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1,236 Possible Causes for 26S, Complex, Proteasome

  • Dementia

    The adverse drug effects were observed in 26 (33.3%) patients in the younger old and in 26 (33.8%) in the oldest old ( P 0.095).[ncbi.nlm.nih.gov] Abstract Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) is an endemic disease observed in the Kii peninsula, Guam, and Papua.[ncbi.nlm.nih.gov] One current theory about why Lewy bodies form is that the cellular mechanisms for degrading and disposing of intracellular protein fragments (proteasomes) are dysfunctional[doi.org]

  • Urinary Tract Infection

    Cumulative incidence of UTI was reported in 10 trials, 17 - 26 which were further analyzed in quantitative synthesis.[doi.org] […] patients 18 years or older, including pyelonephritis, caused by the following susceptible microorganisms: Escherichia coli, K. pneumoniae, and Enterobacter cloacae species complex[ncbi.nlm.nih.gov] CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion . Cell 111 , 553–564 (2002). 71. Miraglia, A.[doi.org]

  • Tuberculosis

    For these samples, 15 of 26 MIRU-VNTR loci had high or moderate discriminatory power according to the Hunter-Gaston discriminatory index.[ncbi.nlm.nih.gov] Bone and soft tissue samples from 85 ancient Egyptian mummies were analyzed for the presence of ancient Mycobacterium tuberculosis complex DNA (aDNA) and further characterized[ncbi.nlm.nih.gov] ., cytokine-inducible SH2 containing protein (CISH), which selectively targets the H V-ATPase subunit A for ubiquitination and degradation by the proteasome ( Queval et al[doi.org]

  • Bortezomib

    The 26S proteasome has a direct impact on cellular transcription regulation, cell-cycle progression, oncogenesis and apoptosis, since the turnover of the vast majority of[doi.org] We previously demonstrated that the Yin Yang 1 (YY1)/polycomb group (PcG) protein/DNA methyltransferase (DNMT) complex is important for CCAAT/enhancer binding protein delta[ncbi.nlm.nih.gov] The proteasome is, thus, a potential target for pharmacological agents.[doi.org]

  • Appendicitis

    Although the overall mortality rate has declined from 26% overall (40% for surgery) to 0.8%, the current rate of perforation is 28%, with a diagnostic accuracy of 82%.[ncbi.nlm.nih.gov] Box 12, Manama, Bahrain. 3 Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain. 4 Department of Pathology, Salmaniya Medical Complex, Manama, Bahrain.[ncbi.nlm.nih.gov] OBJECTIVE: The determination of 20S proteasome concentration in the blood plasma of children with appendicitis and its correlation with CRP.[ncbi.nlm.nih.gov]

  • Lafora Disease

    We herein report clinical and genetic findings of 26 Italian LD patients.[ncbi.nlm.nih.gov] These results suggest that the modification introduced by the laforin-malin complex could affect the subcellular distribution of AMPK beta subunits.[ncbi.nlm.nih.gov] The mutant malin expressing cells also exhibit proteasomal dysfunction and cell death.[ncbi.nlm.nih.gov]

  • Autosomal Recessive Juvenile Parkinson Disease

    View Article Google Scholar 26.[journals.plos.org] Part of a SCF-like complex, consisting of PARK2, CUL1 and FBXW7. Part of a complex, including STUB1, HSP70 and GPR37.[mybiosource.com] Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation.[biossusa.com]

  • Nakajo Syndrome

    Dermatology. 2013;227(1):26-30. doi: 10.1159/000351323. Epub 2013 Aug 8. Author information 1 Department of Dermatology, Wakayama Medical University, Wakayama, Japan.[ncbi.nlm.nih.gov] As with many genetic disorders, the dental manifestations are often overshadowed by other more conspicuous and complex syndromic features.[ncbi.nlm.nih.gov] These results show that a mutation within a proteasome subunit is the direct cause of a human disease and suggest that decreased proteasome activity can cause inflammation[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    Epub 2018 Jun 26.[ncbi.nlm.nih.gov] Inhibition of autophagy by blocking the formation of Beclin1 complex could reverse the phenotype of BTZ resistance in MM.[ncbi.nlm.nih.gov] Second-generation proteasome inhibitors, such as carfilzomib and ixazomib, have been approved, and three proteasome inhibitors were incorporated into several regimens with[ncbi.nlm.nih.gov]

  • Tuberous Sclerosis

    All 26 shagreen patches that were analyzed histopathologically had coarse collagen fibers and 24 of 26 stained with Miller elastic stain had decreased elastic fibers.[ncbi.nlm.nih.gov] Tuberous sclerosis complex.[ncbi.nlm.nih.gov] Cells with activated mTORC1 exhibited elevated levels of intact and active proteasomes through a global increase in the expression of genes encoding proteasome subunits.[omim.org]