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792 Possible Causes for 2, Inhibitors, Topoisomerase

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  • Carbonic Anhydrase Inhibitor

    Called also plasminogen activator inhibitor 3 . serine protease inhibitor ( serine proteinase inhibitor ) serpin . topoisomerase i's a class of antineoplastic agents that[] Selected patients were those prescribed either carbonic anhydrase inhibitors beta-blocker or alpha-2 adrenergic agonists beta-blocker.[] […] deprotonated state, with the nitrogen atom coordinated to Zn(II), and the OH group of the inhibitor making a hydrogen bond with Thr 199.[]

  • Morus

    Abstract Four new 2-arylbenzofuran derivatives, cathafurans A (1), B (2), C (3), and D (4), were isolated from the stem bark of Morus cathayana.[] Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin[] MeOH extracts reduced the level of topoisomerase IIα but increased the level of p27(Kip1), with no significant effect on p21(Cip1/waf1).[]

  • Vicia Faba

    topoisomerase II (IC50: 240-600 μM) activities.[] The major product of nitrosation of 4-chloroindole is 4-chloro-2-hydroxy-N1-nitroso-indolin-3-one oxime.[] This study sheds light on the mode of hyphal growth inhibitory activity of protease inhibitors with antifungal activity.[]

  • Clostridium Botulinum

    In this study, we investigated the binding of type A and E toxins to Caco-2 cells using Western blot analysis.[] These secretion inhibitors are aimed at retargeting the toxin towards a specific cell type to inhibit vesicular secretion.[] The essential topB gene encoding topoisomerase III was found to have been split by the apparent insertion of 34.4 kb of foreign DNA (in a similar manner to that in Group II[]

  • Novobiocin

    Targets Topoisomerase II [1] Topoisomerase IV [1] In vitro Novobiocin also interacts with Hsp90, altering the affinity of the chaperone for geldanamycin and radicicol and[] Abstract We conducted the first phase 2 and pharmacologic study to evaluate the combination of novobiocin (a coumeromycin antibiotic that has been shown to augment alkylating[] Previous studies have shown that novobiocin, an inhibitor for breast cancer resistance proteins (BCRP), inhibited organic anion transport.[]

  • Escherichia Coli

    All the quinolone-resistant E. coli strains were investigated for mutations in the topoisomerases genes gyrA and parC by amplifying and sequencing the quinolone resistance[] Transferability of class 2 integrons was tested by conjugation.[] Among the synthesized macrocycles, potent enzyme inhibitors in the low nanomolar range (e.g. compound 42f, EcLepB IC 50  29 nM) were identified also showing good antimicrobial[]

  • Gonorrhea

    METHODS: A retrospective medical record review was performed at 2 inner-city hospitals.[] inhibitor classes, including the widely used fluoroquinolone class.[] METHODS: We conducted a phase 2 trial of 2 oral doses of solithromycin (1200 and 1000 mg) for treatment of uncomplicated gonorrhea.[]

  • Sulfonamide

    II (DNA gyrase) and Topoisomerase IV Human: Topoisomerase II, Topoisomerase I -oxacin - all end in this Ciprofloxacin - anthrax Gemifloxacin - respiratory Levofloxacin -[] Abstract We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase[] AREAS COVERED IN THIS REVIEW: The article presents the main classes of sulfonamide inhibitors investigated between 2013 and present.[]

  • Leishmania

    topoisomerase I .[] […] and the inhibitors of apoptosis IAP1/2 (cIAP1/2) in cell death resistance showed in L. infantum-infected human macrophages.[] DSF assays confirmed binding of STLs to LmDHODH; moreover, it is suggested that such inhibitors might act in a different site other than the active site.[]

  • Rett Syndrome

    7 , Hayek J 8 , Coletta M 2 , Marini S 2 .[] Treatment with serotonin 1A receptor agonist was initiated at age eight years, whereas treatment using a selective serotonin reuptake inhibitor began at age nine years.[] Down-regulation of these genes by topoisomerase inhibition prevented abnormal axon sprouting.[]