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4,408 Possible Causes for 3, CHINESE, COMPLEMENTING, DEFECTIVE,, HAMSTER,, IN, REPAIR,, X RAY

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  • Xeroderma Pigmentosum

    , COMPLEMENTATION GROUP B; XPB]() Human gene(s) implicated [EXCISION REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 3; ERCC3]() Symptoms and phenotype See general description[flybase.org] This complex is a structure-specific endonuclease responsible for the 5' incision during repair.[ncbi.nlm.nih.gov] PATIENTS AND METHODS: Patients were stratified into high-XPG ( 3) or low-XPG ( 3) groups.[ncbi.nlm.nih.gov] Normal and XP cells repair X-ray damage equally well. (That is correct.) Neither cell can repair X-ray damage. (No, that is incorrect.)[dnaftb.org] METHODS: This study was based on five unrelated Chinese families with six patients clinically suspected to be XP.[ncbi.nlm.nih.gov] These proteins include ERCC1 (ERCC1 excision repair cross complementing 1 gene; the ERCC genes are also called excision repair, complementing defective, in Chinese hamster[themedicalbiochemistrypage.org] A well-circumscribed hemispherical mass measuring 3 cm 3 cm with smooth surface and brown patches was observed beneath his left lower eyelid.[ncbi.nlm.nih.gov] Cell Culture Human 293-H cells (Life Technologies, Carlsbad, CA), human XP4PA and hamster CHO-KI cells (ATCC) were cultured at 37 C with 5% CO2 in complete medium DMEM for[journals.plos.org]

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  • LIG4 Syndrome

    This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK).[okdb.appliedbioinfo.net] Because defects in DNA repair genes involved in double-strand breaks (DSBs) repair, such as BRCA1 and BRCA2 , are implicated in familiar OC, overall DNA repair capacity may[wjgnet.com] Measurement of phosphorylated (p) ATM, SMC1, and H2AX (γH2AX) was performed by flow cytometry to assess DNA repair defects in a 3-year-old girl.[bloodadvances.org] —Sensitivity of Lig4; Rad54 double-mutant flies to X rays.[genetics.org] Association of LIG4 and XRCC4 gene polymorphisms with the risk of human glioma in a Chinese population.[cancerindex.org] We next examined hamster-expressed R814X LIG4 for adenylation activity.[academic.oup.com] Vaccinia Construction of a vaccinia virus deficient in the essential DNA repair enzyme uracil DNA glycosylase by a complementing cell line.[brenda-enzymes.org] DNA Repair (Amsterdam) 6 : 712 -722. Critchlow, S. E., R. P. Bowater, and S. P. Jackson. 1997 .[mcb.asm.org]

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  • Xeroderma Pigmentosum Complementation Group B

    , COMPLEMENTATION GROUP B; XPB]() Human gene(s) implicated [EXCISION REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 3; ERCC3]() Symptoms and phenotype See general description[flybase.org] ERCC1 (Excision Repair Cross Complementing Polypeptide-1): The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of[antibodies-online.com] B) fibroblasts and group 3 rodent mutants did not yield detectable correction.[ncbi.nlm.nih.gov] See also ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6, as well as the XRCC1 gene that corrects the x-ray sensitivity of the CHO mutant cell line EM-9.[cloud-clone.com] […] in DNA repair and defects in approximately 35 different genes.[ashg.org] Aliases for XPC Gene XPC Complex Subunit, DNA Damage Recognition And Repair Factor 2 3 5 Xeroderma Pigmentosum, Complementation Group C 2 3 P125 3 4 XPCC 3 4 Xeroderma Pigmentosum[genecards.org] These four genes participate in DNA damage excision activity, gene-specific repair, and linkage of DNA repair with DNA transcription.[ncbi.nlm.nih.gov] X-ray and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes .[cambridge.org]

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  • Xeroderma Pigmentosum Complementation Group F

    Abstract Genetic complementation studies allowed assignment of a 22-year-old-white woman to the rare complementation group of classic, excision-defective xeroderma pigmentosum[ncbi.nlm.nih.gov] XPF/ERCC1 endonuclease is required for DNA lesion repair.[ncbi.nlm.nih.gov] Mar 2012;132(3 Pt 2):785-96. Warrick E, Garcia M, Chagnoleau C, Chevallier O, Bergoglio V, Sartori D, et al.[afjho.com] XRF X-ray fluorescence XRII X-ray image intensifier XRMR X-linked recessive mental retardation XRN X-linked recessive nephrolithiasis XRS X-ray sensitivity XRT X-ray therapy[globalrph.com] […] cross-complementation group 4 antibody excision repair cross-complementing rodent repair deficiency, complementation group 4 antibody excision-repair, complementing defective, in Chinese hamster[bethyl.com] Complementation assay revealed that transfection of the XPF gene led most efficient DNA repair compared with the other XP genes.[ncbi.nlm.nih.gov] Single skin cancers occurred in only 3 of the 11 patients with an average age of 52 years for their first skin malignancy.[ncbi.nlm.nih.gov] The First Affiliated Hospital of Xinxiang Medical University, Weihui, China [email protected] 3 Department of Neurosurgery, Peking Union Medical College Hospital Chinese[ncbi.nlm.nih.gov]

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  • Cockayne Syndrome

    However, cell fusion complementation tests with CS group A and B cells resulted in correction of RRS after UV irradiation.[ncbi.nlm.nih.gov] repair (BER) of oxidized DNA bases both directly (by interaction with BER proteins) and indirectly (by modulating the expression of the DNA repair genes).[ncbi.nlm.nih.gov] Electronic address: [email protected] 3 Department of Dental Anesthesiology, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka[ncbi.nlm.nih.gov] In contrast, RNA polymerase I-dependent transcription was severely inhibited at 5 Gy in normal cells, indicating different mechanisms of transcription response to X rays.[ncbi.nlm.nih.gov] In this study, we describe the case of a 7-year-old Chinese boy with characteristic symptoms of Cockayne syndrome A and the conduction of mutation screening of the CSA gene[ncbi.nlm.nih.gov] Morten Sunesen, Tinna Stevnsner, Robert M Brosh Jr, Grigory L Dianov and Vilhelm A Bohr , Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product[doi.org] Cockayne syndrome (CS) is a premature aging disorder characterized by developmental defects, multisystem progressive degeneration and sensitivity to ultraviolet light.[ncbi.nlm.nih.gov] In addition, CSB-deficient UV61 Chinese hamster ovary cells show reduced ICL unhooking in G1 following treatment with psoralen/UVA relative to wild-type cells ( 15 ).[doi.org]

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  • Fanconi Anemia

    OBJECTIVE: To characterize the impact of genetic complementation groups on central nervous system anatomy.[ncbi.nlm.nih.gov] Defects in DNA repair pathways have been involved in collapse of early neurogenesis leading to brain development abnormalities and embryonic lethality.[doi.org] Abstract To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical[ncbi.nlm.nih.gov] Special precautions with medicines and diagnostic tests or treatments with X-ray or radiation Fanconi anemia is a life-long disease that can be life threatening.[urmc.rochester.edu] This is the first Chinese FA-L case caused by a novel FANCL mutation.[ncbi.nlm.nih.gov] We identified the gene as human XRCC9, a gene which has been shown to complement the MMC-sensitive Chinese hamster mutant UV40, and is suspected to be involved in DNA post-replication[ncbi.nlm.nih.gov] However, it is still a challenge to assign the complementation group and to characterize the molecular defects in patients with Fanconi anemia.[ncbi.nlm.nih.gov] DNA is constantly damaged by a variety of agents including ultraviolet light from the sun, flourescent lights, and other sources, ionizing radiation from the cosmos, X-ray[forgottendiseases.org]

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  • Xeroderma Pigmentosum Complementation Group C

    Abstract The distribution of ultraviolet-induced DNA repair patches in the genome of xeroderma pigmentosum cells of complementation group C was investigated by determining[ncbi.nlm.nih.gov] Cell Cycle versus DNA Repair Defects 90 Genotype and Phenotype Correlation of AT Patients 93 Mechanisms of DNA Damage and Repair in Alzheimer Disease V Prakash Reddy George[books.google.com] Mar 2012;132(3 Pt 2):785-96. Warrick E, Garcia M, Chagnoleau C, Chevallier O, Bergoglio V, Sartori D, et al.[afjho.com] Using bioinformatics tools, and a combination of several experimental methods (circular dichroism, fluorescence, nuclear magnetic resonance, and small-angle X-ray scattering[ncbi.nlm.nih.gov] We collected two unrelated Chinese patients showing typical symptoms of XPC without neurologic symptoms.[ncbi.nlm.nih.gov] These proteins include ERCC1 (ERCC1 excision repair cross complementing 1 gene; the ERCC genes are also called excision repair, complementing defective, in Chinese hamster[themedicalbiochemistrypage.org] […] or 3.[ncbi.nlm.nih.gov] It also highlights the fact that even though the patients of XP are sensitive to the ionizing effects of UV rays, use of therapeutic X-rays in the form of external beam radiotherapy[ccij-online.org]

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  • UV-Sensitive Syndrome

    However, cell fusion complementation tests with CS group A and B cells resulted in correction of RRS after UV irradiation.[ncbi.nlm.nih.gov] Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways[doi.org] UV-sensitive syndrome type 3 (UVSSA) DNA Test Leave Message Reporting Time: 5 Week Test Cost: 30000.00 /- Rs Sample Type: EDTA blood or DNA UV-sensitive syndrome type 3 (UVSSA[dnalabsindia.com] […] nucleotide-excision repair, preincision complex assembly GO:0006294 9.7 ERCC2 ERCC3 ERCC5 15 response to UV GO:0009411 9.7 ERCC2 ERCC3 ERCC5 ERCC6 ERCC8 PGBD3 16 response to X-ray[malacards.org] […] help diagnosis eye and balance problems Ng or Eng, a surname Velar nasal or eng, a phoneme Eng, Tyrol , an exclave in Tyrol, Austria People with the surname Esther Eng , Chinese–American[newspaperslibrary.org] Spivak G. and Hanawalt P.C. (1996) Fine structure mapping of DNA repair within a 100 kb genomic region in Chinese hamster ovary cells, Mutat. Res. 350:207-216.[stanford.edu] In contrast, Cockayne syndrome (CS) patients exhibit severe developmental and neurological defects, in addition to photosensitivity.[ncbi.nlm.nih.gov] The following procedures may be used in the staging process: Chest x-ray : An x-ray of the organs and bones inside the chest.[my.clevelandclinic.org]

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  • Xeroderma

    , COMPLEMENTATION GROUP B; XPB]() Human gene(s) implicated [EXCISION REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 3; ERCC3]() Symptoms and phenotype See general description[flybase.org] These studies also have served to elucidate the nucleotide excision repair (NER) process, especially the critical role played by the XPA protein.[ncbi.nlm.nih.gov] Chemotherapy with intravenous 5-flourouracil (1000 mg/m) for 5 days and cisplatin (50 mg/m) for 2 days for 3 cycles every 3 weeks was well tolerated.[ncbi.nlm.nih.gov] UV rays cause DNA damage by dimer formation whereas X-rays will cause single- or double-stranded breaks in DNA.[ncbi.nlm.nih.gov] Lookup English - English (Wordnet) English - Vietnamese Vietnamese - English Vietnamese - Vietnamese Vietnamese - French French - Vietnamese Computing English - English Chinese[vdict.com] James Cleaver hypothesized that a defect in a DNA repair system caused the disease.[dnaftb.org] These proteins include ERCC1 (ERCC1 excision repair cross complementing 1 gene; the ERCC genes are also called excision repair, complementing defective, in Chinese hamster[themedicalbiochemistrypage.org] The defect in this condition is not in NER, but is instead in postreplication repair.[emedicine.medscape.com]

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  • Xeroderma Pigmentosum-Cockayne Syndrome Complex

    PMID 8823375 Xeroderma pigmentosum complementation group G--report of two cases.[atlasgeneticsoncology.org] Abstract Two brothers had a complex combination of two DNA repair disorders: Cockayne syndrome and xeroderma pigmentosum.[ncbi.nlm.nih.gov] Normal and XP cells repair X-ray damage equally well. (That is correct.) Neither cell can repair X-ray damage. (No, that is incorrect.)[dnaftb.org] […] hamster, 1 ERCC1 RAD10 126380 3433 ERCC excision repair 2, TFIIH core complex helicase subunit DNA repair defect EM9 of chinese hamster ovary cells, complementation of excision[ukgtn.nhs.uk] DNA Repair 9(1): 2–10.[els.net] Cancer Institute (NCI) ) Brief Summary: Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective[clinicaltrials.gov] , COMPLEMENTATION GROUP B; XPB]() Human gene(s) implicated [EXCISION REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 3; ERCC3]() Symptoms and phenotype See general description[flybase.org] Fig. 3.[pnas.org]

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