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7,044 Possible Causes for 2,, B',, epsilon, human, isoform, phosphatase, protein, protein,, regulatory, subunit

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  • Spinocerebellar Ataxia Type 12

    (C) Seven interruption alleles were observed based on the number of ATTCT repeats observed within each polymorphic stretch (alpha, beta, gamma, delta, epsilon, zeta and eta[] Table 2: Ayurvedic treatment given to a case of spinocerebellar ataxia-2 Click here to view Table 3: Panchakarma procedures adopted in a case of spinocerebellar ataxia-2 Click[] Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa[] […] spots, which were confirmed as nine proteins by LC-MS/MS.[] […] presenting with action tremor, mild cerebellar dysfunction, and hyperreflexia, genetic testing revealed abnormal CAG repeat length in the brain-specific protein phosphatase 2, regulatory[] This hypothesis would predict that the mutation changes the regulation of protein phosphatase 2A, with implications for the phosphoproteome.[] Product name Recombinant Human PPP2R2B protein Protein length Full length protein Nature Recombinant Source Wheat germ Amino Acid Sequence Accession Species Human Sequence[] SCA12 is linked to a CAG repeat expansion mutation in exon 7 of PPP2R2B, a gene that encodes Bβ, a regulatory subunit of protein phosphatase 2A (PP2A).[] […] process protein phosphatase regulator activity regulation of phosphoprotein phosphatase activity peptidyl-serine dephosphorylation Ontology : EGO-EBI protein phosphatase[] The disease is caused by an expansion of or 51 CAGs in the 5' region of the brain- specific phosphatase 2 regulatory subunit B-beta isoform (PPP2R2B) gene.[]

  • Interleukin-2

    […] receptor (FCERI) signaling, organism-specific biosystem (from REACTOME) Fc epsilon receptor (FCERI) signaling, organism-specific biosystem computationally inferred pathway[] […] low dose rIL-2.[] The results showed that DSP30/IL2 was an effective mitogen in mature B-cell disorders, revealing abnormal cytogenetic results in a range of B-cell malignancies.[] RefSeq protein isoforms See the other reference sequence protein isoform for the IL2 gene (XP_016863666.1).[] IL-2, regulatory T cells, and tolerance. J Immunol 2004 ;172: 3983 - 3988 22. Soiffer RJ, Murray C, Gonin R, Ritz J.[] Increased phosphorylation of VE-cadherin was also accompanied by a reduction of Src homology 2 domain-containing protein-tyrosine phosphatase 2, known to maintain vascular[] Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits[] […] recombinant human IL-2 WHO International Standard (NIBSC code: 86/500).[] […] show that MSC expression in human Th17 cells is retinoic acid orphan receptor (ROR)γt-dependent, and allows the upregulation of PPP2R2B, a regulatory member of the protein phosphatase[] GENCODE basic PRINCIPAL1 - APPRIS candidate principal isoform.[]

  • Carney Complex

    The 2p21 region has been recently reported to harbour the protein kinase C-epsilon gene ( PKC- ε) that is amplified in thyroid cancer. 12 We mapped BAC 1D9 containing this[] OBJECTIVE: The objective of the study was to study the antiproliferative effects of 8-Cl-ADO on growth and proliferation in B-lymphocytes of Carney complex patients that have[] AMP-Dependent Protein Kinase RIalpha Subunit PRKAR1A protein, human RNA, Messenger RNA, Small Interfering SMAD3 protein, human Smad3 Protein Transforming Growth Factor beta[] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. ‏[] To accomplish this goal, we introduced null alleles of the PKA catalytic subunits Prkaca (Ca) or Prkacb (Cb) into the Prkar1a-cardiac knockout (R1a-CKO) or limited Schwann[] His laboratory has been interested in the role of oxidants as signaling molecules and the participation of free radicals in human disease. Dr. J.[] An isoform-specific interface is revealed between the protomers.[] Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.[] OBJECTIVE: This study examined how the PRKAR1A mutation affects the PKA signalling pathway in a human somatotrophinoma with a PRKAR1A mutation.[] Kinderman FS, Kim C, von Daake S et al. (2006) A dynamic mechanism for AKAP binding to RII isoforms of cAMP‐dependent protein kinase. Molecular Cell 24: 397–408.[]

  • Hepatitis B Virus

    In the first step of this process, HBV reverse transcriptase binds to the highly conserved encapsidation signal, epsilon (epsilon), situated near the 5' end of the pregenome[] […] cytometry were used to determine the effects of HBx on the proliferation of LX-2 cells.[] Hepatitis B virus Description and Significance Also known as serum hepatitis, Hepatitis B spreads through blood and sexual contact.[] Confocal microscopy also revealed that HBx protein could co-localize with full-length Orail protein in HEK293 cells.[] The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3[] Conversely, her urinary N-acetyl-β-D-glucosaminidase, and serum phosphate, alkaline phosphatase levels did not respond. [Indexed for MEDLINE] Free full text[] RNA expressions for HBs, IκB-α, and NF-κB subunit (p50) were evaluated using real-time PCR.[] , and tested the hypothesis of HBV-human co-divergence.[] Several recent studies provided consistent evidence for a role of HSP90alpha isoform in tumor invasive and metastatic phenotypes [ 19 – 22 ].[] Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. J.[]

  • Phosphorylase Kinase Deficiency

    Column 2: 5ml HiTrap S Column 2 Buffers : Buffer A: 25 mM HEPES, pH 7.0; 200 mM NaCl; 0.5 mM TCEP. Buffer B: 25 mM HEPES, pH 7.0; 2 mM NaCl; 0.5 mM TCEP.[] […] phos·phor·y·lase b ki·nase de·fi·cien·cy/ an X-linked disorder of glycogen storage due to deficiency of the enzyme in the liver, characterized in affected males by hepatomegaly[] The report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic[] Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.[] […] storage diseases such as GSD due to liver phosphorylase deficiency (GSD type VI), GSD due to glycogen debranching enzyme deficiency (GSD type III), and GSD due to glucose-6-phosphatase[] The complete coding sequences of the liver gamma subunit and of the beta subunit of phosphorylase kinase of the proband were analyzed for the presence of mutations, by either[] To our knowledge, this is the first description of a human Phk deficiency mutation.[] Phosphorylase b kinase turns on (activates) the enzyme that breaks down glycogen.[] However, in three of five patients, we identified identical heterozygous R531Q missense mutations of the PRKAG2 gene, which encodes the gamma 2-subunit of AMP-activated protein[] The properties of phosphorylase a, phosphorylase b, phosphorylase kinase and phosphorylase phosphatase present in a human haemolysate were investigated.[]

    Missing: epsilon
  • Influenza

    Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside[] Rimmelzwaan 1 , B. E. E. Martina 2 , T. M. Bestebroer 1 , R. A. M.[] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[] All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory[] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[] Influenza subunit vaccine - ten years experience. Europ J Clin Res 1992; 3: 117-38. [ Links ] 3. Nichol KL, Lind A, Margokis KL, et al .[] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[] This entry describes 2 isoforms i produced by ribosomal frameshifting .[] DOI: 10.1128/AAC.38.8.1864 ABSTRACT Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug[] SEARCH METHODS: We searched trial registries, electronic databases (to 22 July 2013) and regulatory archives, and corresponded with manufacturers to identify all trials.[]

    Missing: epsilon
  • LIG4 Syndrome

    Term Browser Genes (2) Models (2) Disease References using Mouse Models (2)[] We report here on a case of LIG4 syndrome complicated with distinct EBV-associated B-cell lymphoma.[] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[] Zebrafish have p53, p63 and p73 genes, as well as the regulatory mdm2 and mdm4 genes (Lu and Abrams, 2006).[] Mikio Shimada, Lavinia C Dumitrache, Helen R Russell and Peter J McKinnon , Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain[] Epub 2004 Jun 11. 2004 23XRCC6, LIG4, PRKDC, XRCC4, XRCC5 Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4[] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[] This entry has 1 described isoform and 1 potential isoform that is computationally mapped.[] Patient T cells show 2 peaks for CD3 T cells at 1 hour postirradiation (absent at 24 hours).[] […] important vertebrate Gtf that -O-GlcNAcylates a multitude of nuclear and cytoplasmic protein, including transcription elements, cytoskeletal protein, metabolic enzymes, kinases, phosphatases[]

    Missing: epsilon
  • Bacillus Thuringiensis

    Application of poly (epsilon-caprolactone) nanoparticles containing atrazine herbicide as an alternative technique to control weeds and reduce damage to the environment.[] Thus, parasporin-2 acts as a cytolysin that permeabilizes the plasma membrane with target cell specificity and subsequently induces cell decay.[] B. weihenstephanensis , B. mycoides , B. pseudomycoides , B. cytotoxicus and B. toyonensis .[] We have expressed seven different crystal toxin proteins from two largely unstudied Bt crystal protein subfamilies.[] We analyzed the downstream processes of these cascades, i.e. the differential expression of effector and regulatory molecules due to a microbial challenge with a pathogenic[] Various proteins such as cadherin, aminopeptidase-N (APN) and alkaline phosphatase (ALP) have been characterized as potential Cry-receptors.[] Structural determinants for activation of the α-subunit of a heterotrimeric G protein. Nature 369 , 621–628 (1997). 38 Kraulis, P.J.[] The activated parasporin showed strong cytocidal activity against human leukemic T cells (MOLT-4) and human uterus cervix cancer cells (HeLa) but not against normal T cells[] It was thus proposed that the 96-kDa protein was a novel isoform of class 3 APN. (vii) Summary.[] ., Achroia grisella, Acleris gloverana, Acleris variana, Adoxophyes orana, Agrotis epsilon, Alabama argillacea, Alsophila pometaria, Amyelois transitella, Anagasta kuehniella[]

  • Lafora Disease

    Epilepsy, Progressive Myoclonic, 2A PME type 2 EPM2 Progressive myoclonic epilepsy type 2 Lafora Disease Epilepsy progressive myoclonic 2 Lafora body disorder Lafora Body[] In contrast to essential hemeralopia, where the b-wave is completely lacking a gradual recovery of the b-wave was recorded in Lafora disease.[] Binary interactions i GO - Molecular function i identical protein binding Protein-protein interaction databases Structure i 3D structure databases Family & Domains i Phylogenomic[] Here we show that, in addition, laforin interacts with itself and with the glycogen targeting regulatory subunit R5 of protein phosphatase 1 (PP1).[] Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[] We have developed a human LD mutation database using a new generic biological database cross‐referencing platform.[] Active phosphatase isoform 7 and isoform 1 interact with each other, but give rise to lower phosphatase activity than isoform 1 or isoform 7 by themselves (in vitro) (PubMed[] E., Anta, B., de Bernabe, D. B., Lindhout, D., Augustijn, P. B., Tassinari, C. A., Malafosse, R. M., Topcu, M., et al. ( 1999 ) Hum. Mol.[] In fact, laforin is expected to have additional functional domains involved in the interaction with putative regulatory subunits or with the in vivo substrates.[] Casciato S 1 , Gambardella S 1 , Mascia A 1 , Quarato PP 1 , D'Aniello A 1 , Ackurina Y 2 , Albano V 1 , Fornai F 1, 3 , Scala S 1 , Di Gennaro G 1 .[]

    Missing: epsilon
  • Borrelia Burgdorferi

    One emerging PTM is Nε-lysine acetylation-the acetylation of the epsilon amino group of lysine residues.[] Eggers CH 1 , Gray CM 2 , Preisig AM 2 , Glenn DM 2 , Pereira J 2 , Ayers RW 2 , Alshahrani M 2 , Acabbo C 2 , Becker MR 2 , Bruenn KN 2 , Cheung T 2 , Jendras TM 2 , Shepley[] Our case confirms the link between B burgdorferi and some cutaneous lymphomas.[] KEYWORDS: Borrelia burgdorferi; Far-Western; Luciferase assay; Mass spectrometry; Proteinprotein interaction; Proteomics analysis; Two-dimensional (2-D) gel electrophoresis[] KEYWORDS: Borrelia burgdorferi; Electrophoretic mobility assays; Protein-nucleic acid interactions; Regulatory proteins[] Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood 97 : 911 -914. 198. Rakoff-Nahoum, S., and R. Medzhitov. 2007 .[] […] expression of certain pro-inflammatory mediators, such as IL-8 (CXCL8) and TLR2, but had a stimulatory effect on specific molecules such as the Interleukin 10 receptor, alpha subunit[] Borrelia infection-induced monocyte- and T cell-derived cytokines were profiled in peripheral blood from two healthy human cohorts of Western Europeans from the Human Functional[] […] heterologous system and gain-in-function approach, we show for the first time that a highly immunogenic lipoprotein TP0435 can be differentially processed into multiple isoforms[] 3 , α 8 , or α 11 subunit ( 11 , 15 , 42 , 48 , 83 , 85 ).[]