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10,731 Possible Causes for 2,, bone, morphogenetic, mouse, protein

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  • Fibrodysplasia Ossificans Progressiva

    Abstract Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue homeostasis.[ncbi.nlm.nih.gov] This unique knock-in mouse model provides novel insight into the genetic regulation of heterotopic ossification and establishes the first direct in vivo evidence that the[ncbi.nlm.nih.gov] 25, 2015 /PRNewswire/ -- Clementia Pharmaceuticals, Inc. today announced the initiation of enrollment of children as young as 6 years old in the company's ongoing Phase 2[prnewswire.com] First, the pathway forms a cartilage scaffold, then transforms it into bone. The result is normal bone – not just mineral deposits – in the wrong places.[philly.com] Two different HO mouse models, an FOP model mouse expressing FOP-ACVR1 and an FOP-iPSC-based HO model mouse, revealed critical roles for mTOR signaling in vivo.[ncbi.nlm.nih.gov]

  • Osteoporosis

    We hypothesize that overexpression of bone morphogenetic protein 2 may be the underlying mechanism of osteoporosis and recurrent fractures. 2015 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov] Black bear parathyroid hormone has been previously reported to enhance bone mass in the dystrophin-deficient mouse.[ncbi.nlm.nih.gov] […] that BMD correlates negatively with BTMs and positively with E 2 and Mg (2 ) levels.[ncbi.nlm.nih.gov] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[doi.org] Excerpt This first-ever Surgeon General’s Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens.[ncbi.nlm.nih.gov]

  • Diamond-Blackfan Anemia

    Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice . Am. J. Physiol. Gastrointest.[doi.org] Conversely, Rps7 mouse mutants show no anemia or hyperpigmentation, phenotypes associated with mutation of human RPS7 and other murine RPs, respectively.[ncbi.nlm.nih.gov] Importantly, 2 mutations identified in DBA patients, Val15Phe and Gly127Gln, each of which localized to 1 of the 2 NoS, failed to localize RPS19 to the nucleolus.[ncbi.nlm.nih.gov] KEYWORDS: Anemia, Diamond-Blackfan; Bone Marrow Transplantation; Erythrocyte Enzyme Deficiency; Red Cell Enolase Deficiency[ncbi.nlm.nih.gov] , along with rarer abnormalities of additional ribosomal proteins.[ncbi.nlm.nih.gov]

  • Familial Pulmonary Arterial Hypertension

    Mutations in the bone morphogenetic protein receptor 2 (BMPR2) have been identified in at least 70% of FPAH patients.[ncbi.nlm.nih.gov] Bmpr2 pathogenic variant mouse models develop pulmonary hypertension and recapitulate the human condition, and are thus valuable for preclinical trials [ West et al 2008 ,[ncbi.nlm.nih.gov] KEYWORDS: BMPR2; ERAD; FPAH; Missense mutations; Protein misfolding[ncbi.nlm.nih.gov] Nested from those subjects, a case-control study of urinary oestrogen metabolite levels (2-hydroxyoestrogen (2-OHE) and 16alpha-hydroxyoestrone (16alpha-OHE(1))) was conducted[ncbi.nlm.nih.gov] Abstract Heterozygous germ line mutations in the gene encoding the bone morphogenetic protein (BMP) type II receptor occur in more than 80% of patients with familial pulmonary[ncbi.nlm.nih.gov]

  • LIG4 Syndrome

    […] send to {{ username }} {{geneWatchAttr}} Analyze Gene Strain QTL List Functional Annotation unavailable Annotation Distribution unavailable Genomic Variants unavailble for Mouse[rgd.mcw.edu] Term Browser Genes (2) Models (2) Disease References using Mouse Models (2)[informatics.jax.org] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Blood. 87 (1): 386-92. 1996 Jan 1 PubMed Über diesen Artikel Titel Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure[springermedizin.de] Patient T cells show 2 peaks for CD3 T cells at 1 hour postirradiation (absent at 24 hours).[bloodadvances.org]

    Missing: morphogenetic
  • Vitamin K

    Furthermore, vitamin K2 prevented repression by tumor necrosis factor α (TNFα) of SMAD signaling induced by either transforming growth factor ß (TGFß) or bone morphogenetic[ncbi.nlm.nih.gov] Regulation of sulfotransfe-rase activity by vitamin K in mouse brain . Arch Biochem Biophys 1990; 277: 109-113. 128 Sundaram KS. et al.[doi.org] Subjects were randomized into four groups (each having 43 subjects in vitamin K(2) therapy group, vitamin D(3) therapy group, vitamin K(2) and D(3) combined therapy group,[ncbi.nlm.nih.gov] Vitamin K has been purported to play an important role in bone health.[ncbi.nlm.nih.gov] Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex.[ncbi.nlm.nih.gov]

  • Osteogenesis Imperfecta

    Finally, absence of the type I collagen C-propeptidase bone morphogenetic protein 1 (BMP1) causes type XII osteogenesis imperfecta due to altered collagen maturation/processing[ncbi.nlm.nih.gov] The objective of this study was to determine changes in OCN and to elucidate the metabolic phenotype in the Col1a1 Jrt/ mouse, a model of dominant OI caused by a Col1a1 mutation[ncbi.nlm.nih.gov] Table 2.[ncbi.nlm.nih.gov] […] fragility of bone.[patient.info] KEYWORDS: Autophagy; Chemical chaperone; Collagen; Endoplasmic reticulum stress; Osteogenesis imperfecta; Unfolded protein response[ncbi.nlm.nih.gov]

  • Bone Metastasis

    Functional enrichment analysis indicated high bone morphogenetic protein (BMP) signaling in metastases with high bone cell activity and low tumor cell AR activity.[ncbi.nlm.nih.gov] Hutmacher and colleagues have now developed a humanised xenograft mouse model of breast-cancer-induced bone metastasis.[dmm.biologists.org] Conclusions: 89 SrCl 2 can safely and effectively relieve bone pain caused by bone metastasis from lung cancer.[ncbi.nlm.nih.gov] […] the bone.[en.wikipedia.org] MATERIALS AND METHODS: We established a novel murine metastasis model using near-infrared fluorescent protein iRFP720-labelled prostate cancer (PC3) cells.[ncbi.nlm.nih.gov]

  • Monoclonal Gammopathy of Undetermined Significance

    Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts.[bloodjournal.org] PC isolation from mononuclear cell fraction was performed by immunomagnetic bead selection with monoclonal mouse antihuman CD138 antibodies using the AutoMACs automated separation[doi.org] We found 10-fold elevated basic fibroblast growth factor 2 (FGF-2) in the patient's serum and significantly increased basal FGF-2 production of lesional and non-lesional fibroblasts[ncbi.nlm.nih.gov] A number of studies have investigated the relationship between MGUS and bone health outcomes including bone mineral density (BMD), osteoporosis and fractures, but no meta-analysis[ncbi.nlm.nih.gov] RESULTS: Surface-receptor clustering and endocytosis of receptor-ligand (immunoglobulin M/protein zero) complexes were pronounced after exposure to protein zero.[ncbi.nlm.nih.gov]

  • Malignant Neoplasm

    Importantly, in the case of melanoma, tumor cell–driven vasculogenic mimicry has been linked to bone morphogenetic proteins (BMPs; ref. 64 ), secreted morphogen members of[jci.org] In this study, the plasma fraction containing AIS is shown to inhibit mouse erythroblast formation in vitro.[ncbi.nlm.nih.gov] We assessed heterogeneity by using the I 2 statistic. We combined studies when I 2 was 50% or less (15) .[doi.org] NIH: National Cancer Institute After chemotherapy - discharge Bone lesion biopsy Bone scan Bone tumors Bone x-ray Ewing's sarcoma Osteosarcoma Understanding Chemotherapy -[coding-pro.com] […] of the Hmga1 protein and the Brca1 gene.[doi.org]