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4,655 Possible Causes for 2,, Catalytic, Isoform, Phosphatase, Protein, Subunit,, alpha

Did you mean: 2, Catalytic, Isoform, Phosphatase, proteus, Subunit, alpha

  • Toxoplasma Gondii

    Methods: : Four different strains of human Toxoplasma gondii were cultured: a type 1 and type 2 strain isolated from patients in France; a type 2 strain from a US patient[iovs.arvojournals.org] IFN-gamma-induced killing of T. gondii appeared to be partially mediated by TNF-alpha, and addition of TNF-alpha could compensate for the abrogated killing of T. gondii in[ncbi.nlm.nih.gov] Toxoplasma gondii encodes three protein kinase A catalytic (PKAc1-3) and one regulatory (PKAr) subunits to integrate cAMP-dependent signals.[ncbi.nlm.nih.gov] The selected genes include PH domain and leucine- rich-repeat protein phosphatases (PHLPP), casein kinase2 (CK2), vascular endothelial growth factor (VEGF), pigment epithelium-derived[ncbi.nlm.nih.gov] Toxoplasma gondii deploys many effector proteins in order to hijack and manipulate host cell signaling pathways, allowing parasite colonization, subversion of immune responses[ncbi.nlm.nih.gov] In higher Eukaryotes, the four-subunit chromosomal passenger complex (CPC) (Aurora kinase B (ARKB)/INCENP/Borealin/Survivin) promotes chromosome bi-orientation by detaching[ncbi.nlm.nih.gov] Homo sapiens zinc finger protein was found to interact with SAG2.[ncbi.nlm.nih.gov]

  • Brucella Suis

    The misidentification on blood cultures (BCs) of B. suis as O. anthropi by the VITEK 2 system is herein described.[ncbi.nlm.nih.gov] We have previously reported that live brucellae failed to induce tumor necrosis factor alpha (TNF-alpha) production upon human macrophage infection.[ncbi.nlm.nih.gov] Docking studies with two inhibitors showed a good fitting in the catalytic pocket and also interaction with the second lipophilic pocket binding the cofactor NAD( ).[ncbi.nlm.nih.gov] Although these compounds were not highly isoform-selective CA inhibitors (CAIs) for the bacterial over the human CA isoforms, some of them possess inhibition profiles that[ncbi.nlm.nih.gov] The expressed recombinant proteins were confirmed with Western blot analysis using anti-6-His antibody conjugated with alkaline phosphatase.[ncbi.nlm.nih.gov] Only three subunits in SDS-PAGE were identified: two small subunits of 14,000 Da and 15,500 Da, and a major subunit of 66,000 Da.[ncbi.nlm.nih.gov] Brucella suis biovar 2 (BSB2) is mainly encountered in hares and wild boars (Sus scrofa), and is known to have very low pathogenicity to humans with only two case reports[ncbi.nlm.nih.gov]

  • Ehrlichia Chaffeensis

    ERK 1/2 and p38 MAPK were slightly activated at the early stage of E. chaffeensis infection; however, the activations of ERK 1/2 and p38 MAPK by LPS treatment were subsequently[ncbi.nlm.nih.gov] , and antibodies play roles in protective immunity, while a weak CD4 T-helper response, overproduction of TNF-alpha, and very high IL-10 are associated with toxic shock-like[ncbi.nlm.nih.gov] A functional HECT E3 ligase domain with a conserved catalytic site was identified in the C-terminal region of TRP120, and TRP120 autoubiquitination occurred in vitro in the[ncbi.nlm.nih.gov] In human cells, TRP120 was selectively conjugated with SUMO2/3 isoforms.[ncbi.nlm.nih.gov] Yeast two-hybrid analysis revealed that p47 interacts with polycomb group ring finger 5 (PCGF5) protein, Src protein tyrosine kinase FYN (FYN), protein tyrosine phosphatase[ncbi.nlm.nih.gov] […] including translation elongation factor 1 alpha 1 (EF1A1), deleted in azoospermia (DAZ)-associated protein 2 (DAZAP2), ferritin light polypeptide (FTL), CD63, CD14, proteasome subunit[ncbi.nlm.nih.gov] Additional E. chaffeensis surface proteins detected were OMP85, hypothetical protein ECH_0525 (here named Esp73), immunodominant surface protein gp47, and 11 other proteins[ncbi.nlm.nih.gov]

  • Opisthorchis Viverrini

    […] in children were headache (n 3 [2%]), vertigo (n 2 [1%]), and fatigue (n 2 [1%]).[ncbi.nlm.nih.gov] Western blots revealed an expression level of protein tyrosine phosphatase alpha (PTPα) which reached a peak at 1 month and subsequently tended to decrease.[ncbi.nlm.nih.gov] We show that O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes, while stress-related and motor proteins are upregulated.[ncbi.nlm.nih.gov] […] uncharacterized protein C14orf105 isoform X12 were found to be potential markers for OV infection, as they were predominantly found in all OV-infected groups.[ncbi.nlm.nih.gov] The early and accurate detection of this parasite is very important; therefore, new PCR methods targeting cytochrome c oxidase subunit one and NADH dehydrogenase subunit one[ncbi.nlm.nih.gov] . gigantica DM9-1, a parenchymal protein with structural similarity to nematode cytoplasmic motility protein (MFP2).[ncbi.nlm.nih.gov] The population at risk for O. viverrini was screened by SUT-OV-001 with Cronbach’ alpha coefficient, 0.724.[ncbi.nlm.nih.gov]

  • Echinococcus Granulosus

    We present 2 patients who developed biliary complications due to a large hydatid cyst.[ncbi.nlm.nih.gov] […] activation state characterized by upregulation of CD86 without concomitant upregulation of CD40 or secretion of cytokines (interleukin 12 [IL-12], IL-10, tumor necrosis factor alpha[ncbi.nlm.nih.gov] We found that the catalytic subunit isoforms have predicted sequences of 613 and 557 amino acids and are substantially similar to those of the human counterpart, except for[ncbi.nlm.nih.gov] The coding sequence for AgB8/1 subunit of Echinococcus granulosus was selected from GenBank and was gene-optimized.[ncbi.nlm.nih.gov] Lipids are mainly solubilized by various families of lipid binding proteins which participate in their transport between tissues as well as cell compartments.[ncbi.nlm.nih.gov] We report on an 8 1/2-year-old boy with an echinococcus granulosus infection of the liver and lung, drawing particular attention to the therapy applied.[ncbi.nlm.nih.gov] Its protein component belongs to the cestode-specific Hydrophobic Ligand Binding Protein family, which includes five 8-kDa isoforms encoded by a multigene family (EgAgB1-EgAgB5[ncbi.nlm.nih.gov]

  • Promiscuity

    The cyclooxygenases (COX-1 and COX-2) generate prostaglandin H(2) from arachidonic acid (AA).[ncbi.nlm.nih.gov] Platelet-derived growth factor receptor alpha (PDGFRalpha) interacts with PDGFs A, B, C and AB, while PDGFRbeta binds to PDGFs B and D, thus suggesting that PDGFRalpha is[ncbi.nlm.nih.gov] The catalytic promiscuity of hemoglobin (Hb) was explored for regenerating oxidized nicotinamide cofactors [NAD(P) ].[ncbi.nlm.nih.gov] […] an FGFRb isoform, FGFR2b, at 2.1 Å resolution.[ncbi.nlm.nih.gov] This article is part of a Special Issue entitled: Chemistry and mechanism of phosphatases, diesterases and triesterases.[ncbi.nlm.nih.gov] In contrast, the remainder of the GSTA1-1 subunit and the GSTA4-4 protein exhibit folded and unfolded macrostates with a significant energy barrier separating them.[ncbi.nlm.nih.gov] Heterochromatin protein 1 (HP1) proteins were originally identified as critical components in heterochromatin-mediated gene silencing and are now recognized to play essential[ncbi.nlm.nih.gov]

  • Rabies Virus

    RABV lineages in Yunnan result from at least seven independent introductions (95% BCI: 6-9 introductions) and represent each of the three main Asian RABV lineages, SEA-1, -2[ncbi.nlm.nih.gov] The present study reports the interaction of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides with the rabies virus glycoprotein (RABVG) to design potential anti-rabies[ncbi.nlm.nih.gov] PDZ (PSD-95/Dlg/ZO-1) domains play a major role in neuronal homeostasis in which they act as scaffold domains regulating cellular trafficking, self-association and catalytic[ncbi.nlm.nih.gov] Here we show that the largely nuclear P-protein isoform P3 can localize to nucleoli and forms specific interactions with nucleolin.[ncbi.nlm.nih.gov] The results showed specific binding of the nAChRα1-subunit peptides to the RABV.[ncbi.nlm.nih.gov] The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins that are thought to underlie viral antagonism[ncbi.nlm.nih.gov] Therefore, an acidic tail of synuclein (ATS) derived from the C-terminal acidic tail of human alpha-synuclein protein was fused to the C-terminus of scFv57R in order to help[ncbi.nlm.nih.gov]

  • Troglitazone

    Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes. Diabetes Care 25: 1691-1698.[prezi.com] PPAR gamma coactivator-1 alpha (PGC-1 alpha) functioning as an inverse agonist.[ncbi.nlm.nih.gov] However, the addition of GSTT1 did not show any catalytic effect.[ncbi.nlm.nih.gov] It is important to monitor the serum alkaline phosphatase in addition to the serum aminotransferases in patients taking thiazolidinediones.[ncbi.nlm.nih.gov] Troglitazone treatment results in decrease in α5 subunit expression on the cell surface.[ncbi.nlm.nih.gov] Tro, but not Rosi or Pio, selectively stimulated PGC-1α protein degradation.[ncbi.nlm.nih.gov] We report here that troglitazone augments AMP-activated protein kinase-alpha (AMPKalpha) phosphorylation, reduces p70S6 kinase phosphorylation and stimulates autophagy that[ncbi.nlm.nih.gov]

  • Porphyromonas Gingivalis

    Human β-defensin-2 (hBD-2) is typically produced by epithelial tissues after stimulation with microorganisms and inflammatory mediators, and it contributes to the initial[ncbi.nlm.nih.gov] The monocyte, macrophage, and LPS-induced macrophage CM were evaluated for IL-6 and tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) content using ELISA and the[ncbi.nlm.nih.gov] The proteases consist of a catalytic sub-unit and several other protein sub- units referred to as adhesins.[latrobe.edu.au] However, the expression patterns of ceramidase isoforms as well as their role in periodontal disease pathogenesis remain unknown.[ncbi.nlm.nih.gov] Neither phosphatase was inhibited by up to 5 μM okadaic acid, an inhibitor specific for PPP family serine/threonine phosphatases.[pnas.org] The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane.[uniprot.org] Angiopoietin-like protein 2 (ANGPTL2) maintains tissue homeostasis by inducing inflammation and angiogenesis.[ncbi.nlm.nih.gov]

  • Parasite

    Thus, HpARI employs a novel molecular strategy to suppress type 2 immunity in both infection and allergy.[ncbi.nlm.nih.gov] The alpha-fetoprotein (AFP) level was 174,640 ng/ml.[ncbi.nlm.nih.gov] Catalytically important residues are fully conserved between GlPDE and human PDEs, but sequence differences between their catalytic domains suggest that designing Giardia-specific[ncbi.nlm.nih.gov] […] usually positioned near the 3' end of genes; consequently, existing designs are prone to measurement bias and cannot capture complexities such as the occurrence of transcript isoforms[ncbi.nlm.nih.gov] The skin Mcs seem to have more lethal effects on the parasite than the BM Mcs; this is possibly due to the presence of numerous melanosomes with acid phosphatase activity[ncbi.nlm.nih.gov] […] of the recovered worms, followed by a polymerase chain reaction (PCR) of the second internal transcribed spacer region (ITS2) of DNA and the partial cytochrome c oxidase subunit[ncbi.nlm.nih.gov] Alpha-Gal & the Lone Star Tick Our immune response against a foreign molecule present in animal products may play a role in some allergic, autoimmune, and inflammatory disorders[nutritionfacts.org]