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533 Possible Causes for 3, Kinase, MEK

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  • Glomerulonephritis

    Activation of spleen tyrosine kinase (SYK), Bruton's tyrosine kinase (BTK), platelet-derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR) and discoidin[ncbi.nlm.nih.gov] Treatment started in November 2015, with Encorafenib and Binimetinib, new BRAF and MEK inhibitors, respectively.[ncbi.nlm.nih.gov] Abuse may lead to severe psychological or physical dependence. 3 Has a potential for abuse less than those in schedules 1 and 2.[drugs.com]

  • Carbachol

    […] to protein kinase C (PKC) zeta, and by the p70S6K inhibitor rapamycin.[ncbi.nlm.nih.gov] MEK/ERK/RSK pathway plays a critical role in p70S6K1 activation in GPCR-stimulated T84 cells.[ncbi.nlm.nih.gov] In this study, the effect of carbachol on insulin-stimulated PI 3-kinase (PI3K) activity was examined in SH-SY5Y cells.[ncbi.nlm.nih.gov]

  • Ocular Albinism

    Other clinical findings in the complex glycerol kinase deficiency (CGKD) patients are mental retardation, short stature, and hypogonadotropic hypogonadism.[ncbi.nlm.nih.gov] Stimulation of the RAS/RAF/mitogen activated protein kinase kinase (MEK)/extracellular signal‑regulated kinase (ERK) pathway using growth factors enhanced OA1 expression and[ncbi.nlm.nih.gov] S1 - 1st & 2nd Medical Students S2 - 3rd & 4th Medical Students L1 - PGY1 & PGY2 L2 - PGY3 L3 - PGY4 L4 - PGY5 L5 - Fellow L6 - 1-3 years in practice L7 - 3-10 years in practice[medbullets.com]

  • Lyme Disease

    METHODS: In this study, we explored the role of several TLR and EGFR/FGFR/PDGFR tyrosine kinase pathways in inducing inflammation in the presence of B. burgdorferi, using[ncbi.nlm.nih.gov] We report 3 cases with endometriosis and Lyme disease. Of 405 patients with endometriosis treated in our study over a 6-year period, 3(0.8%) had Lyme disease.[ncbi.nlm.nih.gov] The c-di-GMP network of Borrelia burgdorferi, a causative agent of Lyme disease, consists of Rrp1, a diguanylate cyclase/response regulator; Hpk1, a histidine kinase; PdeA[ncbi.nlm.nih.gov]

  • Opioid Withdrawal

    In contrast, opioid withdrawal following chronic activation of MOR uncovers AC superactivation and subsequent increases in cAMP and protein kinase A (PKA) activity.[ncbi.nlm.nih.gov] Data collected included: opioid withdrawal score (WAT-1), opioid taper rate (total dose of opioid per day in morphine equivalents per kilogram [MEK]), pretaper peak MEK, pretaper[ncbi.nlm.nih.gov] At 2 to 3 months follow-up, patients reported decreased, but ongoing pain, with improvements in functional capacity and quality of life.[ncbi.nlm.nih.gov]

  • Indomethacin

    We investigated the role of the intracellular energy-sensing AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway in the in vitro antiglioma effect[ncbi.nlm.nih.gov] Pretreatment with the p38 MAPK inhibitor significantly attenuated the disruption of barrier function, but JNK and MEK/ERK inhibition had no effect.[ncbi.nlm.nih.gov] Among these compounds, 3-[5-methoxy-2-methyl-1-(4-chlorobenzoyl)-1H-indole-3-yl)methyl]-6-(4-methylphenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine (8) was found to be the[ncbi.nlm.nih.gov]

  • Granulosa Cell Tumor

    […] report a case of a 60-year-old woman with a heavily pretreated recurrent, c-kit positive, GCT of the ovary who underwent an experimental therapy with imatinib, a tyrosine kinase[ncbi.nlm.nih.gov] TGFα also rapidly activated the EGFR/MEK/ERK pathway, and P38 MAPK pathways, as indicated by the rapid phosphorylation of EGFR, MEK, ERK1/2, P38, and CREB after TGFα treatment[ncbi.nlm.nih.gov] Thus, analyses of the Foxo1/3/Pten mouse GCTs and human adult GCTs provide strong evidence that impaired functions of the FOXO1/3/PTEN pathways lead to dramatic changes in[ncbi.nlm.nih.gov]

  • Polyploidy

    Many small-molecule inhibitors of Aurora kinases are currently undergoing clinical trials. Aurora A kinase is essential for successful mitotic transition.[ncbi.nlm.nih.gov] […] this study, we show how Ras activation causes aberrant nuclear localization of phosphorylated mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK; MEK[ncbi.nlm.nih.gov] RV-treated PC-3 cells showed enlarged nuclei and an estimated 100-fold increase in cell size.[ncbi.nlm.nih.gov]

  • Esophagitis

    NF-κB-inducing kinase (NIK; MAP3K14) is a key signaling molecule of the noncanonical NF-κB (NFKB1) pathway, an alternative signaling cascade producing chemokines involved[ncbi.nlm.nih.gov] CDX, Caudal-related homeobox; ERK, extracellular-signal-regulated kinase; GORD, gastro-oesophageal reflux disease; IL, interleukin; MAPK, mitogen-activated protein kinase; MEK[biochemsoctrans.org] K 3 , Kon M 3 , Okazaki K 1 .[ncbi.nlm.nih.gov]

  • Anemarrhena

    […] cells with advanced glycation end products (AGEs) to establish the model of endothelial dysfunction in vitro and observed the effect of TPAA (10, 30, or 100 μg/mL) on AMP-Kinase[ncbi.nlm.nih.gov] Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK[ncbi.nlm.nih.gov] Growth inhibition, induction of cell death, morphological features, the presence of DNA ladders, increases in caspase-3-like activity, the effects of a caspase-3 inhibitor[ncbi.nlm.nih.gov]