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25 Possible Causes for 2'deoxyguanosine, 2'deoxyinosine,, HIGH, and, excretion, guanosine,, inosine,, of, urinary

  • Hyperuricemia

    Peaks : 1 , uric acid; 2 , hypoxanthine; 3 , xanthine; 4 , adenine; 5 , inosine; 6 , guanosine; 7 , 2′-deoxyinosine; 8 , 2′-deoxyguanosine; 9 , adenosine; 10 , 2′-deoxyadenosine[clinchem.aaccjnls.org] Urinary excretion of inosine, hypoxanthine, and urate increased greatly after exercise, consistently with the increases in plasma levels.[ncbi.nlm.nih.gov] This study investigates frequency of hyperuricemia and renal failure in renal transplant recipients treated with high-dose MZ.[ncbi.nlm.nih.gov] Diosgenin and Tigogenin increased uric acid excretion via ATP binding cassette subfamily G member 2 (ABCG2).[ncbi.nlm.nih.gov] Routine laboratory data showed hyperuricemia, a high level of plasma oxypurines, increased urinary uric acid excretion, and increased urinary oxypurine excretion, with decreased[ncbi.nlm.nih.gov] We analyzed age at diagnosis, clinical symptoms, uricemia, urinary hypoxanthine and xanthine, HPRT activity in erythrocytes, mutation in the HPRT1 gene, X-inactivation, and[ncbi.nlm.nih.gov] ., ammonia, inosine, hypoxanthine and xanthine, were transiently increased by the exercise and that a subsequent increment in uric acid continued until the following day.[ncbi.nlm.nih.gov] This interference has a dual action, both increasing the conversion of ATP to inosine and hence uric acid and increasing the synthesis of purine.[reliawire.com] High Uric Acid Levels Without Gout Attacks So, why is it that some lucky chaps can have really high uric acid levels, but never get a gout attack?[thegoutkiller.com]

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  • Purine-Nucleoside Phosphorylase Deficiency

    The primary lymphotoxic substrates of ADA and PNP—dAdo and 2′-deoxyguanosine (dGuo) , respectively—are derived largely from the breakdown of DNA associated with cell death[ommbid.mhmedical.com] Incubation with [14C]inosine resulted in a rapid conversion to IMP in the normal intact red cells but in an accumulation of inosine in the medium with the erythrocytes of[ncbi.nlm.nih.gov] Both PNP-deficient patients have abnormally high levels of deoxyguanosine triphosphate (deoxy-GTP) in their erythrocytes (5 and 8 nmol/ml packed erythrocytes).[ncbi.nlm.nih.gov] With this method normal as well as slightly elevated excretions of orotic acid have been found in our patient.[ncbi.nlm.nih.gov] Guanosine triphosphate (GTP) depletion was noted in the erythrocytes of all surviving homozygotes and was of equivalent magnitude to that found in the Lesch-Nyhan syndrome[ncbi.nlm.nih.gov] The high 2,3-diphosphoglycerate level caused a shift to the right of the oxygen dissociation curve (P50 32.9 mm Hg).[ncbi.nlm.nih.gov] Biochemical mechanisms were investigated by measuring deoxyguanosine and guanosine metabolism in normal T and B lymphoblasts and NP-deficient B lymphoblasts.[biochemj.org] Footnotes 2 Dr. H. D.[jimmunol.org] It differed from the normal enzyme by a tenfold increase in the Michaelis constant for inosine, an inability of inosine to protect against thermal lability, and a more positive[ncbi.nlm.nih.gov]

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  • Adenosine Deaminase Deficiency

    The primary lymphotoxic substrates of ADA and PNP—dAdo and 2′-deoxyguanosine (dGuo) , respectively—are derived largely from the breakdown of DNA associated with cell death[ommbid.mhmedical.com] Abstract A complete deficiency of inosine triphosphate pyrophosphohydrolase (ITPase) has been identified, together with high concentrations (mean 157 mumol/l) of the unusual[ncbi.nlm.nih.gov] The high rate of neurologic abnormalities observed in long-term surviving patients with ADA deficiency indicates that HSCT commonly fails to control CNS complications in this[ncbi.nlm.nih.gov] Urinary excretion of uric acid was decreased.[ncbi.nlm.nih.gov] Adenosine deaminase catalyzes the conversion of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively.[symptoma.com] The gene for adenosine deaminase is located on chromosome 20q12-q13.11 and codes for an aminohydrolase that catalyzes the deamination of adenosine and deoxyadenosine to inosine[ncbi.nlm.nih.gov] As a true "orphan drug" developed to treat a very small patient population, the cost per patient of PEG-ADA is very high.[ncbi.nlm.nih.gov] Pathophysiology PNP is an enzyme in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine. [4, 5, 6, 7] In the preceding step of the pathway, ADA[emedicine.medscape.com] ADA works in the salvage pathway of purine synthesis and catalyses the reaction causing the deamination of adenosine to inosine and 2’-deoxy-adenosine to 2deoxyinosine [[autoimmunediseases.imedpub.com]

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  • Acyclovir

    Acyclovir, an analog of 2'-deoxyguanosine, is one of the most important drugs in the current approved antiviral treatment.[ncbi.nlm.nih.gov] Patients were assigned to treatment in one of two groups: (i) inosine pranobex group (active inosine pranobex, 1 g four times daily, and acyclovir placebo); or (ii) acyclovir[ncbi.nlm.nih.gov] Therefore, we developed a sensitive, selective and high-throughput ultra-high-performance liquid chromatography-high-resolution tandem mass spectrometry method to determine[ncbi.nlm.nih.gov] KEYWORDS: absorption; acyclovir; chitosan; pharmacokinetics; renal excretion[ncbi.nlm.nih.gov] Mutation in guanosine homopolymeric strings (G-string mutation) was significantly more frequent in clones during episodic treatment and suppressive therapy than clones from[ncbi.nlm.nih.gov] Author information 1 School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. 2 Department of Genito Urinary[ncbi.nlm.nih.gov] Class: Acyclovir is an acyclic analogue of 2'-deoxyguanosine. Antiviral Activity: Acyclovir has activity against herpesviruses.[antimicrobe.org] OBJECTIVE: To evaluate the incidence of high-dose acyclovir (HD-A) prophylaxis failure in seropositive aSOT recipients (R ).[ncbi.nlm.nih.gov] The drug has a very wide distribution involving almost every organ of the body, with excretion into the urine.[ncbi.nlm.nih.gov]

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  • Zidovudine

    Mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) catalyze the initial phosphorylation of deoxynucleosides in the synthesis of the DNA precursors required[ncbi.nlm.nih.gov] Zidovudine use could indirectly lead to an increase in the levels of inosine monophosphate in an antimetabolite-like manner, which is converted to inosine triphosphate (ITP[ncbi.nlm.nih.gov] A safer dosage needs to be determined because high pAZT levels do not parallel those of icAZT-TP.[ncbi.nlm.nih.gov] It is almost completely absorbed from the GI tract, and 90% of a dose administered PO is excreted unchanged in the urine over several days (human data).[merckvetmanual.com] ( 118-00-3 ) Guanosine-5'-Diphosphate (GDP), Sodium Salt ( 43139-22-6 ) Guanosine-5'-Monophosphate (GMP), Disodium Salt ( 5550-12-9 ) Guanosine-5'-Triphosphate (GTP), Disodium[adventbio.com] AMENDED: To evaluate the pharmacokinetics of intravenously administered AZT to HIV-1 infected pregnant women in labor; to evaluate the pharmacokinetics and urinary excretion[clinicaltrials.gov] During the first six months of ART, 94 patients had digestive AEs (nausea/vomiting) of any grade (EFV 36/126, 29%; ZDV 58/71, 82%, p CONCLUSIONS: We observed an unexpectedly high[ncbi.nlm.nih.gov] Excretion: Parent drug and metabolite excreted by glomerular filtration and tubular secretion in kidneys.[glowm.com] […] frequency , urinary hesitancy [ Ref ] Endocrine Postmarketing reports : Gynecomastia [ Ref ] Local Local reaction, pain, and slight irritation were reported infrequently[drugs.com]

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  • Didanosine

    Mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) catalyze the initial rate limiting phosphorylation of deoxynucleosides and are essential enzymes for[ncbi.nlm.nih.gov] INTRODUCTION Didanosine, (2, 3-dideoxyinosine; ddI) is a dideoxy analogue of the purine nucleoside inosine that potentially inhibits the replication of the human immunodeficiency[scialert.net] Thirty-five of these children showed high-level resistance to at least three PIs.[journals.plos.org] Excretion: Excreted in urine as allantoin, hypoxanthine, xanthine, and uric acid. Serum half-life averages 0.8 hours. Route Onset Peak Duration P.O.[glowm.com] The last section deals with prevention and focuses on urinary biomarkers, pharmacological aspects and drug dosage in renal failure.[books.google.it] Alternate Name(s): Iso-dG 2-Oxo-2'-deoxyadenosine PR 3470 2'-Deoxynebularine C10H12N4O3 4546-68-3 PR 3480 3',5'-Di- O -acetyl-2'- deoxyinosine C14H16N4O6 106568-79-0 PR 3490[berryassoc.com] 9012-76-4 Details Flecainide C17H20F6N2O3 54143-55-4 Details [3-Nitro-4-(phenylmethoxy)phenyl]-oxirane C15H13NO4 51582-41-3 Details 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine[chemicalbook.com] Although it is not known whether didanosine is excreted in breast milk, HIV-infected mothers should not breast feed because of the potential risk of transmitting HIV to an[medicinenet.com] Urinary recovery is approximately 20% after a single oral dose in adults. No accumulation was evident in either adults or children.[home.intekom.com]

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  • Adenosine

    Abstract One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family[ncbi.nlm.nih.gov] KEYWORDS: Adenosine; Endovascular therapy; Flow arrest; High-flow arteriovenous shunt; Vein of Galen aneurysmal malformation[ncbi.nlm.nih.gov] Ado is produced extracellularly from the catabolism of the excreted ATP, or intracellularly from AMP, and then released through its transporter.[ncbi.nlm.nih.gov] Mirabegron did not augment the intracellular levels of cyclic guanosine monophosphate.[ncbi.nlm.nih.gov] The aim of this study was to determine the long-term effects of istradefylline on lower urinary tract symptoms (LUTSs) in PD patients.[ncbi.nlm.nih.gov] .: 9026-93-1 Adenosine deaminase catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to deoxyinosine and inosine.[worthington-biochem.com] Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing . Nat. Rev. Genet. 12 , 81–85 (2011). 9. Nishikura, K.[nature.com] Increased urinary adenosine excretion confirmed ADK deficiency in the siblings.[ncbi.nlm.nih.gov] […] ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HR - MS/MS) was developed to analyse the adenosine (A), cytidine (C), guanosine[ncbi.nlm.nih.gov]

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  • Disorder of Purine Metabolism

    For 2-deoxyinosine, adenosine, 2-deoxyadenosine, guanosine, 2-deoxyguanosine, succinyladenosine, orotic acid, thymine, dihydrouracil, dihydrothymine, uridine, 2-deoxyuridine[clinchem.aaccjnls.org] […] anisopoikilocytosis and stomatocytosis Treatment: Deoxycoformycin Purine nucleoside phosphorylase NP (14q13.1)* Biochemical profile: Hypouricemia; hypouricosuria; high serum inosine[merckmanuals.com] […] protein diet ,which is also rich in NUCLIEC acids and who do have high alcohol consumption have high levels of plasma urate Genetic factor(These are very important factor[powershow.com] Not aU is excreted in urine, some uric acid is excreted in bile. Some is converted to urea and ammonia by the intestinal bacteria.[7med-pdf.com] This enzyme phosphorylates the deoxy counterpart of guanosine ( Fig. 168-1 ) into deoxy GMP. The disorder is discussed in Chapter 176 .[obgynkey.com] Material and Methods: Serum uric acid, urinary uric acid/creatinine ratio, and specific activity of urinary uric acid after intravenous administration of glycine- 14 C (U)[jstage.jst.go.jp] Cytosine diphosphate choline phosphotransferase deficiency • Decreased uric acid level • Hereditary orotic aciduria, type 2 • Hooft's syndrome • Hyperuricuria • Hypouricemia • Inosine[coding-pro.com] CO2 and N10-formyl-tetrahydrofolate locate of purine synthesis 4 stages of purine synthesis synthesis of 5-phosphoriosyl-1 amine make 5-aminoimidazole ribonucleotide form inosine[quizlet.com] These purine ribonucleocides and 2-deoxy nucleosides are converted to hypoxanthine and guanine by purine nucleoside phosphorylase.[homeobook.com]

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  • Disorder of Pyrimidine Metabolism

    For 2-deoxyinosine, adenosine, 2-deoxyadenosine, guanosine, 2-deoxyguanosine, succinyladenosine, orotic acid, thymine, dihydrouracil, dihydrothymine, uridine, 2-deoxyuridine[clinchem.aaccjnls.org] […] anisopoikilocytosis and stomatocytosis Treatment: Deoxycoformycin Purine nucleoside phosphorylase NP (14q13.1)* Biochemical profile: Hypouricemia; hypouricosuria; high serum inosine[merckmanuals.com] Only a small fraction of the purines turned over each day are degraded and excreted.[clinicalgate.com] This enzyme phosphorylates the deoxy counterpart of guanosine ( Fig. 168-1 ) into deoxy GMP. The disorder is discussed in Chapter 176 .[obgynkey.com] Biochemical profile: Elevated urinary orotate Clinical features: Megaloblastic anemia, recurrent infections, cellular immunodeficiency, developmental disabilities Treatment[merckmanuals.com] Similarly, deoxycytidine kinase phosphorylates deoxycytidine and 2′-deoxyguanosine, forming dCMP and dGMP.[basicmedicalkey.com] Myoadenylate Deaminase Deficiency Adenylate deaminase catalyzes the deamination of adenosine monophosphate to inosine monophosphate and is composed of multiple isoenzymes[musculoskeletalkey.com] Gout is a metabolic disorder of purine catabolism and characterized by high level of uric acid in the blood. b.[gradestack.com] […] metabolism Disorder of purine metabolism Disorder of pyrimidine metabolism Hereditary orotic aciduria, type 2 Hereditary xanthinuria Hooft's syndrome Hyperuricuria Hypouricemia Inosine[icd9data.com]

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  • Trimethoprim

    Oxidative modifications were measured as 24-h urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and plasma levels[ncbi.nlm.nih.gov] Of note, inosine and methionine had no effect on TMP susceptibility in E . coli (Supplementary Fig. 2 ).[nature.com] […] associated with the use of high-dose TMP-SMX among hospitalized patients.[ncbi.nlm.nih.gov] Abstract Absorption, distribution, excretion and metabolism of trimethoprim were studied in rats.[jstage.jst.go.jp] Abstract The lack of oral treatment alternatives for enterococcal urinary tract infections (UTIs) has led to a renewed interest in trimethoprim.[ncbi.nlm.nih.gov] Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in adult population. They are prevalent in all age groups both in women and men.[ncbi.nlm.nih.gov] OBJECTIVE: To determine if trimethoprim use for urinary tract infection (UTI) is associated with an increased risk of acute kidney injury, hyperkalaemia, or sudden death in[ncbi.nlm.nih.gov] We supplemented LB with one or a combination of the following molecules: thymidine, glycine, methionine, and inosine.[pnas.org] CONCLUSION: We found a high incidence of ADRs among patients with PJP and AIDS treated with TMP/SMX, and most involved the skin and liver.[ncbi.nlm.nih.gov]

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