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7,830 Possible Causes for 2A, mengovirus, protease

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  • Ulcerative Colitis

    A serine protease inhibitor isolated from the probiotic Bifidobacterium longum NCC2705 (SERPINBL), known to inhibit elastase-like proteases, prevented nerve activation by[ncbi.nlm.nih.gov] We performed a phase 2a open-label study of 103 golimumab-treated patients with moderate-to-severe UC to test whether the baseline gene expression signature could be used[ncbi.nlm.nih.gov] Our data demonstrate that proteases, particularly those signalling through neuronal PAR1, are biomarker candidates for IBS, and protease profiling may be used to characterise[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Cardiac Hypertrophy

    Here, we revealed a crucial role of ubiquitin specific protease 4 (USP4), a deubiquitinating enzyme prominently expressed in the heart, in attenuating pathological cardiac[ncbi.nlm.nih.gov] Therefore, the aim of the present work was to evaluate the mtDNA damage and enzyme repairing the 8-oxo-deoxyguanosine glycosylase mitochondrial isoform 1-2a (OGG1-2a) in the[ncbi.nlm.nih.gov] KLK8 overexpression increased epidermal growth factor (EGF) production, which was blocked by the inhibitors of serine protease.[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Lyme Arthritis

    B burgdorferi do not appear to produce any exported proteases capable of digesting proteoglycans and collagen, but instead, induce and activate host proteases, such as matrix[ncbi.nlm.nih.gov] More significant increases were noted for the 8 - isoPGF(2a) total plasma level, which was enhanced over 4-fold, and for the urine 8 - isoPGF(2a) level, which was increased[ncbi.nlm.nih.gov] The 8 - isoPGF(2a) total plasma level consists of free and esterified form.[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Venezuelan Equine Encephalitis

    […] papain-like human ubiquitin specific proteases (USP).[ncbi.nlm.nih.gov] The half-life of hu1A4A1IgG1-2A in mice was approximately 2 days.[ncbi.nlm.nih.gov] It also has protease activity, allowing cleavage of itself from the growing structural polypeptide during translation.[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Hepatitis A

    KEYWORDS: 2A peptide; Bicistronic expression vector; Caspase-independent cell death; Human hepatitis A virus 3C protease; Suicide gene therapy; Yeast cytosine deaminase/uracil[ncbi.nlm.nih.gov] HAV biomarker 2A allowed the differentiation between previously infected and vaccinated individuals.[ncbi.nlm.nih.gov] Direct sequencing of nested PCR products was performed, and all the examined samples were identical in the VP1/2A region of the hepatitis A virus genome.[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Plague

    This outer membrane protease is an essential virulence factor that is steadily expressed by Y. pestis.[ncbi.nlm.nih.gov] This study was a randomized phase 2a clinical trial aimed to evaluating the immunogenicity and safety of a novel subunit plague vaccine.[ncbi.nlm.nih.gov] Substances Antigens, Bacterial Bacterial Proteins Biomarkers Cytokines Epitopes, B-Lymphocyte Immunoglobulin G Plague Vaccine Vaccines, Live, Unattenuated Virulence Factors Pla protease[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Nasal Polyp

    Activated coagulation factors play important roles not only in thrombosis but also in inflammation through interaction with protease-activated receptors (PAR).[ncbi.nlm.nih.gov] The objectives of this study were to establish patterns of polyp recurrence and evaluate the effect of frontal sinus surgery (Draf 2a vs. Draf 3) on polyp recurrence.[ncbi.nlm.nih.gov] The concentrations of TF and TFPI released into culture medium by normal human nasal epithelial cells treated with thrombin, protease-activated receptor 1 agonist peptide,[ncbi.nlm.nih.gov]

    Missing: mengovirus
  • Classical Swine Fever

    The first protein to be translated is the N-terminal protease (N(pro)).[ncbi.nlm.nih.gov] Three expressed genes had been sequentially connected with foot-and-mouth disease virus 2A (FMDV 2A).[ncbi.nlm.nih.gov] protease activity 1 Active site i 1447 For cysteine protease NS2 activity 1 Active site i 1461 For cysteine protease NS2 activity 1 Active site i 1512 For cysteine protease[uniprot.org]

    Missing: mengovirus
  • Desipramine

    This effect can be prevented by incubation of the cells with the protease inhibitor leupeptin, which suggests that desipramine induces proteolytic degradation of the lysosomal[ncbi.nlm.nih.gov] In the present study, we have characterized the direct interaction between DMI and the α(2A)-adrenergic receptor (α(2A)AR), a key regulator of noradrenergic neurotransmission[ncbi.nlm.nih.gov] Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo.[hivinsite.ucsf.edu]

    Missing: mengovirus
  • Coxsackievirus Infection

    Overexpression of viral protease 2A reproduced CVB3-induced cytoplasmic redistribution of AUF1, while in vitro cleavage assay revealed that viral protease 3C contributed to[ncbi.nlm.nih.gov] We showed that GAB2 is cleaved at G238 during CV-B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N 1-237 and GAB2-C 238-676 .[ncbi.nlm.nih.gov] In an effort to discover how cells detect viral infections, we found that the viral protease 3C(pro) cleaves IkappaBalpha.[ncbi.nlm.nih.gov]

    Missing: mengovirus