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317 Possible Causes for 26S, ATP Dependent, Proteasome

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  • Minoxidil

    dependent K (K ATP ) channels.[tcichemicals.com] The mean age of subjects was 43.5 12.5 years (range, 26-65 years).[ncbi.nlm.nih.gov] In an in vitro VHL binding assay, minoxidil directly inhibited PHD-2, thus preventing the hydroxylation of cellular HIF-1α and VHL-dependent proteasome degradation and resulting[ncbi.nlm.nih.gov]

  • Rickettsia Rickettsii

    Activation was not ATP dependent since no change in activation resulted from addition of an excess of the unhydrolyzable ATP analog ATPgammaS, supplementation with exogenous[ncbi.nlm.nih.gov] We detected LT responses in 26 (51%) of 51 volunteers after vaccination.[ncbi.nlm.nih.gov] However, 100, 200 and 500 microM alpha-lipoic acid increased the viability of infected cells at 96 h to 45, 51 and 70%, respectively compared with 26% for untreated, infected[ncbi.nlm.nih.gov]

  • Ehrlichia Chaffeensis

    Bacterial type IV secretion (T4S) system transports macromolecules across the membrane in an ATP-dependent manner and is increasingly recognized as a virulence factor delivery[ncbi.nlm.nih.gov] Immunosuppressive conditions were reported by 26% of cases. The overall rate for ehrlichiosis has increased 4-fold since 2000.[ncbi.nlm.nih.gov] […] proteins, including translation elongation factor 1 alpha 1 (EF1A1), deleted in azoospermia (DAZ)-associated protein 2 (DAZAP2), ferritin light polypeptide (FTL), CD63, CD14, proteasome[ncbi.nlm.nih.gov]

  • Gallbladder Carcinoma

    […] interfere with the interaction between survivin and Hsp90 (heat shock protein-90) leading to the degradation of survivin to anti-tumor, but also competitively target the ATP-dependent[ncbi.nlm.nih.gov] A study of hospital records was performed in 26 patients with UGC treated in our institution from January 1990 to December 2002.[ncbi.nlm.nih.gov] Proteasome inhibitor MG132 exhibits anti-proliferative and pro-apoptotic properties in many tumors.[ncbi.nlm.nih.gov]

  • Synovial Sarcoma

    The catalytic activities of covalent and ATP-dependent chromatin remodeling are central to regulating the conformational state of chromatin and the resultant transcriptional[ncbi.nlm.nih.gov] Between 2000 and 2015, 26 genetically confirmed PPMSSs were included. The clinicopathologic features of all of the cases were reviewed.[ncbi.nlm.nih.gov] Top scoring drug categories were found to be HDAC inhibitors and proteasomal targeting agents.[ncbi.nlm.nih.gov]

  • Cytarabine

    We performed a phase III trial to determine whether induction therapy with cytarabine and amonafide L-malate, a DNA intercalator and non–ATP-dependent topoisomerase II inhibitor[jco.ascopubs.org] Single-agent bortezomib, a potent, selective and reversible inhibitor of the 26S proteasome, has demonstrated clinical efficacy in relapsed and refractory mantle cell lymphoma[ncbi.nlm.nih.gov] CR/CRi rate was 50% (13/26) among primary refractory and 47% (7/15) among early relapse. Overall, 25 patients (61%) were allografted.[ncbi.nlm.nih.gov]

  • Digitoxin

    Digoxin is a drug with a narrow therapeutic index, which is substrate of the ATP-dependent efflux pump P-glycoprotein.[ncbi.nlm.nih.gov] 25 1 #Up 24 26 27 1 25 26 28 1 26 27 29 1 27 28 30 1 28 29 31 1 29 29 32 1 #Down 30 30 33 1 #Up 31 31 34 1 #Down 32 35 34 1 #Down 33 35 36 1 34 35 37 1 35 36 38 1 36 37 39[genome.jp] Furthermore, D6-MA suppressed Mcl-1 expression via ubiquitin proteasomal degradation that is dependent on activation of glycogen synthase kinase (GSK)-3β signaling.[ncbi.nlm.nih.gov]

  • Alexander Disease

    […] enriched in the RF fraction by immunobloting of both the AxD mouse models and human patients: receptor for activated protein C kinase 1 (RACK1), G1/S-specific cyclin D2, and ATP-dependent[ncbi.nlm.nih.gov] July 01, 1976 ; 26 (7) Articles A report and reappraisal LOUIS S. RUSSO , ALAN ARON , PAUL J.[n.neurology.org] […] with proteasomes actually inhibits proteasomal protease activity.[ncbi.nlm.nih.gov]

  • Dubin-Johnson Syndrome

    Similar ATP-dependent transport mechanisms have been described in erythrocytes.[ncbi.nlm.nih.gov] […] amounts of cysteinyl leukotriene, LTE4 (8-fold), the omega-oxidation product omega-carboxy-LTE4 (15-fold) and the beta-oxidation metabolite omega-carboxy-tetranor-LTE3 (26[ncbi.nlm.nih.gov] Impaired protein maturation followed by proteasomal degradation of inactive MRP2I1173F explain the deficient hepatobiliary elimination observed in this group of Dubin-Johnson[ncbi.nlm.nih.gov]

  • Renal Carcinoma

    The architecture of chromatin is governed, in part, by ATP-dependent chromatin remodelers.[ncbi.nlm.nih.gov] There has been no tumor recurrence after a follow-up of 26 months.[ncbi.nlm.nih.gov] In addition, galangin increased proteasome activity, but galangin had no effect on expression of proteasome subunits (PSMA5 and PSMD4).[ncbi.nlm.nih.gov]