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5,658 Possible Causes for 3,, Aldehyde, homolog, mouse, oxidase

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  • Parasite

    Although heme C is found in many cytochrome c and c1 proteins, heme A is the cofactor of only one known protein, cytochrome c oxidase (CcO).[ncbi.nlm.nih.gov] Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway.[ncbi.nlm.nih.gov] We found that expression of aquaporin-3 (AQP3), a water and glycerol channel, is significantly induced in Plasmodium-infected hepatocytes compared to uninfected cells.[ncbi.nlm.nih.gov] We describe an oxidative enzymatic pathway composed of host semicarbazide-sensitive amine oxidase and a trypanosomal aldehyde dehydrogenase TbALDH3.[ncbi.nlm.nih.gov] Further hybridization analyses against a panel of different monoxenous and heteroxenous trypanosomatids showed kDNA cross-homology with Leptomonas pulexsimulantis a trypanosomatid[ncbi.nlm.nih.gov]

  • Vasodilator

    Furthermore, the nobiletin‑induced VASP phosphorylation was surprisingly reversed by the intracellular antioxidant, N-acetylcysteine (NAC), but not by the inhibitor of NADPH oxidase[ncbi.nlm.nih.gov] […] not modulate vasodilator NO production or superoxide levels in mouse systemic arteries.[ncbi.nlm.nih.gov] Long-chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA) may improve brain functions by acting on endothelial cells in the cerebrovasculature to facilitate vasodilatation[ncbi.nlm.nih.gov] In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature.[ncbi.nlm.nih.gov] Wild-type and sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein-2 knockout mice inoculated with influenza A.[ncbi.nlm.nih.gov]

  • Cassia

    Pretreatment with the three glycosides increased nuclear factor erythroid-2-related factor 2 (Nrf2)-mediated heme oxidase-1 (HO-1) expression.[ncbi.nlm.nih.gov] […] attempt to find potent repigmenting agents for vitiligo therapy, pod extracts of Cassia occidentalis was found to be effective in inducing differentiation and migration of mouse[ncbi.nlm.nih.gov] Two new compounds, cinnamic aldehyde cyclic d-galactitol 3'R,4'S-acetal (1) and cinnamomumolide (2), along with six known compounds, syringaresinol (3), lyoniresinol (4),[ncbi.nlm.nih.gov] CCE significantly reduced p-focal adhesion kinase (FAK) Tyr397, p-FAK Tyr925, p-extracellular signal-regulated kinases (ERK)1/2, and Ras homolog gene family (Rho)A expression[ncbi.nlm.nih.gov] Effect of CO on carrageenan-induced mouse paw oedema inhibition was also assessed. CO significantly decreased maximum protection of 80.8% at 15 microg/ml.[ncbi.nlm.nih.gov]

  • Croton

    COX-2 mRNA expression decreases significantly, while human mitochondrial cytochrome C oxidase subunit IImRNA expression increases significantly in HIEC treated with CO.[ncbi.nlm.nih.gov] The hemolytic potential in mouse erythrocytes was also tested for 1-3.[ncbi.nlm.nih.gov] O-rhamnoside (myricetrin, 1), quercetin-3-O-rhamnoside (2) and quercetin (3) along with an indole alkaloid, (E)-N-(4-hydroxycinnamoyl)-5-hydroxytryptamine, [trans-N-(p-coumaroyl[ncbi.nlm.nih.gov] Among them, compound (1) was the first example of a naturally occurring phorbol ester with the 20-aldehyde group.[ncbi.nlm.nih.gov] Compounds 3- 12 were identified by comparison of their spectroscopic and physical data with those reported in the literature.[ncbi.nlm.nih.gov]

  • Aristolochic Acid

    We previously investigated the efficiencies of human and rat CYPs in the presence of two other components of the mixed-functions-oxidase system, NADPH:CYP oxidoreductase and[ncbi.nlm.nih.gov] We found that NQO1 levels in liver, kidney and lung of Cyp1a1 / , Cyp1a2 / and Cyp1a1/1a2 / knockout mouse lines, as well as in two CYP1A-humanized mouse lines harboring functional[ncbi.nlm.nih.gov] In this study, we found that organic anion transporters (OATs) 1 and 3, proteins known to transport drugs from the blood into the tubular epithelium, are responsible for the[ncbi.nlm.nih.gov] OH \ O / \\ / _pO_p_pO_p \ \ // \ /\/ \ /c/ \/ \ /_o 0\0 \/ \ /0_o 0 / \/ \0_o Elemental composition Acid Acid anhydride Acid salt Acidity regulator Acyl chloride Alcohol Aldehyde[charchem.org] […] factor-2α (eIF2α) phosphorylation, X-box binding protein 1 (XBP1) mRNA splicing and the expression of glucose-regulated protein (GRP) 78 and CAAT/enhancer-binding protein-homologous[ncbi.nlm.nih.gov]

  • Hydralazine

    Aldehyde oxidase (AO) metabolism could lead to significant underestimation of clearance in prediction of human pharmacokinetics as well as unanticipated exposure to AO-generated[ncbi.nlm.nih.gov] The antinuclear antibody (ANA) titer on routine mouse liver substrate was initially negative, but the ANA titer was positive (1:1,920) on human epithelioid cell substrate.[ncbi.nlm.nih.gov] The purpose of this study was to evaluate the influence of the guanine nucleotide-binding proteins (G-proteins), beta-3 subunit (GNB3) genotype on the effectiveness of a fixed-dose[ncbi.nlm.nih.gov] In the present study, a binding model for hydralazine, with a validated homology model of human DNMT, was developed by the use of automated molecular docking and molecular[ncbi.nlm.nih.gov] Hydralazine down regulated the expression of Receptor for Advanced Glycation End products (RAGE), NADPH oxidase (NOX), and super oxide dismutase (SOD).[ncbi.nlm.nih.gov]

  • Francisella Tularensis

    Two other human strains were oxidase negative and H2S negative.[ncbi.nlm.nih.gov] We utilized the system to understand why the clpB gene deletion mutant, ΔclpB, of SCHU S4 shows superior efficacy as a vaccine in the mouse model as compared to the existing[ncbi.nlm.nih.gov] Outbreak and archival genomes frequently differed by only 1-3 of 1 585 229 examined nucleotides.[ncbi.nlm.nih.gov] In addition, the ultrastructural preservation of bacteria was compared using either chemical fixation by aldehydes and a standard resin embedding protocol or high-pressure[duo.uio.no] Only the OxyR homolog is present in F. tularensis, while the SoxR homologs are absent. The functional role of OxyR has not been established in F. tularensis.[ncbi.nlm.nih.gov]

  • Halothane

    Neither the mitochondrial complex I inhibitors rotenone, myxothiazol and sodium cyanide, nor the NADPH oxidase inhibitors diphenylene iodonium and phenylarsine oxide, were[ncbi.nlm.nih.gov] TSLP was constitutively expressed by mouse hepatocytes and increased during HILI.[ncbi.nlm.nih.gov] Galphai-3 nucleotide exchange was measured in crude membranes prepared from COS-7 cells transiently coexpressing the M2 muscarinic receptor and Galphai-3.[ncbi.nlm.nih.gov] Excretion of aldehydes, acetone, and o,o'-dityrosine was measured before and after anesthesia. Blood samples were analysed for clinical markers.[ncbi.nlm.nih.gov] Despite a high level of sequence homology, tandem pore domain halothane-inhibited K( ) channel 1 (THIK1) produces background K( ) currents, whereas THIK2 is silent.[ncbi.nlm.nih.gov]

  • Sorbitol

    The maximum specific alcohol oxidase activity was not affected in the presence of sorbitol, and it was observed that sorbitol and methanol were utilized simultaneously.[ncbi.nlm.nih.gov] In mouse and human kidney tissues, ZAC1 expression was substantial in the papilla and was absent in the cortex.[ncbi.nlm.nih.gov] Moreover, inhibition of JNK, but not ERK1/2 or p38 MAPK, efficiently prevented sorbitol-induced apoptosis and caspase-3 activation.[ncbi.nlm.nih.gov] The role of aldehyde reductase tyrosine phenol group is to serve as a general acid to provide proton to the reduced aldehyde oxygen on glucose.[en.wikipedia.org] […] xylitol dehydrogenases of the medium-chain dehydrogenase/reductase superfamily involves direct or water-mediated interactions from a glutamic acid residue, which substitutes a homologous[ncbi.nlm.nih.gov]

  • Captopril

    […] are ROS- and NAD(P)H oxidase dependent.[ncbi.nlm.nih.gov] Fifteen days after the transplantation of A549 cells, mice (six in each group) were treated with captopril (3.0 mg/mouse) or saline (1000 μl/mouse) for 5 days.[ncbi.nlm.nih.gov] However, ACE-inhibitor renal scanning with 99mTc MAG-3 gave disparate results on the two occasions.[ncbi.nlm.nih.gov] Two other drugs, the aldehyde dehydrogenase inhibitor disulfiram used to treat alcoholism and the anti-HIV protease inhibitor nelfinavir also have a database supporting their[ncbi.nlm.nih.gov] The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with similar but distinct substrate and[ncbi.nlm.nih.gov]

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