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2,315 Possible Causes for 2, FAMILY, H3, HISTONE

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  • Balkan Nephropathy

    We determined some factors implied in cellular immunity, such as the serum level of IL-2 and of IL-2 soluble receptor (sIL-2R), and the presence of IL-2 receptor alpha chain[] The acetylation of histone lysine residues was detected and found increased at specific sites of H3 and total H4 histones isolated from urothelial cells of patients with BN[] […] the ascendency of certain families.[] This study was designed to determine if the frequency of increased urinary beta 2-microglobulin (U beta 2m) in village populations at risk to develop BEN was significantly[]

  • Machado-Joseph Disease

    METHODS: For this phase 2, single-center, double-blind, parallel, placebo-controlled trial ( identifier NCT01096082 ), 62 patients who had MJD/SCA3 with[] The expression of acetyl histone H3 and the induction of c-Fos in response to cAMP were strongly suppressed in cells expressing the protein with the expanded polyglutamine[] A family is described here with typical MJD who are of Italian origin.[] KEYWORDS: Machado-Joseph disease; PABP; ataxin-2; mutant ataxin-3; translation regulation[]

  • Uremia

    Mol Med Rep. 2018 Feb;17(2):3350-3355. doi: 10.3892/mmr.2017.8197. Epub 2017 Dec 6.[] Also, an increase in citrullinated histone H3 was detected in this group compared to the HV.[] We here describe a family with TS, where uremia was a major feature of the disease, causing the death of 2 family members and requiring active replacement therapy in a third[] However, to date, our knowledge about the alterations in histone methylation in uremia is unclear.[]

  • Arginine

    In this case, a gain-of- function of AVPR 2 was found to be responsible for a SIADH-like state.[] The effect is likely due to elevated H3R2me2a, which inhibits the interaction between UHRF1 and histone H3.[] We investigated two Caucasian families with a typical autosomal dominant trait of familial central diabetes insipidus, defined by deficiency of arginine vasopressin.[] […] to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone[]

  • Dilated Cardiomyopathy

    KEYWORDS: DCM; Desmoglein-2; Fibrosis; Intercalated disc; Pediatric dilated cardiomyopathy[] Although the left ventricle of the cohort histologically expressed less 3 histone methylation-related molecules (eg, H3 lysine 4 trimethylation [H3K4me3], H3 lysine 9 dimethylation[] KEYWORDS: FLNC gene; Familial dilated cardiomyopathy; Splicing mutation; Whole Exome Sequencing[] BACKGROUND: To investigate the association between diabetic retinopathy (DR) and myocardial dysfunction in patients with type 2 diabetes and dilated cardiomyopathy (dCMP).[]

  • Formaldehyde

    2 (LOF-H 2 fuel; LOF spent fuel).[] Knockdown of the histone H3.3 gene (an H3 variant), which mimics inhibition of chromatin assembly, facilitated FA-mediated anchorage-independent cell growth.[] Safer Chemicals Healthy Families urges the EPA to use its authority under an updated TSCA to protect people and the environment from toxic chemicals like formaldehyde.[] […] mass spectrometry after derivatization of the formaldehyde to the pentafluorophenylhydrazone and characteristics of the subjects including age, education level, occupation, family[]

  • Acute Kidney Injury

    DIAGNOSES: Here, we report 2 cases of severe tubular necrosis in solid organ recipients, 1 heart and 1 kidney transplant.[] TNF-α, IL-1β, IL-6, COX-2, and NF-κBp65 nucleus translocation, suppressed the HDAC activity which was enhanced in septic AKI mice, and enhanced the acetylation of histone H3[] Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium.[] Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications.[]

  • Sulfonamide

    Abstract We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase[] Further, their target modulating effect, measured as the expression of acetyl-H3 histone and acetyl α-tubulin was determined by Western blots.[] In conclusion, these chalcone-sulfonamide hybrids exhibited dual inhibition of both family of isozymes but was more selective towards c-IAP enzyme.[] A familial predisposition to sulfonamide HS is suspected, but robust predictive genetic risk factors have yet to be identified.[]

  • Thiamine

    Author information 1 Department of Neurological Rehabilitation, Clinic Villa Immacolata, Viterbo, Italy. [email protected] Abstract Spinocerebellar ataxia type 2 is a genetic[] In contrast, in the mouse jejunum, histone H3 is hyper-trimethylated at lysine 27 (repressor mark).[] METHODS: We study a Chinese Zhuang ethnicity family with thiamine-responsive megaloblastic anemia.[] Abstract Thiamine transporter-2 deficiency is a recessive disease caused by mutations in the SLC19A3 gene.[]

  • Diffuse Intrinsic Pontine Glioma

    MTORC1/2 inhibition shows antitumor activity in cell culture models of DIPG due to the effect of MTORC2 inhibition on AKT.[] Furthermore, sodium valproate caused an increase in acetylation of histone H3.[] Hydroxamic Acids Indoles Nuclear Proteins Phenylenediamines Protein Kinase Inhibitors Pyrimidines THZ1 compound Transcription Factors Triazoles Panobinostat Receptors, Eph Family[] KEYWORDS: DIPG; demethylation; histone; methylation; pediatric brain tumor[]