Create issue ticket

7,877 Possible Causes for 2, B, Beta, Phosphatase, Protein, Regulatory, Subunit

Did you mean: 2, B, Beta, Phosphatase, proteus, Regulatory, Subunit

  • Influenza

    Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside[ncbi.nlm.nih.gov] Rimmelzwaan 1 , B. E. E. Martina 2 , T. M. Bestebroer 1 , R. A. M.[doi.org] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[guidance.nice.org.uk] The bound antibodies were detected with an alkaline phosphatase-conjugated antibody against mouse (Sigma).[doi.org] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] The H5N1/97 viruses induced much higher gene transcription of proinflammatory cytokines than did H3N2 or H1N1 viruses, particularly TNF alpha and interferon beta.[ncbi.nlm.nih.gov] DOI: 10.1128/AAC.38.8.1864 ABSTRACT Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug[doi.org]

  • Phosphorylase Kinase Deficiency

    Column 2: 5ml HiTrap S Column 2 Buffers : Buffer A: 25 mM HEPES, pH 7.0; 200 mM NaCl; 0.5 mM TCEP. Buffer B: 25 mM HEPES, pH 7.0; 2 mM NaCl; 0.5 mM TCEP.[thesgc.org] […] phos·phor·y·lase b ki·nase de·fi·cien·cy/ an X-linked disorder of glycogen storage due to deficiency of the enzyme in the liver, characterized in affected males by hepatomegaly[medical-dictionary.thefreedictionary.com] Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.[uniprot.org] […] storage diseases such as GSD due to liver phosphorylase deficiency (GSD type VI), GSD due to glycogen debranching enzyme deficiency (GSD type III), and GSD due to glucose-6-phosphatase[orpha.net] The complete coding sequences of the liver gamma subunit and of the beta subunit of phosphorylase kinase of the proband were analyzed for the presence of mutations, by either[ncbi.nlm.nih.gov] The report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic[ncbi.nlm.nih.gov] Phosphorylase b kinase turns on (activates) the enzyme that breaks down glycogen.[ghr.nlm.nih.gov]

  • Spinocerebellar Ataxia Type 12

    Postepy Biochem. 2005;51(2):215-22. Chai Y, Wu L, Griffin JD, Paulson HL.[bvs.sld.cu] Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa[uniprot.org] […] presenting with action tremor, mild cerebellar dysfunction, and hyperreflexia, genetic testing revealed abnormal CAG repeat length in the brain-specific protein phosphatase 2, regulatory[ncbi.nlm.nih.gov] This hypothesis would predict that the mutation changes the regulation of protein phosphatase 2A, with implications for the phosphoproteome.[ncbi.nlm.nih.gov] […] spots, which were confirmed as nine proteins by LC-MS/MS.[ncbi.nlm.nih.gov] SCA12 is linked to a CAG repeat expansion mutation in exon 7 of PPP2R2B, a gene that encodes Bβ, a regulatory subunit of protein phosphatase 2A (PP2A).[ncbi.nlm.nih.gov] The disease is caused by an expansion of or 51 CAGs in the 5' region of the brain- specific phosphatase 2 regulatory subunit B-beta isoform (PPP2R2B) gene.[ncbi.nlm.nih.gov]

  • Lafora Disease

    Epilepsy, Progressive Myoclonic, 2A PME type 2 EPM2 Progressive myoclonic epilepsy type 2 Lafora Disease Epilepsy progressive myoclonic 2 Lafora body disorder Lafora Body[wikidata.org] In contrast to essential hemeralopia, where the b-wave is completely lacking a gradual recovery of the b-wave was recorded in Lafora disease.[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] Binary interactions i GO - Molecular function i identical protein binding Protein-protein interaction databases Structure i 3D structure databases Family & Domains i Phylogenomic[expasy.org] This reaction occurs when any of the three AMPK subunits (alpha, beta, and gamma) are expressed individually in the cell, and it also occurs on AMPK beta when it is part of[ncbi.nlm.nih.gov] E., Anta, B., de Bernabe, D. B., Lindhout, D., Augustijn, P. B., Tassinari, C. A., Malafosse, R. M., Topcu, M., et al. ( 1999 ) Hum. Mol.[doi.org]

  • Carney Complex

    Analysis of 11 kindreds and linkage to the short arm of chromosome 2.[ncbi.nlm.nih.gov] OBJECTIVE: The objective of the study was to study the antiproliferative effects of 8-Cl-ADO on growth and proliferation in B-lymphocytes of Carney complex patients that have[ncbi.nlm.nih.gov] Carney complex (CNC) is a hereditary multiple neoplasia syndrome resulting from inactivating mutations of the gene encoding the PKA type I alpha regulatory subunit (PRKAR1A[ncbi.nlm.nih.gov] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[books.google.com] To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[ncbi.nlm.nih.gov] BACKGROUND: Carney complex (CNC) is an autosomal dominant multiple neoplasia, caused mostly by inactivating mutations of the regulatory subunit 1A of the protein kinase A[ncbi.nlm.nih.gov] Linkage was obtained for three markers on the short arm of chromosome 2 (2p16), with a maximum two-point lod score of 5.97 at theta 0.03 for the marker CA-2 (odds in favor[jci.org]

  • Glycogen Storage Disease due to Muscle Phosphorylase Kinase Deficiency

    […] regulatory subunit, gamma 2 phosphorylase kinase, gamma 2 (testis) phosphorylase kinase, testis/liver, gamma-2 PHKG2 172471 8931[ukgtn.nhs.uk] A., Philip, B. A. and Caskey, C. T.[link.springer.com] PHKB 78 Annotation score: H3BQ89 H3BQ89_HUMAN Phosphorylase b kinase regulatory s...[uniprot.org] […] kinases such as protein kinase A (PKA, cAMP-dependent kinase).[en.wikipedia.org] Cells of tissues that lack glucose 6-phosphatase retain glucose 6-phosphate for internal carbohydrate metabolism.[sandwalk.blogspot.com] Aliases for PHKB Gene Phosphorylase Kinase Regulatory Subunit Beta 2 3 5 Phosphorylase Kinase Subunit Beta 4 Phosphorylase Kinase, Beta 2 External Ids for PHKB Gene Previous[genecards.org] GO - Molecular function i calmodulin binding enzyme binding Protein-protein interaction databases Chemistry databases Structure i 3D structure databases Family & Domains i[uniprot.org]

  • Interleukin-2

    […] low dose rIL-2.[doi.org] The results showed that DSP30/IL2 was an effective mitogen in mature B-cell disorders, revealing abnormal cytogenetic results in a range of B-cell malignancies.[ncbi.nlm.nih.gov] This synergistic effect was stopped by CD4 CD25 regulatory T cells (Treg), which depleted IL-2 in a cell number-dependent manner.[ncbi.nlm.nih.gov] Increased phosphorylation of VE-cadherin was also accompanied by a reduction of Src homology 2 domain-containing protein-tyrosine phosphatase 2, known to maintain vascular[ncbi.nlm.nih.gov] Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits[rcsb.org] Search results for IL2 Gene & protein summaries for IL2 Gene summary for IL2 Gene & protein summary for IL2 ORGANISMS human Homo sapiens human Homo sapiens house mouse Mus[ebi.ac.uk] Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common[ncbi.nlm.nih.gov]

  • Primary Pigmented Nodular Adrenocortical Disease

    Acronym PPNAD2 Synonyms Adrenal Cushing syndrome due to PPNAD2 Primary pigmented micronodular adrenocortical disease 2 Primary pigmented nodular adrenocortical disease-2 Keywords[uniprot.org] Seite 95 - Santoro M, Carlomagno F, Romano A, Bottaro DP, Dathan NA, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus MH, Et Al. ‎[books.google.de] An analysis of the patient and his mother's genomic DNA identified a novel mutation in the type Iα regulatory subunit of protein kinase A (PRKAR1A) gene; p.E17X (c.49G T).[ncbi.nlm.nih.gov] Genetically lean mice result from targeted disruption of the RIIb subunit of protein kinase A . Nature 382 , 622–626 (1996). 20. Amieux, P.S. et al .[doi.org] […] of Carney complex, a familial lentiginosis-multiple endocrine neoplasia syndrome frequently caused by mutations in PRKAR1A, which encodes the 1alpha regulatory subunit of protein[ncbi.nlm.nih.gov] Nuclear translocation of beta-catenin protein in the PPNAD adenoma suggests activation of the Wnt-beta-catenin pathway in PPNAD.[ncbi.nlm.nih.gov] […] and 23% lymphocytes, platelet 261,000/mm 3 , total protein 7.2g/dl, albumin 4.2g/dl, total bilirubin 0.7mg/dl, direct bilirubin 0.3mg/dl, ALT 17unit, AST 19 unit, alkaline phosphatase[doi.org]

  • Glycogen Storage Disease due to Liver Phosphorylase Kinase Deficiency

    […] regulatory subunit, gamma 2 phosphorylase kinase, gamma 2 (testis) phosphorylase kinase, testis/liver, gamma-2 PHKG2 172471 8931[ukgtn.nhs.uk] Synopsis : Liver phosphorylase b kinase (PhK) deficiency caused due to mutations in X-linked PHKA2 is highly variable.[link.springer.com] Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.[uniprot.org] […] storage diseases such as GSD due to liver phosphorylase deficiency (GSD type VI), GSD due to glycogen debranching enzyme deficiency (GSD type III), and GSD due to glucose-6-phosphatase[orpha.net] Deficiency of glucose-6-phosphate dehydrogenase Generalized glycogen storage disease of infants Glucose 6 phosphatase deficiency Glycogen storage disease Glycogen storage[icd9data.com] Aliases for PHKB Gene Phosphorylase Kinase Regulatory Subunit Beta 2 3 5 Phosphorylase Kinase Subunit Beta 4 Phosphorylase Kinase, Beta 2 External Ids for PHKB Gene Previous[genecards.org] It is inherited in an X-linked or autosomal recessive manner. [2] Signs and symptoms [ edit ] The signs and symptoms in glycogen storage disease type IX include: [2] Enlarged[en.wikipedia.org]

  • Abetalipoproteinemia

    Author information 1 Nutrition, Metabolism and Atherosclerosis Clinic, Institut de Recherches Cliniques de Montréal, Québec, Canada. 2 Nutrition, Metabolism and Atherosclerosis[ncbi.nlm.nih.gov] […] six monoclonal antibodies to different apo B-48 and B-100 epitopes.[ncbi.nlm.nih.gov] Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle.[books.google.ro] Despite normal serum parathormone, serum-ionized calcium and 25-OH vitamin D were low, while serum bone alkaline phosphatase was increased.[ncbi.nlm.nih.gov] Previous studies of abetalipoproteinemic patient, C.L., showed that the 97-kDa subunit was undetectable.[ncbi.nlm.nih.gov] Abstract The microsomal triglyceride transfer protein (MTP) is a dimeric lipid transfer protein consisting of protein disulfide isomerase and a unique 97-kDa subunit.[ncbi.nlm.nih.gov] Beta apolipoproteins Beta apolipoproteins are the largest of the apolipoproteins.[emedicine.com]