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5,610 Possible Causes for 2, B, Epsilon, Phosphatase, Protein, Regulatory, Subunit

Did you mean: 2, B, Epsilon, Phosphatase, proteus, Regulatory, Subunit

  • Spinocerebellar Ataxia Type 12

    Postepy Biochem. 2005;51(2):215-22. Chai Y, Wu L, Griffin JD, Paulson HL.[bvs.sld.cu] Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa[uniprot.org] (C) Seven interruption alleles were observed based on the number of ATTCT repeats observed within each polymorphic stretch (alpha, beta, gamma, delta, epsilon, zeta and eta[journals.plos.org] […] presenting with action tremor, mild cerebellar dysfunction, and hyperreflexia, genetic testing revealed abnormal CAG repeat length in the brain-specific protein phosphatase 2, regulatory[ncbi.nlm.nih.gov] This hypothesis would predict that the mutation changes the regulation of protein phosphatase 2A, with implications for the phosphoproteome.[ncbi.nlm.nih.gov] […] spots, which were confirmed as nine proteins by LC-MS/MS.[ncbi.nlm.nih.gov] SCA12 is linked to a CAG repeat expansion mutation in exon 7 of PPP2R2B, a gene that encodes Bβ, a regulatory subunit of protein phosphatase 2A (PP2A).[ncbi.nlm.nih.gov]

  • Influenza

    Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside[ncbi.nlm.nih.gov] Rimmelzwaan 1 , B. E. E. Martina 2 , T. M. Bestebroer 1 , R. A. M.[doi.org] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[guidance.nice.org.uk] The bound antibodies were detected with an alkaline phosphatase-conjugated antibody against mouse (Sigma).[doi.org] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[scielo.org.ar] DOI: 10.1128/AAC.38.8.1864 ABSTRACT Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug[doi.org] The greatest problems for new and better vaccines appear to be associated with regulatory hurdles and the lack of an adequate market.[doi.org]

    Missing: Epsilon
  • Congenital Myasthenic Syndrome

    We present 3 male and 2 female patients from three unrelated Croatian, Hungarian, and Russian families with autosomal recessive CMS.[ncbi.nlm.nih.gov] J Neurol. 2012; 259 :838–50. [ PubMed : 21975507 ] Habbout K, Poulin H, Rivier F, Giuliano S, Sternberg D, Fontaine B, Eymard B, Morales RJ, Echenne B, King L, Hanna MG, Männikkö[ncbi.nlm.nih.gov] We report 2 patients with CMS due to mutations in the AChR epsilon subunit. The first patient carries two heterozygous frameshift mutations, ε127ins5 and ε1293insG.[ncbi.nlm.nih.gov] That the penultimate prolines in TMD1 of the delta and epsilon subunits exert a reciprocal regulatory effect on the length of the channel opening bursts reveals an unexpected[ncbi.nlm.nih.gov] Most CMS stem from molecular defects in the muscle nicotinic acetylcholine receptor, but they can also be caused by mutations in presynaptic proteins, mutations in proteins[ncbi.nlm.nih.gov] Estephan EP 1 , Sobreira CFDR 2 , Dos Santos ACJ 2 , Tomaselli PJ 2 , Marques W Jr 2 , Ortega RPM 3 , Costa MCM 4 , da Silva AMS 1 , Mendonça RH 1 , Caldas VM 1 , Zambon AA[ncbi.nlm.nih.gov] N-boxes are regulatory sequence elements of mammalian promoters that confer synapse-specific expression of several genes, including the AChR subunit genes.[ncbi.nlm.nih.gov]

    Missing: Phosphatase
  • Interleukin-2

    […] low dose rIL-2.[doi.org] The results showed that DSP30/IL2 was an effective mitogen in mature B-cell disorders, revealing abnormal cytogenetic results in a range of B-cell malignancies.[ncbi.nlm.nih.gov] Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME) Fc epsilon receptor (FCERI) signaling, organism-specific biosystem Mast cells (MC) are distributed[ncbi.nlm.nih.gov] This synergistic effect was stopped by CD4 CD25 regulatory T cells (Treg), which depleted IL-2 in a cell number-dependent manner.[ncbi.nlm.nih.gov] Increased phosphorylation of VE-cadherin was also accompanied by a reduction of Src homology 2 domain-containing protein-tyrosine phosphatase 2, known to maintain vascular[ncbi.nlm.nih.gov] Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits[rcsb.org] Search results for IL2 Gene & protein summaries for IL2 Gene summary for IL2 Gene & protein summary for IL2 ORGANISMS human Homo sapiens human Homo sapiens house mouse Mus[ebi.ac.uk]

  • Congenital Myasthenic Syndrome

    We present 3 male and 2 female patients from three unrelated Croatian, Hungarian, and Russian families with autosomal recessive CMS.[ncbi.nlm.nih.gov] J Neurol. 2012; 259 :838–50. [ PubMed : 21975507 ] Habbout K, Poulin H, Rivier F, Giuliano S, Sternberg D, Fontaine B, Eymard B, Morales RJ, Echenne B, King L, Hanna MG, Männikkö[ncbi.nlm.nih.gov] We report 2 patients with CMS due to mutations in the AChR epsilon subunit. The first patient carries two heterozygous frameshift mutations, ε127ins5 and ε1293insG.[ncbi.nlm.nih.gov] Thus, Dok-7 is essential for neuromuscular synaptogenesis and it appears that the regulatory interaction of Dok-7 with MuSK is integrally involved in this process.[ncbi.nlm.nih.gov] Most CMS stem from molecular defects in the muscle nicotinic acetylcholine receptor, but they can also be caused by mutations in presynaptic proteins, mutations in proteins[ncbi.nlm.nih.gov] Estephan EP 1 , Sobreira CFDR 2 , Dos Santos ACJ 2 , Tomaselli PJ 2 , Marques W Jr 2 , Ortega RPM 3 , Costa MCM 4 , da Silva AMS 1 , Mendonça RH 1 , Caldas VM 1 , Zambon AA[ncbi.nlm.nih.gov] That the penultimate prolines in TMD1 of the delta and epsilon subunits exert a reciprocal regulatory effect on the length of the channel opening bursts reveals an unexpected[ncbi.nlm.nih.gov]

    Missing: Phosphatase
  • Hepatitis B Virus

    […] cytometry were used to determine the effects of HBx on the proliferation of LX-2 cells.[ncbi.nlm.nih.gov] Eight genotypes of hepatitis B virus (A-H) are currently recognized, and subgenotypes have recently been described in four of these genotypes (A, B, C and F).[ncbi.nlm.nih.gov] In the first step of this process, HBV reverse transcriptase binds to the highly conserved encapsidation signal, epsilon (epsilon), situated near the 5' end of the pregenome[ncbi.nlm.nih.gov] The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3[ncbi.nlm.nih.gov] Conversely, her urinary N-acetyl-β-D-glucosaminidase, and serum phosphate, alkaline phosphatase levels did not respond. [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov] RNA expressions for HBs, IκB-α, and NF-κB subunit (p50) were evaluated using real-time PCR.[ncbi.nlm.nih.gov] Confocal microscopy also revealed that HBx protein could co-localize with full-length Orail protein in HEK293 cells.[ncbi.nlm.nih.gov]

  • X-Linked Severe Combined Immunodeficiency

    Diagnosis of X-SCID was established by DNA analysis of the interleukin (IL)-2 receptor gamma chain gene; namely, we detected the novel mutation within exon 2 (221 C-- A),[ncbi.nlm.nih.gov] CD27 is a marker of memory B cells.[ncbi.nlm.nih.gov] […] mutations CD3 delta or epsilon T(-) B( ) NK( ) RAG1/RAG2 mutations RAG1/RAG2 T(-) B(-) NK( ) Artemis gene mutations ARTEMIS T(-) B(-) NK( ) CD45 gene mutations CD45 T(-)[web.archive.org] Vectors incorporating an internal human elongation factor-1alpha regulatory element were capable of fully restoring the lymphoid differentiation potential of gammac-deficient[ncbi.nlm.nih.gov] Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat. Med. 2000. 6 :343-345. Dadi, HK, Simon, AJ, Roifman, CM.[doi.org] Abstract Genetic evidence suggests that mutations in the gamma(c) receptor subunit cause X-linked severe combined immunodeficiency (X-SCID).[ncbi.nlm.nih.gov] This case raises the question of how a dysfunctional protein incapable of mediating STAT5 phosphorylation might nonetheless support T-cell development.[ncbi.nlm.nih.gov]

  • Porphyromonas Gingivalis

    KEYWORDS: Chronic periodontitis; Host response; In vivo; hBD-2[ncbi.nlm.nih.gov] Tell a Friend Antigen: Porphyromonas gingivalis (serotype B specific cell surface antigen) Hybridoma Cells Available: No Antigen Species: Porphyromonas gingivalis Depositor[dshb.biology.uiowa.edu] Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF, Meek DW. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein[ncbi.nlm.nih.gov] We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcription factor in oral keratinocytes was stimulated by the periodontal pathogen[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[uniprot.org] UniProt Primary Accession # UniProt Secondary Accession # NCBI Official Full Name Gingipain R1 UniProt Protein Name Gingipain R1 UniProt Synonym Protein Names Arg-gingipain[mybiosource.com]

  • Lafora Disease

    Epilepsy, Progressive Myoclonic, 2A PME type 2 EPM2 Progressive myoclonic epilepsy type 2 Lafora Disease Epilepsy progressive myoclonic 2 Lafora body disorder Lafora Body[wikidata.org] In contrast to essential hemeralopia, where the b-wave is completely lacking a gradual recovery of the b-wave was recorded in Lafora disease.[ncbi.nlm.nih.gov] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[ncbi.nlm.nih.gov] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] Binary interactions i GO - Molecular function i identical protein binding Protein-protein interaction databases Structure i 3D structure databases Family & Domains i Phylogenomic[expasy.org] E., Anta, B., de Bernabe, D. B., Lindhout, D., Augustijn, P. B., Tassinari, C. A., Malafosse, R. M., Topcu, M., et al. ( 1999 ) Hum. Mol.[doi.org] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[hmg.oxfordjournals.org]

    Missing: Epsilon
  • Bacillus Thuringiensis

    Thus, parasporin-2 acts as a cytolysin that permeabilizes the plasma membrane with target cell specificity and subsequently induces cell decay.[ncbi.nlm.nih.gov] B. weihenstephanensis , B. mycoides , B. pseudomycoides , B. cytotoxicus and B. toyonensis .[efsa.europa.eu] Application of poly (epsilon-caprolactone) nanoparticles containing atrazine herbicide as an alternative technique to control weeds and reduce damage to the environment.[nature.com] Louis MO USA Summary of Regulatory Approvals Click on the country name for country-specific contact and regulatory information.[web.archive.org] Various proteins such as cadherin, aminopeptidase-N (APN) and alkaline phosphatase (ALP) have been characterized as potential Cry-receptors.[ncbi.nlm.nih.gov] Structural determinants for activation of the α-subunit of a heterotrimeric G protein. Nature 369 , 621–628 (1997). 38 Kraulis, P.J.[doi.org] protein.[ncbi.nlm.nih.gov]