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11,185 Possible Causes for 25 hydroxycholesterol, 7alpha hydroxylase, activity

  • Chenodeoxycholic Acid

    In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in increased[ncbi.nlm.nih.gov] CDCA could inhibit the 25-hydroxycholesterol mediated inactivation of SREBP without affecting mRNA levels of SREBPs.[ncbi.nlm.nih.gov] Serum levels of 7alpha-hydroxy-4-cholesten-3-one, reflecting cholesterol 7alpha-hydroxylase activity, and 7-dehydrocholesterol, reflecting HMG CoA reductase activity, and[ncbi.nlm.nih.gov]

  • Clofibrate

    The NADP -dependent dehydrogenase activity of a predominant isoenzyme of human liver 3alpha-hydroxysteroid dehydrogenase was activated by antihyperlipidemic drugs, such as[ncbi.nlm.nih.gov] Clofibrate increased the levels of liver microsomal oxysterols including 25- and 27-hydroxycholesterol, which are potent activators of LXRα.[jstage.jst.go.jp] 5 Year Member Joined: Jun 3, 2012 Messages: 74 Likes Received: 0 Status: Resident [Any Field] I've heard of that, as well as another mechanism by which clofibrate blocks 7alpha-hydroxylase[forums.studentdoctor.net]

  • Autosomal Recessive Spastic Paraplegia Type 26

    , abolishes upregulation of CYP7B1 by estrogen receptor in Hep-G2 cells SP600125 - markedly suppresses basal CYP7B1 promoter activity, abolishes upregulation of CYP7B1 by[brenda-enzymes.org] SPG5 can easily be diagnosed thanks to the significant elevation of two plasma oxysterols: 27- and 25-hydroxycholesterol.[oxfordmedicine.com] 'Spasticity,' is a term that refers to excessive muscle tone or muscle over-activity, with increased velocity-dependent resistance to stretch.[disabled-world.com]

  • Vasodilation

    We report for the first time that the active vasodilator component of cutaneous sympathetic activity in limbs was recorded without any vasoconstrictor component in a patient[ncbi.nlm.nih.gov] However, whether POVPC promotes atherosclerosis like 25-hydroxycholesterol remains unclear.[ncbi.nlm.nih.gov] However, whether vasodilator function assessed with PLM, and therefore NO bioavailability, is preserved in older individuals with greater physical activity and fitness is[ncbi.nlm.nih.gov]

    Missing: 7alpha hydroxylase
  • Pravastatin

    We have previously reported that activation of AMP-activated kinase alpha 2 (AMPKα2) by nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms[ncbi.nlm.nih.gov] […] change the expression of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, liver X receptor alpha (LXRalpha), farnesoid X receptor (FXR), ABCG5, ABCG8, and 7alpha-hydroxylase[ncbi.nlm.nih.gov] Persistent immune activation is thought to contribute to increased cardiovascular disease risk in HIV and statins may help modulate systemic immune activation.[ncbi.nlm.nih.gov]

    Missing: 25 hydroxycholesterol
  • Smith Lemli Opitz Syndrome

    Impaired DHCR7 function is associated with a spectrum of congenital malformations, intellectual impairment, epileptiform activity and autism spectrum disorder.[ncbi.nlm.nih.gov] In the SLOS patients, cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase were not defective.[ncbi.nlm.nih.gov] […] in a membrane fraction enriched with cholesterol, was impaired in SLOS cells as reflected by reduced single channel conductance and a 50 mV rightward shift in the channel activation[ncbi.nlm.nih.gov]

    Missing: 25 hydroxycholesterol
  • Lovastatin

    We also observed that lovastatin inhibited GSK3β activity, a kinase downstream of Akt, by up-regulating GSK3β (Ser9) phosphorylation.[ncbi.nlm.nih.gov] Since 25-hydroxycholesterol (25-HC), a metabolite of cholesterol, can suppress IL-1β production, thus reducing inflammation, we evaluated the effect of 25-HC in an in vitro[ncbi.nlm.nih.gov] A key regulator of the ISR apoptotic response is activating transcription factor 3 (ATF3) and its target gene CHOP/GADD153.[ncbi.nlm.nih.gov]

    Missing: 7alpha hydroxylase
  • Mycobacterial Infection

    The antimycobacterial activity of mBNBD4 was tested through colony-forming unit (cfu) assay.[ncbi.nlm.nih.gov] The side-chain oxidized oxysterols, 25-hydroxycholesterol (25HC) and vitamin D metabolites (vitamin D3 and vitamin D2), are now known to impart physiologically profound effects[ncbi.nlm.nih.gov] Despite the impact of highly active antiretroviral therapy (HAART), mycobacterial infections in patients with AIDS remain a frequent complication.[ncbi.nlm.nih.gov]

    Missing: 7alpha hydroxylase
  • Lassa Virus

    These cells were not activated by LV infection.[ncbi.nlm.nih.gov] The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating[ncbi.nlm.nih.gov] These studies led to an optimized analog (ST-161) possessing subnanomolar activity against LASV and submicromolar activity against a number of other viruses in the Arenaviridae[ncbi.nlm.nih.gov]

    Missing: 7alpha hydroxylase
  • Tangier Disease

    […] and Lp-PLA2 activity in plasma compared to healthy women.[ncbi.nlm.nih.gov] Second, 24-, 25-, and 27-hydroxycholesterol concentrations were moderately increased in TT1 cells, but were increased as much as 200-fold in TT2 cells.[ncbi.nlm.nih.gov] Tangier disease plasma had approximately 3.3-fold higher PAF acetylhydrolase activity (208 /- 9 nmol/min/mL) than controls (63 /- 18 nmol/min/mL).[ncbi.nlm.nih.gov]

    Missing: 7alpha hydroxylase