprotein expression and host immune responses to E. chaffeensis lipoproteins, 13 E. chaffeensis lipoprotein genes were cloned into a mammalian[ncbi.nlm.nih.gov] We evaluated a high-throughput, objective peptide-based enzyme-linked immunosorbent assay (ELISA) for use alone or in combination with IFA.[ncbi.nlm.nih.gov] However, host cell-free bacteria had the ability to take up directly exogenous cholesterol or NBD-cholesterol, a fluorescent cholesterol derivative.[ncbi.nlm.nih.gov] ., Ruiz, C., Liu, C.-C. & Licata, V. J. (2003). Biochem. J. 374 , 785–792. Web of Science CrossRef PubMed CAS Google Scholar Laurent, T. C., Moore, E.[journals.iucr.org] The assay is species specific and provides quantitative results in the range 10 to 10(10) gene copies.[ncbi.nlm.nih.gov] Five-hundred twenty-seven genes had increased transcript levels unique to permissive growth conditions 24 h postinfection.[ncbi.nlm.nih.gov] […] intracellular replication, three functional pairs of two-component systems are sequentially expressed to regulate metabolism, aggregation, and the development of stress-resistance traits[ncbi.nlm.nih.gov] The shared homology among isolates in each group for the 28-kDa OMP locus suggests the derivation of clonal lineages.[ncbi.nlm.nih.gov] In addition, urbanization per se may not be as important a factor as the local density of foliage and the regional concentration of animal reservoirs.[jamanetwork.com]

  • Bipolar Disorder

    Lipid profiles were analyzed and the AIP parameter of logarithm of triglyceride (TG) / high-density lipoprotein cholesterol (HDLc) was calculated for all of the participants[ncbi.nlm.nih.gov] Symptoms of Mania: Excessively “high,” euphoric mood Extreme irritability Unrealistic beliefs in one’s abilities and powers, such as feeling able to control world events Decreased[halfofus.com] Interestingly, the patient carried the c.1639 C   T variant in the GRN gene, resulting in a R547C substitution.[ncbi.nlm.nih.gov] Our goal was to conduct a multipoint quantitative trait linkage analysis to identify quantitative trait loci (QTLs) related to anxiety trait in subjects with BPI.[ncbi.nlm.nih.gov] No data is available on the level of LL-37 in bipolar patients.[ncbi.nlm.nih.gov] Recently, a novel genome-wide significant risk locus at chromosome 4q26 was identified and the top single nucleotide polymorphism rs11098403 in the vicinity of NDST3 gene[ncbi.nlm.nih.gov] Here are 10 signs that mood problems may be due to more than a quirky or difficult personality.[health.com] Weinstein, Amy T. Peters, Andrea C. Katz, David B. Henry, Rick A. Cruz, Mani N.[aacap.org] […] interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus[ncbi.nlm.nih.gov] Reported changes in the brains of people with BD Decreases in the number and density of glial cells in the prefrontal cortex.[faculty.washington.edu]

  • Parasite

    Seropositivity was estimated at 67 and 63% for GLURP(R0) and MSP3 antibodies, respectively, and antibody titers were negatively correlated with parasite density.[ncbi.nlm.nih.gov] , HDL/blood Lipoproteins, HDL/genetics Microscopy Polymerase Chain Reaction Trypanocidal Agents/therapeutic use Trypanosoma/classification Trypanosoma/isolation & purification[ncbi.nlm.nih.gov] In general, the Chinese clinical isolates of T. callipaeda expressed high genetic diversity. Based on the cox1 gene, a total of 21 haplotypes were identified.[ncbi.nlm.nih.gov] These assemblies, enriched in cholesterol and sphingolipids, form highly dynamic, liquid-ordered phases that can be separated from the bulk membranes thanks to their resistance[ncbi.nlm.nih.gov] 1 , López T 2 , Moreno M 2 , Molina I 1 .[ncbi.nlm.nih.gov] METHODS: A simple duplex quantitative PCR method was developed in which distinct fluorescent signals are generated from the human and parasite DNA components in each blood[ncbi.nlm.nih.gov] No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed.[ncbi.nlm.nih.gov] The current understanding of how temperature affects mosquito and parasite life history traits derives from a limited number of empirical studies.[ncbi.nlm.nih.gov] If you consumed any contaminated water during your travels, you may have acquired a parasite of some kind. 10 Signs You May Have a Parasite The signs of a parasite can often[mindbodygreen.com] The alpha-fetoprotein (AFP) level was 174,640 ng/ml.[ncbi.nlm.nih.gov]

    Missing: LOCUS
  • Amyotrophic Lateral Sclerosis

    The brain was removed, right PMC (RPMC) was excised, and MN density was quantified.[ncbi.nlm.nih.gov] Recent studies suggested that antibody to low-density lipoprotein receptor-related protein 4 (LRP4) was a pathogenic agent of myasthenia gravis (MG), and it was also detected[ncbi.nlm.nih.gov] METHODS: In this study, DNA from 28 Hungarian ALS patients was subjected to targeted high-throughput sequencing of the coding regions of three Mendelian ALS genes: FUS, SETX[ncbi.nlm.nih.gov] The progression of ALS was related to the lowering of Caveolin-1 protein levels and the accumulation of cholesterol in a crude mitochondrial fraction.[ncbi.nlm.nih.gov] C , Niehaus L , Opherk C , Raape J , Ratzka P , Rettenmayr C , Riepe MW , Rothmeier J , Sabolek M , Schabet M , Schell C , Schlipf T , Schmauss M , Schoels L , Schuetz K[ncbi.nlm.nih.gov] Schwann cell proliferation and recruitment of inflammatory factors were detected by immunofluorescence staining and quantitative reverse transcription PCR and were compared[ncbi.nlm.nih.gov] ALS patients had clearly increased pNFH levels (p 0.0001), while CgA levels were only modestly lower relative to controls (p 0.0265), with wide value overlap and consequently[ncbi.nlm.nih.gov] Cosegregation of ALS and KFS with an autosomal-dominant trait suggests an impairment of transforming growth factor β signaling pathway, and its potential role is discussed[ncbi.nlm.nih.gov] Chromosomes Gene report of major ALS genes in ALSoD or View Details Locus Gene Gene name Chromosome Select ALS 1 SOD1 Cu/Zn superoxide dismutase 1, soluble (amyotrophic lateral[alsod.iop.kcl.ac.uk] This is the American ICD-10-CM version of G12.21 - other international versions of ICD-10 G12.21 may differ.[icd10data.com]

  • Gaucher Disease Type 1

    ERT improved haematological parameters and visceromegaly, without a clear benefit for bone mineral density.[ncbi.nlm.nih.gov] BACKGROUND: Dyslipidemia in Gaucher disease includes reduced total, low-density lipoprotein (LDL)-, and high-density lipoprotein (HDL)-cholesterol (C).[ncbi.nlm.nih.gov] An initial 64-kDa form, containing high mannose-type oligosaccharide side chains, was processed quantitatively, within 24 h, to a sialylated 69-kDa form.[ncbi.nlm.nih.gov] Risk factors were: age, family history of CL, higher BMI values, LDL-cholesterol (LDL-C), disease severity, splenectomy.[ncbi.nlm.nih.gov] 4.1%; c.1226A   G (N370S), 17.8%; c.1246G   A (G377S), 17.6%; c.1289C   T (P391L), 8.5%; c.1448T   C (L444P), 3%; and c.1504C   T (R463C), 24.5%.[ncbi.nlm.nih.gov] Reduced levels of BDNF (p 0.004) and elevated levels of TNF-α (p 0.017) and IL-4 (p 0.035) were also found in the GD group.[ncbi.nlm.nih.gov] The defective activity of acid beta-glucosidase is the enzymatic basis of GD and is inherited as an autosomal recessive trait.[ncbi.nlm.nih.gov] Abstract Gaucher disease type 1, a non-neuronopathic lysosomal storage disease, is caused by mutations at the acid beta-glucosidase locus.[ncbi.nlm.nih.gov] The following 10 adverse events noted in the eliglustat US Prescribing Information (USPI) and EU Summary of Product Characteristics (SmPC) were evaluated with regard to frequency[ncbi.nlm.nih.gov] BACKGROUND: Gaucher disease type 1 (GD1, OMIM# 230800), is a condition with high impact in patient's quality of life (QoL).[ncbi.nlm.nih.gov]

  • Fish-Eye Disease

    Abstract Serum high density lipoproteins (HDL) were isolated by preparative ultracentrifugation from two patients with fish eye disease (FED).[ncbi.nlm.nih.gov] […] the free cholesterol of these lipoproteins, has been supplemented with normal isolated HDL2 or HDL3 and incubated in vitro at 37 C.[ncbi.nlm.nih.gov] Abstract The activity of lecithin: cholesterol acyl transferase (LCAT), the enzyme which catalyses the esterification of human plasma cholesterol, has been measured by two[ncbi.nlm.nih.gov] DNA sequence analysis of the proband's LCAT gene showed two C to T transitions resulting in the substitution of Thr123 with Ile and Tyr144 with Cys.[ncbi.nlm.nih.gov] It is concluded that a low HDL cholesterol level is not necessarily associated with quantitative abnormalities of biliary lipid metabolism.[ncbi.nlm.nih.gov] Therapy, using presently available agents, in FED should be to optimize LDL-C levels, and 1 proband responded well to statin therapy.[ncbi.nlm.nih.gov] They were able to generate a list of candidate genes for hallmark cave fish traits.[sciencedaily.com] Probable linkage of LCAT locus in man to the α -haptoglobin locus on chromosome 16. Nature 249 (1974) 550–551 Google Scholar Teisberg, P. and Gjone, E.[link.springer.com] The final distance and near vision of the right eye was 8/10 and Snellen 1 respectively.[ncbi.nlm.nih.gov] Abstract Fish-eye disease (FED) in humans is characterized by corneal opacities and markedly decreased plasma concentrations of high-density lipoprotein (HDL) cholesterol,[ncbi.nlm.nih.gov]

  • Sleep Disturbance

    […] lipoprotein and high-density lipoprotein cholesterol, high-sensitivity C reactive protein, cardiovascular disease history, education years and living alone.[ncbi.nlm.nih.gov] BACKGROUND: Sleep problems in people with dementia are common and place a high burden on caregivers.[ncbi.nlm.nih.gov] METHODS: A quantitative cross-sectional study design was used.[ncbi.nlm.nih.gov] Low serum vitamin D levels have been associated with sleep quality in non-HD subjects.[ncbi.nlm.nih.gov] Although environmental factors contribute substantially to self-reported habitual sleep duration and disruption, these traits are heritable and identification of the genes[ncbi.nlm.nih.gov] The ICD-10-CM for Physicians & Hospitals 2018 is brimming with new and revised ICD-10-CM codes and their descriptors, along with expert guidance and the vital features you[books.google.de] Future studies may augment these findings with complementary imaging techniques including cortical thickness and diffusion tensor imaging, as well as high density electroencephalogram[ncbi.nlm.nih.gov] Rates of probable OSA are also high.[ncbi.nlm.nih.gov] RESULTS: Characteristics associated with higher initial levels of sleep disturbance included higher body mass index, poorer functional status, higher trait anxiety, higher[ncbi.nlm.nih.gov] RESULTS: Both parents experienced high levels of stress, anxiety, depression and sleep disturbance.[ncbi.nlm.nih.gov]

    Missing: C T
  • Perhexiline

    Abstract The effects of perhexiline maleate (PM, Pexid) on low density lipoprotein (LDL) processing and cholesterol metabolism were investigated after a 24 h pretreatment[ncbi.nlm.nih.gov] The aim of this study was to develop a high-performance liquid chromatography-mass spectrometry/mass spectrometry method for the determination of plasma perhexiline concentrations[ncbi.nlm.nih.gov] B , bound drug concentration; C F , free drug concentration; B max , maximal binding capacity; K D , equilibrium dissociation constant; C T , total drug concentration; K m[dmd.aspetjournals.org] RESULTS: An LC-MS/MS method, using two novel internal standards, has been validated for the quantitative measurement of PEX and its major hydroxy metabolites in human plasma[ncbi.nlm.nih.gov] Careful therapeutic level monitoring for dose titration is important to prevent acute and chronic toxicity.[ncbi.nlm.nih.gov] Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature . 347(6295):773-6, (1990). Kagimoto M, Heim M, Kagimoto K, et al.[en.wikipedia.org] Alkalinized plasma was extracted with nb-hexane, the organic phase was evaporated, and the residue was dansylated prior to analysis by reversed-phase high-performance liquid[ncbi.nlm.nih.gov] Citation Drury , N E , Howell , N J , Calvert , M J , Weber , R J M , Senanayake , E L , Lewis , M E , Hyde , J A J , Green , D H , Mascaro , J G , Wilson , I C , Graham ,[aura.abdn.ac.uk] Abstract A method for the quantitative determination of perhexiline and its main hydroxylated metabolites in human plasma, based on liquid chromatography-mass spectrometry[ncbi.nlm.nih.gov] Abstract A high-performance liquid chromatographic method for the analysis of perhexiline and its monohydroxy metabolite in plasma has been developed.[ncbi.nlm.nih.gov]

    Missing: TRAIT