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25 Possible Causes for 3-4 Hz Spikes, 3-6 Hz Polyspikes, Genetic Heterogeneity

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  • Benign Adult Familial Myoclonic Epilepsy

    The EEG reveals 4 to 6 Hz bilateral symmetric polyspike-wave complexes or 2-3 Hz spike wave complexes. Photosensitivity is common ( 70%).[] Abstract Benign adult familial myoclonic epilepsy (BAFME) has been mapped to chromosome 8q24; however, genetic heterogeneity has been recently suggested.[] Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24.[]

  • Juvenile Myoclonic Epilepsy

    Interictal electroencephalography (EEG) displays 3-6 Hz spike/polyspike and wave pattern. Photosensitivity is common.[] Abstract Juvenile myoclonic epilepsy (JME) is a clinically and genetically heterogenous, generalized epilepsy syndrome usually starting in adolescence.[] Interictal electroencephalography (EEG) in JME shows interictal epileptiform discharges such as generalized spikes, polyspikes, bilateral-synchronous 4-6/s spike-wave complexes[]

  • Epilepsy

    Progressive myoclonic epilepsies (PME) are a clinically and genetically heterogeneous group of rare diseases characterized by myoclonic seizures, tonic-clonic seizures, and[] […] to 8 years of age, in an otherwise apparently healthy child. 3 The classic electroencephalogram (EEG) shows generalized spike-wave bursts (of 3 Hz) with normal background[] This observation along with our previous findings of hot water genetic loci at 10q21.3-q22.3 (OMIM: 613339) and 4q24-q28 (OMIM: 613340), indicates unanticipated genetic heterogeneity[]

  • Idiopathic Generalized Epilepsy

    5 Hz polyspikes and waves with frontocentral predominance Interictal EEG : 4–6 Hz bilateral polyspike and slow wave Responds well to antiseizure drug therapy; seizures become[] The lack of significant association evidence of single variants with disease in this two-stage approach emphasizes the high genetic heterogeneity of epilepsy disorders, suggests[] […] etiology, where heterogeneous combinations of genetic factors determine the disease phenotype.[]

  • Myoclonic-Astatic Epilepsy

    […] years of age; (3) presence of generalized spike- or polyspike-wave EEG discharges at 2-3 Hz, without focal spike discharges; and (4) exclusion of severe and benign myoclonic[] […] influences and clues for genetic heterogeneity, and discuss strategies that may be helpful in elucidating the etiology of MAE in light of current genetic techniques.[] […] years; EEG findings of generalized spikes or polyspike-wave discharges at 2-3 Hz with an absence of focal spikes; Exclusion of other syndromes, specifically, cryptogenic Lennox-Gastaut[]

  • Generalized Clonic or Tonic-Clonic Seizures

    Genetic Heterogeneity of Progressive Myoclonic EpilepsyProgressive myoclonic epilepsy refers to a clinically and genetically heterogeneous group of neurodegenerative disorders[] The EEG shows generalised spike and wave discharges of 3 to 4 Hz and some with photic sensitivity. This is potentially a lifelong epilepsy.[] Genetic Heterogeneity of Mosaic Variegated Aneuploidy SyndromeSee also MVA2 ( OMIM ), caused by mutation in the CEP57 gene ( OMIM ) on chromosome 11q21, and MVA3 ( OMIM ),[]

  • Juvenile Absence Epilepsy

    An EEG in untreated individuals is typically abnormal with a specific EEG pattern, known as a 3-6 Hz generalized polyspike and wave discharge.[] Página 112 - JC (1998) Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Am. J. Hum.[] Diagnostic methods Diagnosis relies on the clinical features and on electroencephalogram (EEG) recorded awake and during sleep, that displays a generalized 3-4 Hz spike-and-slow-wave[]

  • West Syndrome

    West syndrome is genetically heterogeneous, and its genetic causes have not been fully elucidated.[] This disorder is genetically heterogeneous, with up to a fifth of cases resulting from mutations in the CDKL5 gene.[] Despite the heterogeneity of unexplained West syndrome, the combination of array CGH and whole-exome sequencing is an effective means of evaluating the genetic background[]

  • Lennox-Gastaut Syndrome

    There is no single gene for IS or LGS, but the genetic architecture is heterogeneous.[] Hz theta and G PSW Rarely M Dravet/SIME Febrile, other seizures at 2–3 years Slow with irregular spike wave Rare Rare Yes M AA GTC Focal West Usually Hypsarrhythmia Yes Yes[] The clinical symptoms associated with chromosome 15q duplication syndrome manifest through a heterogeneous group of symptoms characterised by hypotonia, delay in motor skills[]

  • Early Infantile Epileptic Encephalopathy Type 3

    For a general phenotypic description and a discussion of genetic heterogeneity of EIEE, see EIEE1 ({308350}).[] This syndrome is likely to be the earliest age-related specific epileptic reaction of the developing brain to heterogeneous insults Neonatal epileptic seizures - Genetic testing[] The Orphanet rare disease nomenclature is comprised of a heterogeneous typology of entities of decreasing extension, including: groups of disorders, disorders, sub-types.[]

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