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18 Possible Causes for 27 hydroxy 13,19 didesmethyl, C, spirolide

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  • Diflorasone

    C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,[en.wikipedia.org] 22 H 28 F 2 O 5 Molar mass 410.46 g·mol 1 3D model ( JSmol ) C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4 CC( O)C C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C( O)CO)O)C)O)F)C)F InChI 1S/C22H28F2O5[en.wikipedia.org] C 30.8889 -13.6621 9 C1x C 33.1844 -16.3826 10 C1b C 30.9227 -11.8538 11 O5a O 33.2580 -11.8878 12 C7a C 35.6502 -13.4125 13 C1y C 29.7211 -17.0006 14 C1y C 28.5932 -14.9941[genome.jp] @]12C[C@H](C)[C@](O)(C( O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2 CC( O)C C[C@]12C InChI Identifier InChI 1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19[hmdb.ca]

    Missing: 19 didesmethyl spirolide
  • Nerium

    -dihydroxy-12-oleanen-28-oic acid (11), 3beta-hydroxy-20(29)-lupen-28-oic acid (betulinic acid, 12), 20(29)-lupene-3beta,28-diol (betulin, 13), and (20S,24R)-epoxydammarane[ncbi.nlm.nih.gov] […] anticancer compounds from both species are monoglycosidic cardenolides possessing the 3β,14β-dihydroxy-5β-card-20(22)-enolide structure with or without an acetoxy group at C-[ncbi.nlm.nih.gov] Search for Plants Common A · B · C · D · E · F · G · H · I · J · K · L · M · N · O · P · Q · R · S · T · U · V · W · X · Y · Z Scientific A · B · C · D · E · F · G · H · I[calflora.org] The characterisation and antioxidant activity of oosporein from C. kusanoi are reported for the first time.[ncbi.nlm.nih.gov]

    Missing: 19 didesmethyl spirolide
  • Estramustine

    -11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3 IUPAC Name 14-hydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-trien-5-yl N,N-bis[drugbank.ca] Alongi F 1 , Schipani S , Samanes Gajate AM , Rosso A , Cozzarini C , Fiorino C , Alongi P , Picchio M , Gianolli L , Messa C , Di Muzio N .[ncbi.nlm.nih.gov] C 28.0093 -18.4192 9 C1y C 26.8284 -16.3571 10 C1y C 28.0093 -17.0531 11 C1x C 28.0321 -14.3224 12 C1x C 26.8399 -14.9918 13 C1z C 29.2062 -15.0113 14 C1y C 29.1893 -16.3725[genome.jp] Transcriptional activity of the HSD17B7 gene containing the G allele was higher than that of the C allele.[ncbi.nlm.nih.gov]

    Missing: 19 didesmethyl spirolide
  • Hyperammonemia

    -3-methylglutaryl-CoA lyase deficiency AR 13 60 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 deficiency AR 11 27 IVD Isovaleric acidemia AR 39 87 MCCC1 3-Methylcrotonyl-CoA[blueprintgenetics.com] Cobalamin C (Cbl-C) defect is the most common inborn error of cobalamin metabolism which causes a block in the pathway responsible for the synthesis of its two metabolically[ncbi.nlm.nih.gov] Two heterozygous mutations c.978G A (R269H) and c.1506C T (S445L) are identified, respectively. These are both de novo.[ncbi.nlm.nih.gov] Trifunctional protein deficiency AR 18 60 HCFC1 Combined methylmalonic acidemia and hyperhomocysteinemia XL 9 16 HLCS Holocarboxylase synthetase deficiency AR 22 47 HMGCL 3-hydroxy[blueprintgenetics.com]

    Missing: 19 didesmethyl spirolide
  • Chenodeoxycholic Acid

    -2-pyridones DE1921503A1 ( en ) 1969-11-13 A process for the production of acetic acid DE2362247A1 ( en ) 1974-06-27 A process for the manufacture of products by glueing DE2309722A1[google.com.pg] […] forskolin or dibutyryl cyclic AMP, two activators of the protein kinase A-dependent pathway; (b) prevented by staurosporine, a potent protein kinase C inhibitor; (c) partially[ncbi.nlm.nih.gov] Consistently, enforced expression of FXR promoted the phosphorylation of AMPKα, ERK1/2, and C/EBPβ, verifying that C/EBPβ phosphorylation elicited by CDCA results from the[ncbi.nlm.nih.gov] The inhibitory effect of CDCA upon (14) C-BT uptake did not result from a decrease in cell proliferation or viability.[ncbi.nlm.nih.gov]

    Missing: 19 didesmethyl spirolide
  • Urea Cycle Disorder

    -3-methylglutaryl-CoA lyase deficiency AR 13 60 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 deficiency AR 11 27 IVD Isovaleric acidemia AR 39 87 MCCC1 3-Methylcrotonyl-CoA[blueprintgenetics.com] Serrano M 1 , Martins C , Pérez-Dueñas B , Gómez-López L , Murgui E , Fons C , García-Cazorla A , Artuch R , Jara F , Arranz JA , Häberle J , Briones P , Campistol J , Pineda[ncbi.nlm.nih.gov] Copyright (c) 2007 AASLD.[ncbi.nlm.nih.gov] Trifunctional protein deficiency AR 18 60 HCFC1 Combined methylmalonic acidemia and hyperhomocysteinemia XL 9 16 HLCS Holocarboxylase synthetase deficiency AR 22 47 HMGCL 3-hydroxy[blueprintgenetics.com]

    Missing: 19 didesmethyl spirolide
  • Buprenorphine

    -,28 ,29-/m1/s1 IUPAC Name (1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²[drugbank.ca] Buprenorphine facilitates hepatitis C virus (HCV) treatment in opioid-dependent patients with HCV monoinfection.[ncbi.nlm.nih.gov] DISCUSSION: Most cases of hepatotoxicity related to buprenorphine have occurred in hepatitis C-infected patients.[ncbi.nlm.nih.gov] 25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26 ,27[drugbank.ca]

    Missing: 19 didesmethyl spirolide
  • Epirubicin

    -,15-,17-,22-,27-/m0/s1 IUPAC Name (8S,10S)-10-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene[drugbank.ca] […] instillation of mitomycin C.[ncbi.nlm.nih.gov] The GLS of the epicardium and mid-myocardium in groups B and C were not significantly reduced (P .05).[ncbi.nlm.nih.gov] We studied whether the -161 C T germline SNP in UGT2B7 was related to epirubicin metabolism and whether differences exist in the toxicity and efficacy of epirubicin-based[ncbi.nlm.nih.gov]

    Missing: 19 didesmethyl spirolide
  • Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome

    -3-methylglutaryl-CoA lyase deficiency AR 13 60 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 deficiency AR 11 27 IVD Isovaleric acidemia AR 39 87 MCCC1 3-Methylcrotonyl-CoA[blueprintgenetics.com] .; Meli, C.; Donati, A.; Burlina, A.B.; Rizzo, C.; D.C.pua, M.; Fariello, G.; Dionisi-Vici, C. , 2001 : Clinical and molecular findings in hyperornithinemia-hyperammonemia-homocitrullinuria[wwe.geoscience.net] Boldrini , C. Meli , A. Donati , A. B. Burlina , C. Rizzo , M. Di Capua , G. Fariello , C.[neurology.org] Dionisi Vici C, Bachmann C, Gambarara M, Colombo JP, Sabetta G.[springermedizin.de]

    Missing: 19 didesmethyl spirolide
  • Disorder of Ornithine Metabolism

    -3-methylglutaryl-CoA lyase deficiency AR 13 60 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 deficiency AR 11 27 IVD Isovaleric acidemia AR 39 87 MCCC1 3-Methylcrotonyl-CoA[blueprintgenetics.com] PMID 19531057 . a b c d e f g h Lichter-Konecki, U.; Caldovic, L.; Morizono, H.; Simpson, K.; Pagon, R. A.; Adam, M. P.; Bird, T. D.; Dolan, C. R.; Fong, C.[en.wikipedia.org] Santinelli R, Costagliola C, Tolone C et al (2004) Low-protein diet and progression of retinal degeneration in gyrate atrophy of the choroid and retina: a twenty-six-year[link.springer.com] :153237261 c.-970T C NM_005334.2 rs398122908 MUT Chr6:49427219 c.-39-1G A NM_000255.3 MUT Chr6:49404228 c.1957-892C A NM_000255.3 MUT Chr6:49404235 c.1957-899A G NM_000255.3[blueprintgenetics.com]

    Missing: 19 didesmethyl spirolide