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68 Possible Causes for 24 hydroxylase, 3alpha,7alpha,12alpha trihydroxy 5beta cholestanoyl CoA, activity

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  • Bile Salt

    -5beta-cholestanoyl-CoA NADP Na H ATP 5beta-cholesten-7alpha, 12alpha-diol-3-one H AKR1D1 CDCA chenodeoxycholoyl-CoA NADPH CoA-SH TCDCA SCP2-1 DCA choloyl-CoA LCHA propionyl[wikipathways.org] A cholesterol 24-hydroxylase or CYP46A1 (EC 1.14.14.25) is expressed in the brain, and therefore, although the organ cannot export cholesterol, it exports oxysterols.[tuscany-diet.net] […] an overview on transcriptional control of these transporters by the key regulatory nuclear receptors and discuss the potential therapeutic role of novel transcriptional activators[ncbi.nlm.nih.gov] The inhibition of BSEP transport activity can lead to an increase in intracellular bile salt levels and liver injury.[ncbi.nlm.nih.gov] The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol.[reactome.org]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    -5beta-cholestanoyl-CoA NADP Na H ATP 5beta-cholesten-7alpha, 12alpha-diol-3-one H AKR1D1 CDCA chenodeoxycholoyl-CoA NADPH CoA-SH TCDCA SCP2-1 DCA choloyl-CoA LCHA propionyl[wikipathways.org] Metabolism 42:69–74 PubMed CrossRef Google Scholar 24.[link.springer.com] Ten mutations were studied in detail and shown to cause complete loss of enzyme activity and, in two cases, alterations in the size or amount of the transcribed mRNA.[ncbi.nlm.nih.gov] The degree to which the enzyme retains its activity and functional ability can actually be measured by using a substrate of 7α-hydroxycholesterol and cultured skin fibroblasts[symptoma.com] […] substrate for 21-hydroxylase in the adrenal zona fasciculata). 24 The autosomal-recessive mode of genetic transmission of the nonclassic form of 21-hydroxylase deficiency[glowm.com]

  • Clofibrate

    Epub 2009 Nov 24. [ PubMed:19934256 ] Kind Protein Organism Humans Pharmacological action Unknown Actions Inducer General Function Vitamin d 24-hydroxylase activity Specific[drugbank.ca] 5 Year Member Joined: Jun 3, 2012 Messages: 74 Likes Received: 0 Status: Resident [Any Field] I've heard of that, as well as another mechanism by which clofibrate blocks 7alpha-hydroxylase[forums.studentdoctor.net] Abstract The NADP -dependent dehydrogenase activity of a predominant isoenzyme of human liver 3alpha-hydroxysteroid dehydrogenase was activated by antihyperlipidemic drugs[ncbi.nlm.nih.gov] Gene silencing studies demonstrated that CF-induced apoptosis in Jurkat cells is partially dependent on activation of caspase 2.[ncbi.nlm.nih.gov] Clofibrate treatment significantly induced PPARα DNA binding activity, and remarkably reduced cyclooxygenase-2/PGE2 and 5-lipoxygenase/LTB4 inflammatory pathways.[ncbi.nlm.nih.gov]

    Missing: 12alpha trihydroxy 5beta cholestanoyl CoA
  • Chenodeoxycholic Acid

    Thus, B. intestinalis AM-1 possesses 7alpha-hydroxysteroid dehydrogenase (7alpha-HSDH) activity.[ncbi.nlm.nih.gov] Abstract 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic (cholic) and 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic (chenodeoxycholic) acids are the predominant hepatic[ncbi.nlm.nih.gov] The activation of ERK1/2 was responsible for the activating phosphorylation of C/EBPβ.[ncbi.nlm.nih.gov] Entry C02528 Compound Name Chenodeoxycholate; Chenodeoxycholic acid; 3alpha,7alpha-Dihydroxy-5beta-cholanic acid; Chenodiol Formula C24H40O4 Exact mass 392.2927 Mol weight[kegg.jp] 日本薬局方収載医薬品 [BR: jp08311 ] 化学薬品等 D00163 ケノデオキシコール酸 Lipids [BR: br08002 ] ST Sterol Lipids ST04 Bile acids and derivatives ST0401 C24 bile acids, alcohols, and derivatives C02528 3alpha[genome.jp]

    Missing: 24 hydroxylase 12alpha trihydroxy 5beta cholestanoyl CoA
  • Medroxyprogesterone

    Epub 2009 Nov 24. [ PubMed:19934256 ] Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Steroid hydroxylase activity Specific[drugbank.ca] 0.9540 C15126 2,17beta-Dihydroxy-17-methylandrosta-1,4-dien-3-one 0.9540 C15287 11beta,17beta-Dihydroxy-17alpha-methylandrosta-1,4-dien-3-one 0.9540 C15402 17beta-Hydroxy-7alpha[genome.jp] STUDY QUESTION: Does medroxyprogesterone acetate (MPA) impair human dendritic cell (DC) activation and function?[ncbi.nlm.nih.gov] However, mass spectrometry and nuclear magnetic resonance studies identified that the active agent was a novel breakdown product (4-methyl(de-dimethylamine)-tetracycline ([ncbi.nlm.nih.gov] After 24 hours' incubation in serum-free media, 1.0, 0.1, and 0.01 microM of 17beta-estradiol, tibolone, 3alpha-hydroxytibolone and 3beta-hydroxytibolone were added to MCF[thebiogrid.org]

    Missing: 12alpha trihydroxy 5beta cholestanoyl CoA
  • Methyltestosterone

    Epub 2009 Nov 24. [ PubMed:19934256 ] Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific[drugbank.ca] 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha[patents.google.com] ,17beta-di ol and 17alpha-methyl-5beta-androstan-3alpha,17beta-dio l, in human urine. 17alpha-Methyl-[(2)H3]-5alpha-androstan-3alpha,1 7beta-diol and 17alpha-methyl-[(2)H3[ncbi.nlm.nih.gov] […] hydroxyl group in various chemical reactions to access stereoisomeric steroidal compounds with potent activity.[ncbi.nlm.nih.gov] Liver microsomes from Aroclor 1254-induced rats were used as a highly active source of mammalian UDP-glucuronosyltransferases (UGT, EC 2.4.1.17).[ncbi.nlm.nih.gov]

    Missing: 12alpha trihydroxy 5beta cholestanoyl CoA
  • Testosterone

    Epub 2009 Nov 24. [ PubMed:19934256 ] Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific[drugbank.ca] Sundaram K, Kumar N (2000) 7alpha-methyl-19-nortestosterone (MENT): the optimal androgen for male contraception and replacement therapy .[ncbi.nlm.nih.gov] Some studies show an increase in testosterone (T) after sexual activity; this literature has inconsistent findings, focuses mostly on men, and does not employ control activities[ncbi.nlm.nih.gov] A. (2010) 3alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats.[doi.org] Author information 1 Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, P.O.[ncbi.nlm.nih.gov]

    Missing: 12alpha trihydroxy 5beta cholestanoyl CoA
  • Norethindrone

    Epub 2009 Nov 24. [ PubMed:19934256 ] Kind Protein Organism Humans Pharmacological action Unknown Actions Inducer General Function Steroid hydroxylase activity Specific Function[drugbank.ca] The 7alpha-methyl substitution was of special interest as it prevents 5alpha-reduction.[ncbi.nlm.nih.gov] The present study sets out to determine the vasoactive effects of norethisterone and its 5alpha-dihydro (5alpha-norethisterone) and -tetrahydro (3alpha,5alpha-norethisterone[ncbi.nlm.nih.gov] No p53 activation or H2AX phosphorylation was detected using a panel of structurally/functionally related drugs.[ncbi.nlm.nih.gov] John's Wort on oral contraceptive (OC) therapy with respect to the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding.[ncbi.nlm.nih.gov]

    Missing: 12alpha trihydroxy 5beta cholestanoyl CoA
  • Beta-Ureidopropionase Deficiency

    Phenylketonuria (phenylalanine hydroxylase deficiency) (PKU) 21. Hyperphenylalaninemia (variant, benign) (H-PHE) 22. 2-methyl 3-hydroxy butyric aciduria (2M3HBA) 23.[metascreen.com.hk] 2 Hyperbilirubinemia, Rotor type Hyperbiliverdinemia Hypercalcemic tumoral calcinosis Hypercalciuria - bilateral macular coloboma Hypercholesterolemia due to cholesterol 7alpha-hydroxylase[csbg.cnb.csic.es] […] dehydrogenase Deficiency of 3alpha-hydroxysteroid dehydrogenase Deficiency of 3-hydroxyacyl-CoA dehydrogenase Deficiency of 3-hydroxybutyrate dehydrogenase Deficiency of[icd9data.com] No activity of beta-ureidopropionase could be detected in a liver biopsy of the patient, while a normal activity of dihydropyrimidine dehydrogenase and dihydropyrimidinase[ncbi.nlm.nih.gov] No beta-ureidopropionase activity could be detected in a liver biopsy obtained from one of the patients, which reflected the complete absence of the beta-ureidopropionase[ncbi.nlm.nih.gov]

    Missing: 12alpha trihydroxy 5beta cholestanoyl CoA
  • Estrogenic Agents

    Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency . J. Clin. Endocrinol.[doi.org] […] phenolic ring mimicking the 3-OH, (2) H-bond donor mimicking the17beta-OH and O-O distance between 3- and 17beta-OH, (3) precise steric hydrophobic centers mimicking steric 7alpha[ncbi.nlm.nih.gov] In transiently transfected HEK-293 cells, androstenediol, DHEA, and DHEA-S activated ERα.[ncbi.nlm.nih.gov] Activities were generated using a validated ER competitive binding assay, which covers a 10 6 -fold range.[doi.org] Activities were generated using a validated ER competitive binding assay, which covers a 10(6)-fold range.[ncbi.nlm.nih.gov]

    Missing: 3alpha 12alpha trihydroxy 5beta cholestanoyl CoA