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21 Possible Causes for 3-4 Hz Spikes, Variable Psychomotor Retardation

  • Myoclonic-Astatic Epilepsy

    retardation mainly affecting speech.[ipfs.io] […] presence of generalized spike- or polyspike-wave EEG discharges at 2-3 Hz, without focal spike discharges; and (4) exclusion of severe and benign myoclonic epilepsy (SME,[ncbi.nlm.nih.gov] Boys (74%) are more often affected than girls (Doose and Baier 1987a). [2] Prognosis Epilepsy with myoclonic-astatic seizures has a variable course and outcome.[ipfs.io]

  • West Syndrome

    […] clinical manifestations such as hypotonia, psychomotor retardation, and feeding difficulties.[ncbi.nlm.nih.gov] Leigh syndrome (LS) (sub-acute necrotizing encephalomyelopathy) is characterized by symmetric brain lesions occurring mainly in the basal ganglia and associated with variable[ncbi.nlm.nih.gov]

  • Alobar Holoprosencephaly

    Milder forms are associated with variable psychomotor retardation depending on the pathology. Diabetes insipidus is frequent in these patients.[neuropathology-web.org] Childhood absence epilepsy with tonicclonic seizures and electroencephalogram 3-4-Hz spike and multispikeslow wave complexes: linkage to chromosome 8q24.[books.google.es]

  • Lissencephaly

    Clinical manifestations include swallowing and feeding difficulties, abnormal muscular tone, seizures and severe to profound psychomotor retardation.[orpha.net] Childhood absence epilepsy with tonicclonic seizures and electroencephalogram 3-4-Hz spike and multispikeslow wave complexes: linkage to chromosome 8q24.[books.google.es] Female patients display a less severe malformation referred to as ''doublecortex'' or subcortical laminar heterotopia (SCLH) and present with clinical signs of variable severity[orpha.net]

  • Ring Chromosome 10

    The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com] High amplitude 2-3 Hz frontal predominant activity may be seen; symmetrical 4-6 Hz high voltage activity or 3-6 Hz occipital activity overlaid with spikes and sharp waves[epilepsydiagnosis.org]

  • Ring Chromosome 17

    The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com] High amplitude 2-3 Hz frontal predominant activity may be seen; symmetrical 4-6 Hz high voltage activity or 3-6 Hz occipital activity overlaid with spikes and sharp waves[epilepsydiagnosis.org]

  • Ring Chromosome 11 Syndrome

    The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com] High amplitude 2-3 Hz frontal predominant activity may be seen; symmetrical 4-6 Hz high voltage activity or 3-6 Hz occipital activity overlaid with spikes and sharp waves[epilepsydiagnosis.org]

  • Ring Chromosome 14 Syndrome

    The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com] High amplitude 2-3 Hz frontal predominant activity may be seen; symmetrical 4-6 Hz high voltage activity or 3-6 Hz occipital activity overlaid with spikes and sharp waves[epilepsydiagnosis.org]

  • Ring Chromosome 15

    The clinical variability of fourteen r(Jeny6) individuals when reviewed was shown to include growth failure, psychomotor retardation, eye and facial abnormalities and abnormal[tp.amegroups.com] High amplitude 2-3 Hz frontal predominant activity may be seen; symmetrical 4-6 Hz high voltage activity or 3-6 Hz occipital activity overlaid with spikes and sharp waves[epilepsydiagnosis.org]

  • Adenylosuccinate Lyase Deficiency

    As a result, patients may have variable combinations of psychomotor retardation and/or regression, seizures, autistic features and cerebellar vermis hypoplasia.[ncbi.nlm.nih.gov] In childhood, the EEG showed high voltage 4-6 Hz activity and in adulthood it showed rhythmic triphasic 2-3 Hz activity of high amplitude (200-500 mV), mixed with spikes or[pediatricneurosciences.com] The symptoms are variable and include psychomotor retardation, autistic features, hypotonia, and seizures.[ncbi.nlm.nih.gov]

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