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  • Nasal Polyp

    BACKGROUND: In patients with persistent upper airway inflammation, the number of forkhead box protein 3 (Foxp3)( ) regulatory T (Treg) cells is reduced, but the regulation[] Interleukin-6 (IL-6) is a multifunctional cytokine, implicated in various inflammatory conditions, including NP pathogenesis.[] OPN induced VEGF production by DNPCs in a time- and dose-dependent manner through phosphatidylinositol 3-kinase- protein kinase B and the extracellular signal-regulated kinase[] The transcriptional expression of three subunits of ENaC was in the following order: α β γ, in both groups.[] BACKGROUND: To elucidate the interaction between hypoxia-induced autophagy and glycolysis in nasal polyp fibroblasts, and the regulatory role of Sirtuin 6 (SIRT6) in the pathogenesis[]

  • Iris

    Interestingly, the percentage of regulatory T cells (Treg) on the CNS-IRIS patient reached a minimum around 1 month before symptoms onset.[] Purpose: To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model of[] Heterozygous mutation of paired box 6 (PAX6) gene was identified in most cases of aniridia, with iatrogenic mutations accounting for about two-third of the cases and chromosomal[] Her external ocular examination was unremarkable and visual acuity was 6/6 in the right eye (RE) and 6/9 in the LE.[] Epub 2017 Nov 6.[]

  • Orchitis

    PROBLEM: The phenotype and function of regulatory T (Treg) cells in rats with experimental autoimmune orchitis (EAO) was evaluated.[] […] fibrosis, and 3 of 6 cases had plasma cells with an IgG4 /IgG ratio 40%.[] In this study, we show that MC-LR induced immune responses in Sertoli cells (SC), germ cells (GC), and Leydig cells (LC) via activating phosphatidylinositol 3-kinase (PI3K[] Urology. 2011 Dec;78(6):1414-6. doi: 10.1016/j.urology.2011.04.012. Epub 2011 Jun 15.[] ) with a granulomatous reaction and associated seminoma (GS, n 6); and unclassified intratubular granulomatous orchitis not fitting into a specific entity (UGO, n 4).[]

  • Chlorpromazine

    Six polymorphisms across the whole region of this gene were analyzed, namely rs2652511 (T-844C) and rs2975226 (T-71A) in the 5'-regulatory region, rs2963238 (A1491C) in intron[] CPZ inhibited phosphatidylinositol 3-kinase (PI3K)/AKT/ mTOR pathway in U-87MG cells.[] […] double-dummy, active-controlled non-inferiority randomized study in Chinese patients (n 388) with schizophrenia randomly assigned to quetiapine XR or chlorpromazine for 6[] Notably, our previous studies revealed that the switch to chemoresistance in glioma cells is accompanied by a switch from the expression of CcO subunit 4 isoform 2 (COX4-2[] […] and, to a lesser extent, into phosphatidylinositol 4,5-bisphosphate in platelets pulse-labelled with [32P]Pi.[]

  • Isoproterenol

    We conducted experiments to identify the mechanisms involved in the regulatory functions of adrenergic signaling on erythroid differentiation and the expression of hemoglobin[] ET-1 mainly used the mitogen-activated protein kinase and phosphatidylinositol-3-kinase/AKT pathways to activate GSK3β, whereas under ISO stimulation, only the phosphatidylinositol[] OBJECTIVE: To examine the association of plasma interleukin-6 (IL-6) concentrations with adiposity and fat cell metabolism in women.[] In contrast, β2 subunit protein levels decreased (down to 49%), while mRNA levels remained unchanged.[] Vascular Medicine, Peking University Third Hospital, Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory[]

  • Chelidonium

    Based on regulatory and liver unspecific ad hoc causality assessments in 22 spontaneous cases of Germany, causality levels for GC were considered probable in 16 and possible[] -6-yl)ethanols, one as ( )-ethyl 2-(dihydrosanguinarine-6-yl)acetate, and one as ( )-ethyl dihydrosanguinarine-6-carboxylate, respectively.[] The mRNA and protein expressions of major signal proteins like p38, p53, protein kinase B (AKT), phosphatidylinositol 3-kinases (PI3K), Janus kinase 3 (JAK3), signal transducer[] Comparison of lectin and DNase from the sap from leaves and roots of Chelidonium majus proved that both these compounds are composed of 24 kDa monomer subunits which have[] […] found to suppress collagen induced arthritis in mice via an inhibition of TNF-alpha, IL-6, IFN-y, B cells, gamma-delta-T cells (in spleen)and an increased level of CD4 CD25 regulatory[]

  • Newcastle Disease

    Additionally, NDV produced from HeLa-S3 cells is more resistant to complement than NDV from 293F cells, which correlated with higher expression and incorporation of complement regulatory[] Chen S 1, 2, 3 , Zhang Q 1, 4 , Xu D 2, 5 , Li Y 1, 2 , Fan Y 2 , Li W 2 , Yin X 2, 6 , Zhang Y 7 , Liu J 7 , Li X 2, 6, 8 , Sun L 2, 5 , Jin N 1, 2, 6, 8 .[] CONCLUSION: Susceptibility of tumor cells to NDV may be affected by alterations other than those of RAS/ERK and phosphatidylinositol 3-kinase (PI3K)/AKT signaling in uninfected[] HIF-1 is a heterodimeric transcriptional factor consisting of a regulated α (HIF-1α) and a constitutive β subunit (HIF-1β).[] […] immunology T-Lymphocytes, Regulatory/pathology Tumor Burden Substance Interleukin-2[]

  • Malignant Melanoma

    The observed activated phenotypes were attenuated during the course of therapy, but regulatory T cells belonging to the CD3 CD4 CD45RO CD25high fraction increased at disease[] Melanoma/drug therapy* Melanoma/genetics* Melanoma/metabolism Membrane Proteins/antagonists & inhibitors Membrane Proteins/genetics* Membrane Proteins/metabolism Mutation Phosphatidylinositol[] 7 , Kitano S 8 , Fujii T 6 , Udagawa H 7 , Takano T 5 .[] The expression levels of janus kinase (JNK), phosphorylated (P)‑JNK, Jun proto‑oncogene AP‑1 transcription factor subunit (c‑Jun) and p‑c‑Jun were determined following the[] De Smedt J 1, 2 , Van Kelst S 3, 4 , Boecxstaens V 5, 6 , Stas M 5, 6 , Bogaerts K 7, 8 , Vanderschueren D 9, 10 , Aura C 11, 12 , Vandenberghe K 13 , Lambrechts D 14, 15[]

  • Squamous Cell Carcinoma

    We constructed the regulatory network of differentially expressed circRNAs, miRNAs and mRNAs. qPCR findings for the expression of key genes in the network were consistent[] LESSONS: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor[] Hysterectomy specimens tested positive for low-risk human papillomavirus type 6, but negative for other high-risk human papillomavirus types.[] Hospital, 6-4-20 Fujimi, Chuo-ku, Sagamihara, 252-0236, Japan. 3 Department of Surgical Pathology, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo,[] BACKGROUND/AIMS: Considerable evidence indicates that long noncoding RNAs (lncRNAs) exert importantly regulatory functions during human cancer initiation and progression and[]

  • Niemann-Pick Disease Type C

    However, RID-alpha also induces a novel cellular phenotype, suggesting that it activates an autonomous cholesterol regulatory mechanism distinct from NPC disease gene products[] To better characterize this disease in China and improve genetic counseling, mutational analyses of NPC1 gene were carried out in 6 unrelated Chinese patients.[] The absence of ferritin immunoreactivity was shown using two different antisera, raised in rabbits, against ferritin from human spleen containing predominantly light-chain subunits[] Recognition that Niemann-Pick disease Type C and cystic fibrosis both impair cholesterol regulatory pathways also provides a rationale for identifying common therapeutic targets[] Eur J Paediatr Neurol. 2014 Nov;18(6):811-5. doi: 10.1016/j.ejpn.2014.07.009. Epub 2014 Aug 6.[]