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706 Possible Causes for 2,, calcineurin, interactin, mouse, myocyte enriched, protein

Did you mean: 2, calcineurin, interactin, morus, myocyte enriched, proteus

  • Carbachol

    […] borate (2-APB, 300 microM), which impairs inositol trisphosphate (IP3)-induced release of Ca2 , reduced carbachol responses in human detrusor to 60%, in pig to 35% and in mouse[ncbi.nlm.nih.gov] )oxy)-n,n,n-trimethylethanaminumchloride 2-(aminocarbonyl)oxy-n,n,n-trimethyl-ethanaminiuchloride 2-[(aminocarbonyl)oxy]-n,n,n-trimethyl-ethanaminiuchloride 2-[(Aminocarbonyl[chemicalbook.com] Expression experiments revealed that both MKP-1 and a constitutively active mutant of calcineurin A impaired carbachol-induced upregulation of AP-1 activity.[ncbi.nlm.nih.gov] The TAO (for thousand-and-one amino acids) protein kinases activate p38 mitogen-activated protein (MAP) kinase cascades in vitro and in cells by phosphorylating the MAP/ERK[ncbi.nlm.nih.gov] Increasing cytosolic Ca 2 leads to calcineurin activation.[bmccellbiol.biomedcentral.com] Toxicity Oral, mouse: LD 50 15 mg/kg; Oral, rat: LD 50 40 mg/kg.[druglib.com]

    Missing: interactin myocyte enriched
  • Ovariectomy

    […] we explored the skeletal effects of mechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse[ncbi.nlm.nih.gov] (rhBMP-2).[ncbi.nlm.nih.gov] In addition, Cyanidin Chloride abrogated RANKL-induced calcium oscillations, the activation of nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1), and the[ncbi.nlm.nih.gov] proteins of fertilized eggs and reflecting the snail-intrinsic, reversible O-GalNAc glycosylations.[ncbi.nlm.nih.gov] In the present study, we show that bortezomib directly inhibited the receptor activator of nuclear factor κB ligand (RANKL)-dependent osteoclast differentiation of mouse bone[ncbi.nlm.nih.gov] In this study, an ovariectomy (OVX) mouse model was used to evaluate the therapeutic effects of AP on post-menopausal osteoporosis by using micro-computed tomography (micro-CT[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Erythrocytosis

    Studies employing genetically modified mice point to Hif-2α, one of two main Hif-α isoforms, as being the critical regulator of Epo in the adult mouse.[ncbi.nlm.nih.gov] Prolyl-4-hydroxylase 2 (PHD2) is an enzyme encoded by the gene EGLN1.[ncbi.nlm.nih.gov] proteins.[ncbi.nlm.nih.gov] Our hypothesis in this study was that several factors, including toxicity of calcineurin inhibitor, immunologic factors, and chronic allograft nephropathy, can trigger local[ncbi.nlm.nih.gov] Fig. 2.[pnas.org] In the present report, we generated and characterized a mouse line in which a P294R knock-in mutation has been introduced into the mouse Phd2 locus to model the first reported[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Accelerated Atherosclerosis

    To examine the relevance of the ER stress pathway in vivo, we used a streptozotocin-induced hyperglycemic apolipoprotein E-deficient mouse model of atherosclerosis.[ncbi.nlm.nih.gov] The isoapolipoprotein E pattern in both of these siblings was E-3/E-2.[ncbi.nlm.nih.gov] In this study, we further investigate the relationship between H 2 S and conventional protein kinase CβII (cPKCβII) in CHD patients with uremic accelerated atherosclerosis[ncbi.nlm.nih.gov] Judicious use of corticosteroids, calcineurin inhibitors, hormonal replacement therapy, and the cyclooxygenase 2 inhibitors is equally important.[ncbi.nlm.nih.gov] […] signaling and the contribution of glycogen synthase kinase (GSK)-3β activation in hyperglycemic, hyperhomocysteinemic, and high-fat-fed apolipoprotein E-deficient (apoE(-/-)) mouse[ncbi.nlm.nih.gov] […] polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Epidemic Keratoconjunctivitis

    These findings suggest that NF-kappa B was activated in the conjunctiva in the epithelial scraping of the mouse cornea and in human EKC.[ncbi.nlm.nih.gov] The purpose of this study was to analyze the outcome of treating epidemic keratoconjunctivitis (EKC) with 2% povidone-iodine (PVP-I) solution.[ncbi.nlm.nih.gov] Randomized clinical trials have not shown any clear benefit in the acute phase from any of a variety of treatments, including steroids, calcineurin inhibitors, virostatic[ncbi.nlm.nih.gov] Immunodepletion analyses demonstrated that the 50-kDa protein is identical to CD46 (also known as membrane cofactor protein).[ncbi.nlm.nih.gov] Patients were divided into two groups as preterm babies (group 1) and adults (group 2).[ncbi.nlm.nih.gov] E3/49K was synthesized as an 80- to 100-kDa protein, which is unusually large for an E3 protein.[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Echinococcus Granulosus

    Out of 36 mammalian innate receptors with carbohydrate-binding domains, expressed as Fc fusions, only the mouse Kupffer cell receptor (KCR; CLEC4F) bound significantly to[ncbi.nlm.nih.gov] We present 2 patients who developed biliary complications due to a large hydatid cyst.[ncbi.nlm.nih.gov] Calcineurin (CaN) is a Ca(2 )-calmodulin activated serine-threonine protein phosphatase that couples the local or global calcium signals, thus controlling important cellular[ncbi.nlm.nih.gov] Lipids are mainly solubilized by various families of lipid binding proteins which participate in their transport between tissues as well as cell compartments.[ncbi.nlm.nih.gov] Echinococcus Granulosus Antibody (EHG) Summary Immunogen Echinococcus granulosus (EHG) Specificity Echinococcus granulosus (EHG) Isotype IgG1 Clonality Monoclonal Host Mouse[novusbio.com] We report on an 8 1/2-year-old boy with an echinococcus granulosus infection of the liver and lung, drawing particular attention to the therapy applied.[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Arteriosclerosis

    We validated select in vivo A20 targets in human and mouse smooth muscle cell (SMC) cultures.[ncbi.nlm.nih.gov] Type 2 diabetic patients with visceral fat accumulation showed 1) progression of systemic arteriosclerosis, 2) low serum adiponectin levels, and 3) differences in eating behavior[ncbi.nlm.nih.gov] AIP1 (ASK1-interacting protein-1; encoded by the DAB2IP gene), a signaling scaffolding protein, is abundantly expressed in vascular endothelial cells (EC).[ncbi.nlm.nih.gov] Calcineurin inhibitors reduce the acute rejection rate and greatly improve renal allograft survival.[ncbi.nlm.nih.gov] Mouse aortic ECs were isolated for in vitro assays.[ncbi.nlm.nih.gov] Nutritional status was assessed by serum albumin, subjective global assessment and normalized protein catabolic rate (nPCR).[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Netherton Syndrome

    We show that, unlike in humans, transcription of the mouse Spink5 gene generates two mRNAs that differ in the 3' untranslated region.[ncbi.nlm.nih.gov] The human epidermis serves 2 crucial barrier functions: it protects against water loss and prevents penetration of infectious agents and allergens.[ncbi.nlm.nih.gov] Tacrolimus and pimecrolimus belong to the family of calcineurin inhibitors.[ncbi.nlm.nih.gov] NS is due to loss-of-function mutations in the SPINK5 gene and to the consequent lack of expression of its encoded protein LEKTI in the skin and all stratified epithelial[ncbi.nlm.nih.gov] In parallel, KLK5 activates a specific cascade of allergy and inflammation by activating protease-activated receptor-2 (PAR-2) receptors.[ncbi.nlm.nih.gov] […] are limited to topical treatment with mild moisturizers containing petrolatum or lanolin and/or a skin barrier repair formula containing ceramides or cholesterol.Topical calcineurin[firstskinfoundation.org]

    Missing: interactin myocyte enriched
  • Sulindac

    Matrix metalloproteinase 7 (MMP7), a metallohydrolase involved in the development of several cancers, is downregulated in the Apc(Min/ ) colon cancer mouse model following[ncbi.nlm.nih.gov] SULINDAC API Sulindac E IsoMer (Z)-2-(5-Fluoro-2-Methyl-1-(4-(Methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic acid CLINORIL Other APIs Sulindac SynonyMs (Z)-5-Fluoro-2-Methyl[chemicalbook.com] NFATc1, a calcineurin-responsive transcription factor associated with aggressive pancreatic cancer.[ncbi.nlm.nih.gov] ; isolated proteins and peptides were identified by nanoLC-MS-MS.[ncbi.nlm.nih.gov] […] interact with many other medications when they are used in together, including: ACE Inhibitors Aldosterone antagonists Alendronate Amiloride Aspirin Beta blockers Brimonidine Calcineurin[medicinehow.com] We quantified IL-8 secretion in airway epithelial CFBE cells cultured at an air-liquid interface and in a mouse model of CF.[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched
  • Malignant Glioma

    The GL261-Luc2 intracranial mouse model of glioma was used to investigate the effects of the KD on the tumor-specific immune response.[ncbi.nlm.nih.gov] Two human Bcl-2 positive glioblastoma cell lines from our tumor bank (Jon52 and Roc) were both transfected in vitro with bcl-2 antisense (AS) and nonsense (NS) oligonucleotides[ncbi.nlm.nih.gov] Citrullinated proteins were identified by mass spectrometry.[ncbi.nlm.nih.gov] Previously we identified regulator of calcineurin 1 (RCAN1) as an endogenous inhibitor of NF-κB signaling pathway in lymphoma.[ncbi.nlm.nih.gov] Overall survival was assessed in mouse glioma models using human glioma cells and induced mouse brain tumor stem cells (imBTSCs) to determine the effect of DEPDC1 suppression[ncbi.nlm.nih.gov] Furthermore, we constructed nude mouse subcutaneous and intracranial models to verify that IKBKE could attenuate U87-MG tumourigenicity in vivo.[ncbi.nlm.nih.gov]

    Missing: interactin myocyte enriched