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149 Possible Causes for 2, Gene, Neuregulin

  • Diabetes Mellitus

    Abstract We investigated the effect of polymorphisms in four DNA repair genes, viz.[ncbi.nlm.nih.gov] Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder . Arch. Gen.[doi.org] […] type 2 diabetes ( 37 ).[dx.doi.org]

  • Charcot Marie Tooth Disease

    This gene has nerve specific P2 promoter that work synergistically with SOX10 and EGR2 genes to initiate transcription.[ncbi.nlm.nih.gov] Prukop, Lauren Haag, Dirk Czesnik, Theresa Kungl, Tamer A M Abdelaal, Naureen Keric, Christine Stadelmann, Wolfgang Brück, Klaus-Armin Nave and Michael W Sereda , Soluble neuregulin[doi.org] MFN2 encodes mitofusin 2, a mitochondrial fusion protein that is critical for mitochondrial DNA integrity and function.[ncbi.nlm.nih.gov]

  • Metabolic Syndrome

    1–2 servings/day) had a 26% greater risk of developing type 2 diabetes than those in the lowest quantile (none or CONCLUSIONS In addition to weight gain, higher consumption[dx.doi.org] Nitric Oxide, Endothelin were measured and PCR-RFLP was done to identify the iNOS gene C150T polymorphism and its effect on serum nitric oxide levels.[ncbi.nlm.nih.gov] Abstract Neuregulin 4 (Nrg4) has been proposed to play a role in the pathogeneses of obesity, insulin resistance, and dyslipidemia.[ncbi.nlm.nih.gov]

  • Polycystic Ovary Syndrome

    Although several loci have been proposed as PCOS genes including CYP11A , the insulin gene, the follistatin gene, and a region near the insulin receptor, the evidence supporting[doi.org] Abstract Neuregulin 4 (NRG4) is an adipokine that is synthesized in many tissues and has been shown to be associated with the development of obesity and metabolic disorders[ncbi.nlm.nih.gov] She was diagnosed with: (1) type 1 diabetes, with hyperglycemia, impaired insulin secretion, and positive autoantibodies for GAD-65 and IA-2; (2) autoimmune thyroiditis, with[ncbi.nlm.nih.gov]

  • Cystic Fibrosis

    The difficult hurdle of cloning the responsible gene had been accomplished, its function was established and the lung appeared readily accessible for gene replacement.[doi.org] Pulver and David Valle , Fine Mapping on Chromosome 10q22-q23 Implicates Neuregulin 3 in Schizophrenia , The American Journal of Human Genetics , 84 , 1 , (21) , (2009) .[dx.doi.org] This clinical observation describes the enteral nutrition (EN) management of 2 toddlers at high nutrition risk due to cystic fibrosis (CF), exocrine pancreatic insufficiency[ncbi.nlm.nih.gov]

  • Keloid

    Through this innovative in situ microdissection gene profiling approach, we provide better-defined gene signatures of distinct KD regions, thereby addressing KD heterogeneity[ncbi.nlm.nih.gov] During combined laser capture microdissection and microarray analysis-based in situ gene expression profiling, we identified upregulation of the polypeptide growth factor neuregulin[ncbi.nlm.nih.gov] OBJECTIVE: This study was purposed to investigate the effects of hTERT antisense oligodeoxynucleotide (ASODN) on cell apoptosis and expression of hTERT and bcl-2 mRNA in keloid[ncbi.nlm.nih.gov]

  • Congenital Myasthenic Syndrome

    In recent years, the molecular basis of CMS has constantly broadened and disease-associated mutations have been identified in 14 genes encoding proteins of the neuromuscular[ncbi.nlm.nih.gov] . : Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo . Science 1997, 276 :599–603. PubMed CrossRef Google Scholar 59.[link.springer.com] We present 3 male and 2 female patients from three unrelated Croatian, Hungarian, and Russian families with autosomal recessive CMS.[ncbi.nlm.nih.gov]

  • Hirschsprung's Disease

    Herein, we report 2 cases--the first showed abnormality of the L1CAM genes and developed HSCR; and the second, with clinically suspected XLH, was successfully operated on[ncbi.nlm.nih.gov] Of the upregulated genes, 118 were involved in classic signaling pathways, compared with 11 of the downregulated genes (P 2‑fold).[ncbi.nlm.nih.gov] Lemke G (1996) Neuregulins in development. Mol Cell Neurosci 7(4):247–262 PubMed CrossRef Google Scholar 33.[doi.org]

  • Amyotrophic Lateral Sclerosis

    The identification of gene NEK1 means scientists can now develop a gene therapy treating it.[bbc.com] ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19 . Am. J. Hum. Genet. 93 , 900–905 (2013). 253.[doi.org] The intervention period was 2 weeks.[ncbi.nlm.nih.gov]

  • Hereditary Multiple Exostoses

    CONCLUSIONS: The identification of the mutation in the candidate gene indicates that this novel gene is responsible for EXT2 (one of the disease-causing gene of EXT).[ncbi.nlm.nih.gov] […] least, two signaling systems implicated in excitatory synaptic function or viewed as autism-susceptibility genes are known to be modulated by interaction with HS, namely, neuregulin[doi.org] […] gate-keeper' TCF family members for Wnt/β-catenin signaling pathway, and TCF7L2 and EXT2 are among the earliest associated loci reported in genome wide appraisals of type 2[ncbi.nlm.nih.gov]