Create issue ticket

10,731 Possible Causes for 2,, bone, morphogenetic, mouse, protein

Did you mean: 2, bone, morphogenetic, morus, proteus

  • Fibrodysplasia Ossificans Progressiva

    Abstract Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue homeostasis.[] This unique knock-in mouse model provides novel insight into the genetic regulation of heterotopic ossification and establishes the first direct in vivo evidence that the[] 25, 2015 /PRNewswire/ -- Clementia Pharmaceuticals, Inc. today announced the initiation of enrollment of children as young as 6 years old in the company's ongoing Phase 2[] First, the pathway forms a cartilage scaffold, then transforms it into bone. The result is normal bone – not just mineral deposits – in the wrong places.[] Two different HO mouse models, an FOP model mouse expressing FOP-ACVR1 and an FOP-iPSC-based HO model mouse, revealed critical roles for mTOR signaling in vivo.[]

  • Osteoporosis

    We hypothesize that overexpression of bone morphogenetic protein 2 may be the underlying mechanism of osteoporosis and recurrent fractures. 2015 Wiley Periodicals, Inc.[] Black bear parathyroid hormone has been previously reported to enhance bone mass in the dystrophin-deficient mouse.[] […] that BMD correlates negatively with BTMs and positively with E 2 and Mg (2 ) levels.[] A similar increase in risk was observed for animal protein, but no association was found for consumption of vegetable protein.[] Excerpt This first-ever Surgeon General’s Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens.[]

  • Diamond-Blackfan Anemia

    Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice . Am. J. Physiol. Gastrointest.[] Conversely, Rps7 mouse mutants show no anemia or hyperpigmentation, phenotypes associated with mutation of human RPS7 and other murine RPs, respectively.[] Importantly, 2 mutations identified in DBA patients, Val15Phe and Gly127Gln, each of which localized to 1 of the 2 NoS, failed to localize RPS19 to the nucleolus.[] KEYWORDS: Anemia, Diamond-Blackfan; Bone Marrow Transplantation; Erythrocyte Enzyme Deficiency; Red Cell Enolase Deficiency[] , along with rarer abnormalities of additional ribosomal proteins.[]

  • Familial Pulmonary Arterial Hypertension

    Mutations in the bone morphogenetic protein receptor 2 (BMPR2) have been identified in at least 70% of FPAH patients.[] Bmpr2 pathogenic variant mouse models develop pulmonary hypertension and recapitulate the human condition, and are thus valuable for preclinical trials [ West et al 2008 ,[] KEYWORDS: BMPR2; ERAD; FPAH; Missense mutations; Protein misfolding[] Nested from those subjects, a case-control study of urinary oestrogen metabolite levels (2-hydroxyoestrogen (2-OHE) and 16alpha-hydroxyoestrone (16alpha-OHE(1))) was conducted[] Abstract Heterozygous germ line mutations in the gene encoding the bone morphogenetic protein (BMP) type II receptor occur in more than 80% of patients with familial pulmonary[]

  • LIG4 Syndrome

    […] send to {{ username }} {{geneWatchAttr}} Analyze Gene Strain QTL List Functional Annotation unavailable Annotation Distribution unavailable Genomic Variants unavailble for Mouse[] Term Browser Genes (2) Models (2) Disease References using Mouse Models (2)[] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[] Blood. 87 (1): 386-92. 1996 Jan 1 PubMed Über diesen Artikel Titel Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure[] Patient T cells show 2 peaks for CD3 T cells at 1 hour postirradiation (absent at 24 hours).[]

    Missing: morphogenetic
  • Vitamin K

    Furthermore, vitamin K2 prevented repression by tumor necrosis factor α (TNFα) of SMAD signaling induced by either transforming growth factor ß (TGFß) or bone morphogenetic[] Regulation of sulfotransfe-rase activity by vitamin K in mouse brain . Arch Biochem Biophys 1990; 277: 109-113. 128 Sundaram KS. et al.[] Subjects were randomized into four groups (each having 43 subjects in vitamin K(2) therapy group, vitamin D(3) therapy group, vitamin K(2) and D(3) combined therapy group,[] Vitamin K has been purported to play an important role in bone health.[] Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex.[]

  • Osteogenesis Imperfecta

    Finally, absence of the type I collagen C-propeptidase bone morphogenetic protein 1 (BMP1) causes type XII osteogenesis imperfecta due to altered collagen maturation/processing[] The objective of this study was to determine changes in OCN and to elucidate the metabolic phenotype in the Col1a1 Jrt/ mouse, a model of dominant OI caused by a Col1a1 mutation[] Table 2.[] […] fragility of bone.[] KEYWORDS: Autophagy; Chemical chaperone; Collagen; Endoplasmic reticulum stress; Osteogenesis imperfecta; Unfolded protein response[]

  • Bone Metastasis

    Functional enrichment analysis indicated high bone morphogenetic protein (BMP) signaling in metastases with high bone cell activity and low tumor cell AR activity.[] Hutmacher and colleagues have now developed a humanised xenograft mouse model of breast-cancer-induced bone metastasis.[] Conclusions: 89 SrCl 2 can safely and effectively relieve bone pain caused by bone metastasis from lung cancer.[] […] the bone.[] MATERIALS AND METHODS: We established a novel murine metastasis model using near-infrared fluorescent protein iRFP720-labelled prostate cancer (PC3) cells.[]

  • Monoclonal Gammopathy of Undetermined Significance

    Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts.[] PC isolation from mononuclear cell fraction was performed by immunomagnetic bead selection with monoclonal mouse antihuman CD138 antibodies using the AutoMACs automated separation[] We found 10-fold elevated basic fibroblast growth factor 2 (FGF-2) in the patient's serum and significantly increased basal FGF-2 production of lesional and non-lesional fibroblasts[] A number of studies have investigated the relationship between MGUS and bone health outcomes including bone mineral density (BMD), osteoporosis and fractures, but no meta-analysis[] RESULTS: Surface-receptor clustering and endocytosis of receptor-ligand (immunoglobulin M/protein zero) complexes were pronounced after exposure to protein zero.[]

  • Malignant Neoplasm

    Importantly, in the case of melanoma, tumor cell–driven vasculogenic mimicry has been linked to bone morphogenetic proteins (BMPs; ref. 64 ), secreted morphogen members of[] In this study, the plasma fraction containing AIS is shown to inhibit mouse erythroblast formation in vitro.[] We assessed heterogeneity by using the I 2 statistic. We combined studies when I 2 was 50% or less (15) .[] NIH: National Cancer Institute After chemotherapy - discharge Bone lesion biopsy Bone scan Bone tumors Bone x-ray Ewing's sarcoma Osteosarcoma Understanding Chemotherapy -[] […] of the Hmga1 protein and the Brca1 gene.[]