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4,596 Possible Causes for 2,, II,, Mb1, class, histocompatibility, locus, mouse, protein

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  • Clonorchis Sinensis

    In this study, sequence analysis showed that annexin B30 from C. sinensis (CsANXB30) is composed of four annexin repeats which were characterized by type II and III Ca(2 )[ncbi.nlm.nih.gov] […] peroxidation, enzymes involved in lipid peroxidation, and mutagenic DNA adducts in the livers of mice infected with C. sinensis, as well as proinflammatory cytokines in infected mouse[ncbi.nlm.nih.gov] The CCC, PXSC, and CG motives characteristic to extracellular loop 2 (EC2) region of TSP-2 were well conserved.[ncbi.nlm.nih.gov] We identified antigenic proteins from adult C. sinensis liver flukes using immunoproteomic analysis.[ncbi.nlm.nih.gov] Both proteins induced a dose-dependent upregulation in major histocompatibility complex and co-stimulatory molecule expression and increased secretion of pro-inflammatory[ncbi.nlm.nih.gov] One independent monomeric locus and two independent polyubiquitin loci were firstly identified from the genome of carcinogenic liver fluke, Clonorchis sinensis (C. sinensis[ncbi.nlm.nih.gov] This is the first report of an α-NAGAL protein in the Trematode class, suggesting that it is a potential diagnostic or vaccine candidate with strong antigenicity.[ncbi.nlm.nih.gov] […] reaction (RT-PCR) demonstrated an upregulation in fibrogenic genes of smooth muscle α-actin, collagen III, matrix metalloproteinase 2 and tissue inhibitors of metalloproteinase II[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Campylobacter Jejuni

    II/6, pp. 121-138). Washington, USA: ASM International.[orbit.dtu.dk] In human cells in vitro (HEp-2, HT-29) and in a mouse infection model that recapitulated key pathologic features of C. jejuni clinical disease, 2'-FL inhibited pathogenesis[ncbi.nlm.nih.gov] The host cell binding domain of FliD was mapped to the central region of the protein.[ncbi.nlm.nih.gov] Whole proteome of C. jejuni was investigated for varied properties like antigenicity, allergenicity, major histocompatibility class (MHC)-peptide interaction, immune cell[ncbi.nlm.nih.gov] Chicken and human isolates generally had similar distributions of the putative virulence genes and LOS locus classes studied.[ncbi.nlm.nih.gov] In combination, the CPS genotype and LOS class was not discriminative between cases and controls.[ncbi.nlm.nih.gov] […] in the mouse intestine.[ncbi.nlm.nih.gov] We also analyzed lipooligosaccharide biosynthesis locus classes (LOS locus classes) and the numbers of isolates carrying genes coding resistance factors against various antibiotics[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Brucella Melitensis

    Twenty-seven pools of 500 major histocompatibility complex class II (MHC-II) restricted peptides were created by computational prediction of promiscuous MHC-II CD4( ) T cell[ncbi.nlm.nih.gov] In contrast, modified LPS with a defective core purified from Brucella carrying a mutated wadC gene (Bm-wadC), efficiently potentiated mouse and human DC activation and T[ncbi.nlm.nih.gov] B. melitensis RS-α and LS-2 were then expressed in Escherichia coli as fusion proteins with His tag.[ncbi.nlm.nih.gov] Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including[ncbi.nlm.nih.gov] Here, we used a large panel of genetically deficient mice to compare the importance of B cells, transporter associated with antigen processing (TAP-1), and major histocompatibility[ncbi.nlm.nih.gov] Many isolates were single-locus or double-locus variants of closely related B. melitensis isolates from different regions, including the north and south of China.[ncbi.nlm.nih.gov] Although it has been recommended that processing of Brucella cultures should be confined to a Class II biologic safety cabinet, by the time the organism is identified, extensive[ncbi.nlm.nih.gov] In the last few decades, increasing microbial resistance to common antibiotics has attracted researchers' attention to the development of new classes of antibiotics such as[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Brucella Abortus

    B. abortus was not only able to reduce the expression of mature MHC-II, but it also inhibited the expression of invariant chain (Ii)-associated immature MHC-II molecules.[ncbi.nlm.nih.gov] Based on this observation, we explored the interaction of mouse neutrophils with B. abortus In contrast to human, dog, and bovine neutrophils, naive mouse neutrophils fail[ncbi.nlm.nih.gov] CCL20 expression was mainly mediated by JNK1/2 and NF-kB in both Calu-6 and THP-1 cells.[ncbi.nlm.nih.gov] These results suggest that the two recombinant proteins of B. abortus may be potential LPS-free proteins for diagnosis.[ncbi.nlm.nih.gov] However, DHEA treatment increases the expression of costimulatory molecules (CD40, CD86), the adhesion molecule CD54, and major histocompatibility complex class I (MHC-I)[ncbi.nlm.nih.gov] Genotyping was performed using multi-locus variable-number tandem-repeat analysis (MLVA).[ncbi.nlm.nih.gov] Its proteolytic activity enhances the quantity and quality of peptides to be presented by major histocompatibility complex class I (MHC-I) molecules to CD8 T cells.[ncbi.nlm.nih.gov] Moreover, mutants were classified into class I, class II and class III as higher, similar, and lower internalization, respectively, into HeLa cells.[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Idiopathic Pulmonary Fibrosis

    We examined human leukocyte antigen (HLA) alleles in both families, including antigens Class I (locus A, B, and C) and Class II (locus DR).[ncbi.nlm.nih.gov] Penn researchers develop first mouse model of idiopathic pulmonary fibrosis The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening[news-medical.net] To determine the effect of recombinant human pentraxin 2 vs placebo on change from baseline to week 28 in mean forced vital capacity (FVC) percentage of predicted value.[ncbi.nlm.nih.gov] […] misfolded proteins when they accumulate.[ncbi.nlm.nih.gov] The median survival was 43.7 months (23.6-71.7) with a majority (45%) of patients in the group II of the GAP index.[ncbi.nlm.nih.gov] Using a humanized severe combined immunodeficient mouse, we then demonstrated increased fibrosis in murine lungs receiving human lung fibroblasts from rapid progressors compared[stm.sciencemag.org] Drug name Rx / OTC Preg CSA Alcohol Reviews Rating Popularity Ofev Rx D N 1 review 10 Generic name: nintedanib systemic Drug class: multikinase inhibitors For consumers: dosage[drugs.com] In addition, we showed that defective KIF3A-mediated ciliary loss in human type II alveolar epithelial cell lines leads to disruption of SHH signaling.[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Echinococcus Granulosus

    ., cytochrome c oxidase subunit 1 (cox1), NADH dehydrogenase subunit 1 (nad1), ATPase subunit 6 (atp6), 12S rRNA (12S), and Actin II (act II).[ncbi.nlm.nih.gov] Out of 36 mammalian innate receptors with carbohydrate-binding domains, expressed as Fc fusions, only the mouse Kupffer cell receptor (KCR; CLEC4F) bound significantly to[ncbi.nlm.nih.gov] We present 2 patients who developed biliary complications due to a large hydatid cyst.[ncbi.nlm.nih.gov] Lipids are mainly solubilized by various families of lipid binding proteins which participate in their transport between tissues as well as cell compartments.[ncbi.nlm.nih.gov] Western blot analysis was used to determine proteolytic effects of parasitic antigens on major histocompatibility complex (MHC) class II (I-a) contained in membrane proteins[ncbi.nlm.nih.gov] All the six G1 genotype isolates were identical to each other at the cox1 locus; three and two different sequences were obtained at the cytb and nad1 loci, respectively, with[ncbi.nlm.nih.gov] Echinococcus Granulosus Antibody (EHG) Summary Immunogen Echinococcus granulosus (EHG) Specificity Echinococcus granulosus (EHG) Isotype IgG1 Clonality Monoclonal Host Mouse[novusbio.com] Scarce interspecies polymorphism at the p29 locus was observed and affected predominantly E. granulosus s.s.[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Graft Rejection

    The CTL line and the HLA-B7 restricted CD8 CTL clone, but not the HLA class II restricted CD4 CTL clone, inhibited the growth of donor hematopoietic progenitor cells (HPC)[ncbi.nlm.nih.gov] One block of 36 SNPs spanned a region that exhibits conservation of synteny with the mouse H-3 histocompatibility locus and contains the pig homologue of the mouse Zfp106[ncbi.nlm.nih.gov] Mean glomerular filtration rate 1 month after HT was 67.01 28.51 mL/min/m(2).[ncbi.nlm.nih.gov] We hypothesized that an increase in estimated protein excretion rate (ePER) from spot urine samples is associated with graft rejection and predicts rejection phenotype. 151[ncbi.nlm.nih.gov] These findings, considered with individual cases reported by other groups, indicate that transplantation from a cadaver donor with immunogenic mismatched class I HLA antigen[ncbi.nlm.nih.gov] For the in vivo analysis, an allogeneic skin transplantation mouse model was used.[ncbi.nlm.nih.gov] One locus encompasses PTPRO, coding for a receptor-type tyrosine kinase essential for B cell receptor signaling.[ncbi.nlm.nih.gov] CD4 and CD8 T cell counts were reduced significantly in the corneal grafts of groups II, III and IV compared with group I (P 0.05).[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Intramuscular Injection

    We conducted a Phase II study to evaluate the safety of oral administration of vitamin B12 in patients with advanced non-small cell lung cancer who received pemetrexed single[ncbi.nlm.nih.gov] Although recent data suggest that αS pathology can spread within the mouse brain, there is no direct evidence for spread of disease from a peripheral site.[ncbi.nlm.nih.gov] […] intramuscular hydroxocobalamin injection with a 3-month course of 1mg/day sublingual methylcobalamin supplements on serum vitamin B12 concentrations in participants withtype 2[ncbi.nlm.nih.gov] In addition, the sera from the rats with intramuscular injections of AAV9-hEPO contained greater levels of antibodies against both AAV9 capsid protein and hEPO protein than[ncbi.nlm.nih.gov] Muscle pain and spreading hyperalgesia induced by NGF is maintained despite anesthesia of the primary nociceptive locus.[ncbi.nlm.nih.gov] Two approaches were used to analyse these data: (i) a non-compartmental approach; and (ii) a compartmental modelling approach.[ncbi.nlm.nih.gov] This phase II clinical trial is a single-center, prospective, randomized, double-blind, placebo-controlled with 2 arms.[ncbi.nlm.nih.gov] Serotype 2 AAV vector (rAAV2/2) was also investigated, but long-term phenylalanine clearance has been observed only for pseudotypes 1 and 8.[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Vibrio Vulnificus

    Cluster II isolates were further subdivided into two branches.[ncbi.nlm.nih.gov] We describe a novel insulin-degrading enzyme, SidC, that contributes to the proliferation of the human bacterial pathogen Vibrio vulnificus in a mouse model.[ncbi.nlm.nih.gov] Interestingly, biotype 2 comprises a zoonotic clonal complex designated as serovar E that has extended worldwide.[ncbi.nlm.nih.gov] We identified this 62-kDa protein as an immunogenic antigen of V. vulnificus for humans.[ncbi.nlm.nih.gov] Infection with V. vulnificus significantly increased the expression of cell surface molecules, including CD40, CD80 and major histocompatibility complex class II, leading[ncbi.nlm.nih.gov] An established Multi Locus Sequence Typing (MLST) method was also performed.[ncbi.nlm.nih.gov] Sialic acids are found on all vertebrate cell surfaces and are part of a larger class of molecules known as nonulosonic acids.[ncbi.nlm.nih.gov] The CMM781 strain showed significant attenuation in cytotoxicity and mouse lethality.[ncbi.nlm.nih.gov]

    Missing: Mb1
  • Bordetella Bronchiseptica

    Invasion, defined as adhesion to, followed by entrance into HeLa cells by Bordetella bronchiseptica was determined by (i) specific staining of intracellular bacteria and (ii[ncbi.nlm.nih.gov] We also show that pagP is not required for the initial colonization of the mouse respiratory tract by B. bronchiseptica, but is required for persistence of the organism within[ncbi.nlm.nih.gov] After 2-3 h, B. bronchiseptica strains exerted a strong cytotoxic effect on HeLa cells which was evident by rounding of the cells and detachment from the substrate and which[ncbi.nlm.nih.gov] This protein was identified as BopB by the analysis of its N-terminal amino acid sequence.[ncbi.nlm.nih.gov] […] a real-time PCR test for the specific detection of B. bronchiseptica based on the previously described end-point PCR, targeting an intergenomic sequence of the fla gene locus[ncbi.nlm.nih.gov] A narrow-spectrum clavulanic acid-inhibited class A beta-lactamase, BOR-1, was identified in a Bordetella bronchiseptica clinical isolate.[ncbi.nlm.nih.gov] Our results show that B. bronchiseptica flagellin is able to signal effectively through both human and mouse Toll-like receptor 5.[ncbi.nlm.nih.gov] The fimBCD locus is embedded within the fha operon, whose genes encode another putative adhesin, filamentous hemagglutinin (FHA).[ncbi.nlm.nih.gov]

    Missing: Mb1 histocompatibility